human[organism] AND (smok* OR diet) - GEO DataSets

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Select item 2002527981.

Human Platelet Lysate-Cultured Adipose-Derived Stem Cell Sheets Promote Angiogenesis and Accelerate Wound Healing via CCL5 Modulation

(Submitter supplied) To further differentiate the gene expression of HPL-cultured or FBS-cultured ASC sheets, we have employed microarray analysis. ASCs were isolated from the subcutaneous fat tissue of four non-diabetic, non-smoking female donors with an average age of 45 y (32–57 y) and an average body mass index of 24.6 (21.0–26.6). Significantly up-regulated or down-regulated genes are highlighted in the HPL-cultured ASC sheets. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21185
2 Samples

Download data: TXT

Series

Accession:: GSE252798

ID:: 200252798

Select item 2002408612.

Ketogenicdiet versus standard high-carbohydrate nutrition in sepsis: a randomized controlled trial

(Submitter supplied) Sepsis patients suffer from severe metabolic and immunologic dysfunction that may be amplified by standard nutritional approaches relying primarily on carbohydrates. We here hypothesize that a ketogenic diet improves sepsis treatment. We conducted a monocentric open-labeled randomized controlled trial enrolling 40 adult sepsis patients. Patients were randomly assigned to either ketogenic diet (KD) or standard high-carbohydrate nutrition for 14 days and followed up until day 30. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
100 Samples

Download data: TXT

Series

Accession:: GSE240861

ID:: 200240861

Select item 2002684993.

Construction of a ceRNA network and screening of potential biomarkers and molecular targets in male smokers with chronic obstructive pulmonary disease

(Submitter supplied) Background. Circular RNAs (circRNAs) play an important role in the occurrence and development of diseases. However, the role of circRNAs in male smokers with chronic obstructive pulmonary disease (COPD) remains unclear. Methods. Stable COPD patients and healthy controls were recruited. Peripheral blood mononuclear cells (PBMCs) were extracted. After high-throughput RNA sequencing (RNA-Seq) of PBMCs, a bioinformatics method was used to analyse differentially expressed (DE) circRNAs (DEcircRNAs) and mRNAs (DEmRNAs). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL20301
10 Samples

Download data: FA, FASTA, GTF, TXT

Series

Accession:: GSE268499

ID:: 200268499

Select item 2002686034.

Transport of perfluoroalkyl substances across human induced pluripotent stem cell-derived intestinal epithelial cells in comparison with primary human intestinal epithelial cells and Caco-2 cells

(Submitter supplied) Humans can be exposed to per- and polyfluoroalkyl substances (PFASs) via many exposure routes, including diet, which may lead to several adverse health effects. So far, little is known about PFAS transport across the human intestinal barrier. In the current study, we aimed to assess the transport of 5 PFASs (PFOS, PFOA, PFNA, PFHxS and HFPO-DA) in a human induced pluripotent stem cell (hiPSC)-derived intestinal epithelial cell (IEC) model. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: TXT

Series

Accession:: GSE268603

ID:: 200268603

Select item 2002616865.

Ketogenic diet modifies ribosomal protein dysregulation in KMT2D Kabuki Syndrome

(Submitter supplied) Background Kabuki syndrome (KS) is a genetic disorder caused by DNA mutations in KMT2D, a lysine methyltransferase that methylates histones and other proteins, and therefore modifies chromatin structure and subsequent gene expression. Ketones, derived from the ketogenic diet, are histone deacetylase inhibitors that can ‘open’ chromatin and encourage gene expression. Preclinical studies have shown that the ketogenic diet rescues hippocampal memory neurogenesis in mice with KS via the epigenetic effects of ketones. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
5 Samples

Download data: MTX, TSV

Series

Accession:: GSE261686

ID:: 200261686

Select item 2002342056.

Effects of an In Vivo Vaping Challenge on In Vitro IL-6 Biosynthesis Pathways in Arterial Endothelial Cells Derived from Human Embryonic Stem Cells

(Submitter supplied) Electronic nicotine delivery system (ENDs) use among youth and young adults is increasing at a rapid pace and represents a growing public health threat.1 Newer generation devices heat e-liquids to higher temperatures and can achieve higher serum nicotine concentrations than older devices.1 Interleukin-6 (IL-6) is a cytokine that mediates atherogenesis and independently predicts future atherosclerotic cardiovascular disease events.2 Previous in vitro studies have demonstrated increased IL-6 production by human alveolar macrophages exposed to ENDs condensate.3 Although there has been considerable focus on the effects of ENDs use on airway inflammation, there are a paucity of data on the effects of ENDS on arterial inflammation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30173
18 Samples

Download data: TSV

Series

Accession:: GSE234205

ID:: 200234205

Analyze with GEO2R

Select item 2000948197.

