GPL20795[Accession] - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Search results

Items: 1 to 20 of 36152

<< First< Prev

Page of 1808

Select item 2002644451.

A DGCR8/FLII-dominated on-off switch for immediate-early genes governs embryo implantation in mouse and human

(Submitter supplied) As an essential checkpoint for successful pregnancy, mammalian embryo implantation initiates fetal-maternal communication. However, the underlying transcriptional regulation governing such a fast transition is still unknown. Here, we identify a DGCR8/FLII-dominated on-off switch for immediate-early genes (IEGs) governing pluripotency transition and morphogenesis of epiblasts upon embryo implantation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20795
5 Samples

Download data

Series

Accession:: GSE264445

ID:: 200264445

Select item 2002534432.

Investigating the cross-talk between circRNAs and PKR and its implication in the immune response in MS

(Submitter supplied) Circular RNAs (circRNAs) have emerged as a new type of endogenous non-coding RNA characterized by their covalently closed circular structure and a backspliced junction (BSJ) resulting from a back-splicing process. In the last years, several studies have shown that circRNAs are important modulators in the immune system, activation of inflammation, antibacterial and antiviral responses as well as autoimmune diseases, such as multiple sclerosis. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20795
16 Samples

Download data: CSV

Series

Accession:: GSE253443

ID:: 200253443

Select item 2002266203.

CD161 expression of TRM cells counteracts the HPV-associated clinical benefit in oropharyngeal cancer immunotherapy

(Submitter supplied) Oropharyngeal squamous cell carcinoma (OPSCC), a distinct head and neck cancer subtype that develops in the oropharynx, is well known to be categorized into human papillomavirus induced (HPV+) and non-HPV induced (HPV-). While HPV+ OPSCC is reported to be clinically advantageous compared to HPV- OPSCC, the heterogeneous responses in HPV+ OPSCC during immunotherapy treatment have not been well characterized at the molecular level. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL20795
30 Samples

Download data: MTX, RDS, TSV

Series

Accession:: GSE226620

ID:: 200226620

Select item 2002262314.

Capturing totipotency in human cells through spliceosomal repression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
112 Samples

Download data: BW, NARROWPEAK, TXT

Series

Accession:: GSE226231

ID:: 200226231

Select item 2002262295.

Capturing totipotency in human cells through spliceosomal repression [ATAC-seq]

(Submitter supplied) Supplemented with splicing inhibitor PlaB, we realize in vitro culturing of human totipotent stem cells comparable to 2-4-cell blastomeres Assay for transposase accessible chromatin with high-throughput sequencing in hESC sand hTBLCs

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
2 Samples

Download data: NARROWPEAK

Series

Accession:: GSE226229

ID:: 200226229

Select item 2002262286.

Capturing totipotency in human cells through spliceosomal repression [scRNA-seq]

(Submitter supplied) Supplemented with splicing inhibitor PlaB, we realize in vitro culturing of human totipotent stem cells comparable to 2-4-cell blastomeres

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20795
14 Samples

Download data: TXT

Series

Accession:: GSE226228

ID:: 200226228

Select item 2002262277.

Capturing totipotency in human cells through spliceosomal repression [ChIP-seq]

(Submitter supplied) Supplemented with splicing inhibitor PlaB, we realize in vitro culturing of human totipotent stem cells comparable to 2-4-cell blastomeres Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for h3k4me3 and h3k27me3 in hESC sand hTBLCs

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
4 Samples

Download data: BW

Series

Accession:: GSE226227

ID:: 200226227

Select item 2002247948.

Capturing totipotency in human cells through spliceosomal repression [RNA-Seq]

(Submitter supplied) Supplemented with splicing inhibitor PlaB, we realize in vitro culturing of human totipotent stem cells comparable to 2-4-cellb blastomeres Poly(A) RNA-seq is performed on hESCs cultured in MYCP medium

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20795
92 Samples

Download data: CSV

Series

Accession:: GSE224794

ID:: 200224794

Select item 2002632999.

Mis-splicing of mitotic regulators sensitizes SF3B1-mutated human HSCs to CHK1 inhibition [RNA-seq]

(Submitter supplied) Splicing factor SF3B1 mutations are frequent somatic lesions in myeloid neoplasms that transform hematopoietic stem cells (HSCs) by inducing mis-splicing of target genes. However, the molecular and functional consequences of SF3B1 mutations in human HSCs remain unclear. Here, we identify the mis-splicing program in human HSCs as a targetable vulnerability by precise gene editing of SF3B1 K700E mutations in primary CD34+ cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20795
10 Samples

Download data: CSV

Series

Accession:: GSE263299

ID:: 200263299

Select item 20025526810.

