Figure 28 displays a forest plot for the network meta-analysis reporting all discontinuations in studies comparing Non-TNF biologics plus MTX with csDMARDs. Four comparisons were used in this analysis. Study-level data used in this Figure are presented in Appendix C. This figure is described further in the KQ3 Results section “Non-TNF Biologic Plus MTX Versus Either Non-TNF Biologic or MTX” as follows: “In NWMA, the csDMARD ABA plus MTX had fewer overall discontinuations than SSZ (RR 0.47; 95% CI, 0.24 to 0.92)” and “There was no difference in overall discontinuation between ABA plus MTX and MTX alone”.

Figure 28Forest plot for network meta-analysis of all discontinuations: Non-TNF + MTX versus csDMARD

95% CI = 95% confidence interval; MTX = methotrexate; RR = relative risk; TNF = tumor necrosis factor; vs. = versus.

From: Results

Cover of Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update
Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update [Internet].
Comparative Effectiveness Review, No. 211.
Donahue KE, Gartlehner G, Schulman ER, et al.
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