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Items: 7

1.

Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision

(Submitter supplied) Efforts to genetically reverse C9orf72 pathology have been hampered by our incomplete understanding of the regulation of this complex locus. We generated five different genomic excisions at the C9orf72 locus in a patient-derived iPSC line and a WT line (11 total isogenic lines), and examined gene expression and pathological hallmarks of C9 FTD/ALS in motor neurons differentiated from these lines. Comparing the excisions in these isogenic series removed the confounding effects of different genomic backgrounds and allowed us to probe the effects of specific genomic changes. more...
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL28352
5 Samples
Download data: BAM, BED, BW
Series
Accession:
GSE252200
ID:
200252200

PubMed Full text in PMC Similar studies

2.

Sequel II (Homo sapiens)

Organism:
Homo sapiens
129 Series
483 Samples
Download data
Platform
Accession:
GPL28352
ID:
100028352

3.

C9P5 HET(WT)x

Organism:
Homo sapiens
Source name:
iPSCs
Platform:
GPL28352
Series:
GSE252200
Download data: BAM, BED, BW
Sample
Accession:
GSM7996588
ID:
307996588

SRA Run Selector

4.

C9P5 1Ax

Organism:
Homo sapiens
Source name:
iPSCs
Platform:
GPL28352
Series:
GSE252200
Download data: BAM, BED, BW
Sample
Accession:
GSM7996587
ID:
307996587

SRA Run Selector

5.

C9P5 HET(Mut)x

Organism:
Homo sapiens
Source name:
iPSCs
Platform:
GPL28352
Series:
GSE252200
Download data: BAM, BED, BW
Sample
Accession:
GSM7996586
ID:
307996586

SRA Run Selector

6.

C9P5 Rex

Organism:
Homo sapiens
Source name:
iPSCs
Platform:
GPL28352
Series:
GSE252200
Download data: BAM, BED, BW
Sample
Accession:
GSM7996585
ID:
307996585

SRA Run Selector

7.

C9P5 unedited

Organism:
Homo sapiens
Source name:
iPSCs
Platform:
GPL28352
Series:
GSE252200
Download data: BAM, BED, BW
Sample
Accession:
GSM7996584
ID:
307996584

SRA Run Selector

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db=gds|term=GSE252200[Accession]|query=1|qty=2|blobid=MCID_665c614cb6fda62199281a83|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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