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Sahota O, Narayanasamy M, Bastounis A, et al. Bisphosphonate alternative regimens for the prevention of osteoporotic fragility fractures: BLAST-OFF, a mixed-methods study. Southampton (UK): National Institute for Health and Care Research; 2024 Apr. (Health Technology Assessment, No. 28.21.)

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Bisphosphonate alternative regimens for the prevention of osteoporotic fragility fractures: BLAST-OFF, a mixed-methods study.

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Acknowledgements

We would first like to acknowledge the intervention participants for taking part in this study and sharing their views and experiences on being involved.

We would like to thank our external trial steering committee members, led Dr Nicola Peel (Chair), Professor Karen Barker, Dr Alex Thompson and Ms Lindsey Wallis (Nottingham Osteoporosis Society patient support group), members of the Royal Osteoporosis Society Francesca Thompson (Clinical and Operations Director), Jill Griffin (Professional Development Lead, ROS) and Belinda Thompson (Research Manager, ROS). Finally, a thank you to Rachael Taylor (Research Nurse/Study Coordinator, Nottingham University Hospital) and Maribel Cameron (Research Practitioner, Nottingham University Hospital).

Elizabeth Cottrell (NIHR Academic Clinical Lecturer in Primary Care) was the Co-Applicant for Stakeholder/consensus methodology (Stage 2) and was involved in conduct, analysis and dissemination. Dawn van Berkel (Research Fellow) supported the ethics submissions for Stage 1A.

We had a strong ethnic and gender split within the research team, with a commitment to empowerment and improving male and female workforce productivity.

Two of our research fellows were junior members, supported and guided by the more senior members within the team.

Contributions of the authors

Opinder Sahota (https://orcid.org/0000-0003-0055-7637) (Chief Investigator) was responsible for the overall conception, design, data acquisition and analysis and interpretation of findings at each phase of this research. He is responsible for the overall content of this report and supervision of Dawn van Berkel.

Melanie Narayanasamy (https://orcid.org/0000-0003-3483-0777) (Research Fellow) was the recruited Research Fellow for the study and oversaw the day-to-day management of stage 1A. She led the recruitment of participants, conducted or oversaw the data collection and analysis and supported Simon Bishop.

Anastasios Bastounis (https://orcid.org/0000-0001-5861-9373) (Research Fellow) was the recruited Research Fellow for the study and oversaw the day-to-day management of stage 1B of the study. He led the reviews, conducted and oversaw the data collection and analysis, supported by Tessa Langley and Jo Leonardi-Bee.

Zoe Paskins (https://orcid.org/0000-0002-7783-2986) (Senior Reader and Honorary Consultant Rheumatologist) was the Co-Applicant Lead for Stage 2 and was involved in trial design, conduct, analysis and dissemination.

Simon Bishop (https://orcid.org/0000-0001-8527-7081) (Associate Professor in Organisational Behaviour) was the Co-Applicant Lead for Stage 1A and was involved in trial design, conduct, analysis and dissemination and supervision of Melanie Narayanasamy.

Tessa Langley (https://orcid.org/0000-0001-9560-1148) (Associate Professor in Health Economics) was the Co-Applicant Lead for Stage 1B and was involved in trial design, conduct, analysis and dissemination and supervision of Anastasios Bastounis.

Neil Gittoes (https://orcid.org/0000-0001-5963-214X) (Honorary Professor and Consultant Endocrinologist) was a Co-Applicant and was involved in overall trial design, conduct and analysis.

Sarah Davis (https://orcid.org/0000-0002-6609-4287) (Senior Lecturer in Health Economics) was a Co-Applicant for Health Economic Modelling (Stage 1B) and was involved in analysis and dissemination.

Ann Baily (Lay Member) was a Co-Applicant and Chair of PPI for Nottingham Osteoporosis Society Patient Support group.

Moira Holmes (Lay Member) was a Co-Applicant and a PPI member of Nottingham Osteoporosis Society Patient Support group.

Jo Leonardi-Bee (https://orcid.org/0000-0003-0893-6068) (Professor and Head of the Systematic Review Research group) was a Co-Applicant for Systematic review (Stage 1A) and was involved in trial conduct and analysis.

Publications

Bastounis A, Langley T, Davis S, Paskins Z, Gittoes N, Leonardi-Bee J, Sahota O. Assessing the effectiveness of bisphosphonates for the prevention of fragility fractures: an updated systematic review and network meta-analyses. JBMR Plus 2022;6(5):e10620. https://doi.org/10.1002/jbm4.10620. eCollection 2022 May.

Paskins Z, Bullock L, Manning F, Bishop S, Campbell P, Cottrell E, et al. Acceptability of, and preferences for, remote consulting during COVID-19 among older patients with two common long-term musculoskeletal conditions: findings from three qualitative studies and recommendations for practice. BMC Musculoskelet Disord 2022;23(1):312. https://doi.org/10.1186/s12891-022-05273-1

Paskins Z, Crawford-Manning F, Cottrell E, Corp N, Wright J, Jinks C, et al. Acceptability of bisphosphonates among patients, clinicians and managers: a systematic review and framework synthesis. BMJ Open 2020;10(11):e040634. https://doi.org/10.1136/bmjopen-2020-040634

Data-sharing statement

Owing to the sample size, known geographical locations and personal and organisational sensitivities, the qualitative and quantitative data sets will not be available for sharing. All requests for data should be sent to the corresponding author.

Ethics statement

Ethics approval required and achieved for Chapter 3: Jan 2020, North West – Preston Research Ethics Committee, REF: 19/NW/0714/.

Information governance statement

Nottingham University Hospitals NHS Trust (NUH) is committed to handling all personal information in line with the UK Data Protection Act (2018) and the General Data Protection Regulation (EU GDPR) 2016/679. Under Data Protection legislation NUH is the Data Processor; the Department for Health and Social Care (DHSC) is the Data Controller, and we process personal data in accordance with their instructions. You can find out more about how we handle personal data, including how to exercise your individual rights and the contact details for DHSC’s Data Protection Officer here (https://www.nuh.nhs.uk/data-requests-your-privacy).

Department of Health and Social Care disclaimer

This publication presents independent research commissioned by the National Institute for Health and Care Research (NIHR). The views and opinions expressed by the interviewees in this publication are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, MRC, NIHR Coordinating Centre, the HTA programme or the Department of Health and Social Care.

This monograph was published based on current knowledge at the time and date of publication. NIHR is committed to being inclusive and will continually monitor best practice and guidance in relation to terminology and language to ensure that we remain relevant to our stakeholders.

Disclaimers

This manuscript presents independent research funded by the National Institute for Health and Care Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, the HTA programme or the Department of Health and Social Care. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, the HTA programme or the Department of Health and Social Care.

Copyright © 2024 Sahota et al.

This work was produced by Sahota et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This is an Open Access publication distributed under the terms of the Creative Commons Attribution CC BY 4.0 licence, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. See: https://creativecommons.org/licenses/by/4.0/. For attribution the title, original author(s), the publication source – NIHR Journals Library, and the DOI of the publication must be cited.

Bookshelf ID: NBK602865

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