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Conserved domains on  [gi|62161305|ref|YP_214871|]
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cytochrome c oxidase subunit I (mitochondrion) [Axinella corrugata]

Protein Classification

cytochrome-c oxidase subunit 1( domain architecture ID 10791099)

cytochrome-c oxidase subunit 1 is the catalytic subunit of cytochrome c oxidase, which is the component of the respiratory chain that catalyzes the reduction of oxygen to water

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COX1 MTH00184
cytochrome c oxidase subunit I; Provisional
 1-519 0e+00

cytochrome c oxidase subunit I; Provisional


:

Pssm-ID: 177235  Cd Length: 519  Bit Score: 899.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    1 MSSYLSRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGF 80
Cdd:MTH00184   1 MSLYLSRWLFSTNHKDIGTLYLLFGAFAGMIGTAFSMLIRLELSAPGSMLGDDHLYNVIVTAHAFVMIFFLVMPVMIGGF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   81 GNWFVPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSI 160
Cdd:MTH00184  81 GNWFVPLYIGAPDMAFPRLNNISFWLLPPALTLLLGSAFVEQGAGTGWTVYPPLSSIQAHSGGSVDMAIFSLHLAGISSI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  161 LGAMNFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFF 240
Cdd:MTH00184 161 LGAMNFITTIFNMRAPGITMDRMPLFVWSILVTTFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  241 GHPEVYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGI 320
Cdd:MTH00184 241 GHPEVYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAMVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGI 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  321 KIFSWVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFG 400
Cdd:MTH00184 321 KIFSWIATIFGGSLRLDTPMLWAIGFVFLFTMGGLTGIVLANSSLDVVLHDTYYVVAHFHYVLSMGAVFAIFGGFYYWFG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  401 KISGYCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAR 480
Cdd:MTH00184 401 KITGYCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDSFAGWNQISSLGSVISIVGVVWFIYIVYDAYVR 480

                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 62161305  481 EEIFIGWADDMGHYSTLEWVQATPPAHHTYNELPYVYKG 519
Cdd:MTH00184 481 EIKFVGWVEDSGHYPSLEWAQTSPPAHHTYNELPYVYKG 519
 
Name Accession Description Interval E-value
COX1 MTH00184
cytochrome c oxidase subunit I; Provisional
 1-519 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177235  Cd Length: 519  Bit Score: 899.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    1 MSSYLSRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGF 80
Cdd:MTH00184   1 MSLYLSRWLFSTNHKDIGTLYLLFGAFAGMIGTAFSMLIRLELSAPGSMLGDDHLYNVIVTAHAFVMIFFLVMPVMIGGF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   81 GNWFVPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSI 160
Cdd:MTH00184  81 GNWFVPLYIGAPDMAFPRLNNISFWLLPPALTLLLGSAFVEQGAGTGWTVYPPLSSIQAHSGGSVDMAIFSLHLAGISSI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  161 LGAMNFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFF 240
Cdd:MTH00184 161 LGAMNFITTIFNMRAPGITMDRMPLFVWSILVTTFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  241 GHPEVYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGI 320
Cdd:MTH00184 241 GHPEVYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAMVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGI 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  321 KIFSWVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFG 400
Cdd:MTH00184 321 KIFSWIATIFGGSLRLDTPMLWAIGFVFLFTMGGLTGIVLANSSLDVVLHDTYYVVAHFHYVLSMGAVFAIFGGFYYWFG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  401 KISGYCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAR 480
Cdd:MTH00184 401 KITGYCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDSFAGWNQISSLGSVISIVGVVWFIYIVYDAYVR 480

                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 62161305  481 EEIFIGWADDMGHYSTLEWVQATPPAHHTYNELPYVYKG 519
Cdd:MTH00184 481 EIKFVGWVEDSGHYPSLEWAQTSPPAHHTYNELPYVYKG 519
Cyt_c_Oxidase_I cd01663
Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 12-499 0e+00

Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function, but subunit III, which is also conserved, may play a role in assembly or oxygen delivery to the active site. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit I contains a heme-copper binuclear center (the active site where O2 is reduced to water) formed by a high-spin heme (heme a3) and a copper ion (CuB). It also contains a low-spin heme (heme a), believed to participate in the transfer of electrons to the binuclear center. For every reduction of an O2 molecule, eight protons are taken from the inside aqueous compartment and four electrons are taken from cytochrome c on the opposite side of the membrane. The four electrons and four of the protons are used in the reduction of O2; the four remaining protons are pumped across the membrane. This charge separation of four charges contributes to the electrochemical gradient used for ATP synthesis. Two proton channels, the D-pathway and K-pathway, leading to the binuclear center have been identified in subunit I. A well-defined pathway for the transfer of pumped protons beyond the binuclear center has not been identified. Electrons are transferred from cytochrome c (the electron donor) to heme a via the CuA binuclear site in subunit II, and directly from heme a to the binuclear center.


Pssm-ID: 238833  Cd Length: 488  Bit Score: 879.51  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  12 TNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGFGNWFVPLYIGA 91
Cdd:cd01663   1 TNHKDIGTLYLIFGLWSGLVGTSLSLLIRLELSQPGSQLGNDQLYNVIVTAHALIMIFFMVMPALIGGFGNWLVPLMIGA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  92 PDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGAMNFITTIF 171
Cdd:cd01663  81 PDMAFPRLNNLSFWLLPPSLLLLLLSALVEGGAGTGWTVYPPLSSILAHSGPSVDLAIFSLHLAGISSILGAINFITTIF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 172 NMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILP 251
Cdd:cd01663 161 NMRAPGMTLEKMPLFVWSVLITAFLLLLSLPVLAGAITMLLTDRNFNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILP 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 252 GFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFSWVATMFG 331
Cdd:cd01663 241 GFGIISHIISTFSGKKPVFGYLGMVYAMLSIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAVPTGIKVFSWLATMWG 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 332 GSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISGYCYNEVY 411
Cdd:cd01663 321 GSIKFETPMLWALGFIFLFTIGGLTGVVLANSSLDIALHDTYYVVAHFHYVLSMGAVFAIFAGFYYWFPKITGLSYNETL 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 412 GKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAREEIFIgwADDM 491
Cdd:cd01663 401 GKIHFWLMFIGVNLTFFPQHFLGLAGMPRRYPDYPDAYAGWNMISSIGSLISFVSVLLFLFIVWESFVSGRKVI--FNVG 478


                ....*...
gi 62161305 492 GHYSTLEW 499
Cdd:cd01663 479 EGSTSLEW 486
CtaD_CoxA TIGR02891
cytochrome c oxidase, subunit I; This large family represents subunit I's (CtaD, CoxA, CaaA) ...
 9-510 0e+00

cytochrome c oxidase, subunit I; This large family represents subunit I's (CtaD, CoxA, CaaA) of cytochrome c oxidases of bacterial origin. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits I-III form the functional core of the enzyme complex. Subunit I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit II and heme a of subunit I to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer. In the bacilli an apparent split (paralogism) has created a sister clade (TIGR02882) encoding subunits (QoxA) of the aa3-type quinone oxidase complex which reacts directly with quinones, bypassing the interaction with soluble cytochrome c. This model attempts to exclude these sequences, placing them between the trusted and noise cutoffs. These families, as well as archaeal and eukaryotic cytochrome c subunit I's are included within the superfamily model, pfam00115. [Energy metabolism, Electron transport]


