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Conserved domains on  [gi|1034612418|ref|XP_016859075|]
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EGF-containing fibulin-like extracellular matrix protein 1 isoform X1 [Homo sapiens]

Protein Classification

EGF_CA domain-containing protein( domain architecture ID 10541562)

EGF_CA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EGF_CA pfam07645
Calcium-binding EGF domain;
173-204 3.68e-09

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 51.85  E-value: 3.68e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1034612418 173 DIDECTAGTHNCRADQVCINLRGSFACQCPPG 204
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
214-253 2.03e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 2.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034612418  214 DIDECrTSSYLCQY--QCVNEPGKFSCMCPQGYQvvRSRTCQ 253
Cdd:smart00179   1 DIDEC-ASGNPCQNggTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
254-298 2.89e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.89e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1034612418  254 DINECETTNECREDEMCWNYHGGFRCYprnpCQDPYilTPENRCV 298
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCE----CPPGY--TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
44-71 1.07e-03

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*...
gi 1034612418  44 DIDECDIVPDACKGGMKCVNHYGGYLCL 71
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECR 28
 
Name Accession Description Interval E-value
EGF_CA pfam07645
Calcium-binding EGF domain;
173-204 3.68e-09

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 51.85  E-value: 3.68e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1034612418 173 DIDECTAGTHNCRADQVCINLRGSFACQCPPG 204
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
173-213 9.16e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 9.16e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034612418  173 DIDECTAGtHNCRADQVCINLRGSFACQCPPGYQkRGEQCV 213
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 173-213 2.87e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 2.87e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034612418 173 DIDECTAGtHNCRADQVCINLRGSFACQCPPGYqkRGEQCV 213
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGY--TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
214-253 2.03e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 2.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034612418  214 DIDECrTSSYLCQY--QCVNEPGKFSCMCPQGYQvvRSRTCQ 253
Cdd:smart00179   1 DIDEC-ASGNPCQNggTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
254-298 2.89e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.89e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1034612418  254 DINECETTNECREDEMCWNYHGGFRCYprnpCQDPYilTPENRCV 298
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCE----CPPGY--TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 214-253 3.68e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 3.68e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034612418 214 DIDECrTSSYLCQY--QCVNEPGKFSCMCPQGYqvvRSRTCQ 253
Cdd:cd00054     1 DIDEC-ASGNPCQNggTCVNTVGSYRCSCPPGY---TGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
44-71 1.07e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*...
gi 1034612418  44 DIDECDIVPDACKGGMKCVNHYGGYLCL 71
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECR 28
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 254-292 2.61e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 2.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1034612418 254 DINECETTNECREDEMCWNYHGGFRCYprnpCQDPYILT 292
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCS----CPPGYTGR 35
EGF_CA pfam07645
Calcium-binding EGF domain;
214-243 9.02e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 33.75  E-value: 9.02e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1034612418 214 DIDECRTSSYLCQYQ--CVNEPGKFSCMCPQG 243
Cdd:pfam07645   1 DVDECATGTHNCPANtvCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
EGF_CA pfam07645
Calcium-binding EGF domain;
173-204 3.68e-09

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 51.85  E-value: 3.68e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1034612418 173 DIDECTAGTHNCRADQVCINLRGSFACQCPPG 204
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
173-213 9.16e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 9.16e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034612418  173 DIDECTAGtHNCRADQVCINLRGSFACQCPPGYQkRGEQCV 213
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 173-213 2.87e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 2.87e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034612418 173 DIDECTAGtHNCRADQVCINLRGSFACQCPPGYqkRGEQCV 213
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGY--TGRNCE 38
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 177-212 6.28e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.59  E-value: 6.28e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1034612418 177 CTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQC 212
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 164-205 1.81e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 42.76  E-value: 1.81e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034612418 164 EQSEHNVCQDIDECTAGTHNCraDQVCINLRGSFACQCPPGY 205
Cdd:cd01475   177 KKFQGKICVVPDLCATLSHVC--QQVCISTPGSYLCACTEGY 216
EGF_CA smart00179
Calcium-binding EGF-like domain;
214-253 2.03e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 2.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034612418  214 DIDECrTSSYLCQY--QCVNEPGKFSCMCPQGYQvvRSRTCQ 253
Cdd:smart00179   1 DIDEC-ASGNPCQNggTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
254-298 2.89e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.89e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1034612418  254 DINECETTNECREDEMCWNYHGGFRCYprnpCQDPYilTPENRCV 298
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCE----CPPGY--TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 214-253 3.68e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 3.68e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034612418 214 DIDECrTSSYLCQY--QCVNEPGKFSCMCPQGYqvvRSRTCQ 253
Cdd:cd00054     1 DIDEC-ASGNPCQNggTCVNTVGSYRCSCPPGY---TGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
44-71 1.07e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*...
gi 1034612418  44 DIDECDIVPDACKGGMKCVNHYGGYLCL 71
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECR 28
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 212-244 1.20e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.06  E-value: 1.20e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1034612418 212 CVDIDECRTSSYLCQYQCVNEPGKFSCMCPQGY 244
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGY 216
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 254-292 2.61e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 2.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1034612418 254 DINECETTNECREDEMCWNYHGGFRCYprnpCQDPYILT 292
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCS----CPPGYTGR 35
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 176-206 3.02e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.15  E-value: 3.02e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1034612418 176 ECtAGTHNCRADQVCINLRGSFACQCPPGYQ 206
Cdd:cd00053     1 EC-AASNPCSNGGTCVNTPGSYRCVCPPGYT 30
EGF_CA pfam07645
Calcium-binding EGF domain;
214-243 9.02e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 33.75  E-value: 9.02e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1034612418 214 DIDECRTSSYLCQYQ--CVNEPGKFSCMCPQG 243
Cdd:pfam07645   1 DVDECATGTHNCPANtvCVNTIGSFECRCPDG 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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