txid7215[Organism:exp] - GEO DataSets

Select item 2002473771.

A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer promoter communication

(Submitter supplied) 3D genome folding plays a fundamental role for the regulation of developmental genes by facilitating or constraining chromatin interactions between cis-regulatory elements (CREs). Polycomb response elements (PREs) are a specific kind of CREs involved in the memory of transcriptional states in Drosophila melanogaster. PREs act as nucleation sites for Polycomb group (PcG) proteins, which deposit the repressive histone mark H3K27me3, leading to the formation of a class of topologically associating domain (TADs) called Polycomb domains. more...

Organism:: Drosophila melanogaster

Type:: Other

Platforms:: GPL32218 GPL25244
62 Samples

Download data: BIGWIG, TAR, TXT

Series

Accession:: GSE247377

ID:: 200247377

Select item 2002231172.

Conserved intronic secondary structures with concealed branch sites regulate alternative splicing of poison exons

(Submitter supplied) Alternative splicing (AS) generates large amounts of RNA isoforms and dramatically increases the complexities of transcriptomes and proteomes. However, it remains unclear how RNA structures contribute to AS regulation. Here, we systematically search transcriptomes for secondary structures with concealed branch-sites (BSs) in the alternatively spliced introns and predict thousands from six organisms, of which many are evolutionarily conserved. more...

Organism:: Drosophila melanogaster; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL20795 GPL23702
29 Samples

Download data: TXT

Series

Accession:: GSE223117

ID:: 200223117

Select item 2002688213.

Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation [RNA-Seq]

(Submitter supplied) Mono-methylation of Lysine 20 of histone H4 (H4K20me1) is catalyzed by Set8 and thought to play important roles in many aspects of genome function that are mediated by H4K20me-binding proteins. We interrogated this model in a developing animal by comparing in parallel the transcriptomes of Set8null, H4K20R/A, and l(3)mbt mutant Drosophila melanogaster. We found that the gene expression profiles of H4K20A and H4K20R larvae are markedly different than Set8null larvae despite similar reductions in H4K20me1. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25244
47 Samples

Download data: TXT

Series

Accession:: GSE268821

ID:: 200268821

Select item 2002688204.

Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation [GFP-L3mbt_CUT&RUN]

(Submitter supplied) Mono-methylation of Lysine 20 of histone H4 (H4K20me1) is catalyzed by Set8 and thought to play important roles in many aspects of genome function that are mediated by H4K20me-binding proteins. We interrogated this model in a developing animal by comparing in parallel the transcriptomes of Set8null, H4K20R/A, and l(3)mbt mutant Drosophila melanogaster. We found that the gene expression profiles of H4K20A and H4K20R larvae are markedly different than Set8null larvae despite similar reductions in H4K20me1. more...

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL30203
8 Samples

Download data: BED, BW

Series

Accession:: GSE268820

ID:: 200268820

Select item 2002688195.

Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation [H4K20me1_CUT&RUN]

(Submitter supplied) Mono-methylation of Lysine 20 of histone H4 (H4K20me1) is catalyzed by Set8 and thought to play important roles in many aspects of genome function that are mediated by H4K20me-binding proteins. We interrogated this model in a developing animal by comparing in parallel the transcriptomes of Set8null, H4K20R/A, and l(3)mbt mutant Drosophila melanogaster. We found that the gene expression profiles of H4K20A and H4K20R larvae are markedly different than Set8null larvae despite similar reductions in H4K20me1. more...

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL30203
27 Samples

Download data: BED, BW

Series

Accession:: GSE268819

ID:: 200268819

Select item 2001338776.

Analysis of genes regulated by miRNAs upon Toll pathway activation in shmCherry and shAgo1 flies

(Submitter supplied) This micro-array helps establish Toll activated-genes dampened by miRNAs in Drosophila melanogaster.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL16820
12 Samples

Download data: TAB, TXT

Series

Accession:: GSE133877

ID:: 200133877

Analyze with GEO2R

Select item 2002299097.

Single-cell RNA sequencing of Drosophila wing discs harboring the scrib mutant clones in combination with RasV12, YkiS168A or NAct signals.

