C0346153[trait identifier] AND "Leiden Open Variation Database"[submit - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 126568	NM_024675.3(PALB2):c.*347A>C	PALB2	Single nucleotide variant	Familial cancer of breast	GLikely benign
Select item 126567	NM_024675.4(PALB2):c.*232G>T	PALB2	Single nucleotide variant (3 prime UTR variant)	Fanconi anemia complementation group N	GUncertain significance
Select item 128144	NM_024675.4(PALB2):c.3549C>A (p.Tyr1183Ter)	PALB2 (Y1183*)	Single nucleotide variant (nonsense)	Familial cancer of breast	GPathogenic FDA Recognized database
Select item 1245	NM_024675.4(PALB2):c.3549C>G (p.Tyr1183Ter)	PALB2 (Y1183*)	Single nucleotide variant (nonsense)	PALB2-related disorder +4 more	GPathogenic/Likely pathogenic
Select item 126747	NM_024675.4(PALB2):c.3539T>C (p.Ile1180Thr)	PALB2 (I1180T)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 141320	NM_024675.4(PALB2):c.3508C>T (p.His1170Tyr)	PALB2 (H1170Y)	Single nucleotide variant (missense variant)	not specified +3 more	GConflicting classifications of pathogenicity
Select item 140978	NM_024675.4(PALB2):c.3507_3508del (p.His1170fs)	PALB2 (H1170fs)	Microsatellite (frameshift variant)	not provided +5 more	GPathogenic/Likely pathogenic
Select item 830209	NM_024675.4(PALB2):c.3504C>G (p.Asp1168Glu)	PALB2 (D1168E)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 482010	NM_024675.4(PALB2):c.3500C>T (p.Thr1167Ile)	PALB2 (T1167I)	Single nucleotide variant (missense variant)	Familial cancer of breast +2 more	GUncertain significance
Select item 143975	NM_024675.4(PALB2):c.3497_3498del (p.Gly1166fs)	PALB2 (G1166fs)	Deletion (frameshift variant)	Familial cancer of breast +1 more	GPathogenic
Select item 126745	NM_024675.4(PALB2):c.3495G>A (p.Ser1165=)	PALB2	Single nucleotide variant (synonymous variant)	Familial cancer of breast +5 more	GBenign/Likely benign
Select item 126744	NM_024675.4(PALB2):c.3483T>C (p.Phe1161=)	PALB2	Single nucleotide variant (synonymous variant)	not provided +2 more	GBenign/Likely benign
Select item 216756	NM_024675.4(PALB2):c.3473A>G (p.His1158Arg)	PALB2 (H1158R)	Single nucleotide variant (missense variant)	Breast and/or ovarian cancer +2 more	GConflicting classifications of pathogenicity
Select item 128142	NM_024675.4(PALB2):c.3456dup (p.Pro1153fs)	PALB2 (P1153fs)	Duplication (frameshift variant)	PALB2-related disorder +4 more	GPathogenic
Select item 830207	NM_024675.4(PALB2):c.3453C>T (p.Leu1151=)	PALB2	Single nucleotide variant (synonymous variant)	Familial cancer of breast +1 more	GLikely benign
Select item 126742	NM_024675.4(PALB2):c.3433G>C (p.Gly1145Arg)	PALB2 (G1145R)	Single nucleotide variant (missense variant)	Familial cancer of breast +1 more	GUncertain significance
Select item 415976	NM_024675.4(PALB2):c.3432C>T (p.Leu1144=)	PALB2	Single nucleotide variant (synonymous variant)	PALB2-related disorder +6 more	GLikely benign
Select item 185799	NM_024675.4(PALB2):c.3426_3429del (p.Leu1142fs)	PALB2 (L1142fs)	Microsatellite (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 5 +3 more	GPathogenic
Select item 126741	NM_024675.4(PALB2):c.3428T>C (p.Leu1143Pro)	PALB2 (L1143P)	Single nucleotide variant (missense variant)	Familial cancer of breast +3 more	GUncertain significance
Select item 143974	NM_024675.4(PALB2):c.3426dup (p.Leu1143fs)	PALB2 (L1143fs)	Duplication (frameshift variant)	not provided +2 more	GPathogenic
Select item 183828	NM_024675.4(PALB2):c.3418T>G (p.Trp1140Gly)	PALB2 (W1140G)	Single nucleotide variant (missense variant)	Familial cancer of breast +4 more	GUncertain significance
Select item 182775	NM_024675.4(PALB2):c.3404G>A (p.Gly1135Glu)	PALB2 (G1135E)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GConflicting classifications of pathogenicity
Select item 490083	NM_024675.4(PALB2):c.3379T>C (p.Cys1127Arg)	PALB2 (C1127R)	Single nucleotide variant (missense variant)	Familial cancer of breast +2 more	GConflicting classifications of pathogenicity
