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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
Drug Levels and Effects
Summary of Use during Lactation
Information in this record refers to the use of (14C)-glycocholic acid as a diagnostic agent. Breastfeeding does not need to be suspended after administration of (14C)-glycocholic acid.[1,2]
Drug Levels
Carbon 14 is a low-energy beta emitter with a physical half-life of about 5730 years. (14C)- glycocholic acid has an effective half-life of 143 hours. Approximately 9.2% of the injected radioactivity is excreted into breastmilk.[1]
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Leide-Svegborn S, Ahlgren L, Johansson L, et al. Excretion of radionuclides in human breast milk after nuclear medicine examinations. Biokinetic and dosimetric data and recommendations on breastfeeding interruption. Eur J Nucl Med Mol Imaging. 2016;43:808–21. [PubMed: 26732471]
- 2.
- Mattsson S, Johansson L, Leide Svegborn S, et al. Radiation dose to patients from radiopharmaceuticals: A compendium of current information related to frequently used substances. Annex D. Recommendations on breast-feeding interruptions. Ann ICRP. 2015;44(2) Suppl:319–21. [PubMed: 26069086]
Substance Identification
Substance Name
(14C)-Glycocholic Acid
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Review (1-14C)-Triolein.[Drugs and Lactation Database (...]Review (1-14C)-Triolein.. Drugs and Lactation Database (LactMed®). 2006
- Review d-Xylose C14.[Drugs and Lactation Database (...]Review d-Xylose C14.. Drugs and Lactation Database (LactMed®). 2006
- Long-term biokinetics and radiation exposure of patients undergoing 14C-glycocholic acid and 14C-xylose breath tests.[Cancer Biother Radiopharm. 2007]Long-term biokinetics and radiation exposure of patients undergoing 14C-glycocholic acid and 14C-xylose breath tests.Gunnarsson M, Leide-Svegborn S, Stenström K, Skog G, Nilsson LE, Thorsson O, Hellborg R, Mattsson S. Cancer Biother Radiopharm. 2007 Dec; 22(6):762-71.
- Effects of a meal on plasma clearance of [14C]glycocholic acid and indocyanine green in man.[Clin Sci (Lond). 1981]Effects of a meal on plasma clearance of [14C]glycocholic acid and indocyanine green in man.Marigold JH, Gilmore IT, Thompson RP. Clin Sci (Lond). 1981 Sep; 61(3):325-30.
- Plasma disappearance of 14C-glycocholic acid as a test of liver dysfunction. Relation to liver histology.[Scand J Gastroenterol. 1985]Plasma disappearance of 14C-glycocholic acid as a test of liver dysfunction. Relation to liver histology.Einarsson K, Angelin B, Glaumann H. Scand J Gastroenterol. 1985 Mar; 20(2):175-8.
- (14C)-Glycocholic Acid - Drugs and Lactation Database (LactMed®)(14C)-Glycocholic Acid - Drugs and Lactation Database (LactMed®)
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