"PreventionGenetics, part of Exact Sciences"[submitter] AND "DICER1"[g - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 315099	NM_177438.3(DICER1):c.*5G>A	DICER1	Single nucleotide variant (3 prime UTR variant)	DICER1-related tumor predisposition	GLikely benign FDA Recognized database
Select item 479616	NM_177438.3(DICER1):c.*4C>T	DICER1	Single nucleotide variant (3 prime UTR variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 477273	NM_177438.3(DICER1):c.5762A>G (p.Asn1921Ser)	DICER1 (N1921S)	Single nucleotide variant (3 prime UTR variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 242143	NM_177438.3(DICER1):c.5748A>G (p.Gln1916=)	DICER1	Single nucleotide variant (3 prime UTR variant +1 more)	DICER1-related tumor predisposition +2 more	GLikely benign
Select item 220945	NM_177438.3(DICER1):c.5643T>C (p.Thr1881=)	DICER1 (L1827P)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition +4 more	GLikely benign
Select item 417064	NM_177438.3(DICER1):c.5625C>T (p.Asp1875=)	DICER1 (T1821M)	Single nucleotide variant (missense variant +1 more)	DICER1-related disorder +3 more	GLikely benign
Select item 727919	NM_177438.3(DICER1):c.5527+7T>C	DICER1	Single nucleotide variant (intron variant)	DICER1-related disorder +1 more	GLikely benign
Select item 242140	NM_177438.3(DICER1):c.5527+7T>A	DICER1	Single nucleotide variant (intron variant)	DICER1-related disorder +3 more	GConflicting classifications of pathogenicity
Select item 412116	NM_177438.3(DICER1):c.5504A>G (p.Tyr1835Cys)	DICER1 (Y1835C)	Single nucleotide variant (missense variant +1 more)	Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome +3 more	GConflicting classifications of pathogenicity
Select item 477261	NM_177438.3(DICER1):c.5479del (p.Leu1827fs)	DICER1 (L1827fs)	Deletion (frameshift variant +1 more)	DICER1-related tumor predisposition	GPathogenic FDA Recognized database
Select item 412119	NM_177438.3(DICER1):c.5441C>T (p.Ser1814Leu)	DICER1 (S1814L)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic FDA Recognized database
Select item 690482	NM_177438.3(DICER1):c.5389_5392del (p.Glu1797fs)	DICER1 (E1797fs)	Deletion (frameshift variant +1 more)	DICER1-related tumor predisposition +1 more	GPathogenic/Likely pathogenic
Select item 261926	NM_177438.3(DICER1):c.5391G>A (p.Glu1797=)	DICER1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 242135	NM_177438.3(DICER1):c.5388A>G (p.Glu1796=)	DICER1	Single nucleotide variant (synonymous variant +1 more)	not specified +3 more	GLikely benign
Select item 242137	NM_177438.3(DICER1):c.5337G>A (p.Lys1779=)	DICER1	Single nucleotide variant (synonymous variant)	not provided +2 more	GBenign/Likely benign
Select item 242133	NM_177438.3(DICER1):c.5241G>A (p.Ser1747=)	DICER1	Single nucleotide variant (synonymous variant)	not specified +4 more	GBenign/Likely benign
Select item 690481	NM_177438.3(DICER1):c.5222ACA[1] (p.Asn1742del)	DICER1 (N1742del)	Microsatellite (inframe_deletion)	DICER1-related tumor predisposition	GLikely pathogenic FDA Recognized database
Select item 690456	NM_177438.3(DICER1):c.5216T>C (p.Leu1739Pro)	DICER1 (L1739P)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 477247	NM_177438.3(DICER1):c.5190G>A (p.Gly1730=)	DICER1	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GBenign/Likely benign
Select item 417131	NM_177438.3(DICER1):c.5187G>A (p.Pro1729=)	DICER1	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +2 more	GBenign/Likely benign
Select item 690455	NM_177438.3(DICER1):c.5171C>T (p.Pro1724Leu)	DICER1 (P1724L)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GUncertain significance FDA Recognized database
Select item 221050	NM_177438.3(DICER1):c.5145C>T (p.Leu1715=)	DICER1	Single nucleotide variant (synonymous variant)	not provided +3 more	GBenign/Likely benign
Select item 690454	NM_177438.3(DICER1):c.5138A>T (p.Asp1713Val)	DICER1 (D1713V)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GLikely pathogenic FDA Recognized database
Select item 690453	NM_177438.3(DICER1):c.5126A>C (p.Asp1709Ala)	DICER1 (D1709A)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 690480	NM_177438.3(DICER1):c.5125G>A (p.Asp1709Asn)	DICER1 (D1709N)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GPathogenic FDA Recognized database