Select item 126739	NM_024675.4(PALB2):c.3362del (p.Gly1121fs)	PALB2	Deletion (frameshift variant)	Familial cancer of breast	GLikely pathogenic FDA Recognized database
Select item 126738	NM_024675.4(PALB2):c.3356T>C (p.Leu1119Pro)	PALB2 (L1119P)	Single nucleotide variant (missense variant)	Familial cancer of breast +2 more	GConflicting classifications of pathogenicity
Select item 126736	NM_024675.4(PALB2):c.3350+16T>G	PALB2	Single nucleotide variant (intron variant)	Fanconi anemia complementation group N +3 more	GLikely benign
Select item 126735	NM_024675.4(PALB2):c.3350+11A>G	PALB2	Single nucleotide variant (intron variant)	Familial cancer of breast +2 more	GConflicting classifications of pathogenicity
Select item 665824	NM_024675.4(PALB2):c.3332C>T (p.Pro1111Leu)	PALB2 (P1111L)	Single nucleotide variant (missense variant)	Fanconi anemia complementation group N +3 more	GUncertain significance
Select item 460990	NM_024675.4(PALB2):c.3324C>G (p.Tyr1108Ter)	PALB2 (Y1108*)	Single nucleotide variant (nonsense)	Familial cancer of breast +1 more	GPathogenic/Likely pathogenic
Select item 126734	NM_024675.4(PALB2):c.3323del (p.Tyr1108fs)	PALB2	Deletion (frameshift variant)	not provided +5 more	GPathogenic
Select item 126733	NM_024675.4(PALB2):c.3321G>A (p.Leu1107=)	PALB2	Single nucleotide variant (synonymous variant)	Familial cancer of breast +1 more	GConflicting classifications of pathogenicity
Select item 126732	NM_024675.4(PALB2):c.3307G>A (p.Val1103Met)	PALB2 (V1103M)	Single nucleotide variant (missense variant)	not specified +4 more	GConflicting classifications of pathogenicity
Select item 230327	NM_024675.4(PALB2):c.3306C>T (p.Ser1102=)	PALB2	Single nucleotide variant (synonymous variant)	not provided +3 more	GLikely benign
Select item 126731	NM_024675.4(PALB2):c.3306C>G (p.Ser1102Arg)	PALB2 (S1102R)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 830203	NM_024675.4(PALB2):c.3301C>T (p.Leu1101Phe)	PALB2 (L1101F)	Single nucleotide variant (missense variant)	Familial cancer of breast	GUncertain significance
Select item 126730	NM_024675.4(PALB2):c.3300T>G (p.Thr1100=)	PALB2	Single nucleotide variant (synonymous variant)	not specified +7 more	GBenign/Likely benign
Select item 492217	NM_024675.4(PALB2):c.3297G>C (p.Thr1099=)	PALB2	Single nucleotide variant (synonymous variant)	Familial cancer of breast +1 more	GLikely benign
Select item 410162	NM_024675.4(PALB2):c.3296C>T (p.Thr1099Met)	PALB2 (T1099M)	Single nucleotide variant (missense variant)	Familial cancer of breast +6 more	GUncertain significance
Select item 142504	NM_024675.4(PALB2):c.3296C>G (p.Thr1099Arg)	PALB2 (T1099R)	Single nucleotide variant (missense variant)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 140834	NM_024675.4(PALB2):c.3290C>G (p.Pro1097Arg)	PALB2 (P1097R)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 830201	NM_024675.4(PALB2):c.3288C>A (p.Asn1096Lys)	PALB2 (N1096K)	Single nucleotide variant (missense variant)	Familial cancer of breast +1 more	GUncertain significance
Select item 183891	NM_024675.4(PALB2):c.3287A>G (p.Asn1096Ser)	PALB2 (N1096S)	Single nucleotide variant (missense variant)	Familial cancer of breast +1 more	GUncertain significance
Select item 142035	NM_024675.4(PALB2):c.3257G>A (p.Arg1086Gln)	PALB2 (R1086Q)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 126729	NM_024675.4(PALB2):c.3256C>T (p.Arg1086Ter)	PALB2 (R1086*)	Single nucleotide variant (nonsense)	Familial cancer of breast +9 more	GPathogenic/Likely pathogenic
Select item 126728	NM_024675.4(PALB2):c.3252G>A (p.Ser1084=)	PALB2	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +5 more	GBenign/Likely benign
Select item 126727	NM_024675.4(PALB2):c.3251C>T (p.Ser1084Leu)	PALB2 (S1084L)	Single nucleotide variant (missense variant)	not provided +5 more	GConflicting classifications of pathogenicity
Select item 126726	NM_024675.4(PALB2):c.3249G>C (p.Glu1083Asp)	PALB2 (E1083D)	Single nucleotide variant (missense variant)	Familial cancer of breast	GBenign FDA Recognized database
