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Bookshelf ID: NBK501353PMID: 30000412
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 23155-02-4
Drug Levels and Effects
Summary of Use during Lactation
Limited information indicates that fosfomycin produces low levels in milk and is unlikely to be absorbed well by the infant because of the binding to calcium in the milk.[1] It is unlikely to cause any adverse effects in breastfed infants.
Drug Levels
Maternal Levels. After 1 to 2 grams of fosfomycin given by injection, colostrum levels in 2 women were 4.8 mg/L and milk levels were 3.6 mg/L.[2,3] Further details of the studies were not given.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
References
- 1.
- Lebedevs T. Fosfomycin and breastfeeding. Aust Prescr 2020;43:113. Letter. doi: 10.18773/austprescr.2020.042. [PMC free article: PMC7450774] [PubMed: 32921885] [CrossRef]
- 2.
- Gallego A, Rodríguez A, Mata A. Fosfomycin: pharmacological studies. Drugs Today (Barc). 1974;10 Suppl 1:161–8.
- 3.
- Kirby WM. Pharmacokinetics of fosfomycin. Chemotherapy. 1977;23 Suppl 1:141–51. [PubMed: 832510]
Substance Identification
Substance Name
Fosfomycin
CAS Registry Number
23155-02-4
Drug Class
Breast Feeding
Lactation
Antibacterial Agents
Anti-Infective Agents, Urinary
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.