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Select item 67675451.

Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long‐term follow‐up of predictors, surveillance, and outcome in clinical practice

Johanna Karlsson Sundbaum, Niclas Eriksson, Pär Hallberg, Niklas Lehto, Mia Wadelius, Eva Baecklund

Int J Rheum Dis. 2019 Jul; 22(7): 1226–1232. Published online 2019 Apr 22. doi: 10.1111/1756-185X.13576

PMCID:: PMC6767545

Abstract Article PDF–582K

Select item 64648792.

Low-dose methotrexate toxicity

Kevin Pivovarov, Jonathan S. Zipursky

CMAJ. 2019 Apr 15; 191(15): E423. doi: 10.1503/cmaj.181054

PMCID:: PMC6464879

Article PDF–34K

Select item 64464513.

Noninvasive Tests to Monitor Methotrexate‐Induced Liver Injury

Jessica G. Labadie, Manish Jain

Clin Liver Dis (Hoboken) 2019 Mar; 13(3): 67–71. Published online 2019 Mar 29. doi: 10.1002/cld.765

PMCID:: PMC6446451

Article PDF–343K

Select item 61085224.

Non-alcoholic steatohepatitis-like pattern in liver biopsy of rheumatoid arthritis patients with persistent transaminitis during low-dose methotrexate treatment

Shunsuke Mori, Nobuyuki Arima, Masahiro Ito, Shigetoshi Fujiyama, Yasuhiro Kamo, Yukitaka Ueki

PLoS One. 2018; 13(8): e0203084. Published online 2018 Aug 24. doi: 10.1371/journal.pone.0203084

PMCID:: PMC6108522

Abstract Article PDF–1.1M

Select item 59533055.

Monitoring methotrexate-induced liver fibrosis in patients with psoriasis: utility of transient elastography

Harriet S Cheng, Marius Rademaker

Psoriasis (Auckl) 2018; 8: 21–29. Published online 2018 May 9. doi: 10.2147/PTT.S141629

PMCID:: PMC5953305

Abstract Article PDF–728K

Select item 58189426.

Liver Illness and Psoriatic Patients

Marco Fiore, Sebastiano Leone, Alberto Enrico Maraolo, Emilio Berti, Giovanni Damiani

Biomed Res Int. 2018; 2018: 3140983. Published online 2018 Feb 6. doi: 10.1155/2018/3140983

PMCID:: PMC5818942

Abstract Article PDF–794K

Select item 55613757.

Quantifying the hepatotoxic risk of alcohol consumption in patients with rheumatoid arthritis taking methotrexate

Jenny H Humphreys, Alexander Warner, Ruth Costello, Mark Lunt, Suzanne M M Verstappen, William G Dixon

Ann Rheum Dis. 2017 Sep; 76(9): 1509–1514. Published online 2017 Mar 23. doi: 10.1136/annrheumdis-2016-210629

PMCID:: PMC5561375

Abstract Article PDF–570K

Select item 55002438.

Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity

Julie Massart, Karima Begriche, Caroline Moreau, Bernard Fromenty

J Clin Transl Res. 2017 Feb 17; 3(1): 212–232. Published online 2017 Feb 12. doi: 10.18053/jctres.03.2017S1.006

PMCID:: PMC5500243

Abstract Article PDF–1.8M

Select item 54242919.

Hepatic complications induced by immunosuppressants and biologics in inflammatory bowel disease

My-Linh Tran-Minh, Paula Sousa, Marianne Maillet, Matthieu Allez, Jean-Marc Gornet

World J Hepatol. 2017 May 8; 9(13): 613–626. Published online 2017 May 8. doi: 10.4254/wjh.v9.i13.613

PMCID:: PMC5424291

Abstract Article PDF–1000K

Select item 515333210.

Preventing and Managing Toxicities of High-Dose Methotrexate

Scott C. Howard, John McCormick, Ching-Hon Pui, Randall K. Buddington, R. Donald Harvey

Oncologist. 2016 Dec; 21(12): 1471–1482. Published online 2016 Aug 5. doi: 10.1634/theoncologist.2015-0164

PMCID:: PMC5153332

Abstract Article PDF–1.0M

Select item 477215811.