Select item 186946	NM_024675.4(PALB2):c.3244A>G (p.Ser1082Gly)	PALB2 (S1082G)	Single nucleotide variant (missense variant)	Pancreatic cancer, susceptibility to, 3 +3 more	GUncertain significance
Select item 232150	NM_024675.4(PALB2):c.3232T>A (p.Cys1078Ser)	PALB2 (C1078S)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 492213	NM_024675.4(PALB2):c.3226C>T (p.His1076Tyr)	PALB2 (H1076Y)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 126723	NM_024675.4(PALB2):c.3202-1G>C	PALB2	Single nucleotide variant (intron variant +1 more)	not provided +2 more	GPathogenic/Likely pathogenic
Select item 126724	NM_024675.4(PALB2):c.3202-45A>G	PALB2	Single nucleotide variant (intron variant)	Familial cancer of breast	GLikely benign
Select item 830180	NM_024675.3(PALB2):c.2835-324_3202-1757dup	PALB2	Duplication	Familial cancer of breast	GPathogenic
Select item 126719	NM_024675.4(PALB2):c.3201+1125T>C	PALB2	Single nucleotide variant (intron variant)	Familial cancer of breast	GUncertain significance
Select item 830194	NM_024675.4(PALB2):c.3114-3511_3201+191del	PALB2	Deletion (splice acceptor variant +1 more)	Familial cancer of breast	GPathogenic
Select item 126721	NM_024675.4(PALB2):c.3201+115T>C	PALB2	Single nucleotide variant (intron variant)	Familial cancer of breast	GLikely benign
Select item 126720	NM_024675.4(PALB2):c.3201+112A>G	PALB2	Single nucleotide variant (intron variant)	Familial cancer of breast	GUncertain significance
Select item 126722	NM_024675.4(PALB2):c.3201+96G>A	PALB2	Single nucleotide variant (intron variant)	Hereditary breast ovarian cancer syndrome	GLikely benign
Select item 143972	NM_024675.4(PALB2):c.3201+1G>C	PALB2	Single nucleotide variant (intron variant +1 more)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 830197	NM_024675.4(PALB2):c.3194C>T (p.Ser1065Phe)	PALB2 (S1065F)	Single nucleotide variant (missense variant)	Familial cancer of breast	GUncertain significance
Select item 126717	NM_024675.4(PALB2):c.3143A>G (p.Lys1048Arg)	PALB2 (K1048R)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 126716	NM_024675.4(PALB2):c.3128G>C (p.Gly1043Ala)	PALB2 (G1043A)	Single nucleotide variant (missense variant)	not provided +5 more	GUncertain significance
Select item 126715	NM_024675.4(PALB2):c.3116del (p.Asn1039fs)	PALB2	Deletion (frameshift variant)	not provided +6 more	GPathogenic/Likely pathogenic
Select item 231919	NM_024675.4(PALB2):c.3114G>A (p.Trp1038Ter)	PALB2 (W1038*)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic
Select item 126712	NM_024675.4(PALB2):c.3114-40T>G	PALB2	Single nucleotide variant (intron variant)	Familial cancer of breast	GLikely benign
Select item 126713	NM_024675.4(PALB2):c.3114-42G>T	PALB2	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 126714	NM_024675.4(PALB2):c.3114-51=	PALB2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 830193	NM_024675.4(PALB2):c.3113+1376C>G	PALB2	Single nucleotide variant (intron variant)	not specified	GBenign
Select item 126710	NM_024675.4(PALB2):c.3113+131G>T	PALB2	Single nucleotide variant (intron variant)	Familial cancer of breast	GLikely benign
Select item 231961	NM_024675.4(PALB2):c.3113+5G>C	PALB2	Single nucleotide variant (intron variant)	Familial cancer of breast +2 more	GPathogenic/Likely pathogenic
Select item 126711	NM_024675.4(PALB2):c.3113G>A (p.Trp1038Ter)	PALB2 (W1038*)	Single nucleotide variant (nonsense)	Familial cancer of breast	GPathogenic FDA Recognized database
Select item 188131	NM_024675.4(PALB2):c.3106G>C (p.Val1036Leu)	PALB2 (V1036L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GUncertain significance
Select item 219857	NM_024675.4(PALB2):c.3103A>T (p.Ile1035Phe)	PALB2 (I1035F)	Single nucleotide variant (missense variant)	not provided +4 more	GUncertain significance
