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Conserved domains on  [gi|1370479368|ref|XP_024308973|]
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interleukin-18 receptor 1 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 324-466 2.39e-35

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


:

Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 129.41  E-value: 2.39e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368 324 FVSYLkeCRPENGEEHTFAVEILPRVleKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSN-EVRYEL 402
Cdd:pfam01582   1 YDVFL--SFRGSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWCLDEL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368 403 ESGLHEALvERKIKIILIEFTPVTDFT-----FLPQSLKLLKSH----RVLKWKAD----------KSLSYNSRFWKNLL 463
Cdd:pfam01582  77 VKILECAL-DLGQKVIPIFYEVDPSDVrkqtgSFGKAFKKHKKVlteeKVLKWRGAlnevaniwhsKSVSDESKFWKKIA 155


                  ...
gi 1370479368 464 YLM 466
Cdd:pfam01582 156 YDI 158
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 129-208 7.83e-08

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05757:

Pssm-ID: 472250  Cd Length: 92  Bit Score: 50.02  E-value: 7.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368 129 IVEVKKFFQITC-ENSYYQTLVNSTSL--YKNCKKLLLENN----KNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKT 201
Cdd:cd05757     6 KLPITKGGKITCpDLDDYKNENVLPPIqwYKDCKPLQGDKRfipkGSKLLIQNVTEEDAGNYTCKFTYTHNGKQYNVTRT 85


                  ....*..
gi 1370479368 202 FNITIVE 208
Cdd:cd05757    86 ISLTVTE 92
V-set super family cl46292
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-100 4.21e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


The actual alignment was detected with superfamily member pfam07686:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 39.75  E-value: 4.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368  28 ITVVEGEPFYLkHCSCSLAHEIETTTKSWYK-SSGSQEHVELNPRSSSR--------------IALHDCVLEFWPVELND 92
Cdd:pfam07686   6 VTVALGGSVTL-PCTYSSSMSEASTSVYWYRqPPGKGPTFLIAYYSNGSeegvkkgrfsgrgdPSNGDGSLTIQNLTLSD 84


                  ....*...
gi 1370479368  93 TGSYFFQM 100
Cdd:pfam07686  85 SGTYTCAV 92
PHA02785 super family cl31505
IL-beta-binding protein; Provisional
 171-312 1.18e-03

IL-beta-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02785:

Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 41.15  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368 171 IKKNaefeDQGYYSCVHFLHHNGKLFNITKtfnITIVEDRSNIVPvllgPKL---NHVAVELGKNVRLNCSALLNEEDV- 246
Cdd:PHA02785  184 VRKN----DAGYYTCVLKYIYGDKTYNVTR---IVKLEVRDRIIP----PTMqlpEGVVTSIGSNLTIACRVSLRPPTTd 252

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370479368 247 --IYW----MFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVlYNC---TVASTGGTDTKSFI 312
Cdd:PHA02785  253 adVFWisngMYYEEDDEDGDGRISVANKIYTTDKRRVITSRLNINPVKEEDATT-FTCmafTIPSISKTVTISIT 326
 
Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 324-466 2.39e-35

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 129.41  E-value: 2.39e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368 324 FVSYLkeCRPENGEEHTFAVEILPRVleKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSN-EVRYEL 402
Cdd:pfam01582   1 YDVFL--SFRGSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWCLDEL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368 403 ESGLHEALvERKIKIILIEFTPVTDFT-----FLPQSLKLLKSH----RVLKWKAD----------KSLSYNSRFWKNLL 463
Cdd:pfam01582  77 VKILECAL-DLGQKVIPIFYEVDPSDVrkqtgSFGKAFKKHKKVlteeKVLKWRGAlnevaniwhsKSVSDESKFWKKIA 155


                  ...
gi 1370479368 464 YLM 466
Cdd:pfam01582 156 YDI 158
TIR smart00255
Toll - interleukin 1 - resistance;
320-469 6.85e-34

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 124.36  E-value: 6.85e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368  320 TYDAFVSYlkecrpenGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNE-V 398
Cdd:smart00255   1 EYDVFISY--------SGKEDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEwC 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370479368  399 RYELESGLHEALVERKIKIILIEFTPVT-DFTFLPQSLKLLKSHRVLKWKADKSLsynsRFWKNLLYLMPAK 469
Cdd:smart00255  73 LDELVAALENALEEGGLRVIPIFYEVIPsDVRKQPGKFRKVFKKNYLKWPEDEKE----QFWKKALYAVPSK 140
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 129-208 7.83e-08

