Learn More (trisomy rescue)

A trisomic conceptus consisting of a total of 47 chromosomes is usually non-viable; the trisomic chromosomes can be 2 maternal / 1 paternal or 1 maternal / 2 paternal. The outcomes of trisomy rescue (see Table) may be normal or abnormal.

Outcomes of Trisomy Rescue
Chromosomes Maternal/Paternal Contribution Phenotype
461 mat / 1 pat (disomy)Normal
462 mat / OR 2 pat (uniparental disomy)Possibly abnormal 1
1. The phenotype is abnormal if the chromosome involved has imprinted gene(s).

trisomy rescue

Last revision: 5-7-03

Related terms: aneuploidy; imprinting; postzygotic; uniparental disomy

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