Similar studies for GEO DataSets (Select 200260815) - GEO DataSets

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Items: 17

Select item 2002608151.

The microglial transcriptome of age-associated deep subcortical white matter lesions suggests a neuroprotective response to blood-brain barrier dysfunction (microarray)

(Submitter supplied) Age-associated deep-subcortical white matter lesions (DSCL) are an independent risk factor for dementia, displaying high levels of CD68+ microglia. This study aimed to characterise the transcriptomic profile of microglia in DSCL and surrounding radiologically normal-appearing white matter (NAWM) compared to non-lesional control white matter. CD68+ microglia were isolated from white matter groups (n=4 cases per group) from the Cognitive Function and Ageing Study neuropathology cohort by immuno-laser capture microdissection. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23159
12 Samples

Download data: CEL

Series

Accession:: GSE260815

ID:: 200260815

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Select item 2002606192.

The microglial transcriptome of age-associated deep subcortical white matter lesions suggests a neuroprotective response to blood-brain barrier dysfunction

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: XLSX

Series

Accession:: GSE260619

ID:: 200260619

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Select item 2001573633.

Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response

(Submitter supplied) Age-associated Periventricular white matter lesions (PVL), reflecting white matter injury, are a common feature of the ageing brain. The aim of this study was to evaluate the transcriptomic profile of PVL using microarray analysis, in order to identify which pathways and/or gene expression changes may contribute to the pathogenesis of these lesions.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
18 Samples

Download data: CEL

Series

Accession:: GSE157363

ID:: 200157363

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Select item 2000836704.

Gene expression profiling of the astrocyte transcriptome in multiple sclerosis normal appearing white matter reveals a neuroprotective role

(Submitter supplied) Gene expression profiling has been performed on astrocytes isolated using laser capture microdissection (LCM) from multiple sclerosis normal appearing white matter (NAWM) and control WM to identify whether specific glial changes exist in NAWM which contribute to lesion development or prevent disease progression

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
7 Samples

Download data: CEL

Series

Accession:: GSE83670

ID:: 200083670

Select item 2001386145.

Next-generation sequencing study in multiple sclerosis white matter brain lesions

(Submitter supplied) Total RNA seq on human brain tissue samples.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21697
98 Samples

Download data: TXT

Series

Accession:: GSE138614

ID:: 200138614

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Select item 2001794276.

Brain macrophages adopt distinct profiles prior to demyelination in multiple sclerosis

(Submitter supplied) Multiple sclerosis is a disease of the central nervous system (CNS) that is characterized by inflammation and focal areas of demyelination, ultimately resulting in axonal degradation and neuronal death. Several lines of evidence point towards a role for microglia and other CNS-associated macrophages in disease initiation and progression, but exactly how lesion formation is triggered is currently unknown. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19057 GPL18573
87 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE179427

ID:: 200179427

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Select item 2001119727.

Transcriptional profiling of human microglia reveals grey-white matter heterogeneity and multiple sclerosis-associated changes

(Submitter supplied) Microglia are brain-resident, myelin-phagocytosing cells, yet their role in lesion initiation in grey and white matter regions in multiple sclerosis (MS) is unclear. We isolated primary microglia from both, occipital cortex and corpus callosum, of 10 MS and 11 control donors and studied their transcriptional profile by RNA sequencing, thereby identifying regional and MS-associated changes. Identification of pathways underlying regional differences showed a relatively increased type I interferon response in cortical grey matter microglia, while white matter microglia more highly expressed NF-κB pathway genes. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
31 Samples

Download data: TXT

Series

Accession:: GSE111972

ID:: 200111972

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Select item 2001268028.

Transcriptome analysis of normal-appearing white matter reveals cortisol- and disease-associated gene expression profiles in multiple sclerosis

(Submitter supplied) Inter-individual differences in cortisol production by the hypothalamus–pituitary–adrenal (HPA) axis are thought to contribute to clinical and pathological heterogeneity of multiple sclerosis (MS). At the same time, accumulating evidence indicates that MS pathogenesis may originate in the normal-appearing white matter (NAWM). Therefore, we performed a genome-wide transcriptional analysis of post-mortem NAWM of 9 control subjects and 18 MS patients to investigate to what extent gene expression reflects disease heterogeneity and HPA-axis activity. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13497
54 Samples

Download data: TXT

Series

Accession:: GSE126802

ID:: 200126802

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Select item 2001662079.