Pssm-ID: 213748  Cd Length: 499  Bit Score: 609.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305     9 LFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLiGGFGNWFVPLY 88
Cdd:TIGR02891   1 LTTVDHKRIGILYLVTAFAFFLVGGVLALLMRAQLATPGNTFMDAETYNQLFTMHGTIMIFLFAIPIL-AGFGNYLLPLM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    89 IGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGAMNFIT 168
Cdd:TIGR02891  80 IGARDMAFPRLNAFSYWLYLFGGLLLLASFFTGGAPDTGWTMYPPLSSTSGSPGVGVDLWLLGLHLLGISSILGAVNFIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   169 TIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVYIL 248
Cdd:TIGR02891 160 TILNMRAPGMTLMRMPLFVWGILVTSILILLAFPVLIAALILLLLDRLFGTHFFDPARGGDPLLWQHLFWFFGHPEVYII 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   249 ILPGFGIISQIIPTFaAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFSWVAT 328
Cdd:TIGR02891 240 FLPAFGIISEILPTF-ARKPIFGYRAMVYATVAIGFLSFGVWAHHMFTTGMPPLALAFFSAATMLIAVPTGVKVFNWIAT 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   329 MFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISGYCYN 408
Cdd:TIGR02891 319 LWGGSIRFTTPMLFALGFIFLFVIGGLTGVMLASVPLDWQLHDTYFVVAHFHYVLVGGSVFAIFAAIYYWFPKVTGRMYN 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   409 EVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDF--HDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAREEIFig 486
Cdd:TIGR02891 399 ERLGRWHFWLTFVGFNLTFFPMHLLGLLGMPRRYYTYppQMGFATLNLISTIGAFILAAGFLVFLWNLIWSLRKGPKA-- 476

                         490       500
                  ....*....|....*....|....
gi 62161305   487 wADDMGHYSTLEWVQATPPAHHTY 510
Cdd:TIGR02891 477 -GANPWGATTLEWTTSSPPPAHNF 499
CyoB COG0843
Heme/copper-type cytochrome/quinol oxidase, subunit 1 [Energy production and conversion];
5-520 0e+00

Heme/copper-type cytochrome/quinol oxidase, subunit 1 [Energy production and conversion];


Pssm-ID: 440605  Cd Length: 535  Bit Score: 605.58  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   5 LSRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPvLIGGFGNWF 84
Cdd:COG0843   6 WRRWLTTVDHKRIGIMYLVTAFVFLLIGGLLALLMRLQLAGPGLGLLSPETYNQLFTMHGTIMIFFFATP-FLAGFGNYL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  85 VPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGAM 164
Cdd:COG0843  85 VPLQIGARDMAFPRLNALSFWLYLFGGLLLLISLFVGGAADVGWTFYPPLSGLEASPGVGVDLWLLGLALFGVGSILGGV 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 165 NFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPE 244
Cdd:COG0843 165 NFIVTILKMRAPGMTLMRMPLFTWAALVTSILILLAFPVLAAALLLLLLDRSLGTHFFDPAGGGDPLLWQHLFWFFGHPE 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 245 VYILILPGFGIISQIIPTFAAKKqIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFS 324
Cdd:COG0843 245 VYILILPAFGIVSEIIPTFSRKP-LFGYKAMVLATVAIAFLSFLVWAHHMFTPGISPLVKAFFSIATMLIAVPTGVKVFN 323

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 325 WVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISG 404
Cdd:COG0843 324 WIATMWRGRIRFTTPMLFALGFIILFVIGGLTGVMLASVPLDYQVHDTYFVVAHFHYVLIGGVVFAFFAGLYYWFPKMTG 403

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 405 YCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDF--HDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAREE 482
Cdd:COG0843 404 RMLNERLGKIHFWLWFIGFNLTFFPMHILGLLGMPRRYATYppEPGWQPLNLISTIGAFILAVGFLLFLINLVVSLRKGP 483

                       490       500       510
                ....*....|....*....|....*....|....*...
gi 62161305 483 IFigwADDMGHYSTLEWVQATPPAHHTYNELPYVYKGH 520
Cdd:COG0843 484 KA---GGNPWGARTLEWATPSPPPLYNFASIPVVRSRD 518
COX1 pfam00115
Cytochrome C and Quinol oxidase polypeptide I; Cytochrome c oxidase (E.C:7.1.1.9) is a key ...
 16-462 2.21e-142

Cytochrome C and Quinol oxidase polypeptide I; Cytochrome c oxidase (E.C:7.1.1.9) is a key enzyme in aerobic metabolism. Proton pumping haem-copper oxidases represent the terminal, energy-transfer enzymes of respiratory chains in prokaryotes and eukaryotes. The CuB-haem a3 (or haem o) binuclear centre, associated with the largest subunit I of cytochrome c and ubiquinol oxidases (E.C:1.10.3.11), is directly involved in the coupling between dioxygen reduction and proton pumping. Some terminal oxidases generate a transmembrane proton gradient across the plasma membrane (prokaryotes) or the mitochondrial inner membrane (eukaryotes). The enzyme complex consists of 3-4 subunits (prokaryotes) up to 13 polypeptides (mammals) of which only the catalytic subunit (equivalent to mammalian subunit I (COXI) is found in all haem-copper respiratory oxidases. The presence of a bimetallic centre (formed by a high-spin haem and copper B) as well as a low-spin haem, both ligated to six conserved histidine residues near the outer side of four transmembrane spans within CO I is common to all family members.


Pssm-ID: 459678  Cd Length: 432  Bit Score: 416.97  E-value: 2.21e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    16 DIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVlIGGFGNWFVPLYIGAPDMA 95
Cdd:pfam00115   1 RIGLLYLVTALVWFLVGGLLGLLIRLQLAFPGLNFLSPLTYNQLRTLHGNLMIFWFATPF-LFGFGNYLVPLMIGARDMA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    96 FPRLNNISFWLLPPSLTLLLGSAfveQGAGTGWTVYPPLASiqahsggsVDMVIFSLHLAGISSILGAMNFITTIFNMRA 175
Cdd:pfam00115  80 FPRLNALSFWLVVLGAVLLLASF---GGATTGWTEYPPLVG--------VDLWYIGLLLAGVSSLLGAINFIVTILKRRA 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   176 PGITMdRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNttffdpAGGGDPILYQHLFWFFGHPEVYILILPGFGI 255
Cdd:pfam00115 149 PGMTL-RMPLFVWAILATAILILLAFPVLAAALLLLLLDRSLG------AGGGDPLLDQHLFWWFGHPEVYILILPAFGI 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   256 ISQIIPTFAaKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFSWVATMFGGSLK 335
Cdd:pfam00115 222 IYYILPKFA-GRPLFGYKLSVLAFWLIAFLGFLVWAHHLFTTGLPPWLQALFSVFSMLIAVPSGVKVFNWLATLWGGWIR 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   336 L-ETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISGYCYNEVYGKI 414
Cdd:pfam00115 301 FrTTPMLFFLGFAFLFIIGGLTGVMLALPPVNYYVHDTYFVVAHFHYVLFGGVVFALFGGIYYWLPKLTGRMYSEKLGKL 380

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 62161305   415 HFWLMFIGVNLTFFPQHFLGLAGLPRRYSDF----HDTFAGWNQISSLGSMI 462
Cdd:pfam00115 381 HFWLLFIGFNLTFFPMHILGLLGMPRRYAPPfietVPAFQPLNWIRTIGGVL 432
 
Name Accession Description Interval E-value
COX1 MTH00184
cytochrome c oxidase subunit I; Provisional
 1-519 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177235  Cd Length: 519  Bit Score: 899.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    1 MSSYLSRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGF 80
Cdd:MTH00184   1 MSLYLSRWLFSTNHKDIGTLYLLFGAFAGMIGTAFSMLIRLELSAPGSMLGDDHLYNVIVTAHAFVMIFFLVMPVMIGGF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   81 GNWFVPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSI 160
Cdd:MTH00184  81 GNWFVPLYIGAPDMAFPRLNNISFWLLPPALTLLLGSAFVEQGAGTGWTVYPPLSSIQAHSGGSVDMAIFSLHLAGISSI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  161 LGAMNFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFF 240
Cdd:MTH00184 161 LGAMNFITTIFNMRAPGITMDRMPLFVWSILVTTFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  241 GHPEVYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGI 320
Cdd:MTH00184 241 GHPEVYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAMVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGI 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  321 KIFSWVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFG 400
Cdd:MTH00184 321 KIFSWIATIFGGSLRLDTPMLWAIGFVFLFTMGGLTGIVLANSSLDVVLHDTYYVVAHFHYVLSMGAVFAIFGGFYYWFG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  401 KISGYCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAR 480
Cdd:MTH00184 401 KITGYCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDSFAGWNQISSLGSVISIVGVVWFIYIVYDAYVR 480

