ClinVar for Gene (Select 324) - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 3236466	NM_000038.6(APC):c.1141G>A (p.Ala381Thr)	APC (A322T +6 more)	Single nucleotide variant (missense variant +2 more)	Pancreatic ductal adenocarcinoma	OLikely oncogenic
Select item 3235960	NM_000038.6(APC):c.6239dup (p.Leu2080fs)	APC (L1696fs +18 more)	Duplication (frameshift variant +1 more)	Familial adenomatous polyposis 1	GLikely pathogenic
Select item 3233122	NM_000038.6(APC):c.1561T>G (p.Ser521Ala)	APC (S137A +18 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3232796	NM_000038.6(APC):c.1484T>C (p.Ile495Thr)	APC (I111T +18 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3232718	NM_000038.6(APC):c.1477T>A (p.Tyr493Asn)	APC (Y109N +18 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3232417	NM_000038.6(APC):c.1422C>T (p.Ala474=)	APC	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3232245	NM_000038.6(APC):c.1380del (p.Glu461fs)	APC (E178fs +12 more)	Deletion (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3232052	NM_000038.6(APC):c.1312A>C (p.Met438Leu)	APC (M155L +12 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231901	NM_000038.6(APC):c.1259G>A (p.Cys420Tyr)	APC (C137Y +12 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231892	NM_000038.6(APC):c.981G>C (p.Lys327Asn)	APC (K268N +6 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231876	NM_000038.6(APC):c.941T>C (p.Met314Thr)	APC (M255T +6 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231860	NM_000038.6(APC):c.918T>A (p.Ser306Arg)	APC (S23R +6 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231839	NM_000038.6(APC):c.892C>G (p.His298Asp)	APC (H15D +6 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231809	NM_000038.6(APC):c.8471A>T (p.Glu2824Val)	APC (E2440V +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231802	NM_000038.6(APC):c.8438C>G (p.Thr2813Arg)	APC (T2754R +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231787	NM_000038.6(APC):c.836G>C (p.Gly279Ala)	APC (G220A +5 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231776	NM_000038.6(APC):c.8321G>A (p.Ser2774Asn)	APC (S2390N +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231775	NM_000038.6(APC):c.8319T>A (p.Pro2773=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3231773	NM_000038.6(APC):c.8312G>A (p.Ser2771Asn)	APC (S2387N +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231772	NM_000038.6(APC):c.8301A>G (p.Ser2767=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3231771	NM_000038.6(APC):c.82G>C (p.Glu28Gln)	APC (E28Q)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231743	NM_000038.6(APC):c.8152_8153del (p.Leu2718fs)	APC (L2334fs +18 more)	Deletion (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3231729	NM_000038.6(APC):c.809A>T (p.Asn270Ile)	APC (N211I +5 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231709	NM_000038.6(APC):c.8058T>C (p.Val2686=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3231672	NM_000038.6(APC):c.8027del (p.Thr2676fs)	APC (T2292fs +18 more)	Deletion (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3231642	NM_000038.6(APC):c.7998T>C (p.Ile2666=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3231603	NM_000038.6(APC):c.7921A>G (p.Lys2641Glu)	APC (K2257E +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231587	NM_000038.6(APC):c.7898G>A (p.Gly2633Asp)	APC (G2249D +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231541	NM_000038.6(APC):c.7840A>G (p.Lys2614Glu)	APC (K2230E +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231519	NM_000038.6(APC):c.1164C>G (p.His388Gln)	APC (H105Q +6 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231475	NM_000038.6(APC):c.7751C>A (p.Ala2584Glu)	APC (A2200E +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231405	NM_000038.6(APC):c.7662T>G (p.His2554Gln)	APC (H2170Q +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231388	NM_000038.6(APC):c.763dup (p.His255fs)	APC (H196fs +5 more)	Duplication (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3231365	NM_000038.6(APC):c.7589G>C (p.Arg2530Pro)	APC (R2540P +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231329	NM_000038.6(APC):c.7536T>A (p.Ser2512Arg)	APC (S2128R +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231326	NM_000038.6(APC):c.7534A>G (p.Ser2512Gly)	APC (S2128G +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231324	NM_000038.6(APC):c.7526C>A (p.Pro2509His)	APC (P2125H +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231322	NM_000038.6(APC):c.7517A>C (p.Lys2506Thr)	APC (K2122T +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231298	NM_000038.6(APC):c.7452A>G (p.Leu2484=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3231296	NM_000038.6(APC):c.7447G>C (p.Val2483Leu)	APC (V2099L +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231282	NM_000038.6(APC):c.7421C>T (p.Pro2474Leu)	APC (P2090L +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231276	NM_000038.6(APC):c.7412C>A (p.Pro2471Gln)	APC (P2087Q +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231270	NM_000038.6(APC):c.1110G>T (p.Leu370Phe)	APC (L311F +6 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231252	NM_000038.6(APC):c.7331T>A (p.Ile2444Asn)	APC (I2060N +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231184	NM_000038.6(APC):c.7199G>A (p.Gly2400Glu)	APC (G2016E +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231174	NM_000038.6(APC):c.7173T>G (p.Ile2391Met)	APC (I2007M +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231149	NM_000038.6(APC):c.7103C>T (p.Ser2368Phe)	APC (S1984F +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231145	NM_000038.6(APC):c.7085G>T (p.Gly2362Val)	APC (G1978V +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231143	NM_000038.6(APC):c.7054A>T (p.Ser2352Cys)	APC (S1968C +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231142	NM_000038.6(APC):c.7051C>T (p.Pro2351Ser)	APC (P1967S +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231137	NM_000038.6(APC):c.7030C>T (p.Gln2344Ter)	APC (Q1960* +18 more)	Single nucleotide variant (nonsense +1 more)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3231132	NM_000038.6(APC):c.7024T>C (p.Leu2342=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3231122	NM_000038.6(APC):c.7007T>G (p.Ile2336Arg)	APC (I1952R +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231118	NM_000038.6(APC):c.697C>A (p.Gln233Lys)	APC (Q174K +3 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231090	NM_000038.6(APC):c.1051G>T (p.Gly351Ter)	APC (G292* +6 more)	Single nucleotide variant (nonsense +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3231082	NM_000038.6(APC):c.6925C>T (p.Pro2309Ser)	APC (P1925S +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231077	NM_000038.6(APC):c.6913A>C (p.Arg2305=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3231046	NM_000038.6(APC):c.6841G>C (p.Glu2281Gln)	APC (E1897Q +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231027	NM_000038.6(APC):c.6791G>A (p.Gly2264Asp)	APC (G1880D +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3231020	NM_000038.6(APC):c.6779G>C (p.Ser2260Thr)	APC (S1876T +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230981	NM_000038.6(APC):c.6710G>T (p.Arg2237Leu)	APC (R1853L +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230953	NM_000038.6(APC):c.6654A>C (p.Gln2218His)	APC (Q1834H +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230944	NM_000038.6(APC):c.6634C>G (p.Gln2212Glu)	APC (Q1828E +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230930	NM_000038.6(APC):c.659G>A (p.Arg220Lys)	APC (R161K +3 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230926	NM_000038.6(APC):c.6594G>T (p.Leu2198Phe)	APC (L1814F +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230918	NM_000038.6(APC):c.656C>G (p.Ala219Gly)	APC (A160G +3 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230905	NM_000038.6(APC):c.6498A>G (p.Arg2166=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230888	NM_000038.6(APC):c.6450T>C (p.Leu2150=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230887	NM_000038.6(APC):c.645+3A>T	APC	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230859	NM_000038.6(APC):c.6330C>G (p.Ser2110=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230857	NM_000038.6(APC):c.6294T>C (p.Asn2098=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230852	NM_000038.6(APC):c.626dup (p.Asp209fs)	APC (D150fs +3 more)	Duplication (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3230847	NM_000038.6(APC):c.6230_6231insCA (p.Leu2078fs)	APC (L1694fs +18 more)	Insertion (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3230844	NM_000038.6(APC):c.6181G>A (p.Glu2061Lys)	APC (E1677K +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230843	NM_000038.6(APC):c.616A>G (p.Thr206Ala)	APC (T147A +3 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230836	NM_000038.6(APC):c.6099C>T (p.Asp2033=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230833	NM_000038.6(APC):c.6043_6057del (p.Glu2015_Val2019del)	APC	Deletion (inframe_deletion +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230828	NM_000038.6(APC):c.600G>A (p.Met200Ile)	APC (M141I +3 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230826	NM_000038.6(APC):c.6003A>T (p.Lys2001Asn)	APC (K1617N +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230821	NM_000038.6(APC):c.5981A>C (p.Asp1994Ala)	APC (D1610A +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230820	NM_000038.6(APC):c.597del (p.Met200fs)	APC (M141fs +3 more)	Deletion (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3230816	NM_000038.6(APC):c.592G>T (p.Val198Phe)	APC (V139F +3 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230813	NM_000038.6(APC):c.58A>G (p.Asn20Asp)	APC (N20D)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230807	NM_000038.6(APC):c.5839A>T (p.Thr1947Ser)	APC (T1563S +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230785	NM_000038.6(APC):c.571T>A (p.Tyr191Asn)	APC (Y132N +3 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230781	NM_000038.6(APC):c.5691C>G (p.His1897Gln)	APC (H1513Q +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230777	NM_000038.6(APC):c.5651C>A (p.Ala1884Glu)	APC (A1500E +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230773	NM_000038.6(APC):c.5625C>A (p.Ser1875=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230772	NM_000038.6(APC):c.5620C>T (p.Leu1874Phe)	APC (L1490F +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230763	NM_000038.6(APC):c.5537A>G (p.Tyr1846Cys)	APC (Y1462C +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230761	NM_000038.6(APC):c.5529T>G (p.Pro1843=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230751	NM_000038.6(APC):c.5469C>T (p.Phe1823=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230740	NM_000038.6(APC):c.5383T>A (p.Ser1795Thr)	APC (S1411T +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230739	NM_000038.6(APC):c.5383_5384del (p.Ser1795fs)	APC (S1411fs +18 more)	Deletion (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3230736	NM_000038.6(APC):c.5381A>C (p.Asp1794Ala)	APC (D1410A +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230729	NM_000038.6(APC):c.5333C>A (p.Pro1778His)	APC (P1394H +18 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230713	NM_000038.6(APC):c.5277A>G (p.Ala1759=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230679	NM_000038.6(APC):c.5228_5229del (p.Val1743fs)	APC (V1359fs +18 more)	Microsatellite (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3230666	NM_000038.6(APC):c.5199C>A (p.Pro1733=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230626	NM_000038.6(APC):c.5083_5099del (p.Arg1695fs)	APC (R1311fs +18 more)	Deletion (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome	GPathogenic

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