Select item 225884	NM_177438.3(DICER1):c.5103C>A (p.Tyr1701Ter)	DICER1 (Y1701*)	Single nucleotide variant (nonsense)	not provided +2 more	GPathogenic/Likely pathogenic
Select item 1118766	NM_177438.3(DICER1):c.5096-8C>T	DICER1	Single nucleotide variant (intron variant)	DICER1-related tumor predisposition +1 more	GLikely benign
Select item 135513	NM_177438.3(DICER1):c.5095+13C>T	DICER1	Single nucleotide variant (intron variant)	not specified +3 more	GBenign/Likely benign
Select item 656892	NM_177438.3(DICER1):c.5095+1G>A	DICER1 (G1564D +1 more)	Single nucleotide variant (missense variant +1 more)	not provided +1 more	GPathogenic/Likely pathogenic
Select item 242128	NM_177438.3(DICER1):c.5052C>G (p.Leu1684=)	DICER1	Single nucleotide variant (synonymous variant)	DICER1-related tumor predisposition	GLikely benign FDA Recognized database
Select item 690452	NM_177438.3(DICER1):c.5013_5017del (p.Lys1671fs)	DICER1 (K1671fs)	Microsatellite (frameshift variant)	not provided +1 more	GPathogenic/Likely pathogenic
Select item 1361992	NM_177438.3(DICER1):c.5013G>T (p.Lys1671Asn)	DICER1 (K1671N)	Single nucleotide variant (missense variant)	DICER1-related disorder +3 more	GUncertain significance
Select item 690479	NM_177438.3(DICER1):c.4956_4959del (p.His1652fs)	DICER1 (H1652fs)	Deletion (frameshift variant)	not provided	GLikely pathogenic
Select item 133973	NM_177438.3(DICER1):c.4923T>G (p.Cys1641Trp)	DICER1 (C1641W)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition +7 more	GConflicting classifications of pathogenicity
Select item 242127	NM_177438.3(DICER1):c.4910C>T (p.Ser1637Leu)	DICER1 (S1637L)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GBenign FDA Recognized database
Select item 242126	NM_177438.3(DICER1):c.4901T>C (p.Leu1634Ser)	DICER1 (L1634S)	Single nucleotide variant (missense variant)	DICER1-related disorder +3 more	GConflicting classifications of pathogenicity
Select item 417054	NM_177438.3(DICER1):c.4896T>C (p.Ser1632=)	DICER1	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 221072	NM_177438.3(DICER1):c.4891T>G (p.Ser1631Ala)	DICER1 (S1631A)	Single nucleotide variant (missense variant)	not specified +9 more	GBenign/Likely benign
Select item 483406	NM_177438.3(DICER1):c.4838A>T (p.Gln1613Leu)	DICER1 (Q1613L)	Single nucleotide variant (missense variant)	Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome +3 more	GUncertain significance
Select item 479635	NM_177438.3(DICER1):c.4805C>G (p.Ala1602Gly)	DICER1 (A1602G)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition +2 more	GConflicting classifications of pathogenicity
Select item 242120	NM_177438.3(DICER1):c.4802A>T (p.Lys1601Met)	DICER1 (K1601M)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition +3 more	GConflicting classifications of pathogenicity
Select item 220667	NM_177438.3(DICER1):c.4773C>T (p.Leu1591=)	DICER1	Single nucleotide variant (synonymous variant)	DICER1-related tumor predisposition +4 more	GConflicting classifications of pathogenicity
Select item 690478	NM_177438.3(DICER1):c.4695_4700del (p.Leu1566_Leu1567del)	DICER1	Deletion (inframe_deletion)	not provided	GUncertain significance
Select item 715134	NM_177438.3(DICER1):c.4698G>C (p.Leu1566=)	DICER1	Single nucleotide variant (synonymous variant)	DICER1-related tumor predisposition +2 more	GLikely benign
Select item 261925	NM_177438.3(DICER1):c.4680G>A (p.Ala1560=)	DICER1	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GBenign
Select item 429137	NM_177438.3(DICER1):c.4654C>T (p.Gln1552Ter)	DICER1 (Q1552*)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic/Likely pathogenic
Select item 225885	NM_177438.3(DICER1):c.4633dup (p.Ser1545fs)	DICER1 (S1545fs)	Duplication (frameshift variant)	not provided +2 more	GPathogenic/Likely pathogenic
Select item 254337	NM_177438.3(DICER1):c.4605_4606del (p.Cys1535fs)	DICER1 (C1535fs)	Microsatellite (frameshift variant)	Vertebral anomalies and variable endocrine and T-cell dysfunction +3 more	GPathogenic
Select item 242113	NM_177438.3(DICER1):c.4554T>A (p.Val1518=)	DICER1	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +4 more	GBenign/Likely benign