(Submitter supplied) It has long been proposed that cell competition functions to remove precancerous clones. A classical model is the removal of polarity-deficient clones such as the scribble (scrib) mutant clones in Drosophila imaginal discs. The activation of Ras, Yki or Notch signaling robustly reverses the scrib mutant clonal fate from elimination to tumorous growth. Using single-cell transcriptomics techniques to profile wing imaginal discs harboring the scrib mutant clones in combination with different signals, we found that a critical converging point downstream of Ras, Yki and Notch signals is the upregulation of Upd2, which is necessary to promote tumorous growth. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21306
8 Samples

Download data: CSV

Series

Accession:: GSE229909

ID:: 200229909

Select item 2002681268.

Co-transcriptional splicing facilitates transcription of gigantic genes

(Submitter supplied) Although introns are typically tens to thousands of nucleotides, there are notable exceptions. In flies as well as humans, a small number of genes contain introns that are more than 1000 times larger than typical introns, exceeding hundreds of kilobases (kb) to megabases (Mb). It remains unknown why gigantic introns exist and how cells overcome the challenges associated with their transcription and RNA processing. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25244
9 Samples

Download data: TXT

Series

Accession:: GSE268126

ID:: 200268126

Select item 2002639859.

Molecular insights into female hybrid sterility in interspecific crosses between Drosophila melanogaster and Drosophila simulans

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster; Drosophila simulans; Drosophila melanogaster x Drosophila simulans

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL34386 GPL25244 GPL33169
12 Samples

Download data

Series

Accession:: GSE263985

ID:: 200263985

Select item 20026398310.

Molecular insights into female hybrid sterility in interspecific crosses between Drosophila melanogaster and Drosophila simulans (small RNA-Seq)

(Submitter supplied) Species of the genus Drosophila have served as favorite models in speciation studies, however genetic factors of the interspecific hybrid sterility are underinvestigated to date. Here we performed the analysis of reproductive incompatibilities of hybrid females in crossing Drosophila melanogaster females and Drosophila simulans males. Using transcriptomic data analysis, molecular, cellular and genetic approaches we analyzed differential gene expression, transposable element (TE) activity, piRNA biogenesis and functional defects of oogenesis in hybrids. more...

Organism:: Drosophila simulans; Drosophila melanogaster; Drosophila melanogaster x Drosophila simulans

Type:: Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL25244 GPL33169 GPL34386
6 Samples

Download data: CSV

Series

Accession:: GSE263983

ID:: 200263983

Select item 20026398211.

Molecular insights into female hybrid sterility in interspecific crosses between Drosophila melanogaster and Drosophila simulans (RNA-Seq)

(Submitter supplied) Species of the genus Drosophila have served as favorite models in speciation studies, however genetic factors of the interspecific hybrid sterility are underinvestigated to date. Here we performed the analysis of reproductive incompatibilities of hybrid females in crossing Drosophila melanogaster females and Drosophila simulans males. Using transcriptomic data analysis, molecular, cellular and genetic approaches we analyzed differential gene expression, transposable element (TE) activity, piRNA biogenesis and functional defects of oogenesis in hybrids. more...

Organism:: Drosophila simulans; Drosophila melanogaster; Drosophila melanogaster x Drosophila simulans

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL33169 GPL25244 GPL34386
6 Samples

Download data: CSV

Series

Accession:: GSE263982

ID:: 200263982

Select item 20026773212.

Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis [RNA-Seq2]

(Submitter supplied) Genome organization can regulate gene expression and promote cell fate transitions. The differentiation of germline stem cells (GSCs) to oocytes in Drosophila involves changes in genome organization mediated by heterochromatin and the nuclear pore complex (NPC). Heterochromatin represses germ-cell genes during differentiation and NPCs anchor these silenced genes to the nuclear periphery, maintaining silencing to allow for oocyte development. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19132
5 Samples

Download data: CSV

Series

Accession:: GSE267732

ID:: 200267732

Select item 20026306913.

Transcriptome profiling of wild type and DNMT3L-overexpressing Drosophila larvae brains

(Submitter supplied) The objective of the study was to examine the gene expression changes caused by human DNMT3L overexpression in Drosophila melanogaster brains. There were 6 samples in total- C1, C2, C3, D1, D2, and D3. C1-C3 were larvae brains from the strain of elavC155-Gal4, which were used as the control group (C). D1-D3 were larvae brains from the strain with DNMT3L overexpression, which were bred by crossing the strains of elavC155-Gal4 and w/w;P(UAS-DNMT3L,w+)/Cyo;TM2/TM6B and used as the DNMT3L overexpressing group (D). more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23323
6 Samples

Download data: TXT

Series

Accession:: GSE263069

ID:: 200263069

Select item 20025035114.

Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL25244 GPL19132
37 Samples

Download data: BED, BW

Series

Accession:: GSE250351

ID:: 200250351

Select item 20025035015.

Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis [CUT&RUN]

(Submitter supplied) Genome organization can regulate gene expression and promote cell fate transitions. The differentiation of germline stem cells (GSCs) to oocytes in Drosophila involves changes in Genome organization mediated by heterochromatin and the nuclear pore complex (NPC). Heterochromatin represses germ-cell genes during differentiation and NPCs anchor these silenced genes to the nuclear periphery, maintaining silencing to allow for oocyte development. more...

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL25244
24 Samples

Download data: BED, BW

Series

Accession:: GSE250350

ID:: 200250350

Select item 20024805716.

Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis [RNA-seq]

(Submitter supplied) Genome organization can regulate gene expression and promote cell fate transitions. The differentiation of germline stem cells (GSCs) to oocytes in Drosophila involves changes in genome organization mediated by heterochromatin and the nuclear pore complex (NPC). Heterochromatin represses germ-cell genes during differentiation and NPCs anchor these silenced genes to the nuclear periphery, maintaining silencing to allow for oocyte development. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19132
8 Samples

Download data: CSV

Series

Accession:: GSE248057

ID:: 200248057

Select item 20026392917.

Senescent glia link neuronal mitochondrial dysfunction and lipid droplet accumulation with age [19082_28_MASTER]

(Submitter supplied) Senescence is a cellular state linked to aging and age-onset disease across many mammalian species. Acutely, senescent cells promote wound healing and prevent tumor formation; but they are also pro-inflammatory, thus chronically exacerbate tissue decline. While senescent cells are active targets for anti-aging therapy, why these cells form in vivo, how they affect tissue aging, and the impact of their elimination remain unclear. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25244
16 Samples

Download data: TSV

Series

Accession:: GSE263929

ID:: 200263929

Select item 20026392818.

Senescent glia link neuronal mitochondrial dysfunction and lipid droplet accumulation with age

(Submitter supplied) Senescence is a cellular state linked to aging and age-onset disease across many mammalian species. Acutely, senescent cells promote wound healing and prevent tumor formation; but they are also pro-inflammatory, thus chronically exacerbate tissue decline. While senescent cells are active targets for anti-aging therapy, why these cells form in vivo, how they affect tissue aging, and the impact of their elimination remain unclear. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25244
18 Samples

Download data: TSV

Series

Accession:: GSE263928

ID:: 200263928

Select item 20026392719.

Senescent glia link neuronal mitochondrial dysfunction and lipid droplet accumulation with age [19082-12_MASTER]

(Submitter supplied) Senescence is a cellular state linked to aging and age-onset disease across many mammalian species. Acutely, senescent cells promote wound healing and prevent tumor formation; but they are also pro-inflammatory, thus chronically exacerbate tissue decline. While senescent cells are active targets for anti-aging therapy, why these cells form in vivo, how they affect tissue aging, and the impact of their elimination remain unclear. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25244
16 Samples

Download data: TSV

Series

Accession:: GSE263927

ID:: 200263927

Select item 20026392620.

Senescent glia link neuronal mitochondrial dysfunction and lipid droplet accumulation with age [19082R-38_MASTER]

(Submitter supplied) Senescence is a cellular state linked to aging and age-onset disease across many mammalian species. Acutely, senescent cells promote wound healing and prevent tumor formation; but they are also pro-inflammatory, thus chronically exacerbate tissue decline. While senescent cells are active targets for anti-aging therapy, why these cells form in vivo, how they affect tissue aging, and the impact of their elimination remain unclear. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25244
12 Samples

Download data: TSV

Series

Accession:: GSE263926

ID:: 200263926

GEO DataSets

Functional Genomics Studies

Result Filters

Entry type

Organism

Study type

Author

Attribute name

Publication dates

Custom date range

Additional filters

Send to:

Search results

Items: 1 to 20 of 132289

Send to:

Supplemental Content

Find related data

Search details

Important Links

Recent activity

GEO DataSets

Functional Genomics Studies

Result Filters

Entry type

Organism

Study type

Author

Attribute name

Publication dates

Custom date range

Additional filters

Search results

Items: 1 to 20 of 132289

Page of 6615

Page of 6615

Supplemental Content

Find related data

Search details

Important Links

Recent activity