GEO DataSets

Analysis of cerebral cortex from C57BL/6J and C3H/J strains at post-natal day 1 and week 11. These strains share similar collateral vessel anatomy but exhibit significantly different infarct volume. Results provide insight into molecular mechanisms modulating infarct volume.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 age, 2 other, 2 strain sets

Platform:

GPL1261

Series:

GSE46443

12 Samples

Download data: CEL

(Submitter supplied) Differential gene expression of cerebral cortex might be responsible for distinct neurovascular developments between different mouse strains We used Affymetrix microarray to explore the global gene expression patterns of mouse cerebral cortex of different mouse strains at two developmental stages

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5270

Platform:

GPL1261

12 Samples

Download data: CEL

(Submitter supplied) The first goal of the study was to find the genes that explain the difference in progression of age-related retinal degeneration (ageRD) between the inbred strains C57BL/6J-c2J (B6a) and BALB/cByJ (C). The specific goal was to find the candidate genes that explain the chromosome 6 and chromosome 10 quantitative trait loci (QTL) found in a previous study. Genes differentially expressed in retina between both strains and that map to the QTL are candidate genes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL9214

16 Samples

Download data

(Submitter supplied) A congenic line was constructed by introgressing a C3H chromosome 1 region harboring Bglu3 into C57BL/6 apoE-/- background. RNA was extracted from liver using a QIAGEN kit . Total RNA was pooled in an equal amount from 3 mice for each group. Standard Affymetrix procedures were performed using 8ug of total RNA. Microarrays were used to detect gene expression in the liver of Bglu3 congenic mice and C57BL/6 apoE-deficient mouse strains fed a western diet.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

2 Samples

Download data: CEL

(Submitter supplied) The pathogenesis of viral myocarditis is a multifactorial process involving host genetics, viral genetics and the environment in which they interact. Here, we used a model of infection with Coxsackievirus B3 to characterize the contribution of host genetics to viral myocarditis. We determined heart CVB3 load in mice from a classical intercross between progenitors A/J (H2a) and B10.A-H2a (B10.A) of different genetic backgrounds but with a common H2 haplotype. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

24 Samples

Download data: TXT

(Submitter supplied) Several studies have shown that bone mineral density (BMD), a clinically measurable predictor of osteoporotic fracture, is the sum of genetic and environmental influences. In addition, serum IGF-1 levels have been correlated to both BMD and fracture risk. We previously identified a Quantitative Trait Locus (QTL) for Bone Mineral Density (BMD) on mouse Chromosome (Chr) 6 that overlaps a QTL for serum IGF-1. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2442

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of livers of animals with decreased serum insulin-like growth factor-I (IGF-I) levels. The liver is the major source of serum IGF-I. The level of serum IGF-I is correlated to bone mineral density (BMD) and fracture risk. Results provide insight into the relationship between IGF-I and BMD.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 other, 2 strain sets

Platform:

GPL1261

Series:

GSE5959

6 Samples

Download data: CEL

(Submitter supplied) Our data demonstrates enrichment of the GO term extracellular region among the decreased lung transcripts of JF1 throughout the process of lung development and maturation in consistent to the altered elastin to collagen ratio. Our microarray data showed increased ~4 fold increased elastin transcripts in JF1 lungs at P70. Specific CL‐saline/air ratio in JF1 mice compared to C3H (JF1-male: 2.68±01.10 versus C3H-male: 2.15±0.42, p<0.05; JF1-female: 3.22±0.88 versus C3H-female: 2.27±0.23, p<0.05) suggests that surface tension contributes more than the elastic recoiling properties of lung in determining the lung compliance as assessed by air filling. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

30 Samples

Download data: CEL