Select item 242112	NM_177438.3(DICER1):c.4515T>C (p.Ser1505=)	DICER1	Single nucleotide variant (synonymous variant)	not specified +3 more	GBenign/Likely benign
Select item 417111	NM_177438.3(DICER1):c.4509C>T (p.Tyr1503=)	DICER1	Single nucleotide variant (synonymous variant)	DICER1-related disorder +3 more	GLikely benign
Select item 477208	NM_177438.3(DICER1):c.4484C>T (p.Ser1495Leu)	DICER1 (S1495L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 483407	NM_177438.3(DICER1):c.4475T>C (p.Met1492Thr)	DICER1 (M1492T)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GLikely benign FDA Recognized database
Select item 429122	NM_177438.3(DICER1):c.4458dup (p.Ser1487fs)	DICER1 (S1487fs)	Duplication (frameshift variant)	DICER1-related tumor predisposition +3 more	GPathogenic/Likely pathogenic
Select item 690451	NM_177438.3(DICER1):c.4442G>A (p.Trp1481Ter)	DICER1 (W1481*)	Single nucleotide variant (nonsense)	DICER1-related tumor predisposition +1 more	GPathogenic/Likely pathogenic
Select item 261924	NM_177438.3(DICER1):c.4407T>C (p.Leu1469=)	DICER1	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GBenign/Likely benign
Select item 477202	NM_177438.3(DICER1):c.4406T>C (p.Leu1469Pro)	DICER1 (L1469P)	Single nucleotide variant (missense variant)	Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome +4 more	GConflicting classifications of pathogenicity
Select item 422631	NM_177438.3(DICER1):c.4405_4406del (p.Leu1469fs)	DICER1 (L1469fs)	Microsatellite (frameshift variant)	not provided +1 more	GPathogenic/Likely pathogenic
Select item 254332	NM_177438.3(DICER1):c.4309_4312del (p.Asp1437fs)	DICER1 (D1437fs)	Deletion (frameshift variant)	not provided +2 more	GPathogenic
Select item 417076	NM_177438.3(DICER1):c.4281G>A (p.Leu1427=)	DICER1	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 647083	NM_177438.3(DICER1):c.4216T>G (p.Cys1406Gly)	DICER1 (C1406G)	Single nucleotide variant (missense variant)	DICER1-related disorder +2 more	GUncertain significance
Select item 242105	NM_177438.3(DICER1):c.4207-3C>T	DICER1	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 3036165	NM_177438.3(DICER1):c.4206+9_4206+29del	DICER1	Deletion (intron variant)	DICER1-related disorder	GLikely benign
Select item 543700	NM_177438.3(DICER1):c.4206+9_4206+23del	DICER1	Deletion (intron variant)	DICER1-related tumor predisposition +2 more	GBenign/Likely benign
Select item 1050748	NM_177438.3(DICER1):c.4206+11_4206+13del	DICER1	Deletion (intron variant)	DICER1-related disorder +1 more	GLikely benign
Select item 315105	NM_177438.3(DICER1):c.4206+9G>T	DICER1	Single nucleotide variant (intron variant)	Euthyroid goiter +3 more	GBenign/Likely benign
Select item 221129	NM_177438.3(DICER1):c.4206+7_4206+8dup	DICER1	Duplication (intron variant)	DICER1-related tumor predisposition +2 more	GConflicting classifications of pathogenicity
Select item 429136	NM_177438.3(DICER1):c.4206+1G>T	DICER1	Single nucleotide variant (splice donor variant)	DICER1-related tumor predisposition +2 more	GPathogenic/Likely pathogenic
Select item 412173	NM_177438.3(DICER1):c.4199A>G (p.Asp1400Gly)	DICER1 (D1400G)	Single nucleotide variant (missense variant)	DICER1-related disorder +3 more	GConflicting classifications of pathogenicity
Select item 242100	NM_177438.3(DICER1):c.4178_4180dup (p.Asn1393dup)	DICER1	Duplication (inframe_insertion)	DICER1-related tumor predisposition	GLikely benign FDA Recognized database
Select item 690477	NM_177438.3(DICER1):c.4147C>T (p.Pro1383Ser)	DICER1 (P1383S)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 429133	NM_177438.3(DICER1):c.4140G>A (p.Trp1380Ter)	DICER1 (W1380*)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic/Likely pathogenic
Select item 417062	NM_177438.3(DICER1):c.4101C>T (p.Ser1367=)	DICER1	Single nucleotide variant (synonymous variant)	DICER1-related disorder +2 more	GLikely benign
Select item 690476	NM_177438.3(DICER1):c.4051-1G>A	DICER1	Single nucleotide variant (splice acceptor variant)	not provided +2 more	GLikely pathogenic
Select item 690475	NM_177438.3(DICER1):c.4050+12dup	DICER1	Duplication (intron variant)	not provided +2 more	GBenign/Likely benign
