U.S. flag

An official website of the United States government

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

SNP FAQ Archive [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2005-.

  • This publication is provided for historical reference only and the information may be out of date.

This publication is provided for historical reference only and the information may be out of date.

Discrepancies between Cluster Report data and Other Genome Resources

Created: ; Last Update: February 18, 2014.

Estimated reading time: 1 minute

Ensembl shows rs3210531 on chromosome 11 strand +1, however, NCBI shows it on chromosome 6 strand -1. Why?

We conduct two different mapping procedures for each SNP. First one places the SNP on contigs, and according to our database, rs3210531 hits chromosome 11 across all assemblies:

snp_idposchrassembly
32105314640692511reference
32105314659841811Celera
32105314615704211HuRef

An additional hit to chr6 was rejected due to our "absolute hit" strategy. This strategy states that if the mapping process finds a 100% identity hit, then the process will reject hits with lower scores as irrelevant.

Mapping to underlying sequences is a separate process and it produced the following hits for rs3210531:

snp_idoffsetaccessionaccession_veraln_quality
3210531366U1497211
3210531423BC00195511
3210531423BC00501211
3210531369BC00103221
3210531367BC07023511
3210531379BC07194611
3210531456BC07379911
3210531418NM_00101431

We are working now on a synchronization mechanism for two these processes. (09/29/08)

The data for rs13306584 is not the same in the UCSC Genome Browser, Ensembl, or dbSNP. Why is this?

The UCSC Genome Browser and Ensembl haven't yet updated to build 128, which is the current dbSNP build. USCS is updated only to build 126, while Ensembl is updated to build 127. Since the data for rs13306584 has changed between these three builds, the data for the three databases will not be the same until the UCSC Genome Browser and Ensembl update to dbSNP build 128. (11/23/07)

Views

Other titles in this collection

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...