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Conserved domains on  [gi|226958325|ref|NP_064648|]
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neurexin-1 isoform 1 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
503-652 2.03e-39

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 142.86  E-value: 2.03e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325    503 SISFDFRTTEPNGLILFSHGKPRHqkdakhpqmikvDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQR 582
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGG------------DYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226958325    583 DGRSGTISVN-TLRTPYTAPGESEILDLDDELYLGGLPENKaglvfptEVWTALLNYGYVGCIRDLFIDGQ 652
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDL-------KLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
933-1061 1.29e-33

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 126.00  E-value: 1.29e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   933 FKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKgSSNKPLNDNQWHNVMISRDTSNLhTVKIDTKITTQ 1012
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL-SSGKNLNDGQWHSVRVERNGNTL-TLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 226958325  1013 ITAGARN--LDLKSDLYIGGVAketYKSLPKLVHAKEGFQGCLASVDLNGR 1061
Cdd:pfam02210   79 SLPPGESllLNLNGPLYLGGLP---PLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
307-446 1.30e-30

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 117.83  E-value: 1.30e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325    307 EITLSFKTLQRNGLMLHTGKSA--DYVNLALKNGAVSLVINLGSGAFEalVEPVNGKFNDNAWHDVKVTRNLRQhsgigh 384
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSGPAR--LTSDPTPLNDGQWHRVAVERNGRS------ 72
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226958325    385 amVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 446
Cdd:smart00282   73 --VTLSVDGGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
30-190 1.04e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 115.98  E-value: 1.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   30 GLEFPGaeGQWTRFPKW-NACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILtRGGRLQLSFSIFcAEPATLLADTP 108
Cdd:cd00110     1 GVSFSG--SSYVRLPTLpAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALEL-EDGRLVLRYDLG-SGSLVLSSKTP 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  109 VNDGAWHSVRIRRQFRNTTLYIDRaeAKWVEVKSKRRD--MTVFSGLFVGGLPPELRAAALKLtlasvreREPFKGWIRD 186
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDG--ERVVESGSPGGSalLNLDGPLYLGGLPEDLKSPGLPV-------SPGFVGCIRD 147

                  ....
gi 226958325  187 VRVN 190
Cdd:cd00110   148 LKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
746-876 1.78e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.41  E-value: 1.78e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   746 FRSQRAYGILMATTSRDSaDTLRLELDAGRVKLTVNLdcirincnSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTV 825
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDL--------GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV 71
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 226958325   826 DDQQAMTGQMAGDHTRLefhNIETGI------ITERRYLSSVPSNFIGHLQSLTFNG 876
Cdd:pfam02210   72 DGQTVVSSLPPGESLLL---NLNGPLylgglpPLLLLPALPVRAGFVGCIRDVRVNG 125
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
1156-1304 3.19e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 85.16  E-value: 3.19e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  1156 FSTVQKEAVLVrvDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 1235
Cdd:pfam02210    1 FRTRQPNGLLL--YAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226958325  1236 RYPAGNNDnerlaiarqripyrlgrvvdewlldkgrqltIFNSQATIIIGG---------KEQGQPFQGQLSGLYYNG 1304
Cdd:pfam02210   79 SLPPGESL-------------------------------LLNLNGPLYLGGlppllllpaLPVRAGFVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
680-713 2.14e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 2.14e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 226958325  680 CLS-NPCKNNGMCRDGWNRYVCDCSgTGYLGRSCE 713
Cdd:cd00054     5 CASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
4.1m smart00294
putative band 4.1 homologues' binding motif;
1452-1470 3.03e-05

putative band 4.1 homologues' binding motif;


:

Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.13  E-value: 3.03e-05
                            10
                    ....*....|....*....
gi 226958325   1452 MYKYRNRDEGSYHVDESRN 1470
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
503-652 2.03e-39

