Similar studies for GEO DataSets (Select 200123847) - GEO DataSets

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Items: 20

Select item 2001238471.

RNA sequencing after forced turnover of adult and aged microglia

(Submitter supplied) The goal of this study was to determine whether depletion and repopulation of microglia in adult and aged mice reversed age-related immune priming.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
48 Samples

Download data: CSV

Series

Accession:: GSE123847

ID:: 200123847

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Select item 2001241692.

Microglial RNA-sequencing after stress-sensitization by repeated social defeat

(Submitter supplied) Stress is associated with an increased prevalence of anxiety and depression. Repeated social defeat (RSD) stress in mice increases the release of monocytes from the bone marrow that are recruited to the brain by microglia. These monocytes enhance inflammatory signaling and augment anxiety. Moreover, RSD promotes stress sensitization, in which exposure to acute stress 24 days after cessation of RSD causes anxiety recurrence. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
13 Samples

Download data: CSV

Series

Accession:: GSE124169

ID:: 200124169

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Select item 2000940423.

Microglial repopulation rewires and rejuvenates the aged brain

(Submitter supplied) Changes in microglial form and function contribute to age-related cognitive impairment. Developing methods to target microglia is critical to understand and prevent the adverse effects of aging. Using a specific colony-stimulating factor 1 receptor (CSF1R) inhibitor, our lab has shown that the majority of microglia can be eliminated from the CNS (Elmore et al., 2014). Withdrawal of the CSF1R inhibitor, stimulates brain-wide repopulation with new cells, that express microglial markers (Elmore et al., 2014; Elmore et al., 2015). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
9 Samples

Download data: CSV, XLSX

Series

Accession:: GSE94042

ID:: 200094042

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Select item 2001155714.

Single-cell transcriptomics reveals distinct microglia signatures under inflammation

(Submitter supplied) Microglia are specialized parenchymal-resident phagocytes of the central nervous system (CNS) that actively support, defend and modulate the neural environment. Dysfunctional microglia responses are believed to worsen CNS diseases, nevertheless their impact during the neuroinflammatory processes remains largely obscure. Here, using a combination of multicolor flow cytometry and single-cell RNA sequencing, we comprehensively profiled microglia in the brain of lipopolysaccharide (LPS)-injected mice. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
2 Samples

Download data: TXT

Series

Accession:: GSE115571

ID:: 200115571

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Select item 2001936255.

Astrocyte immunosenescence in IL-10 and cholesterol signaling in the aged brain impairs microglial regulation following peripheral immune activation

(Submitter supplied) The purpose of this study was to determine the cell-, age-, and time-specific transcriptional profiles of cells within the brain after peripheral immune challenge with lipopolysaccharide.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: RDS

Series

Accession:: GSE193625

ID:: 200193625

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Select item 2001607636.

Single-cell sequencing of cortical cells following murine traumatic brain injury [scRNA-seq]

(Submitter supplied) Traumatic brain injury (TBI) can lead to significant neuropsychiatric problemsand neurodegenerative pathologies, which develop and persist years after injury. Neuroinflammatory processes evolve over this same period. Cortical mRNA analysis showed a robust contribution of microglia to neuroinflammatory pathways that persisted over time post-injury. These data also indicate that inflammation persists in the subacute and chronic time points after TBI, which may affect surrounding neurons, oligodendrocytes and astrocytes. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
8 Samples

Download data: MTX, TSV

Series

Accession:: GSE160763

ID:: 200160763

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Select item 2001606517.

Cortical neuropathology RNA expression time-course after diffuse traumatic brain injury

(Submitter supplied) Traumatic brain injury (TBI) can lead to significant neuropsychiatric problems and neurodegenerative pathologies, which develop and persist years after injury. Neuroinflammatory processes evolve over this same period. Therefore, we aimed to determine the contribution of microglia to neuropathology at acute (1-day post-injury; dpi), subacute (7 dpi), and chronic (30 dpi) time-points. Microglia were depleted with PLX5622, a CSF1R antagonist, prior to midline fluid percussion injury in male mice and cortical neuropathology/inflammation was assessed using a neuropathology mRNA panel. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL29331
55 Samples

Download data: RCC

Series

Accession:: GSE160651

ID:: 200160651

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Select item 2001906078.

Single-cell Sequencing of Microglia following Repopulation Reveals Distinct Clusters and Transcriptomic Signatures in the 3xTg Alzheimer's Disease Model

(Submitter supplied) In this study, we aimed to deplete the aging microglia and investigate the impact of the newly-born microglia in Alzheimer's pathology using the 3xTg mouse model. Specifically, >24 mo male 3xTg mice were given chow containing 1200mg/kg PLX5622 (AIN-76A-D1001i, Research Diests, NJ, USA) for 2 weeks to deplete their microglia. Control diet with the same base formula were given to control group and to experimental groups during a 4-week repopulation phase immediately following PLX treatment. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
3 Samples

Download data: TAR

Series

Accession:: GSE190607

ID:: 200190607

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Select item 2000803049.

RNA Sequencing Facilitates Quantitative Analysis of Primary Microglia Transcriptomes II

(Submitter supplied) Using RNA-seq, we report here that primary microglia (PM) cells have a distinct transcriptomic signature and express a unique cluster of transcripts in response to 2hrs or 4 hrs with LPS.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
9 Samples

Download data: TXT

Series

Accession:: GSE80304

ID:: 200080304

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Select item 20007989810.