                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 62161305  481 EEIFIGWADDMGHYSTLEWVQATPPAHHTYNELPYVYKG 519
Cdd:MTH00184 481 EIKFVGWVEDSGHYPSLEWAQTSPPAHHTYNELPYVYKG 519
Cyt_c_Oxidase_I cd01663
Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 12-499 0e+00

Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function, but subunit III, which is also conserved, may play a role in assembly or oxygen delivery to the active site. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit I contains a heme-copper binuclear center (the active site where O2 is reduced to water) formed by a high-spin heme (heme a3) and a copper ion (CuB). It also contains a low-spin heme (heme a), believed to participate in the transfer of electrons to the binuclear center. For every reduction of an O2 molecule, eight protons are taken from the inside aqueous compartment and four electrons are taken from cytochrome c on the opposite side of the membrane. The four electrons and four of the protons are used in the reduction of O2; the four remaining protons are pumped across the membrane. This charge separation of four charges contributes to the electrochemical gradient used for ATP synthesis. Two proton channels, the D-pathway and K-pathway, leading to the binuclear center have been identified in subunit I. A well-defined pathway for the transfer of pumped protons beyond the binuclear center has not been identified. Electrons are transferred from cytochrome c (the electron donor) to heme a via the CuA binuclear site in subunit II, and directly from heme a to the binuclear center.


Pssm-ID: 238833  Cd Length: 488  Bit Score: 879.51  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  12 TNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGFGNWFVPLYIGA 91
Cdd:cd01663   1 TNHKDIGTLYLIFGLWSGLVGTSLSLLIRLELSQPGSQLGNDQLYNVIVTAHALIMIFFMVMPALIGGFGNWLVPLMIGA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  92 PDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGAMNFITTIF 171
Cdd:cd01663  81 PDMAFPRLNNLSFWLLPPSLLLLLLSALVEGGAGTGWTVYPPLSSILAHSGPSVDLAIFSLHLAGISSILGAINFITTIF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 172 NMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILP 251
Cdd:cd01663 161 NMRAPGMTLEKMPLFVWSVLITAFLLLLSLPVLAGAITMLLTDRNFNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILP 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 252 GFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFSWVATMFG 331
Cdd:cd01663 241 GFGIISHIISTFSGKKPVFGYLGMVYAMLSIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAVPTGIKVFSWLATMWG 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 332 GSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISGYCYNEVY 411
Cdd:cd01663 321 GSIKFETPMLWALGFIFLFTIGGLTGVVLANSSLDIALHDTYYVVAHFHYVLSMGAVFAIFAGFYYWFPKITGLSYNETL 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 412 GKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAREEIFIgwADDM 491
Cdd:cd01663 401 GKIHFWLMFIGVNLTFFPQHFLGLAGMPRRYPDYPDAYAGWNMISSIGSLISFVSVLLFLFIVWESFVSGRKVI--FNVG 478


                ....*...
gi 62161305 492 GHYSTLEW 499
Cdd:cd01663 479 EGSTSLEW 486
COX1 MTH00153
cytochrome c oxidase subunit I; Provisional
 5-518 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177210  Cd Length: 511  Bit Score: 873.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    5 LSRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGFGNWF 84
Cdd:MTH00153   1 MNKWLFSTNHKDIGTLYFIFGAWSGMVGTSLSLLIRAELGQPGSLIGDDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   85 VPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGAM 164
Cdd:MTH00153  81 VPLMLGAPDMAFPRMNNMSFWLLPPSLTLLLSSSMVESGAGTGWTVYPPLSSNIAHSGASVDLAIFSLHLAGISSILGAI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  165 NFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPE 244
Cdd:MTH00153 161 NFITTIINMRSKGMTLDRMPLFVWSVLITAILLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  245 VYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFS 324
Cdd:MTH00153 241 VYILILPGFGMISHIISQESGKKETFGTLGMIYAMLAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFS 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  325 WVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISG 404
Cdd:MTH00153 321 WLATLHGSQINYSPSLLWALGFVFLFTIGGLTGVVLANSSIDIILHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFTG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  405 YCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAREEIF 484
Cdd:MTH00153 401 LTMNPKWLKIQFFIMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTSWNVISSIGSTISLISILFFIFIIWESMISKRPV 480

                        490       500       510
                 ....*....|....*....|....*....|....
gi 62161305  485 IGWaddMGHYSTLEWVQATPPAHHTYNELPYVYK 518
Cdd:MTH00153 481 LFS---LNLSSSIEWLQNLPPAEHSYSELPLLTN 511
COX1 MTH00182
cytochrome c oxidase subunit I; Provisional
 1-518 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 214451  Cd Length: 525  Bit Score: 859.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    1 MSSYLSRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGF 80
Cdd:MTH00182   1 KNLYLTRWVFSTNHKDIGTLYLVFGAGAGMIGTAFSMLIRLELSAPGAMLGDDHLYNVIVTAHAFIMIFFLVMPVMIGGF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   81 GNWFVPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSI 160
Cdd:MTH00182  81 GNWLVPLYIGAPDMAFPRLNNISFWLLPPALILLLGSAFVEQGAGTGWTVYPPLSSIQAHSGGAVDMAIFSLHLAGVSSI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  161 LGAMNFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFF 240
Cdd:MTH00182 161 LGAINFITTIFNMRAPGVTFNRLPLFVWSILITAFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILFQHLFWFF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  241 GHPEVYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGI 320
Cdd:MTH00182 241 GHPEVYILILPGFGMISQIIPTFVAKKQIFGYLGMVYAMLSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGI 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  321 KIFSWVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFG 400
Cdd:MTH00182 321 KVFSWLATIYGGTLRLDTPMLWAMGFVFLFTLGGLTGVVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIFGGFYYWFG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  401 KISGYCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAR 480
Cdd:MTH00182 401 KITGYCYNELYGKIHFWLMFIGVNLTFFPQHFLGLAGFPRRYSDFADAFAGWNLVSSLGSIISIVGVVWFIYIIYDAYVR 480

                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 62161305  481 EEIFIGWADDMG-HYSTLEWVQATPPAHHTYNELPYVYK 518
Cdd:MTH00182 481 EEKFIGWKEGTGeSWASLEWVHSSPPLFHTYNELPFVYK 519
COX1 MTH00167
cytochrome c oxidase subunit I; Provisional
 4-516 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177222  Cd Length: 512  Bit Score: 820.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    4 YLSRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGFGNW 83
Cdd:MTH00167   2 WINRWLFSTNHKDIGTLYFIFGAWAGMVGTALSLLIRAELSQPGSLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNW 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   84 FVPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGA 163
Cdd:MTH00167  82 LVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLAIFSLHLAGVSSILGS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  164 MNFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHP 243
Cdd:MTH00167 162 INFITTIINMKPPGITQYQTPLFVWSILVTTILLLLSLPVLAAAITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  244 EVYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIF 323
Cdd:MTH00167 242 EVYILILPGFGMISHIVVYYSGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKVF 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  324 SWVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKIS 403
Cdd:MTH00167 322 SWLATLHGGKIKWETPMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFTHWFPLFT 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  404 GYCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAREEI 483
Cdd:MTH00167 402 GLTLNETWTKIHFFVMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNVVSSIGSLISLVAVILFLFIIWEAFSSKRK 481