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 50.02  E-value: 7.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368 129 IVEVKKFFQITC-ENSYYQTLVNSTSL--YKNCKKLLLENN----KNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKT 201
Cdd:cd05757     6 KLPITKGGKITCpDLDDYKNENVLPPIqwYKDCKPLQGDKRfipkGSKLLIQNVTEEDAGNYTCKFTYTHNGKQYNVTRT 85


                  ....*..
gi 1370479368 202 FNITIVE 208
Cdd:cd05757    86 ISLTVTE 92
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-100 4.21e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 39.75  E-value: 4.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368  28 ITVVEGEPFYLkHCSCSLAHEIETTTKSWYK-SSGSQEHVELNPRSSSR--------------IALHDCVLEFWPVELND 92
Cdd:pfam07686   6 VTVALGGSVTL-PCTYSSSMSEASTSVYWYRqPPGKGPTFLIAYYSNGSeegvkkgrfsgrgdPSNGDGSLTIQNLTLSD 84


                  ....*...
gi 1370479368  93 TGSYFFQM 100
Cdd:pfam07686  85 SGTYTCAV 92
Ig1_IL1R_like cd05756
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 19-104 7.72e-04

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409414  Cd Length: 96  Bit Score: 38.56  E-value: 7.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368  19 AESCTSRPHITVVEGEPFYLKhcsCSL-AHEIETTTKS---WYKSsGSQEHVELNPRSssRIALHDCVLEFWPVELNDTG 94
Cdd:cd05756     1 DEWGEDIKILVVLEGEPDVIK---CPLfPNFLAQSAGLnltWYKN-DSETPISFEPDS--RIHQEKDKLWFVPALLEDSG 74

                          90
                  ....*....|
gi 1370479368  95 SYFFQMKNYT 104
Cdd:cd05756    75 NYYCVVRNST 84
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 171-312 1.18e-03

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 41.15  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368 171 IKKNaefeDQGYYSCVHFLHHNGKLFNITKtfnITIVEDRSNIVPvllgPKL---NHVAVELGKNVRLNCSALLNEEDV- 246
Cdd:PHA02785  184 VRKN----DAGYYTCVLKYIYGDKTYNVTR---IVKLEVRDRIIP----PTMqlpEGVVTSIGSNLTIACRVSLRPPTTd 252

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370479368 247 --IYW----MFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVlYNC---TVASTGGTDTKSFI 312
Cdd:PHA02785  253 adVFWisngMYYEEDDEDGDGRISVANKIYTTDKRRVITSRLNINPVKEEDATT-FTCmafTIPSISKTVTISIT 326
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-111 2.73e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 2.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368   26 PHITVVEGEPFYLkhcSCSlAHEIETTTKSWYKssGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKN--- 102
Cdd:smart00410   2 PSVTVKEGESVTL---SCE-ASGSPPPEVTWYK--QGGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNssg 75

                           90
                   ....*....|
gi 1370479368  103 -YTQKWKLNV 111
Cdd:smart00410  76 sASSGTTLTV 85
 
Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 324-466 2.39e-35

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 129.41  E-value: 2.39e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368 324 FVSYLkeCRPENGEEHTFAVEILPRVleKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSN-EVRYEL 402
Cdd:pfam01582   1 YDVFL--SFRGSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWCLDEL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368 403 ESGLHEALvERKIKIILIEFTPVTDFT-----FLPQSLKLLKSH----RVLKWKAD----------KSLSYNSRFWKNLL 463
Cdd:pfam01582  77 VKILECAL-DLGQKVIPIFYEVDPSDVrkqtgSFGKAFKKHKKVlteeKVLKWRGAlnevaniwhsKSVSDESKFWKKIA 155


                  ...
gi 1370479368 464 YLM 466
Cdd:pfam01582 156 YDI 158
TIR smart00255
Toll - interleukin 1 - resistance;
320-469 6.85e-34

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 124.36  E-value: 6.85e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368  320 TYDAFVSYlkecrpenGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNE-V 398
Cdd:smart00255   1 EYDVFISY--------SGKEDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEwC 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370479368  399 RYELESGLHEALVERKIKIILIEFTPVT-DFTFLPQSLKLLKSHRVLKWKADKSLsynsRFWKNLLYLMPAK 469
Cdd:smart00255  73 LDELVAALENALEEGGLRVIPIFYEVIPsDVRKQPGKFRKVFKKNYLKWPEDEKE----QFWKKALYAVPSK 140
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 324-421 1.17e-11