A novel synthetic jumonji H3K27 demethylase inhibitor GSK-J4 exert immunosuppressive activities

(Submitter supplied) Using RNA-seq, we report that jumonji H3K27 demethylase inhibitor, GSK-J4, exerts potent anti-inflammatory effects on LPS-stimulated BV-2 microglial cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
15 Samples

Download data: TXT

Series

Accession:: GSE79898

ID:: 200079898

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Select item 20013361711.

Transcriptome analysis of purified microglial cells from striatum and midbrain

(Submitter supplied) Microglia constitutes a diverse population of cells that present a broad spectrum of responses when they become activated. Here, microglial status was studied under steady-state conditions from different brain regions involved in neurodegenerative diseases. Under basal conditions, midbrain microglia showed an immune-alert state not observed in striatum. Unique subpopulations of microglia expressing TLR4 and MHC-II with antigen presenting properties, and a higher proportion of infiltrating CD4+ T cells were identified in the midbrain. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
10 Samples

Download data: TXT

Series

Accession:: GSE133617

ID:: 200133617

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Select item 20009004612.

C/EBPβ deficiency reshapes microglial gene expression

(Submitter supplied) CCAAT/enhancer binding protein β (C/EBPβ) is a transcription factor that regulates the expression of important pro-inflammatory genes in microglia. Mice deficient for C/EBPβ show protection against excitotoxic and ischemic CNS damage but the involvement of the various C/EBPβ expressing cell types in this neuroprotective effect is not solved. Since C/EBPβ-deficient microglia show attenuated neurotoxicity in culture we hypothesized that specific C/EBPβ deficiency in microglia could be neuroprotective in vivo. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11002
21 Samples

Download data: TXT

Series

Accession:: GSE90046

ID:: 200090046

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Select item 20005596813.

Transcriptome of Irradiated Microglia

(Submitter supplied) Whole brain irradiation remains important in the management of brain tumors. Although necessary for improving survival outcomes, cranial irradiation also results in cognitive decline in long-term survivors. A chronic inflammatory state characterized by microglial activation has been implicated in radiation-induced brain injury, and here we present a comprehensive transcriptional profile of irradiated microglia. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
12 Samples

Download data: CEL

Series

Accession:: GSE55968

ID:: 200055968

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Select item 20026081514.

The microglial transcriptome of age-associated deep subcortical white matter lesions suggests a neuroprotective response to blood-brain barrier dysfunction (microarray)

(Submitter supplied) Age-associated deep-subcortical white matter lesions (DSCL) are an independent risk factor for dementia, displaying high levels of CD68+ microglia. This study aimed to characterise the transcriptomic profile of microglia in DSCL and surrounding radiologically normal-appearing white matter (NAWM) compared to non-lesional control white matter. CD68+ microglia were isolated from white matter groups (n=4 cases per group) from the Cognitive Function and Ageing Study neuropathology cohort by immuno-laser capture microdissection. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23159
12 Samples

Download data: CEL

Series

Accession:: GSE260815

ID:: 200260815

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Select item 20026061915.

The microglial transcriptome of age-associated deep subcortical white matter lesions suggests a neuroprotective response to blood-brain barrier dysfunction

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: XLSX

Series

Accession:: GSE260619

ID:: 200260619

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Select item 20020661816.

Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with hyperphagocytosis and inflammatory neurodegeneration

(Submitter supplied) Lipofuscin is an autofluorescent (AF) pigment formed by lipids and misfolded proteins that accumulates in post-mitotic cells with advanced age. Here we immunophenotyped microglia in the brain of old C57BL/6 mice (>18 months-old) and demonstrate that in comparison to young mice, one third of old microglia are AF, characterized by profound changes in lipid and iron content, phagocytic activity, and oxidative stress. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
15 Samples

Download data: CSV

Series

Accession:: GSE206618

ID:: 200206618

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Select item 20024435817.

LPS-induced systemic inflammation mediates a protective effect against ischemic injury via microglia

(Submitter supplied) LPS-induced systemic inflammation mediates a protective action on ischemic injury via microglia. We used RNA sequencing analysis (RNA-seq) to gain molecular insights into microglia-mediated protection of cerebral infarction.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28457
6 Samples

Download data: TXT

Series

Accession:: GSE244358

ID:: 200244358

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Select item 20018898918.

Cortical diurnal rhythms remain intact with microglial depletion

(Submitter supplied) This dataset allows for the exploration of cortical genes at across different timepoints (ZT2, ZT6, ZT10, ZT14, ZT 18, ZT22) in control C57BL/6J mice compared to microglia-depleted C57BL/6J mice (10 day PLX5622 treatment).

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
47 Samples

Download data: CSV, TXT

Series

Accession:: GSE188989

ID:: 200188989

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Select item 20014236119.

Transcriptomic and Functional Studies Reveal Undermined Chemotactic and Angiostimulatory Properties of Aged Microglia During Stroke Recovery

(Submitter supplied) Age-dependent alterations in microglia behavior have been implicated in neurodegeneration and CNS injuries. Here, we compared the transcriptional profiles of young versus aged microglia during stroke recovery. CD45intermediateCD11b+ microglia were FACS-isolated from the brains of young (10-week-old) and aged (18-month-old) male mice 14 days after distal middle cerebral artery occlusion (dMCAO) or sham operation and subjected to RNA-sequencing analysis. more...