From: Genome Reference Consortium
The NCBI Handbook [Internet]. 2nd edition.
Bethesda (MD): National Center for Biotechnology Information (US); 2013-.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Figure 4.
Top panel: RefSeq copy of GRCh37 chromosome 9 (NC_000009.11). The annotated RefSeq chromosome NC_000009.11 is a copy of the GRC chromosome CM000671.1. Bottom panel: Annotated RefSeq copy (NW_003315925.1) of the GRC fix patch GL339450.1. A: The blue bars represent each of the components that make up the tiling paths of the patch scaffold and chromosome. B: NCBI annotated genes. C: Top panel: alignment of chromosome to patch; Bottom panel: alignment of patch to chromosome. Red ticks in the alignment highlight mismatches, blue triangles represent deletions, and thin lines indicate insertions. The anchor component (AL732364.9) of the patch is marked (D). Note how the ABO locus (E) in the fix patch is derived from a single component, as opposed to the two components on the GRCh37 chromosome.