                        490       500       510
                 ....*....|....*....|....*....|...
gi 62161305  484 FIGWaddMGHYSTLEWVQATPPAHHTYNELPYV 516
Cdd:MTH00167 482 LLPV---ELTSTNVEWLHGCPPPHHTWEEPPFV 511
COX1 MTH00223
cytochrome c oxidase subunit I; Provisional
 6-520 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177260  Cd Length: 512  Bit Score: 796.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    6 SRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGFGNWFV 85
Cdd:MTH00223   1 MRWLFSTNHKDIGTLYLIFGMWSGLVGTSLSLLIRAELGQPGALLGDDQLYNVIVTAHAFVMIFFLVMPMMIGGFGNWLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   86 PLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGAMN 165
Cdd:MTH00223  81 PLMLGAPDMAFPRLNNMSFWLLPPSLYLLLSSSAVESGVGTGWTVYPPLSSNLAHAGPSVDLAIFSLHLAGVSSILGAIN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  166 FITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEV 245
Cdd:MTH00223 161 FITTIINMRSPGMQLERLPLFVWSVKVTAFLLLLSLPVLAGAITMLLTDRNFNTSFFDPAGGGDPILYQHLFWFFGHPEV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  246 YILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFSW 325
Cdd:MTH00223 241 YILILPGFGMISHIVSHYSSKKEVFGTLGMIYAMLSIGVLGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKVFSW 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  326 VATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISGY 405
Cdd:MTH00223 321 LATIYGSKIKYEAPMLWALGFIFLFTVGGLTGIILSNSSLDIMLHDTYYVVAHFHYVLSMGAVFALFAGFNHWFPLFTGV 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  406 CYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAY--AREEI 483
Cdd:MTH00223 401 TLHRRWAKAHFFLMFLGVNLTFFPQHFLGLAGMPRRYSDYPDCYTKWNQVSSFGSMISFVSVLFFMFIVWEAFvsQRSVV 480

                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 62161305  484 FIGwaddmGHYSTLEWVQATPPAHHTYNELPYVYKGH 520
Cdd:MTH00223 481 WSG-----HLSTSLEWDNLLPADFHNNSETGALVINP 512
COX1 MTH00116
cytochrome c oxidase subunit I; Provisional
 3-517 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177177  Cd Length: 515  Bit Score: 792.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    3 SYLSRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGFGN 82
Cdd:MTH00116   1 MFITRWLFSTNHKDIGTLYLIFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   83 WFVPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILG 162
Cdd:MTH00116  81 WLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSTVEAGAGTGWTVYPPLAGNLAHAGASVDLAIFSLHLAGVSSILG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  163 AMNFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGH 242
Cdd:MTH00116 161 AINFITTCINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGH 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  243 PEVYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKI 322
Cdd:MTH00116 241 PEVYILILPGFGIISHIVTYYAGKKEPFGYMGMVWAMLSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGIKV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  323 FSWVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKI 402
Cdd:MTH00116 321 FSWLATLHGGTIKWDPPMLWALGFIFLFTIGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFTHWFPLF 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  403 SGYCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAREE 482
Cdd:MTH00116 401 TGYTLHQTWTKAQFGVMFTGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTISSIGSLISMTAVIMLMFIIWEAFSSKR 480

                        490       500       510
                 ....*....|....*....|....*....|....*
gi 62161305  483 IFIGWADDMGHystLEWVQATPPAHHTYNELPYVY 517
Cdd:MTH00116 481 KVLQPELTTTN---IEWIHGCPPPYHTFEEPAFVQ 512
COX1 MTH00142
cytochrome c oxidase subunit I; Provisional
 5-518 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 214431  Cd Length: 511  Bit Score: 774.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    5 LSRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGFGNWF 84
Cdd:MTH00142   1 MMRWLFSTNHKDIGTLYFLFGAWAGMVGTGLSLLIRAELGQPGSLLGDDQLYNVIVTAHAFVMIFFMVMPVMIGGFGNWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   85 VPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGAM 164
Cdd:MTH00142  81 VPLMLGAPDMAFPRMNNMSFWLLPPALLLLLSSAAVESGAGTGWTVYPPLSSNLAHSGGSVDLAIFSLHLAGVSSILGAI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  165 NFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPE 244
Cdd:MTH00142 161 NFITTVINMRAGGMKFERVPLFVWSVKITAILLLLSLPVLAGAITMLLTDRNFNTSFFDPAGGGDPILYQHLFWFFGHPE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  245 VYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFS 324
Cdd:MTH00142 241 VYILILPGFGMISHIINHYSGKKEVFGTLGMIYAMLSIGLLGFIVWAHHMFTVGMDVDTRAYFTAATMVIAVPTGIKVFS 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  325 WVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISG 404
Cdd:MTH00142 321 WLATLHGSKVKYEPPMLWALGFIFLFTVGGLTGIVLANSSLDVVLHDTYYVVAHFHYVLSMGAVFALFAGFIHWFPLFTG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  405 YCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAREEIF 484
Cdd:MTH00142 401 LTLNPRWLKAHFYTMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTTWNVVSSLGSMISFIAVLMFVFIVWESFVSQRLV 480

                        490       500       510
                 ....*....|....*....|....*....|....
gi 62161305  485 IgWADDMGhySTLEWVQATPPAHHTYNELPYVYK 518
Cdd:MTH00142 481 M-WSSHLS--TSLEWSHRLPPDFHTYDELPILVV 511
COX1 MTH00037
cytochrome c oxidase subunit I; Provisional
 4-518 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177112  Cd Length: 517  Bit Score: 713.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    4 YLSRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGFGNW 83
Cdd:MTH00037   2 QLSRWLFSTNHKDIGTLYLIFGAWAGMVGTAMSVIIRTELAQPGSLLQDDQIYNVIVTAHALVMIFFMVMPIMIGGFGNW 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   84 FVPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGA 163
Cdd:MTH00037  82 LIPLMIGAPDMAFPRMNNMSFWLIPPSFLLLLASAGVESGAGTGWTIYPPLSSNIAHAGGSVDLAIFSLHLAGASSILAS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  164 MNFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHP 243
Cdd:MTH00037 162 INFITTIINMRTPGMTFDRLPLFVWSVFITAFLLLLSLPVLAGAITMLLTDRNINTTFFDPAGGGDPILFQHLFWFFGHP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  244 EVYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIF 323
Cdd:MTH00037 242 EVYILILPGFGMISHVIAHYSGKQEPFGYLGMVYAMIAIGILGFLVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKVF 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  324 SWVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKIS 403
Cdd:MTH00037 322 SWMATLQGSNLRWETPLLWALGFVFLFTIGGLTGIVLANSSIDVVLHDTYYVVAHFHYVLSMGAVFAIFAGFTHWFPLFS 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  404 GYCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYA--RE 481
Cdd:MTH00037 402 GVSLHPLWSKVHFFLMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTVSSIGSTISLVATLFFLFLIWEAFAsqRE 481

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 62161305  482 EIFIGWADdmghySTLEWVQAT-PPAHHTYNELPYVYK 518
Cdd:MTH00037 482 VISPEFSS-----SSLEWQYSSfPPSHHTFDETPSTVI 514
COX1 MTH00183
cytochrome c oxidase subunit I; Provisional
 5-516 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177234  Cd Length: 516  Bit Score: 709.77  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    5 LSRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGFGNWF 84
Cdd:MTH00183   3 ITRWFFSTNHKDIGTLYLVFGAWAGMVGTALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   85 VPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGAM 164
Cdd:MTH00183  83 IPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  165 NFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPE 244
Cdd:MTH00183 163 NFITTIINMKPPAISQYQTPLFVWAVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPE 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  245 VYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFS 324
Cdd:MTH00183 243 VYILILPGFGMISHIVAYYSGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFS 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  325 WVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISG 404
Cdd:MTH00183 323 WLATLHGGSIKWETPLLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAAFVHWFPLFSG 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  405 YCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYA--REE 482
Cdd:MTH00183 403 YTLHSTWTKIHFGVMFVGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTVSSIGSLISLVAVIMFLFILWEAFAakREV 482

