Structured Abstract

Contents

• Preface
• Acknowledgments
• Technical Expert Panel
• Peer Reviewers
• Executive Summary
• Introduction
  • Background
  • Scope and Key Questions
• Methods
  • Topic Development
  • Literature Search
  • Study Selection
  • Data Extraction
  • Quality Assessment
  • Applicability Assessment
  • Grading Strength of Evidence
  • Data Synthesis
  • Peer Review
• Results
  • KQ 1 Reductions in Disease Activity, Limitations of Disease Progression, and Maintenance of Remission
  • KQ 2 Functional Capacity and Quality of Life
  • KQ 3 Harms, Tolerability, Adverse Effects, or Adherence
• Discussion
  • Key Findings
  • Future Research
• References
• Appendixes
  • Appendix A Search Strings
  • Appendix B Review and Abstraction Forms
  • Appendix C Articles by Database Searched
  • Appendix D Excluded Studies
  • Appendix E Evidence Tables
  • Appendix F Criteria for Assessing the Quality of Individual Studies
  • Appendix G Clinical and Self-Reported Scales and Instruments Commonly Used in Studies of Drug Therapy for Rheumatoid Arthritis and Psoriatic Arthritis
  • Appendix H Characteristics of Studies with Poor Internal Validity
  • Appendix I Strength of Evidence Tables

Updated June 2012. Errata: Tables 2, 3, and 4 have been corrected.

Prepared for: Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services¹, Contract No. HHSA-290-2007-10056-I, Prepared by: RTI International–University of North Carolina Evidence-based Practice Center, Research Triangle Park, NC

Suggested citation:

Donahue KE, Jonas DE, Hansen RA, Roubey R, Jonas B, Lux LJ, Gartlehner G, Harden E, Yuen A, Thieda P, Morgan LC, Crotty K, Van Noord M. Drug Therapy for Psoriatic Arthritis in Adults: Update of a 2007 Report. Comparative Effectiveness Review No. 54. (Prepared by RTI-UNC Evidence-based Practice Center under Contract No. 290-02-0016-I.) Rockville, MD: Agency for Healthcare Research and Quality; April 2012. www.effectivehealthcare.ahrq.gov/reports/final.cfm.

This report is based on research conducted by the RTI International–University of North Carolina (RTI–UNC) Evidence-based Practice Center under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. HHSA-290-2007-10056-I). The findings and conclusions in this document are those of the authors, who are responsible for its content, and do not necessarily represent the views of AHRQ. No statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

The information in this report is intended to help healthcare decisionmakers—patients and clinicians, health system leaders, and policymakers, among others—make well-informed decisions and thereby improve the quality of health care services. This report is not intended to be a substitute for the application of clinical judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical reference and in conjunction with all other pertinent information, i.e., in the context of available resources and circumstances presented by individual patients.

This report may be used, in whole or in part, as the basis for the development of clinical practice guidelines and other quality enhancement tools, or as a basis for reimbursement and coverage policies. AHRQ or U.S. Department of Health and Human Services endorsement of such derivative products may not be stated or implied.

None of the investigators has any affiliations or financial involvement that conflicts with the material presented in this report.

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