Biology and Ontogeny of Human Small Airway Epithelium Club Cells Identified with Single Cell Transcriptome and Principle Component Gradient Analysis

(Submitter supplied) Club (“Clara”) cells, dome shaped cells with disease cytoplasmic granules and microvilli, are the major secretory cell of the human small (>6 generation) airways. Little is known regarding the biology of club cells in the human airway, nor of the ontogeny of this cell type. Taking advantage of the SCGB1A1 as the marker for club cells and our ability to sample the normal small airway epithelium by bronchoscopy and brushing healthy volunteers, we defined the transcriptome of the normal human airway club cell using single cell transcriptome sequencing. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
157 Samples

Download data: CSV

Series

Accession:: GSE94819

ID:: 200094819

SRA Run Selector

Select item 2000645998.

The Role of Interleukin-23 in the Early Development of Emphysema in HIV1+ Smokers

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL570 GPL9115
42 Samples

Download data: CEL, CHP

Series

Accession:: GSE64599

ID:: 200064599

Analyze with GEO2R

Select item 2000645989.

The Role of Interleukin-23 in the Early Development of Emphysema in HIV1+ Smokers [RNA-seq]

(Submitter supplied) Matrix metalloproteinase-9 (MMP-9) expression is up-regulated in alveolar macrophages (AM) of HIV1+ smokers who develop emphysema. Based on the knowledge that lung epithelial lining fluid (ELF) of HIV1+ smokers has increased levels of inflammatory cytokines compared to HIV1- smokers, we hypothesized up-regulation of lung cytokines in HIV1+ smokers may be functionally related to increased MMP-9 expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9115
8 Samples

Download data: TXT

Series

Accession:: GSE64598

ID:: 200064598

Analyze with GEO2R SRA Run Selector

Select item 20006459310.

The Role of Interleukin-23 in the Early Development of Emphysema in HIV1+ Smokers [Affymetrix]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
34 Samples

Download data: CEL, CHP

Series

Accession:: GSE64593

ID:: 200064593

Analyze with GEO2R

Select item 20006446111.

Endothelial MMP14 is required for endothelial dependant growth support of human airway basal cells

(Submitter supplied) Human airway basal cells (BC) are the stem/progenitor population of the airway epithelium, and play a central role in anchoring the epithelium to the basement membrane. The anatomic position of BC allows for potential paracrine signaling between BC and the underlying non-epithelial stromal cells. In support of this, we previously demonstrated endothelial cells (EC) support growth of BC during co-culture via vascular endothelial growth factor A (VEGFA)-mediated signaling. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
10 Samples

Download data: FPKM_TRACKING

Series

Accession:: GSE64461

ID:: 200064461

Analyze with GEO2R SRA Run Selector

Select item 20004486512.

Vitamin-D Responsive SGPP2 Variants Associated with Lung Cell Expression and Lung Function

(Submitter supplied) Background: Vitamin D is associated with lung health in epidemiologi studies, but mechanisms mediating observed associations are poorly understood. This study explores mechanisms for an effect of vitamin D in lung through an in vivo gene expression study, an expression quantitative trait loci (eQTL) analysis in lung tissue, and a population-based cohort study of sequence variants. Methods: Microarray analysis investigated the association of gene expression in small airway epithelial cell with serum 25[OH]D in adult nonsmokers. more...

Organism:: Homo sapiens

Type:: Expression profiling by array; SNP genotyping by SNP array; Genome variation profiling by SNP array

Platforms:: GPL6804 GPL570
142 Samples

Download data: CEL, CHP

Series

Accession:: GSE44865

ID:: 200044865

Analyze with GEO2R

Select item 20003203013.

Empirical Bayes Conditional Independence Graphs for Dense Regulatory Network Recovery

(Submitter supplied) Motivation: Computational inference methods that make use of graphical models to extract regulatory networks from gene expression data can have difficulty reconstructing dense regions of a network, a consequence of both computational complexity and unreliable parameter estimation when sample size is small. As a result, identification of hub genes is of special difficulty for these methods.Methods: We present a new algorithm, Empirical Light Mutual Min (ELMM), for large network reconstruction that has properties well suited for dense graph recovery. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
270 Samples

Download data: CEL, CHP

Series

Accession:: GSE32030

ID:: 200032030

Analyze with GEO2R

Select item 20003144914.