                        490       500       510
                 ....*....|....*....|....*....|....
gi 62161305  483 IFIGWAddmghYSTLEWVQATPPAHHTYNELPYV 516
Cdd:MTH00183 483 LSVELT-----STNVEWLHGCPPPYHTFEEPAFV 511
COX1 MTH00026
cytochrome c oxidase subunit I; Provisional
 1-519 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 164599  Cd Length: 534  Bit Score: 709.09  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    1 MSSYLsRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGF 80
Cdd:MTH00026   1 MTSFV-RWFFSCNHKDIGSLYLVFGALSGAIGTAFSMLIRLELSSPGSMLGDDHLYNVIVTAHAFVMIFFLVMPTMIGGF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   81 GNWFVPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSI 160
Cdd:MTH00026  80 GNWFVPLMIGAPDMAFPRLNNISFWLLPPALFLLLGSSLVEQGAGTGWTVYPPLASIQAHSGGSVDMAIFSLHLAGLSSI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  161 LGAMNFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFF 240
Cdd:MTH00026 160 LGAMNFITTVMNMRTPGMTMSRIPLFVWSVFITAILLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFF 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  241 GHPEVYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGI 320
Cdd:MTH00026 240 GHPEVYILILPGFGIISQILSLFSYKKQIFGYLGMVYAMLAIGVLGFIVWAHHMYVVGMDVDTRAYFTAATMIIAVPTGI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  321 KIFSWVATMFGG--SLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYW 398
Cdd:MTH00026 320 KIFSWLATVSGSgrNLIFTTPMAWALGFIFLFTIGGLTGIVLSNSSLDILLHDTYYVVAHFHFVLSMGAVFAIFGGFYLW 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  399 FGKISGYCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAY 478
Cdd:MTH00026 400 FGKITGYAYKDIYGLIHFWLMFIGVNITFFPQHFLGLAGLPRRYADYPDNFEDFNQISSFGSIISIIAVIWFIVVIFDAY 479

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 62161305  479 AREEIF----------IGWADDMGHYSTLEWVQATPPAHHTYNELPYVYKG 519
Cdd:MTH00026 480 YREEPFdinimakgplIPFSCQPAHFDTLEWSLTSPPEHHTYNELPYIVGG 530
COX1 MTH00077
cytochrome c oxidase subunit I; Provisional
 5-518 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 214419  Cd Length: 514  Bit Score: 702.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    5 LSRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGFGNWF 84
Cdd:MTH00077   3 ITRWLFSTNHKDIGTLYLVFGAWAGMVGTALSLLIRAELSQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   85 VPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGAM 164
Cdd:MTH00077  83 VPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  165 NFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPE 244
Cdd:MTH00077 163 NFITTSINMKPPSMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPVLYQHLFWFFGHPE 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  245 VYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFS 324
Cdd:MTH00077 243 VYILILPGFGMISHIVTYYSAKKEPFGYMGMVWAMMSIGLLGFIVWAHHMFTVDLNVDTRAYFTSATMIIAIPTGVKVFS 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  325 WVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISG 404
Cdd:MTH00077 323 WLATMHGGAIKWDAAMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSG 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  405 YCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAREEIF 484
Cdd:MTH00077 403 YTLHSTWSKIHFGVMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTVSSIGSLISLVAVIMMMFIIWEAFSSKREV 482

                        490       500       510
                 ....*....|....*....|....*....|....
gi 62161305  485 IGWADDMghySTLEWVQATPPAHHTYNELPYVYK 518
Cdd:MTH00077 483 LTTELTS---TNIEWLHGCPPPYHTFEEPSFVQT 513
COX1 MTH00103
cytochrome c oxidase subunit I; Validated
 4-516 0e+00

cytochrome c oxidase subunit I; Validated


Pssm-ID: 177165  Cd Length: 513  Bit Score: 698.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    4 YLSRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGFGNW 83
Cdd:MTH00103   2 FINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNW 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   84 FVPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGA 163
Cdd:MTH00103  82 LVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  164 MNFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHP 243
Cdd:MTH00103 162 INFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  244 EVYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIF 323
Cdd:MTH00103 242 EVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVF 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  324 SWVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKIS 403
Cdd:MTH00103 322 SWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFS 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  404 GYCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYA--RE 481
Cdd:MTH00103 402 GYTLNDTWAKIHFTIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTWNTVSSMGSFISLTAVMLMIFMIWEAFAskRE 481

                        490       500       510
                 ....*....|....*....|....*....|....*
gi 62161305  482 EIFIGWADdmghySTLEWVQATPPAHHTYNELPYV 516
Cdd:MTH00103 482 VLTVELTT-----TNLEWLHGCPPPYHTFEEPTYV 511
COX1 MTH00007
cytochrome c oxidase subunit I; Validated
 7-512 0e+00

cytochrome c oxidase subunit I; Validated


Pssm-ID: 133649  Cd Length: 511  Bit Score: 684.71  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    7 RWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGFGNWFVP 86
Cdd:MTH00007   2 RWLYSTNHKDIGTLYFILGVWGGLLGTSMSLLIRIELGQPGAFLGSDQLYNTIVTAHAFLMIFFLVMPVFIGGFGNWLVP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   87 LYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGAMNF 166
Cdd:MTH00007  82 LMLGAPDMAFPRLNNMSFWLLPPALILLVSSAAVEKGVGTGWTVYPPLASNLAHAGPSVDLAIFSLHLAGVSSILGAINF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  167 ITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVY 246
Cdd:MTH00007 162 ITTVINMRWKGLRLERIPLFVWAVVITVVLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVY 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  247 ILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFSWV 326
Cdd:MTH00007 242 ILILPGFGAISHIVTHYAGKLEPFGTLGMIYAMLGIGVLGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKVFSWL 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  327 ATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISGYC 406
Cdd:MTH00007 322 ATIHGSPIKYETPMLWALGFIFLFTTGGLTGIVLSNSSLDIILHDTYYVVAHFHYVLSMGAVFAIFAAFNHWFPLFTGLT 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  407 YNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAREEIFIG 486
Cdd:MTH00007 402 LHDRWAKAHFFLMFLGVNLTFFPQHFLGLSGMPRRYSDYPDAYTKWNVVSSFGSMLSFVALLLFIFILWEAFSAQRGVIA 481

                        490       500
                 ....*....|....*....|....*..
gi 62161305  487 waddMGHYST-LEWVQATPPAHHTYNE 512
Cdd:MTH00007 482 ----SPHMSSsLEWQDTLPLDFHNLPE 504
COX1 MTH00079
cytochrome c oxidase subunit I; Provisional
 2-477 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177148  Cd Length: 508  Bit Score: 653.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    2 SSYLSRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGFG 81
Cdd:MTH00079   1 QGGLSVWLESSNHKDIGTLYFLFGLWSGMVGTSLSLIIRLELSKPGLLLGNGQLYNSVITAHAILMIFFMVMPSMIGGFG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   82 NWFVPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLaSIQAHSGGSVDMVIFSLHLAGISSIL 161
Cdd:MTH00079  81 NWMLPLMLGAPDMSFPRLNNLSFWLLPTSLFLILDSCFVDMGPGTSWTVYPPL-STLGHPGSSVDLAIFSLHCAGISSIL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  162 GAMNFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFG 241
Cdd:MTH00079 160 GGINFMVTTKNLRSSSISLEHMSLFVWTVFVTVFLLVLSLPVLAGAITMLLTDRNLNTSFFDPSTGGNPLLYQHLFWFFG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  242 HPEVYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIK 321
Cdd:MTH00079 240 HPEVYILILPAFGIISQSTLYLTGKKEVFGSLGMVYAILSIGLIGCVVWAHHMYTVGMDLDSRAYFTAATMVIAVPTGVK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  322 IFSWVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGK 401
Cdd:MTH00079 320 VFSWLATLFGMKMKFQPLLLWVLGFIFLFTIGGLTGVILSNSSLDIILHDTYYVVSHFHYVLSLGAVFGIFTGISLWWPF 399

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62161305  402 ISGYCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDA 477
Cdd:MTH00079 400 MTGIVYDKLMMSAVFFLMFVGVNLTFFPLHFAGLHGMPRKYLDYPDVYSVWNVISSYGSMISVFALFLFIYVLLES 475
CtaD_CoxA TIGR02891
cytochrome c oxidase, subunit I; This large family represents subunit I's (CtaD, CoxA, CaaA) ...
 9-510 0e+00

cytochrome c oxidase, subunit I; This large family represents subunit I's (CtaD, CoxA, CaaA) of cytochrome c oxidases of bacterial origin. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits I-III form the functional core of the enzyme complex. Subunit I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit II and heme a of subunit I to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer. In the bacilli an apparent split (paralogism) has created a sister clade (TIGR02882) encoding subunits (QoxA) of the aa3-type quinone oxidase complex which reacts directly with quinones, bypassing the interaction with soluble cytochrome c. This model attempts to exclude these sequences, placing them between the trusted and noise cutoffs. These families, as well as archaeal and eukaryotic cytochrome c subunit I's are included within the superfamily model, pfam00115. [Energy metabolism, Electron transport]


Pssm-ID: 213748  Cd Length: 499  Bit Score: 609.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305     9 LFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLiGGFGNWFVPLY 88
Cdd:TIGR02891   1 LTTVDHKRIGILYLVTAFAFFLVGGVLALLMRAQLATPGNTFMDAETYNQLFTMHGTIMIFLFAIPIL-AGFGNYLLPLM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    89 IGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGAMNFIT 168
Cdd:TIGR02891  80 IGARDMAFPRLNAFSYWLYLFGGLLLLASFFTGGAPDTGWTMYPPLSSTSGSPGVGVDLWLLGLHLLGISSILGAVNFIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   169 TIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVYIL 248
Cdd:TIGR02891 160 TILNMRAPGMTLMRMPLFVWGILVTSILILLAFPVLIAALILLLLDRLFGTHFFDPARGGDPLLWQHLFWFFGHPEVYII 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   249 ILPGFGIISQIIPTFaAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFSWVAT 328
Cdd:TIGR02891 240 FLPAFGIISEILPTF-ARKPIFGYRAMVYATVAIGFLSFGVWAHHMFTTGMPPLALAFFSAATMLIAVPTGVKVFNWIAT 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   329 MFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISGYCYN 408
Cdd:TIGR02891 319 LWGGSIRFTTPMLFALGFIFLFVIGGLTGVMLASVPLDWQLHDTYFVVAHFHYVLVGGSVFAIFAAIYYWFPKVTGRMYN 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   409 EVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDF--HDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAREEIFig 486
Cdd:TIGR02891 399 ERLGRWHFWLTFVGFNLTFFPMHLLGLLGMPRRYYTYppQMGFATLNLISTIGAFILAAGFLVFLWNLIWSLRKGPKA-- 476

                         490       500
                  ....*....|....*....|....
gi 62161305   487 wADDMGHYSTLEWVQATPPAHHTY 510
Cdd:TIGR02891 477 -GANPWGATTLEWTTSSPPPAHNF 499
Heme_Cu_Oxidase_I cd00919
Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in ...
 14-478 0e+00

Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is diverse in terms of electron donors, subunit composition, and heme types. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. It has been proposed that Archaea acquired heme-copper oxidases through gene transfer from Gram-positive bacteria. Membership in the superfamily is defined by subunit I, which contains a heme-copper binuclear center (the active site where O2 is reduced to water) formed by a high-spin heme and a copper ion. It also contains a low-spin heme, believed to participate in the transfer of electrons to the binuclear center. Only subunit I is common to the entire superfamily. For every reduction of an O2 molecule, eight protons are taken from the inside aqueous compartment and four electrons are taken from the electron donor on the opposite side of the membrane. The four electrons and four of the protons are used in the reduction of O2; the four remaining protons are pumped across the membrane. This charge separation of four charges contributes to the electrochemical gradient used for ATP synthesis. Two proton channels, the D-pathway and K-pathway, leading to the binuclear center have been identified in subunit I of cytochrome c oxidase (CcO) and ubiquinol oxidase. A well-defined pathway for the transfer of pumped protons beyond the binuclear center has not been identified. Electron transfer occurs in two segments: from the electron donor to the low-spin heme, and from the low-spin heme to the binuclear center. The first segment can be a multi-step process and varies among the different families, while the second segment, a direct transfer, is consistent throughout the superfamily.


Pssm-ID: 238461  Cd Length: 463  Bit Score: 607.61  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  14 HKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGFGNWFVPLyIGAPD 93
Cdd:cd00919   1 HKDIGLLYLIFAFVALLLGGLLALLIRLELATPGSLFLDPQLYNQLVTAHGVIMIFFFVMPAIFGGFGNLLPPL-IGARD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  94 MAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGAMNFITTIFNM 173
Cdd:cd00919  80 LAFPRLNNLSFWLFPPGLLLLLSSVLVGGGAGTGWTFYPPLSTLSYSSGVGVDLAILGLHLAGVSSILGAINFITTILNM 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 174 RAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGF 253
Cdd:cd00919 160 RAPGMTLDKMPLFVWSVLVTAILLLLALPVLAAALVMLLLDRNFGTSFFDPAGGGDPVLYQHLFWFFGHPEVYILILPAF 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 254 GIISQIIPTFAAKKqIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFSWVATMFGGS 333
Cdd:cd00919 240 GAISEIIPTFSGKP-LFGYKLMVYAFLAIGFLSFLVWAHHMFTVGLPVDTRAYFTAATMIIAVPTGIKVFNWLATLWGGR 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 334 LKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISGYCYNEVYGK 413
Cdd:cd00919 319 IRFDPPMLFALGFLFLFTIGGLTGVVLANVPLDIVLHDTYYVVAHFHYVLSGGVVFAIFAGLYYWFPKMTGRMLSEKLGK 398

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62161305 414 IHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAY 478
Cdd:cd00919 399 IHFWLWFIGFNLTFFPMHFLGLLGMPRRYADYPDGFAPWNFISSVGAFILGLGLLLFLGNLFLSL 463
CyoB COG0843
Heme/copper-type cytochrome/quinol oxidase, subunit 1 [Energy production and conversion];
5-520 0e+00

Heme/copper-type cytochrome/quinol oxidase, subunit 1 [Energy production and conversion];


Pssm-ID: 440605  Cd Length: 535  Bit Score: 605.58  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   5 LSRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPvLIGGFGNWF 84
Cdd:COG0843   6 WRRWLTTVDHKRIGIMYLVTAFVFLLIGGLLALLMRLQLAGPGLGLLSPETYNQLFTMHGTIMIFFFATP-FLAGFGNYL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  85 VPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGAM 164
Cdd:COG0843  85 VPLQIGARDMAFPRLNALSFWLYLFGGLLLLISLFVGGAADVGWTFYPPLSGLEASPGVGVDLWLLGLALFGVGSILGGV 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 165 NFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPE 244
Cdd:COG0843 165 NFIVTILKMRAPGMTLMRMPLFTWAALVTSILILLAFPVLAAALLLLLLDRSLGTHFFDPAGGGDPLLWQHLFWFFGHPE 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 245 VYILILPGFGIISQIIPTFAAKKqIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFS 324
Cdd:COG0843 245 VYILILPAFGIVSEIIPTFSRKP-LFGYKAMVLATVAIAFLSFLVWAHHMFTPGISPLVKAFFSIATMLIAVPTGVKVFN 323

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 325 WVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISG 404
Cdd:COG0843 324 WIATMWRGRIRFTTPMLFALGFIILFVIGGLTGVMLASVPLDYQVHDTYFVVAHFHYVLIGGVVFAFFAGLYYWFPKMTG 403

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 405 YCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDF--HDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAREE 482
Cdd:COG0843 404 RMLNERLGKIHFWLWFIGFNLTFFPMHILGLLGMPRRYATYppEPGWQPLNLISTIGAFILAVGFLLFLINLVVSLRKGP 483

                       490       500       510
                ....*....|....*....|....*....|....*...
gi 62161305 483 IFigwADDMGHYSTLEWVQATPPAHHTYNELPYVYKGH 520
Cdd:COG0843 484 KA---GGNPWGARTLEWATPSPPPLYNFASIPVVRSRD 518
Ubiquinol_Oxidase_I cd01662
Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory ...
 8-508 0e+00

Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits in ubiquinol oxidase varies from two to five. Subunit I contains a heme-copper binuclear center (the active site where O2 is reduced to water) formed by a high-spin heme and a copper ion. It also contains a low-spin heme, believed to participate in the transfer of electrons from ubiquinol to the binuclear center. For every reduction of an O2 molecule, eight protons are taken from the inside aqueous compartment and four electrons are taken from ubiquinol on the opposite side of the membrane. The four electrons and four of the protons are used in the reduction of O2; the four remaining protons are pumped across the membrane. This charge separation of four charges contributes to the electrochemical gradient used for ATP synthesis. Two proton channels, the D-pathway and K-pathway, leading to the binuclear center have been identified in subunit I. It is generally believed that the channels contain water molecules that act as 'proton wires' to transfer the protons. A well-defined pathway for the transfer of pumped protons beyond the binuclear center has not been identified. Electrons are believed to be transferred directly from ubiquinol (the electron donor) to the low-spin heme, and directly from the low-spin heme to the binuclear center.


