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    Map60 Microtubule-associated protein 60 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35991, updated on 10-May-2024

    Summary

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    Official Symbol
    Map60provided by FlyBase
    Official Full Name
    Microtubule-associated protein 60provided by FlyBase
    Primary source
    FLYBASE:FBgn0010342
    Locus tag
    Dmel_CG1825
    See related
    AllianceGenome:FB:FBgn0010342
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1825; CP-60; Cp60; CP60; DMAP 60; DMAP-60; DMAP60; Dmel\CG1825; MAP60
    Summary
    Enables microtubule binding activity. Located in centrosome and nucleus. Is expressed in several structures, including ectoderm; embryonic brain; embryonic/larval nervous system; endocrine system component; and extended germ band embryo. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Map60 in Genome Data Viewer
    Location:
    45F5-45F6; 2-61 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9590867..9592744)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5478372..5480249)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L31 Neighboring gene closca Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and molecular organization of the centromere-kinetochore complex. Brinkley BR, et al. Trends Cell Biol, 1992 Jan. PMID 14731633
    2. Studies on the centrosome and cytoplasmic organization in the early Drosophila embryo. Kellogg DR, et al. Cold Spring Harb Symp Quant Biol, 1991. PMID 1840267
    3. Two proteins that cycle asynchronously between centrosomes and nuclear structures: Drosophila CP60 and CP190. Oegema K, et al. J Cell Sci, 1997 Jul. PMID 9247191
    4. The 190 kDa centrosome-associated protein of Drosophila melanogaster contains four zinc finger motifs and binds to specific sites on polytene chromosomes. Whitfield WG, et al. J Cell Sci, 1995 Nov. PMID 8586650
    5. The cell cycle-dependent localization of the CP190 centrosomal protein is determined by the coordinate action of two separable domains. Oegema K, et al. J Cell Biol, 1995 Dec. PMID 8522588, Free PMC Article

    See all (87) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The MADF-BESS Protein CP60 Is Recruited to Insulators via CP190 and Has Redundant Functions in Drosophila.
      Title: The MADF-BESS Protein CP60 Is Recruited to Insulators via CP190 and Has Redundant Functions in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Microtubule-associated protein 60
    Names
    CG1825-PA
    Map60-PA
    centrosome associated protein 60

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9590867..9592744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057604.5 → NP_476952.1  Microtubule-associated protein 60 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476952.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24147, Q7K180
      Related
      FBpp0087613
      Conserved Domains (1) summary
      cl23759
      Location:7 → 84
      GT1; GT1, myb-like, SANT family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24147 Q24147
    Q7K180 Q7K180

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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