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 61.56  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368 324 FVSYlkecrpeNGEEHTFAVEILPRvLEKHfGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNE-VRYEL 402
Cdd:pfam13676   2 FISY-------AGEDRAWAEWLADA-LEAA-GYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPwCRAEW 72

                          90
                  ....*....|....*....
gi 1370479368 403 ESGLHEALVERKIKIILIE 421
Cdd:pfam13676  73 EAALADPEGRKRLIPVRLE 91
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 129-208 7.83e-08

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 50.02  E-value: 7.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368 129 IVEVKKFFQITC-ENSYYQTLVNSTSL--YKNCKKLLLENN----KNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKT 201
Cdd:cd05757     6 KLPITKGGKITCpDLDDYKNENVLPPIqwYKDCKPLQGDKRfipkGSKLLIQNVTEEDAGNYTCKFTYTHNGKQYNVTRT 85


                  ....*..
gi 1370479368 202 FNITIVE 208
Cdd:cd05757    86 ISLTVTE 92
Ig2_IL1R_like cd20994
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 155-208 2.45e-07

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409586  Cd Length: 94  Bit Score: 48.61  E-value: 2.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370479368 155 YKNCKKLLLENN-----KNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVE 208
Cdd:cd20994    36 YKDCKPLLLDDKrfaglESDLLIFNVTVQDQGNYTCHTSYTYMGKQYNISRTISLIVLE 94
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-100 4.21e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 39.75  E-value: 4.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368  28 ITVVEGEPFYLkHCSCSLAHEIETTTKSWYK-SSGSQEHVELNPRSSSR--------------IALHDCVLEFWPVELND 92
Cdd:pfam07686   6 VTVALGGSVTL-PCTYSSSMSEASTSVYWYRqPPGKGPTFLIAYYSNGSeegvkkgrfsgrgdPSNGDGSLTIQNLTLSD 84


                  ....*...
gi 1370479368  93 TGSYFFQM 100
Cdd:pfam07686  85 SGTYTCAV 92
Ig1_IL1R_like cd05756
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 19-104 7.72e-04

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409414  Cd Length: 96  Bit Score: 38.56  E-value: 7.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368  19 AESCTSRPHITVVEGEPFYLKhcsCSL-AHEIETTTKS---WYKSsGSQEHVELNPRSssRIALHDCVLEFWPVELNDTG 94
Cdd:cd05756     1 DEWGEDIKILVVLEGEPDVIK---CPLfPNFLAQSAGLnltWYKN-DSETPISFEPDS--RIHQEKDKLWFVPALLEDSG 74

                          90
                  ....*....|
gi 1370479368  95 SYFFQMKNYT 104
Cdd:cd05756    75 NYYCVVRNST 84
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 171-312 1.18e-03

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 41.15  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368 171 IKKNaefeDQGYYSCVHFLHHNGKLFNITKtfnITIVEDRSNIVPvllgPKL---NHVAVELGKNVRLNCSALLNEEDV- 246
Cdd:PHA02785  184 VRKN----DAGYYTCVLKYIYGDKTYNVTR---IVKLEVRDRIIP----PTMqlpEGVVTSIGSNLTIACRVSLRPPTTd 252

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370479368 247 --IYW----MFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVlYNC---TVASTGGTDTKSFI 312
Cdd:PHA02785  253 adVFWisngMYYEEDDEDGDGRISVANKIYTTDKRRVITSRLNINPVKEEDATT-FTCmafTIPSISKTVTISIT 326
Ig_6 pfam18452
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 56-143 1.38e-03

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


Pssm-ID: 465773  Cd Length: 128  Bit Score: 38.94  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368  56 WYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYF--FQMKNytqkwklnviRRNKHSCFterqvtsKIV-EV 132
Cdd:pfam18452  48 WYWQPKNGDPLEAITESSPHIIQEGNALWFLPVGVNDSGSYIcrPRIRS----------PQDEACCL-------KIIlEV 110

                          90
                  ....*....|.
gi 1370479368 133 KKFFQITCENS 143
Cdd:pfam18452 111 QPKTNASCSGS 121
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-111 2.73e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 2.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479368   26 PHITVVEGEPFYLkhcSCSlAHEIETTTKSWYKssGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKN--- 102
Cdd:smart00410   2 PSVTVKEGESVTL---SCE-ASGSPPPEVTWYK--QGGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNssg 75

                           90
                   ....*....|
gi 1370479368  103 -YTQKWKLNV 111
Cdd:smart00410  76 sASSGTTLTV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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