DNA methylation changes in glial cells implicate functional changes in oligodendrocytes, astrocytes and microglial cells in the normal appearing white matter of Multiple Sclerosis patients

(Submitter supplied) Background. Multiple Sclerosis is a chronic inflammatory disease of the central nervous system (CNS) characterized by autoimmune demyelination and subsequent neuro-axonal degeneration. Despite major progress in deciphering MS immunopathogenesis and treating early stages of disease, CNS-confined processes underpinning later progressive form of MS remain elusive, alluding to the poor accessibility to the target organ. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL21145
44 Samples

Download data: IDAT, TXT

Series

Accession:: GSE166207

ID:: 200166207

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Select item 20012384710.

RNA sequencing after forced turnover of adult and aged microglia

(Submitter supplied) The goal of this study was to determine whether depletion and repopulation of microglia in adult and aged mice reversed age-related immune priming.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
48 Samples

Download data: CSV

Series

Accession:: GSE123847

ID:: 200123847

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Select item 20019972411.

Transcriptional profiling of multiple system atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease [Oligodendrocytes LCM data]

(Submitter supplied) Multiple system atrophy (MSA) is a rare adult-onset neurodegenerative disease of unknown cause, with no effective therapeutic options, and no cure. Limited work to date has attempted to characterize the transcriptional changes associated with the disease, which presents as either predominating parkinsonian (MSA-P) or cerebellar (MSC-C) symptoms. We report here the results of RNA expression profiling of cerebellar white matter (CWM) tissue from two independent cohorts of MSA patients (n = 66) and healthy controls (HC; n = 66). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE199724

ID:: 200199724

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Select item 20019971512.

Transcriptional profiling of multiple system atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease [cohort 2]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
94 Samples

Download data: TXT

Series

Accession:: GSE199715

ID:: 200199715

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Select item 20013268813.

Unique microglia expression profile in developing white matter.

(Submitter supplied) Recently we demonstrated that amoeboid microglia in white matter regions are essential for proper oligodendrocyte homeostasis and myelinogenesis in the first postnatal week of mice. Amoeboid microglia in the corpus callosum change their activation profile already within few days after postnatal day (P)7 and microglia of the cerebellum show similar features to callosal microglia. Here we expanded our previous transcriptional analysis and performed bulk RNA sequencing of microglia during development in a detailed way in P7, P10 and P42 microglia from corpus callosum, cortex and cerebellum. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15103
33 Samples

Download data: TXT

Series

Accession:: GSE132688

ID:: 200132688

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Select item 20016135514.

Type 2 Diabetes Mellitus is Associated with Transcriptome Alterations in Cortical Neurones and Associated Neurovascular Unit Cells in the Ageing Brain

(Submitter supplied) Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. In addition to its contribution to small and large vessel disease, T2D may directly damage cells of the brain neurovascular unit. In this study, we investigated the transcriptomic changes in cortical neurones, and associated astrocytes and endothelial cells of the neurovascular unit, in the ageing brain

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
33 Samples

Download data: CEL

Series

Accession:: GSE161355

ID:: 200161355

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Select item 20001874015.

Luteolin has anti-inflammatory and neurotrophic effects on microglia

(Submitter supplied) Our aim was to identify genes that were differentially expressed in microglia stimulated with Lipopolysaccharide, Luteolin, or both. Affymetrix microarrays were used to analyze RNA samples

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3613
Platform:: GPL1261
12 Samples

Download data: CEL

Series

Accession:: GSE18740

ID:: 200018740

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Select item 361316.

Luteolin effect on pro-inflammatory challenged microglial cell line

Analysis of lipopolysaccharide-activated microglial BV-2 cells treated with luteolin, a plant derived flavonoid. Luteolin possesses the ability to scavenge oxygen and nitrogen species, and exhibits anti-inflammatory activities. Results provide insight into the immuno-modulatory effects of luteolin.