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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 78755-81-4
Drug Levels and Effects
Summary of Use during Lactation
No information is available on the clinical use of flumazenil during breastfeeding. Because flumazenil is not orally absorbed it is unlikely to adversely affect the breastfed infant. If the mother requires flumazenil, it is not a reason to discontinue breastfeeding. The half-life of the drug is 54 minutes, so withholding breastfeeding for 4 to 5 hours after a dose should minimize transfer to the infant.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Substance Identification
Substance Name
Flumazenil
CAS Registry Number
78755-81-4
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Synthesis of ethyl 8-fluoro-5,6-dihydro-5-[11C]methyl-6-oxo-4H-imidazo [1,5-a] [1,4]benzodiazepine-3-carboxylate (RO 15.1788-11C): a specific radioligand for the in vivo study of central benzodiazepine receptors by positron emission tomography.[Int J Appl Radiat Isot. 1984]Synthesis of ethyl 8-fluoro-5,6-dihydro-5-[11C]methyl-6-oxo-4H-imidazo [1,5-a] [1,4]benzodiazepine-3-carboxylate (RO 15.1788-11C): a specific radioligand for the in vivo study of central benzodiazepine receptors by positron emission tomography.Maziere M, Hantraye P, Prenant C, Sastre J, Comar D. Int J Appl Radiat Isot. 1984 Oct; 35(10):973-6.
- Determination of the benzodiazepine antagonist Ro 15-1788 in plasma by high-performance liquid chromatography with UV detection.[Arzneimittelforschung. 1983]Determination of the benzodiazepine antagonist Ro 15-1788 in plasma by high-performance liquid chromatography with UV detection.Timm U, Zell M. Arzneimittelforschung. 1983; 33(3):358-62.
- Comparison of lorazepam [7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one] occupancy of rat brain gamma-aminobutyric acid(A) receptors measured using in vivo [3H]flumazenil (8-fluoro 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester) binding and [11C]flumazenil micro-positron emission tomography.[J Pharmacol Exp Ther. 2007]Comparison of lorazepam [7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one] occupancy of rat brain gamma-aminobutyric acid(A) receptors measured using in vivo [3H]flumazenil (8-fluoro 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester) binding and [11C]flumazenil micro-positron emission tomography.Atack JR, Scott-Stevens P, Beech JS, Fryer TD, Hughes JL, Cleij MC, Baron JC, Clark JC, Hargreaves RJ, Aigbirhio FI. J Pharmacol Exp Ther. 2007 Mar; 320(3):1030-7. Epub 2006 Dec 12.
- Review 2’-[(18)F]Fluoroflumazenil.[Molecular Imaging and Contrast...]Review 2’-[(18)F]Fluoroflumazenil.The MICAD Research Team. Molecular Imaging and Contrast Agent Database (MICAD). 2004
- Review Ethyl 8-fluoro-5-[(11)C]methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate.[Molecular Imaging and Contrast...]Review Ethyl 8-fluoro-5-[(11)C]methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate.Chopra A. Molecular Imaging and Contrast Agent Database (MICAD). 2004
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