Similar studies for GEO DataSets (Select 200244388) - GEO DataSets

Select item 2002443881.

PCB126 Modifies the Murine Hepatic Transcriptome and Metallome to Promote Alcohol-associated Liver Disease Pathogenesis

(Submitter supplied) Background: Environmental pollutants, including polychlorinated biphenyls (PCBs) have been shown to alter and promote the development of alcohol-associated liver disease (ALD). Our group recently demonstrated that PCB126 promoted steatosis, hepatomegaly, and modulated intermediary metabolism in an ALD rodent model. Objectives: To better understand how PCB126 promoted ALD, the current study adopts transcriptomic and metallomic approaches to identify mechanistic pathways involved in this promotion. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
24 Samples

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Series

Accession:: GSE244388

ID:: 200244388

PubMed Full text in PMC Similar studies

Select item 2002023862.

Identification of m6A-mediated changes in mouse liver after exposure to polychlorinated biphenyls (PCB126 and Aroclor1260) and high fat diet

(Submitter supplied) Exposure to polychlorinated biphenyls (PCBs) has been associated with liver injury in human cohorts and with nonalcoholic steatohepatitis (NASH) in mice fed a high fat diet (HFD). N(6)-methyladenosine (m6A) modification of mRNA regulates transcript fate, but the contribution of m6A modification on regulation of transcription in PCB-induced steatosis and fibrosis is unknown. This study tested the hypothesis that PCB and HFD exposure alters the levels of m6A modification in transcripts that play a role in NASH in vivo. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL19057
44 Samples

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Series

Accession:: GSE202386

ID:: 200202386

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Select item 2001732713.

Identification of m6A-mediated transcriptome changes in mouse liver after exposure to HFD, PCB126 and Aroclor mixtures

(Submitter supplied) Exposure to polychlorinated biphenyls (PCBs) and high fat diet (HFD) results in nonalcoholic steatohepatitis (NASH) in mice by altering intracellular signaling and inhibiting epidermal growth factor receptor (EGFR) signaling. Post-transcriptional chemical modification (PTM) of RNA regulates biological processes. This study tested the hypothesis that PCB exposure alters the global RNA epitranscriptome in HFD-fed male mouse liver. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
20 Samples

Download data: TXT

Series

Accession:: GSE173271

ID:: 200173271

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Select item 2002217134.

Retinoic Acid Receptor β Loss in Hepatocytes Increases Steatosis and Elevates the Integrated Stress Response in Alcohol-Associated Liver Disease

(Submitter supplied) Background & Aims: Alcohol-associated liver disease (ALD) is associated with loss of vitamin A (retinoids), increased steatosis, and greater oxidative stress. Although a strong correlation has been observed between loss of retinoids and ALD, if retinoid loss plays a causal role in the pathophysiology of ALD is not clear. Approach & Results: Based on our prior published data indicating that a selective retinoic acid receptor beta (RARβ) agonist limits nonalcohol-related liver disease (NAFLD) pathology, we generated AlbCre;RARβ knockout (BKO) mice and fed these mice a Lieber DeCarli ethanol diet (ETOH). more...