Similar studies for GEO DataSets (Select 200253782) - GEO DataSets

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Items: 2

Select item 2002537821.

Whole blood transcriptomics reveals G-CSF as a mediator of cardiopulmonary bypass- induced systemic inflammatory response syndrome

(Submitter supplied) Objectives: Systemic inflammatory response syndrome (SIRS) is a frequent complication of cardiopulmonary bypass (CPB). SIRS is associated with significant morbidity and mortality, but its pathogenesis remains incompletely understood, and as a result biomarkers are lacking, and treatment remains expectant and supportive. This study aimed to understand the pathophysiological mechanisms driving SIRS induced by CPB and identify novel therapeutic targets that might reduce systemic inflammation and improve patient outcomes. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
77 Samples

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Series

Accession:: GSE253782

ID:: 200253782

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001437802.

Shear Stresses Associated with Cardiopulmonary Bypass Activate Expression Inflammatory Cytokines and Induce Necroptosis in Monocytes Via Calcium Dependent Signaling

(Submitter supplied) Cardiopulmonary bypass (CPB), the mechanical support required during the majority of cardiac surgeries, causes significant systemic inflammation and multi-organ dysfunction that is especially severe in neonatal patients. Currently, the limited understanding of the molecular mechanisms that underlie CPB-associated inflammation presents a significant barrier to the development of therapeutic interventions. more...