Copyright Notice
Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.
Bookshelf ID: NBK562679PMID: 33017116
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 50-21-5; 77-92-9; 868-14-4
Drug Levels and Effects
Summary of Use during Lactation
No information is available on the use of vaginal lactic acid, citric acid, and potassium bitartrate as a contraceptive. The ingredients are normal components of maternal blood and absorption from the vagina should be minimal. No special precautions are required during breastfeeding.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Substance Identification
Substance Name
Lactic Acid, Citric Acid, and Potassium Bitartrate
CAS Registry Number
50-21-5; 77-92-9; 868-14-4
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
- User and Medical Advice Disclaimer
- Drugs and Lactation Database (LactMed) - Record Format
- LactMed - Database Creation and Peer Review Process
- Fact Sheet. Drugs and Lactation Database (LactMed)
- Drugs and Lactation Database (LactMed) - Glossary
- LactMed Selected References
- Drugs and Lactation Database (LactMed) - About Dietary Supplements
- Breastfeeding Links
- PubChem SubstanceRelated PubChem Substances
- Review Lactic acid, citric acid, and potassium bitartrate non-hormonal prescription vaginal pH modulator (VPM) gel for the prevention of pregnancy.[Expert Rev Clin Pharmacol. 2022]Review Lactic acid, citric acid, and potassium bitartrate non-hormonal prescription vaginal pH modulator (VPM) gel for the prevention of pregnancy.Su S, Vincent KL. Expert Rev Clin Pharmacol. 2022 Jun; 15(6):659-670. Epub 2022 Jul 21.
- Lactic Acid, Citric Acid, and Potassium Bitartrate (Phexxi) Vaginal Gel for Contraception.[Am Fam Physician. 2021]Lactic Acid, Citric Acid, and Potassium Bitartrate (Phexxi) Vaginal Gel for Contraception.Steinberg J, Lynch SE. Am Fam Physician. 2021 May 15; 103(10):628-629.
- EVO100 prevents chlamydia and gonorrhea in women at high risk of infection.[Am J Obstet Gynecol. 2021]EVO100 prevents chlamydia and gonorrhea in women at high risk of infection.Chappell BT, Mena LA, Maximos B, Mollan S, Culwell K, Howard B. Am J Obstet Gynecol. 2021 Aug; 225(2):162.e1-162.e14. Epub 2021 Mar 8.
- Review Mechanisms of action of currently available woman-controlled, vaginally administered, non-hormonal contraceptive products.[Ther Adv Reprod Health. 2022]Review Mechanisms of action of currently available woman-controlled, vaginally administered, non-hormonal contraceptive products.Chappell BT, Griffin BL, Howard B. Ther Adv Reprod Health. 2022 Jan-Dec; 16:26334941221107120. Epub 2022 Jul 7.
- Review NTP Developmental and Reproductive Toxicity Technical Report on the Prenatal Development Studies of Dimethylaminoethanol Bitartrate (CASRN 5988-51-2) in Sprague Dawley (Hsd:Sprague Dawley(®) SD(®)) Rats (Gavage Studies): DART Report 04[ 2020]Review NTP Developmental and Reproductive Toxicity Technical Report on the Prenatal Development Studies of Dimethylaminoethanol Bitartrate (CASRN 5988-51-2) in Sprague Dawley (Hsd:Sprague Dawley(®) SD(®)) Rats (Gavage Studies): DART Report 04National Toxicology Program. 2020 Jun
- Lactic Acid, Citric Acid, and Potassium Bitartrate - Drugs and Lactation Databas...Lactic Acid, Citric Acid, and Potassium Bitartrate - Drugs and Lactation Database (LactMed®)
Your browsing activity is empty.
Activity recording is turned off.
See more...