"Genetic Services Laboratory, University of Chicago"[submitter] AND "M - ClinVar - NCBI

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Items: 15

	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 2443181	NM_002439.5(MSH3):c.161_162insCGCAGCGGC (p.Ala62_Pro63insAlaAlaAla)	DHFR, MSH3	Insertion (5 prime UTR variant +2 more)	not specified	GUncertain significance
Select item 730678	NM_000791.4(DHFR):c.-411G>A	DHFR, MSH3 (A58V)	Single nucleotide variant (5 prime UTR variant +2 more)	not specified +2 more	GBenign/Likely benign
Select item 787823	NM_000791.4(DHFR):c.-437GGGGCGCTG[4]	DHFR, MSH3	Microsatellite (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GBenign/Likely benign
Select item 778210	NM_000791.4(DHFR):c.-437GGGGCGCTG[5]	DHFR, MSH3	Microsatellite (5 prime UTR variant +2 more)	Inborn genetic diseases +3 more	GBenign/Likely benign
Select item 788096	NM_002439.5(MSH3):c.356C>T (p.Ser119Phe)	MSH3 (S119F)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GBenign/Likely benign
Select item 757367	NM_002439.5(MSH3):c.1194C>T (p.Gly398=)	MSH3	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 743358	NM_002439.5(MSH3):c.1469C>A (p.Ser490Tyr)	MSH3 (S490Y)	Single nucleotide variant (missense variant)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 780543	NM_002439.5(MSH3):c.1567G>A (p.Glu523Lys)	MSH3 (E523K)	Single nucleotide variant (missense variant)	MSH3-related disorder +5 more	GBenign/Likely benign
Select item 648147	NM_002439.5(MSH3):c.1858G>A (p.Asp620Asn)	MSH3 (D620N)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 1125613	NM_002439.5(MSH3):c.2223T>C (p.Ser741=)	MSH3	Single nucleotide variant (synonymous variant)	not provided +1 more	GLikely benign
Select item 658298	NM_002439.5(MSH3):c.2262A>G (p.Ile754Met)	MSH3 (I754M)	Single nucleotide variant (missense variant)	Endometrial carcinoma +4 more	GConflicting classifications of pathogenicity
Select item 780544	NM_002439.5(MSH3):c.2511G>A (p.Leu837=)	MSH3	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 710845	NM_002439.5(MSH3):c.2732T>G (p.Leu911Trp)	MSH3 (L911W)	Single nucleotide variant (missense variant)	not specified +2 more	GConflicting classifications of pathogenicity
Select item 757273	NM_002439.5(MSH3):c.2740A>G (p.Ile914Val)	MSH3 (I914V)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 658815	NM_002439.5(MSH3):c.3174A>G (p.Gln1058=)	MSH3	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity