GEO DataSets

(Submitter supplied) The liver is the central organ in the regulation of nutrient metabolism, xenobiotic metabolism, and detoxification. Aging leads to a marked change in liver structure and function, characterized by a decline in weight, blood flow, regeneration rate, and detoxification. However, the mechanisms that contribute to these changes are poorly described. Global gene expression profiles of aged versus young adult dogs have not been compared previously. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3979

12 Samples

Download data: CEL

(Submitter supplied) The global changes in cardiac gene expression in dogs with alloxan-induced diabetes were studied using Affymetrix Canine Array. Cardiac RNA was extracted from the control and DM (n=4). The array data revealed that 797 genes were differentially expressed (P<0.01; fold change of at least ±2). 150 genes were expressed at significantly greater levels in diabetic dogs and 647 were significantly reduced.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3979

8 Samples

Download data: CEL, CHP

(Submitter supplied) Aging alters gastrointestinal morphology, microbiota, and functionality, and is associated with increased incidence of intestinal disease. The mechanisms that contribute to these changes are poorly described. Gene expression in dogs has been evaluated for a few select genes under pathogenic or varying dietary conditions, but global gene expression profiles of aged versus young adult dogs have not been compared previously. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3979

12 Samples

Download data: CEL

(Submitter supplied) Pulmonary metastasis continues to be the most common cause of death in osteosarcoma. Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has not significantly changed in over 20 years. Further understanding of the mechanisms of metastasis and resistance for this aggressive pediatric cancer is necessary. Pet dogs naturally develop osteosarcoma providing a novel opportunity to model metastasis development and progression. more...

Organism:

Canis lupus familiaris; Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL3979 GPL96

80 Samples

Download data: CEL

(Submitter supplied) Pulmonary metastasis continues to be the most common cause of death in osteosarcoma. Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has not significantly changed in over 20 years. Further understanding of the mechanisms of metastasis and resistance for this aggressive pediatric cancer is necessary. Pet dogs naturally develop osteosarcoma providing a novel opportunity to model metastasis development and progression. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3979

23 Samples

Download data: CEL

(Submitter supplied) mRNA trafficking and local protein translation are associated with protrusive cellular domains, such as neuronal growth cones, and deregulated control of protein translation is associated with tumor malignancy. We show here that activated RhoA, but not Rac1, is enriched in pseudopodia of MSV-MDCK-INV tumor cells and that Rho, Rho kinase (ROCK) and myosin II regulate the microtubule-independent targeting of RNA to these tumor cell domains. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3979

6 Samples

Download data: CEL, TXT

(Submitter supplied) Analysis of changes of gene expression profiles in the left ventricle (LV) during the progression of heart failure (HF) in the canine tachypacing induced HF model. Gene expression profiling was performed on samples collected at different time points representing various stages of LV dysfunction, i.e. tachypaced for 3 days (Day-3), 1 week (Week-1), 2 weeks (Week-2), 3-4 weeks (End stage), and unpaced controls (Day-0). more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3979

45 Samples

Download data: CEL, CHP

(Submitter supplied) Aging animals display a decline in a multitude of physical and physiological functions, including muscle function and strength. Muscle gene expression in dogs has been evaluated for a few select genes under pathogenic or varying dietary conditions, but global gene expression profiles of aged animals has not been performed. Because the mechanisms contributing to age-related decline in muscle function are poorly defined, we used canine microarrays to compare gene expression profiles of muscle tissue from geriatric and young adult dogs. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Dataset:

GDS3538

Platform:

GPL3979

12 Samples

Download data: CEL

(Submitter supplied) Mechanisms contributing to age-related cognitive decline are poorly defined. Thus, we used canine microarrays to compare gene expression profiles of brain tissue from geriatric and young adult dogs. Cerebral cortex samples were collected from 6 geriatric (12 yr-old) and 6 young adult (1 yr-old) female beagles after being fed one of two diets (animal protein-based versus plant-protein based) for 12 months. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3979

12 Samples

Download data: CEL

(Submitter supplied) Evaluation of global expression patterns provides a molecular portrait of mitral valve disease, yields insight into the pathophysiologic aspects of DMVD, and identifies intriguing genes and pathways for further study. (Am J Vet Res 2006;67:1307–1318) Keywords: control vs diseased

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3979

8 Samples

Download data: CEL, CHP

(Submitter supplied) This study attempts at investigating the changes in cardiac gene expression that occur in Dilated Cardiomyopathy (DCM). DCM in Dobermans and Boxers are the focus of this study. Control heart tissue as well as Pacing tissue used is from mongrel dogs. Keywords: control vs pacing vs disease; strain specific disease

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3979

13 Samples

Download data: CEL

(Submitter supplied) Hyperhomocysteinemia (HHCy) has been established as a risk factor for development of cardiovascular disease. Previous studies have focused on the alterations in vascular biology such as vasodilation and white cell infiltration. We have shown that in rats and mice with HHCy, superoxide reduces the ability of NO to regulate mitochondrial function. Molecular mechanisms responsible for HHCy changes in cardiac function and myocardial metabolism are not yet understood. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Dataset:

GDS2517

Platform:

GPL3979

8 Samples

Download data: CEL

(Submitter supplied) We have used chronic cardiac pacing in conscious dogs to study mechanism related to the development of dilated cardiomyopathy and the transition from compensated dysfunction (CD) to decompensated heart failure (HF). This occurs from the 3rd to 4th week of pacing with end-stage HF at 30?1 days. Keywords: disease state analysis

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Dataset:

GDS2424

Platform:

GPL3979

12 Samples

Download data: CEL