Methotrexate is not associated with increased liver cirrhosis in a population-based cohort of rheumatoid arthritis patients with chronic hepatitis B

Kuo-Tung Tang, Wei-Ting Hung, Yi-Hsing Chen, Ching-Heng Lin, Der-Yuan Chen

Sci Rep. 2016; 6: 22387. Published online 2016 Mar 1. doi: 10.1038/srep22387

PMCID:: PMC4772158

Abstract Article PDF–452K

Select item 452989112.

Drug Induced Steatohepatitis: An Uncommon Culprit of a Common Disease

Liane Rabinowich, Oren Shibolet

Biomed Res Int. 2015; 2015: 168905. Published online 2015 Jul 26. doi: 10.1155/2015/168905

PMCID:: PMC4529891

Abstract Article PDF–880K

Select item 444623513.

Features and Outcomes of 899 Patients with Drug-induced Liver Injury: The DILIN Prospective Study

N Chalasani, HL Bonkovsky, R Fontana, W Lee, A Stolz, J Talwalkar, KR Reddy, PB Watkins, V Navarro, H Barnhart, J Gu, J Serrano, for the United States Drug Induced Liver Injury Network

Gastroenterology. Author manuscript; available in PMC 2016 Jun 1.

Published in final edited form as: Gastroenterology. 2015 Jun; 148(7): 1340–1352.e7. Published online 2015 Mar 6. doi: 10.1053/j.gastro.2015.03.006

PMCID:: PMC4446235

Abstract Article PDF–546K

Select item 439621314.

Significance of liver biopsy for the evaluation of methotrexate-induced liver damage in patients with rheumatoid arthritis

Tatsuya Osuga, Yoshihiro Ikura, Chikara Kadota, Seiichi Hirano, Yasuhiro Iwai, Takanobu Hayakumo

Int J Clin Exp Pathol. 2015; 8(2): 1961–1966. Published online 2015 Feb 1.

PMCID:: PMC4396213

Abstract Article PDF–1.3M

Select item 433480815.

Increased Susceptibility to Methotrexate-Induced Toxicity in Nonalcoholic Steatohepatitis

Rhiannon N. Hardwick, John D. Clarke, April D. Lake, Mark J. Canet, Tarun Anumol, Stephanie M. Street, Matthew D. Merrell, Michael J. Goedken, Shane A. Snyder, Nathan J. Cherrington

Toxicol Sci. 2014 Nov 1; 142(1): 45–55. Published online 2014 Jul 31. doi: 10.1093/toxsci/kfu156

PMCID:: PMC4334808

Abstract Article PDF–19M

Select item 426408316.

Autoimmune hepatitis as an adverse effect of long-term methotrexate therapy

Kamilia Ksouda, Hanen Affes, Rim Atheymen, Mariem Ezzeddine, Khaled Zeghal, Serria Hammami

Indian J Pharmacol. 2014 Nov-Dec; 46(6): 649–650. doi: 10.4103/0253-7613.144940

PMCID:: PMC4264083

Abstract Article

Select item 411216817.

Identification of risk factors for elevated transaminases in methotrexate users through an electronic health record

Gabriela Schmajuk, Yinghui Miao, Jinoos Yazdany, W John Boscardin, David I Daikh, Michael A Steinman

Arthritis Care Res (Hoboken) Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: Arthritis Care Res (Hoboken). 2014 Aug; 66(8): 1159–1166. doi: 10.1002/acr.22294

PMCID:: PMC4112168

Abstract Article PDF–103K

Select item 399225018.

Drug-Induced Acute Liver Failure: Results of a U.S. Multicenter, Prospective Study

Adrian Reuben, David G. Koch, William M. Lee, the Acute Liver Failure Study Group

Hepatology. Author manuscript; available in PMC 2014 Apr 20.

Published in final edited form as: Hepatology. 2010 Dec; 52(6): 2065–2076. Published online 2010 Oct 14. doi: 10.1002/hep.23937

PMCID:: PMC3992250

Abstract Article PDF–328K

Select item 365424419.

Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States

Naga Chalasani, Robert J. Fontana, Herbert L. Bonkovsky, Paul B. Watkins, Timothy Davern, Jose Serrano, Hongqiu Yang, James Rochon, for the Drug Induced Liver Injury Network (DILIN)

Gastroenterology. Author manuscript; available in PMC 2013 May 15.

Published in final edited form as: Gastroenterology. 2008 Dec; 135(6): 1924–1934.e4. Published online 2008 Sep 17. doi: 10.1053/j.gastro.2008.09.011