Select item 225887	NM_177438.3(DICER1):c.4050+1G>A	DICER1	Single nucleotide variant (splice donor variant)	DICER1-related tumor predisposition +3 more	GPathogenic/Likely pathogenic
Select item 221087	NM_177438.3(DICER1):c.4014G>A (p.Ala1338=)	DICER1	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GBenign/Likely benign
Select item 690449	NM_177438.3(DICER1):c.4005C>A (p.Tyr1335Ter)	DICER1 (Y1335*)	Single nucleotide variant (nonsense)	DICER1-related tumor predisposition +1 more	GPathogenic/Likely pathogenic
Select item 543686	NM_177438.3(DICER1):c.3993A>G (p.Leu1331=)	DICER1	Single nucleotide variant (synonymous variant)	not provided +3 more	GLikely benign
Select item 690474	NM_177438.3(DICER1):c.3988del (p.Tyr1330fs)	DICER1 (Y1330fs)	Deletion (frameshift variant)	not provided +1 more	GLikely pathogenic
Select item 412114	NM_177438.3(DICER1):c.3987A>G (p.Thr1329=)	DICER1	Single nucleotide variant (synonymous variant)	DICER1-related disorder +2 more	GConflicting classifications of pathogenicity
Select item 220744	NM_177438.3(DICER1):c.3972G>A (p.Lys1324=)	DICER1	Single nucleotide variant (synonymous variant)	DICER1-related tumor predisposition +5 more	GBenign/Likely benign
Select item 575211	NM_177438.3(DICER1):c.3957dup (p.Asp1320fs)	DICER1 (D1320fs)	Duplication (frameshift variant)	DICER1-related tumor predisposition +1 more	GPathogenic/Likely pathogenic
Select item 242096	NM_177438.3(DICER1):c.3957C>T (p.Gly1319=)	DICER1	Single nucleotide variant (synonymous variant)	DICER1-related tumor predisposition +2 more	GConflicting classifications of pathogenicity
Select item 417072	NM_177438.3(DICER1):c.3939G>A (p.Glu1313=)	DICER1	Single nucleotide variant (synonymous variant)	DICER1-related disorder +2 more	GConflicting classifications of pathogenicity
Select item 3050826	NM_177438.3(DICER1):c.3924T>C (p.Asp1308=)	DICER1	Single nucleotide variant (synonymous variant +1 more)	DICER1-related disorder	GLikely benign
Select item 242092	NM_177438.3(DICER1):c.3823A>G (p.Met1275Val)	DICER1 (M1275V)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition +2 more	GConflicting classifications of pathogenicity
Select item 2630009	NM_177438.3(DICER1):c.3785C>G (p.Pro1262Arg)	DICER1 (P1073R +4 more)	Single nucleotide variant (missense variant +1 more)	DICER1-related disorder	GUncertain significance
Select item 1734576	NM_177438.3(DICER1):c.3752C>T (p.Thr1251Ile)	DICER1 (T1251I +4 more)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition +2 more	GUncertain significance
Select item 417047	NM_177438.3(DICER1):c.3741T>C (p.Ala1247=)	DICER1	Single nucleotide variant (synonymous variant)	DICER1-related disorder +3 more	GLikely benign
Select item 690473	NM_177438.3(DICER1):c.3737del (p.Asn1246fs)	DICER1 (N1246fs)	Deletion (frameshift variant)	not provided	GLikely pathogenic
Select item 690472	NM_177438.3(DICER1):c.3675C>A (p.Tyr1225Ter)	DICER1 (Y1225*)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +2 more	GPathogenic/Likely pathogenic
Select item 690448	NM_177438.3(DICER1):c.3665dup (p.Leu1222fs)	DICER1 (L1222fs)	Duplication (frameshift variant)	DICER1-related tumor predisposition +1 more	GPathogenic/Likely pathogenic
Select item 412099	NM_177438.3(DICER1):c.3631G>C (p.Val1211Leu)	DICER1 (V1211L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 477149	NM_177438.3(DICER1):c.3567T>C (p.Tyr1189=)	DICER1	Single nucleotide variant (synonymous variant)	DICER1-related tumor predisposition +2 more	GLikely benign
Select item 133970	NM_177438.3(DICER1):c.3553G>A (p.Ala1185Thr)	DICER1 (A1185T)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GBenign FDA Recognized database
Select item 242086	NM_177438.3(DICER1):c.3496G>A (p.Val1166Ile)	DICER1 (V1166I)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 570911	NM_177438.3(DICER1):c.3475G>C (p.Glu1159Gln)	DICER1 (E1159Q)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 479610	NM_177438.3(DICER1):c.3474C>T (p.Ser1158=)	DICER1	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 261923	NM_177438.3(DICER1):c.3465G>T (p.Thr1155=)	DICER1	Single nucleotide variant (synonymous variant)	DICER1-related tumor predisposition +2 more	GLikely benign

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