Select item 830191	NM_024675.4(PALB2):c.3094A>T (p.Met1032Leu)	PALB2 (M1032L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 830190	NM_024675.4(PALB2):c.3088A>G (p.Thr1030Ala)	PALB2 (T1030A)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 822770	NM_024675.4(PALB2):c.3062G>A (p.Gly1021Glu)	PALB2 (G1021E)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 484207	NM_024675.4(PALB2):c.3060A>G (p.Gln1020=)	PALB2	Single nucleotide variant (synonymous variant)	Familial cancer of breast +1 more	GLikely benign
Select item 126709	NM_024675.4(PALB2):c.3056T>C (p.Val1019Ala)	PALB2 (V1019A)	Single nucleotide variant (missense variant)	Familial cancer of breast +3 more	GConflicting classifications of pathogenicity
Select item 420826	NM_024675.4(PALB2):c.3054G>T (p.Glu1018Asp)	PALB2 (E1018D)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 126708	NM_024675.4(PALB2):c.3054G>C (p.Glu1018Asp)	PALB2 (E1018D)	Single nucleotide variant (missense variant)	Familial cancer of breast	GBenign FDA Recognized database
Select item 576952	NM_024675.4(PALB2):c.3053A>C (p.Glu1018Ala)	PALB2 (E1018A)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 830187	NM_024675.4(PALB2):c.3049G>A (p.Ala1017Thr)	PALB2 (A1017T)	Single nucleotide variant (missense variant)	Familial cancer of breast	GUncertain significance FDA Recognized database
Select item 126707	NM_024675.4(PALB2):c.3048del (p.Phe1016fs)	PALB2 (F1016fs)	Deletion (frameshift variant)	Familial cancer of breast +5 more	GPathogenic/Likely pathogenic
Select item 574028	NM_024675.4(PALB2):c.3037A>G (p.Ile1013Val)	PALB2 (I1013V)	Single nucleotide variant (missense variant)	Familial cancer of breast +3 more	GConflicting classifications of pathogenicity
Select item 830185	NM_024675.4(PALB2):c.3026C>T (p.Pro1009Leu)	PALB2 (P1009L)	Single nucleotide variant (missense variant)	Familial cancer of breast	GUncertain significance
Select item 126706	NM_024675.4(PALB2):c.3026del (p.Pro1009fs)	PALB2 (P1009fs)	Deletion (frameshift variant)	not provided +2 more	GPathogenic
Select item 419928	NM_024675.4(PALB2):c.3025C>T (p.Pro1009Ser)	PALB2 (P1009S)	Single nucleotide variant (missense variant)	PALB2-related disorder +5 more	GUncertain significance
Select item 126705	NM_024675.4(PALB2):c.3024C>T (p.Pro1008=)	PALB2	Single nucleotide variant (synonymous variant)	Familial cancer of breast +1 more	GLikely benign
Select item 126704	NM_024675.4(PALB2):c.2997-624G>C	PALB2	Single nucleotide variant (intron variant)	Familial cancer of breast	GBenign
Select item 126702	NM_024675.4(PALB2):c.2996+183del	PALB2	Deletion (intron variant)	not provided	GBenign
Select item 126700	NM_024675.4(PALB2):c.2996+124C>T	PALB2	Single nucleotide variant (intron variant)	Familial cancer of breast	GLikely benign
Select item 126703	NM_024675.4(PALB2):c.2996+58T>C	PALB2	Single nucleotide variant (intron variant)	Familial cancer of breast	GLikely benign
Select item 126701	NM_024675.4(PALB2):c.2996+17T>C	PALB2	Single nucleotide variant (intron variant)	Breast-ovarian cancer, familial, susceptibility to, 5 +6 more	GBenign/Likely benign
Select item 126699	NM_024675.4(PALB2):c.2993G>A (p.Gly998Glu)	PALB2 (G998E)	Single nucleotide variant (missense variant)	not specified +7 more	GBenign/Likely benign
Select item 126697	NM_024675.4(PALB2):c.2982dup (p.Ala995fs)	PALB2 (A995fs)	Duplication (frameshift variant)	Hereditary cancer-predisposing syndrome +2 more	GPathogenic/Likely pathogenic
Select item 231886	NM_024675.4(PALB2):c.2971G>T (p.Val991Phe)	PALB2 (V991F)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 530214	NM_024675.4(PALB2):c.2966_2968del (p.Val989del)	PALB2 (V989del)	Deletion (inframe_deletion)	not specified +1 more	GUncertain significance
Select item 1246	NM_024675.4(PALB2):c.2962C>T (p.Gln988Ter)	PALB2 (Q988*)	Single nucleotide variant (nonsense)	Familial cancer of breast +2 more	GPathogenic
Select item 830183	NM_024675.4(PALB2):c.2955T>C (p.Ser985=)	PALB2	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 830182	NM_024675.4(PALB2):c.2941A>G (p.Ser981Gly)	PALB2 (S981G)	Single nucleotide variant (missense variant)	Familial cancer of breast	GUncertain significance

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