Pssm-ID: 238832  Cd Length: 501  Bit Score: 547.56  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   8 WLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGgFGNWFVPL 87
Cdd:cd01662   1 WLTTVDHKRIGIMYIITAFVFFLRGGVDALLMRTQLALPGNDFLSPEHYNQIFTMHGTIMIFLFAMPLVFG-LMNYLVPL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  88 YIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGAMNFI 167
Cdd:cd01662  80 QIGARDVAFPRLNALSFWLFLFGGLLLNASLLIGGFPDAGWFAYPPLSGLEYSPGVGVDYWILGLQFSGIGTLLGAINFI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 168 TTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVYI 247
Cdd:cd01662 160 VTILKMRAPGMTLMRMPIFTWTTLVTSILILFAFPVLTAALALLELDRYFGTHFFTNALGGNPMLWQHLFWIFGHPEVYI 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 248 LILPGFGIISQIIPTFAaKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFSWVA 327
Cdd:cd01662 240 LILPAFGIFSEIVPTFS-RKPLFGYRSMVYATVAIGFLSFGVWVHHMFTTGAGALVNAFFSIATMIIAVPTGVKIFNWLF 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 328 TMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISGYCY 407
Cdd:cd01662 319 TMWRGRIRFETPMLWAIGFLVTFVIGGLTGVMLASPPADFQVHDTYFVVAHFHYVLIGGVVFPLFAGFYYWFPKMFGRML 398

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 408 NEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDF--HDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAREEIFI 485
Cdd:cd01662 399 NERLGKWSFWLWFIGFNLTFFPMHILGLMGMPRRVYTYlpGPGWDPLNLISTIGAFLIAAGVLLFLINVIVSIRKGKRDA 478

                       490       500
                ....*....|....*....|...
gi 62161305 486 GwaDDMGHYSTLEWVQATPPAHH 508
Cdd:cd01662 479 T--GDPWGARTLEWATSSPPPAY 499
COX1 MTH00048
cytochrome c oxidase subunit I; Provisional
 4-486 6.77e-164

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177123  Cd Length: 511  Bit Score: 474.55  E-value: 6.77e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    4 YLSRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIGGFGNW 83
Cdd:MTH00048   3 SLLSWLFTLDHKRIGVIYTLLGVWSGFVGLSLSLLIRLNFLDPYYNVISLDVYNFLITNHGIIMIFFFLMPVLIGGFGNY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   84 FVPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVeqGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGA 163
Cdd:MTH00048  83 LLPLLLGLSDLNLPRLNALSAWLLVPSIVFLLLSMCL--GAGVGWTFYPPLSSSLFSSSWGVDFLMFSLHLAGVSSLFGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  164 MNFITTIFNMRAPGITMdRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHP 243
Cdd:MTH00048 161 INFICTIYSAFMTNVFS-RTSIILWSYLFTSILLLLSLPVLAAAITMLLFDRNFGSAFFDPLGGGDPVLFQHMFWFFGHP 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  244 EVYILILPGFGIISQIIPTFAAKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIF 323
Cdd:MTH00048 240 EVYVLILPGFGIISHICLSLSNNDDPFGYYGLVFAMFSIVCLGSVVWAHHMFTVGLDVKTAVFFSSVTMIIGVPTGIKVF 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  324 SWVATMFGGSLKLETPML-WAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKI 402
Cdd:MTH00048 320 SWLYMLLNSRVRKSDPVVwWVVSFIVLFTIGGVTGIVLSASVLDNVLHDTWFVVAHFHYVLSLGSYSSVVIMFIWWWPLI 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  403 SGYCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDAYAREE 482
Cdd:MTH00048 400 TGLSLNKYLLQCHCIISMIGFNLCFFPMHYFGLCGLPRRVCVYEPSYYWINVVCTVGSFISAFSGCFFVFILWESLVVKN 479


                 ....
gi 62161305  483 IFIG 486
Cdd:MTH00048 480 EVLG 483
COX1 pfam00115
Cytochrome C and Quinol oxidase polypeptide I; Cytochrome c oxidase (E.C:7.1.1.9) is a key ...
 16-462 2.21e-142

Cytochrome C and Quinol oxidase polypeptide I; Cytochrome c oxidase (E.C:7.1.1.9) is a key enzyme in aerobic metabolism. Proton pumping haem-copper oxidases represent the terminal, energy-transfer enzymes of respiratory chains in prokaryotes and eukaryotes. The CuB-haem a3 (or haem o) binuclear centre, associated with the largest subunit I of cytochrome c and ubiquinol oxidases (E.C:1.10.3.11), is directly involved in the coupling between dioxygen reduction and proton pumping. Some terminal oxidases generate a transmembrane proton gradient across the plasma membrane (prokaryotes) or the mitochondrial inner membrane (eukaryotes). The enzyme complex consists of 3-4 subunits (prokaryotes) up to 13 polypeptides (mammals) of which only the catalytic subunit (equivalent to mammalian subunit I (COXI) is found in all haem-copper respiratory oxidases. The presence of a bimetallic centre (formed by a high-spin haem and copper B) as well as a low-spin haem, both ligated to six conserved histidine residues near the outer side of four transmembrane spans within CO I is common to all family members.


Pssm-ID: 459678  Cd Length: 432  Bit Score: 416.97  E-value: 2.21e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    16 DIGTLYLLLGAFSGMIGTAFSVLIRLELSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVlIGGFGNWFVPLYIGAPDMA 95
Cdd:pfam00115   1 RIGLLYLVTALVWFLVGGLLGLLIRLQLAFPGLNFLSPLTYNQLRTLHGNLMIFWFATPF-LFGFGNYLVPLMIGARDMA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    96 FPRLNNISFWLLPPSLTLLLGSAfveQGAGTGWTVYPPLASiqahsggsVDMVIFSLHLAGISSILGAMNFITTIFNMRA 175
Cdd:pfam00115  80 FPRLNALSFWLVVLGAVLLLASF---GGATTGWTEYPPLVG--------VDLWYIGLLLAGVSSLLGAINFIVTILKRRA 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   176 PGITMdRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNttffdpAGGGDPILYQHLFWFFGHPEVYILILPGFGI 255
Cdd:pfam00115 149 PGMTL-RMPLFVWAILATAILILLAFPVLAAALLLLLLDRSLG------AGGGDPLLDQHLFWWFGHPEVYILILPAFGI 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   256 ISQIIPTFAaKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFSWVATMFGGSLK 335
Cdd:pfam00115 222 IYYILPKFA-GRPLFGYKLSVLAFWLIAFLGFLVWAHHLFTTGLPPWLQALFSVFSMLIAVPSGVKVFNWLATLWGGWIR 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   336 L-ETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISGYCYNEVYGKI 414
Cdd:pfam00115 301 FrTTPMLFFLGFAFLFIIGGLTGVMLALPPVNYYVHDTYFVVAHFHYVLFGGVVFALFGGIYYWLPKLTGRMYSEKLGKL 380

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 62161305   415 HFWLMFIGVNLTFFPQHFLGLAGLPRRYSDF----HDTFAGWNQISSLGSMI 462
Cdd:pfam00115 381 HFWLLFIGFNLTFFPMHILGLLGMPRRYAPPfietVPAFQPLNWIRTIGGVL 432
CyoB TIGR02843
cytochrome o ubiquinol oxidase, subunit I; Cytochrome o terminal oxidase complex is the ...
 8-516 1.01e-133

cytochrome o ubiquinol oxidase, subunit I; Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain which reacts with oxygen, reducing it to water with the concomitant transport of 4 protons across the membrane. Also known as the cytochrome bo complex, cytochrome o ubiquinol oxidase contains four subunits, two heme b cofactors and a copper atom which is believed to be the oxygen active site. This complex is structurally related to the cytochrome caa3 oxidases which utilize cytochrome c as the reductant and contain heme a cofactors, as well as the intermediate form aa3 oxidases which also react directly with quinones as the reductant. [Energy metabolism, Electron transport]


