Figure 1. . T2-weighted (A, C, D) and FLAIR (B) axial images of the brain in an adult with LBSL show extensive, patchy abnormalities with increased signal in the periventricular and deep cerebral white matter and posterior limb of the internal capsule.

Figure 1.

T2-weighted (A, C, D) and FLAIR (B) axial images of the brain in an adult with LBSL show extensive, patchy abnormalities with increased signal in the periventricular and deep cerebral white matter and posterior limb of the internal capsule. In the posterior fossa the superior cerebellar peduncles, the intraparenchymal trajectories of the trigeminal nerves, the pyramidal tracts, and medial lemniscus in the pons are affected (D). T2-weighted spinal cord images (E, F) show increased signal over the entire length of the spinal cord (E) with involvement of the (lateral) corticospinal tracts and dorsal columns (F).

From: Leukoencephalopathy with Brain Stem and Spinal Cord Involvement and Lactate Elevation

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