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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 17141-74-1
Drug Levels and Effects
Summary of Use during Lactation
Because sodium zirconium cyclosilicate is not orally absorbed it is unlikely to reach the breastmilk or adversely affect the breastfed infant. No special precautions are required.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Substance Identification
Substance Name
Sodium Zirconium Cyclosilicate
CAS Registry Number
17141-74-1
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- Sodium Zirconium Cyclosilicate among Individuals with Hyperkalemia: A 12-Month Phase 3 Study.[Clin J Am Soc Nephrol. 2019]Sodium Zirconium Cyclosilicate among Individuals with Hyperkalemia: A 12-Month Phase 3 Study.Spinowitz BS, Fishbane S, Pergola PE, Roger SD, Lerma EV, Butler J, von Haehling S, Adler SH, Zhao J, Singh B, et al. Clin J Am Soc Nephrol. 2019 Jun 7; 14(6):798-809. Epub 2019 May 20.
- Review Sodium Zirconium Cyclosilicate (ZS-9): A Novel Agent for the Treatment of Hyperkalemia.[Pharmacotherapy. 2016]Review Sodium Zirconium Cyclosilicate (ZS-9): A Novel Agent for the Treatment of Hyperkalemia.Linder KE, Krawczynski MA, Laskey D. Pharmacotherapy. 2016 Aug; 36(8):923-33. Epub 2016 Aug 2.
- Zirconium cyclosilicate: An oral sorbent for potassium, four decades in the making.[Artif Organs. 2022]Zirconium cyclosilicate: An oral sorbent for potassium, four decades in the making.Ash SR. Artif Organs. 2022 Jun; 46(6):1192-1197. Epub 2022 Apr 19.
- Radiopacity of sodium zirconium cyclosilicate on CT imaging.[CEN Case Rep. 2021]Radiopacity of sodium zirconium cyclosilicate on CT imaging.Kolesnik M, Berezovsky D, Sayegh M, Samarneh M. CEN Case Rep. 2021 Nov; 10(4):559-562. Epub 2021 May 19.
- Review Pharmacodynamics and pharmacokinetics of sodium zirconium cyclosilicate [ZS-9] in the treatment of hyperkalemia.[Expert Opin Drug Metab Toxicol...]Review Pharmacodynamics and pharmacokinetics of sodium zirconium cyclosilicate [ZS-9] in the treatment of hyperkalemia.Packham DK, Kosiborod M. Expert Opin Drug Metab Toxicol. 2016 May; 12(5):567-73. Epub 2016 Apr 5.
- Sodium Zirconium Cyclosilicate - Drugs and Lactation Database (LactMed®)Sodium Zirconium Cyclosilicate - Drugs and Lactation Database (LactMed®)
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