GEO DataSets

Analysis of primary cultured hepatocytes exposed to 4 uM cadmium for 3 hours. Cadmium is a potent carcinogen. Results provide insight into the molecular basis of cadmium toxicity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL341

Series:

GSE8013

8 Samples

Download data: CEL, EXP

(Submitter supplied) The study was performed using primary rat hepatocyte in culture from 4 adult male Sprague-Dawley rats to investigate the changes in gene expression under low dose (4μM) and short exposure (3hrs) of cadmium chloride. By comparing the gene expression profiles of control and cadmium-treated cells, the most dramatic and significant changes were for those genes associated with transcriptional regulation, antioxidant response and control of protein integrity. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3632

Platform:

GPL341

8 Samples

Download data: CEL, EXP

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) Field-selected tolerance to heavy metals has been reported for Orchesella cincta (Arthropoda: Collembola) populations occurring at metal-contaminated mining sites. This tolerance is correlated with heritable increase of metal excretion efficiency; less pronounce cadmium induced growth reduction and, over-expression of the metallothionein gene. We applied transcriptomics to determine differential gene expression caused by this abiotic stress in reference and cadmium tolerant populations. more...

Organism:

Orchesella cincta

Type:

Expression profiling by array

Platform:

GPL7876

16 Samples

Download data: TXT

(Submitter supplied) Cephaloridine (CER) is a classical beta-lactam antibiotic that has long served as a model drug for the study of cephalosporin antibiotic-induced acute tubular necrosis. In the present study, we analyzed gene expression profiles in the kidney of rats given subtoxic and toxic doses of CER in order to identify gene expression alterations closely associated with CER-induced nephrotoxicity. Male Fisher 344 rats were intravenously injected with three different doses (150, 300, and 600 mg/kg) of CER, and sacrificed after 24 h. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3400

Platform:

GPL4135

12 Samples

Download data: TXT

Analysis of kidneys of animals treated with various doses of cephaloridine (CER). CER is a cephalosporin antibiotic used for studying cephalosporin antibiotic-induced renal tubule damage. Results provide insight into the mechanisms underlying cephalosporin antibiotic-induced nephrotoxicity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 4 dose sets

Platform:

GPL4135

Series:

GSE10034

12 Samples

Download data: TXT

(Submitter supplied) Cadmium (Cd) is a metal present in working and living environments known to be toxic and carcinogenic, but its mechanism of action remains still unclear. We investigated the gene expression modulation in human hepatoma cell line HepG2 after exposure to 2 µm and 10 µm cadmium using Agilent Whole human genome expression microarray.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5179

Platform:

GPL4133

9 Samples

Download data: TXT

Analysis of HepG2 liver cells treated with 2 or 10 uM cadmium. Cadmium is an environmental toxicant. Results provide insight into the molecular basis of cadmium toxicity.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 dose sets

Platform:

GPL4133

Series:

GSE31286

9 Samples

Download data: TXT