Positional Identity of Branching-associated HOXB2 and B3 Gene Expression is Maintained by Adult Human Airway Epithelial Progenitor Cells

(Submitter supplied) In the context that HOX mutant mice have profound deficits in airway branching morphogenesis, we asked whether the positional identity of HOX genes is maintained in the epithelium of the adult human tracheobronchial tree and if so, whether these positional differences are embedded in the stem/progenitor population derived from nonbranching vs branching airways. We found that 10 of 39 HOX genes are expressed in varying degrees in the nonbranching (trachea) or branching (large and small airways) human airway epithelium. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
60 Samples

Download data: CEL, CHP

Series

Accession:: GSE31449

ID:: 200031449

Analyze with GEO2R

Select item 20002308715.

Genotype-Smoking Environment Interactions affecting eQTL in the Human Lung

(Submitter supplied) Background: Cases where genotype-phenotype relationships depend on environmental factors have been quantified for many complex diseases. Such genotype-environment interactions (GEI or GxE) may also affect expression Quantitative Trait Loci (eQTL) present in tissues critical for the manifestation of disease. To assess this hypothesis, we performed an analysis of eQTL-GEI resulting from an individual's smoking environment in the lung small airway epithelium (SAE). more...

Organism:: Homo sapiens

Type:: Expression profiling by array; SNP genotyping by SNP array

Platforms:: GPL570 GPL6804
180 Samples

Download data: CEL, CHP

Series

Accession:: GSE23087

ID:: 200023087

Analyze with GEO2R

Select item 20002135916.

Association of CXCL14 in the Human Airway Epithelium with Chronic Obstructive Lung Disease and Lung Cancer

(Submitter supplied) CXCL14, a recently described chemokine constitutively expressed in various epithelia, has multiple putative roles in inflammation and carcinogenesis. Based on the knowledge that cigarette smoking and the smoking-induced disorders, such as chronic obstructive pulmonary disease (COPD) and lung cancer, are associated with inflammation, we hypothesized that the airway epithelium, the primary site of smoking-induced pathologic changes in COPD and adenocarcinoma, responds to cigarette smoking with an altered CXCL14 gene expression as a part of disease-relevant molecular phenotype. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
135 Samples

Download data: CEL, CHP

Series

Accession:: GSE21359

ID:: 200021359

Analyze with GEO2R

Select item 20001393217.

Genetic Variability Modulation of SPOCK3 Gene Expression in the Human Small Airway Epithelium

(Submitter supplied) Testican 3 (coded for by SPOCK3), is an extracellular matrix heparan/chondroitin sulphate proteoglycan that possesses serine and cysteine protease inhibitor-like domains Based on the knowledge that serine proteases contribute to the destruction of the lung in cigarette smokers, but that only a fraction of smokers develop smoking-induced lung disease, we hypothesized that smokers expressed SPOCK3 at lower levels in the small airway epithelium, the initial site of smoking-induced disease, and further, that genetic variability modulates the expression of SPOCK3 in the airway epithelium. more...

Organism:: Homo sapiens

Type:: Expression profiling by array; SNP genotyping by SNP array; Genome variation profiling by SNP array

Platforms:: GPL570 GPL6804
212 Samples

Download data: CEL, CHP

Series

Accession:: GSE13932

ID:: 200013932

Analyze with GEO2R

Select item 20024617018.

Glucose deprivation regulates the expression of BACH1-upregulated pro-metastatic genes

(Submitter supplied) Since the primary effect of the ketogenic diet is to establish a glucose-deprived condition in vivo, we, therefore, used glucose starvation in vitro to mimic the effects of the keto diet. In our endeavor to comprehend the influence of glucose starvation on pro-metastatic genes associated with BACH1, we performed RNA-Seq analysis on MDA-MB-231 ctrl cells and BACH1 knockout cells.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
10 Samples

Download data: XLSX

Series

Accession:: GSE246170

ID:: 200246170

Analyze with GEO2R

Select item 20022128919.

rhBMP-2 synergizes with other signals to induce hBM-MSC multiple phenotype differentiation

(Submitter supplied) The Recombinant human bone morphogenetic protein 2 (rhBMP-2) and the human bone marrow mesenchymal stromal cells (hBM-MSCs) have been thoroughly studied with research and translational bone regenerative purposes. rhBMP-2 induces in vivo the endochondral ossification and bone formation processes, while hBM-MSCs are considered its target, bone forming cells. The in vitro ability of rhBMP-2 to induce hBM-MSC osteogenic differentiation has been previously tested. more...