Differential gene expression analysis of wild type and heterozygous RB1 mutant human iPSC derived retinal organoids.

(Submitter supplied) Recent in vitro studies using RB1+/- fibroblasts and MSCs have shown molecular and functional disruptions without the need for biallelic loss of RB1. However, this was not reflected in the recent in vitro studies employing RB1+/- retinal organoids. To gain further insights into the molecular disruptions in the RB1+/- retinal organoids we performed a high throughput RNA-sequencing analysis.iPSCs were generated from RB1+/+ and RB1+/- Orbital adipose mesenchymal stem cells (OAMSCs) derived from retinoblastoma patients. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20795
8 Samples

Download data: TXT

Series

Accession:: GSE255268

ID:: 200255268

Select item 20025238111.

TWEAK/Fn14 signalling in Breast Cancer [p52_ChIP]

(Submitter supplied) This study explores the transcriptiomic and epigenetic roles of TWEAK/Fn14 signalling in Breast Cancer

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
2 Samples

Download data: BED, BW

Series

Accession:: GSE252381

ID:: 200252381

Select item 20023148312.

TWEAK/Fn14 signalling in Breast Cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL20795 GPL24676
64 Samples

Download data: BED, BW

Series

Accession:: GSE231483

ID:: 200231483

Select item 20023148213.

TWEAK/Fn14 signalling in Breast Cancer [patient K27 ChIP]

(Submitter supplied) This study explores the transcriptiomic and epigenetic roles of TWEAK/Fn14 signalling in Breast Cancer

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
24 Samples

Download data: BED, BW

Series

Accession:: GSE231482

ID:: 200231482

Select item 20023148114.

TWEAK/Fn14 signalling in Breast Cancer [patient ATAC-seq]

(Submitter supplied) This study explores the transcriptiomic and epigenetic roles of TWEAK/Fn14 signalling in Breast Cancer

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
12 Samples

Download data: BED, BW

Series

Accession:: GSE231481

ID:: 200231481

Select item 20023148015.

TWEAK/Fn14 signalling in Breast Cancer [cell line RNA-seq]

(Submitter supplied) This study explores the transcriptiomic and epigenetic roles of TWEAK/Fn14 signalling in Breast Cancer

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20795
24 Samples

Download data: TXT

Series

Accession:: GSE231480

ID:: 200231480

Select item 20023147916.

TWEAK/Fn14 signalling in Breast Cancer [cell line K27 ChIP]

(Submitter supplied) This study explores the transcriptiomic and epigenetic roles of TWEAK/Fn14 signalling in Breast Cancer

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
24 Samples

Download data: BED, BW

Series

Accession:: GSE231479

ID:: 200231479

Select item 20023147817.

TWEAK/Fn14 signalling in Breast Cancer [cell line hiChIP]

(Submitter supplied) This study explores the transcriptiomic and epigenetic roles of TWEAK/Fn14 signalling in Breast Cancer

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
4 Samples

Download data: COOL

Series

Accession:: GSE231478

ID:: 200231478

Select item 20023147718.

TWEAK/Fn14 signalling in Breast Cancer [cell line ATAC-seq]

(Submitter supplied) This study explores the transcriptiomic and epigenetic roles of TWEAK/Fn14 signalling in Breast Cancer

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
14 Samples

Download data: BED, BW

Series

Accession:: GSE231477

ID:: 200231477

Select item 20022419819.

Single-cell multi-omics analysis revealing immune features of inactivated SARS-CoV-2 vaccination in systemic lupus erythematosus patients

(Submitter supplied) The COVID-19 vaccine-induced immunity has been widely reported in the general population, but the protective immune response of COVID-19 vaccines in SLE patients (SLEs) remains largely unknown. Here, we performed a comprehensive and time-series investigation of immunological alterations induced by inactivated COVID-19 vaccines in SLEs and healthy controls using single-cell multi-omics methods. Compared with healthy controls (HCs), the lower titres of neutralizing antibodies and global transcriptomic and epigenomic changes in peripheral immune cells were detected in SLEs. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
26 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE224198

ID:: 200224198

Select item 20022320420.

Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver -HCC scRNAseq

(Submitter supplied) ADAR1 is thought to be an immune suppressor maintaining self-tolerance to endogenous nucleic acids. ADAR1 is often overexpressed in hepatocellular carcinoma tumors, and might contribute to immunosuppression and immune evasion of cancer cells. We performed single cell RNA sequencing on non-tumor and tumor HCC samples. Constructed libraries were sequenced on the HiSeq X platform. Over 150 million pairs of mappable reads for each sample were obtained.