Pssm-ID: 131890  Cd Length: 646  Bit Score: 402.13  E-value: 1.01e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305     8 WLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLELS-APGSMLG--DDQLYNVIVTAHAFVMIFFLVMPVLIGGFgNWF 84
Cdd:TIGR02843  47 WLTTVDHKKIGIMYIIVALVMLLRGFADAIMMRTQQAlASGGSAGylPPHHYDQIFTAHGVIMIFFVAMPFVFGLM-NLV 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    85 VPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGISSILGAM 164
Cdd:TIGR02843 126 VPLQIGARDVAFPFLNSLSFWLTVVGAILVNVSLGVGEFAQTGWLAYPPLSELQYSPGVGVDYYIWALQISGIGTLLTGI 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   165 NFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPE 244
Cdd:TIGR02843 206 NFFVTIIKMRAPGMTLMKMPVFTWTSLCSNVLIIASFPILTVTLALLTLDRYLGMHFFTNEAGGNPMMYVNLIWAWGHPE 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   245 VYILILPGFGIISQIIPTFAaKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFS 324
Cdd:TIGR02843 286 VYILILPAFGIFSEVVATFS-RKRLFGYTSMVWATIAITVLSFIVWLHHFFTMGAGANVNAFFGIATMIIAIPTGVKIFN 364

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   325 WVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYWFGKISG 404
Cdd:TIGR02843 365 WLFTMYKGRIRFETPMLWTIGFMVTFSIGGMTGVLLAVPPADFVLHNSLFLIAHFHNVIIGGVVFGCFAGLTYWFPKAFG 444

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   405 YCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHD-TFAGWNQISSLGSMISIIGVVWFLYIVYDAYAREEI 483
Cdd:TIGR02843 445 FKLNEKLGKRSFWCWFIGFYLAFMPLYILGFMGMTRRLNHYDNpEWHPMLIIAAFGAFLIACGILCQIIQIFVSIRDRDQ 524

                         490       500       510
                  ....*....|....*....|....*....|...
gi 62161305   484 FIGWADDMGHYSTLEWVQATPPAHHTYNELPYV 516
Cdd:TIGR02843 525 NRDTTGDPWGGRTLEWSTSSPPPFYNFAVIPKV 557
PRK15017 PRK15017
cytochrome o ubiquinol oxidase subunit I; Provisional
 3-522 1.11e-116

cytochrome o ubiquinol oxidase subunit I; Provisional


Pssm-ID: 184978  Cd Length: 663  Bit Score: 358.86  E-value: 1.11e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305    3 SYL-SRWLFSTNHKDIGTLYLLLGAFSGMIGTAFSVLIRLE---LSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMPVLIG 78
Cdd:PRK15017  42 TYLwKEWLTSVDHKRLGIMYIIVAIVMLLRGFADAIMMRSQqalASAGEAGFLPPHHYDQIFTAHGVIMIFFVAMPFVIG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305   79 gFGNWFVPLYIGAPDMAFPRLNNISFWLLPPSLTLLLGSAFVEQGAGTGWTVYPPLASIQAHSGGSVDMVIFSLHLAGIS 158
Cdd:PRK15017 122 -LMNLVVPLQIGARDVAFPFLNNLSFWFTVVGVILVNVSLGVGEFAQTGWLAYPPLSGIEYSPGVGVDYWIWSLQLSGIG 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  159 SILGAMNFITTIFNMRAPGITMDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFW 238
Cdd:PRK15017 201 TTLTGINFFVTILKMRAPGMTMFKMPVFTWASLCANVLIIASFPILTVTVALLTLDRYLGTHFFTNDMGGNMMMYINLIW 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  239 FFGHPEVYILILPGFGIISQIIPTFAaKKQIFGYLGMVYAIVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPT 318
Cdd:PRK15017 281 AWGHPEVYILILPVFGVFSEIAATFS-RKRLFGYTSLVWATVCITVLSFIVWLHHFFTMGAGANVNAFFGITTMIIAIPT 359

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  319 GIKIFSWVATMFGGSLKLETPMLWAIGFVFLFTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAMFGGFYYW 398
Cdd:PRK15017 360 GVKIFNWLFTMYQGRIVFHSAMLWTIGFIVTFSVGGMTGVLLAVPGADFVLHNSLFLIAHFHNVIIGGVVFGCFAGMTYW 439

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  399 FGKISGYCYNEVYGKIHFWLMFIGVNLTFFPQHFLGLAGLPRRYS-DFHDTFAGWNQISSLGSMISIIGVVWFLYIVYDA 477
Cdd:PRK15017 440 WPKAFGFKLNETWGKRAFWFWIIGFFVAFMPLYALGFMGMTRRLSqQIDPQFHTMLMIAASGAALIALGILCQVIQMYVS 519

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*
gi 62161305  478 YAREEIFIGWADDMGHYSTLEWVQATPPAHHTYNELPYVYKGHIF 522
Cdd:PRK15017 520 IRDRDQNRDLTGDPWGGRTLEWATSSPPPFYNFAVVPHVHERDAF 564
ba3-like_Oxidase_I cd01660
ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are ...
 17-476 1.08e-21

ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the membrane. It has been proposed that Archaea acquired heme-copper oxidases through gene transfer from Gram-positive bacteria. The ba3 family contains oxidases that lack the conserved residues that form the D- and K-pathways in CcO and ubiquinol oxidase. Instead they contain a potential alternative K-pathway. Additional proton channels have been proposed for this family of oxidases but none have been identified definitively. For general information on the heme-copper oxidase superfamily, please see cd00919.


Pssm-ID: 238830  Cd Length: 473  Bit Score: 97.74  E-value: 1.08e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  17 IGTLYLLLGAFSGMIgtafSVLIRlelSAPGSMLGDDQLYNVIVTAHAFVMIFFLVMpVLIGGFGNWFVPLYIGAPDMAf 96
Cdd:cd01660  12 VAFLALLLGGLFGLL----QVLVR---TGVFPLPSSGILYYQGLTLHGVLLAIVFTT-FFIMGFFYAIVARALLRSLFN- 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305  97 PRLNNISFWLLPPSLTLLLGSAFVEQgAGTGWTVYPPLasiQAHSG---GSVDMVIFSLhlagissILGAMNFITT-IFN 172
Cdd:cd01660  83 RRLAWAGFWLMVIGTVMAAVPILLGQ-ASVLYTFYPPL---QAHPLfyiGAALVVVGSW-------ISGFAMFVTLwRWK 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 173 MRAPGitmDRMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNFNTTffdpaGGGDPILYQHLFWFFGHPEVYILILPG 252
Cdd:cd01660 152 KANPG---KKVPLATFMVVTTMILWLVASLGVALEVLFQLLPWSLGLV-----DTVDVLLSRTLFWWFGHPLVYFWLLPA 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 253 FGIISQIIPTFAAKKQIFGYLGMVyAIVSIGILGFIVWAHHMFT-VGMDVDTRAYFTAATMIIAVPTGIKIFSWVATM-- 329
Cdd:cd01660 224 YIAWYTILPKIAGGKLFSDPLARL-AFILFLLFSTPVGFHHQFAdPGIGPGWKFIHMVLTFMVALPSLLTAFTVFASLei 302

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 330 ----------FGGSLKLE--TPMLWAIGFVFL-FTLGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSmGAVFAMFGGFY 396
Cdd:cd01660 303 agrlrggkglFGWIRALPwgDPMFLALFLAMLmFIPGGAGGIINASYQLNYVVHNTAWVPGHFHLTVG-GAVALTFMAVA 381

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62161305 397 YWFgkISGYCYNEVYGK----IHFWLMFIGVNLTFFPQHFLGLAGLPRR-----YSDFH--DTFAGWNQISSLGSMISII 465
Cdd:cd01660 382 YWL--VPHLTGRELAAKrlalAQPWLWFVGMTIMSTAMHVAGLLGAPRRtaeaqYGGLPaaGEWAPYQQLMAIGGTILFV 459

                       490
                ....*....|.
gi 62161305 466 GVVWFLYIVYD 476
Cdd:cd01660 460 SGALFLYILFR 470
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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