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Propionibacterium acnes is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. ... It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

This is a reference genome for the Human Microbiome Project. This project is co-owned with the Human Microbiome Project DACC. Source DNA provided by Martin Blaser, New York University School of Medicine, OBV 6 A606, 550 First Avenue, New York NY 10016, USA (Martin.Blaser@nyumc.org). Funded by National Institute of Allergy and Infectious Diseases on behalf of the NIH Roadmap Human Microbiome Project (U54-AI-084844-01).

Finishing comments The chromosome contains two unresolved homopolymer indels at the following locations: 2023501 and 2060638.
The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/  more

##Genome-Annotation-Data-START##
Annotation Provider::NCBI RefSeq
Annotation Name::GCF_000025765.1-RS_2024_03_30
Annotation Date::03/30/2024 00:40:35
Annotation Pipeline::NCBI Prokaryotic Genome Annotation Pipeline (PGAP)
Annotation Method::Best-placed reference protein set; GeneMarkS-2+
Annotation Software revision::6.7
Features Annotated::Gene; CDS; rRNA; tRNA; ncRNA
Genes (total)::2,444
CDSs (total)::2,386
Genes (coding)::2,324
CDSs (with protein)::2,324
Genes (RNA)::58
rRNAs::3, 3, 3 (5S, 16S, 23S)
complete rRNAs::3, 3, 3 (5S, 16S, 23S)
tRNAs::45
ncRNAs::4
Pseudo Genes (total)::62
CDSs (without protein)::62
Pseudo Genes (ambiguous residues)::0 of 62
Pseudo Genes (frameshifted)::27 of 62
Pseudo Genes (incomplete)::25 of 62
Pseudo Genes (internal stop)::18 of 62
Pseudo Genes (multiple problems)::6 of 62
##Genome-Annotation-Data-END##

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