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 142.86  E-value: 2.03e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325    503 SISFDFRTTEPNGLILFSHGKPRHqkdakhpqmikvDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQR 582
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGG------------DYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226958325    583 DGRSGTISVN-TLRTPYTAPGESEILDLDDELYLGGLPENKaglvfptEVWTALLNYGYVGCIRDLFIDGQ 652
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDL-------KLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
481-650 1.08e-38

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 141.79  E-value: 1.08e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  481 PITFETPeSFISLPKWNAKKT-GSISFDFRTTEPNGLILFSHGKPRHqkdakhpqmikvDFFAIEMLDGHLYLLLDMGSG 559
Cdd:cd00110     1 GVSFSGS-SYVRLPTLPAPRTrLSISFSFRTTSPNGLLLYAGSQNGG------------DFLALELEDGRLVLRYDLGSG 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  560 TIKIKAlQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPY-TAPGESEILDLDDELYLGGLPENKaglvfptEVWTALLNY 638
Cdd:cd00110    68 SLVLSS-KTPLNDGQWHSVSVERNGRSVTLSVDGERVVEsGSPGGSALLNLDGPLYLGGLPEDL-------KSPGLPVSP 139
                         170
                  ....*....|..
gi 226958325  639 GYVGCIRDLFID 650
Cdd:cd00110   140 GFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
508-652 4.09e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.54  E-value: 4.09e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   508 FRTTEPNGLILFSHGKPRhqkdakhpqmikvDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSG 587
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-------------DFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTL 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226958325   588 TISVNTLRT-PYTAPGESEILDLDDELYLGGLPEnkaglvfPTEVWTALLNYGYVGCIRDLFIDGQ 652
Cdd:pfam02210   68 TLSVDGQTVvSSLPPGESLLLNLNGPLYLGGLPP-------LLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
933-1061 1.29e-33

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 126.00  E-value: 1.29e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   933 FKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKgSSNKPLNDNQWHNVMISRDTSNLhTVKIDTKITTQ 1012
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL-SSGKNLNDGQWHSVRVERNGNTL-TLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 226958325  1013 ITAGARN--LDLKSDLYIGGVAketYKSLPKLVHAKEGFQGCLASVDLNGR 1061
Cdd:pfam02210   79 SLPPGESllLNLNGPLYLGGLP---PLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
307-446 1.30e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 117.83  E-value: 1.30e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325    307 EITLSFKTLQRNGLMLHTGKSA--DYVNLALKNGAVSLVINLGSGAFEalVEPVNGKFNDNAWHDVKVTRNLRQhsgigh 384
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSGPAR--LTSDPTPLNDGQWHRVAVERNGRS------ 72
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226958325    385 amVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 446
Cdd:smart00282   73 --VTLSVDGGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
906-1059 2.23e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.90  E-value: 2.23e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  906 PVTFkTKSSYVALATLQA-YTSMHLFFQFKTTSLDGLILYN-SGDGNDFIVVELVKGYLHYVFDLGNGANLIkgSSNKPL 983
Cdd:cd00110     1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALELEDGRLVLRYDLGSGSLVL--SSKTPL 77
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226958325  984 NDNQWHNVMISRDTSNLhTVKIDTK--ITTQITAGARNLDLKSDLYIGGVAkETYKSLPKLVHakEGFQGCLASVDLN 1059
Cdd:cd00110    78 NDGQWHSVSVERNGRSV-TLSVDGErvVESGSPGGSALLNLDGPLYLGGLP-EDLKSPGLPVS--PGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
284-443 5.29e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 116.75  E-value: 5.29e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  284 ATFKGSEYfcYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTG--KSADYVNLALKNGAVSLVINLGSGafEALVEPVNgK 361
Cdd:cd00110     2 VSFSGSSY--VRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGsqNGGDFLALELEDGRLVLRYDLGSG--SLVLSSKT-P 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  362 FNDNAWHDVKVTRNLRQhsgighamVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEV 441
Cdd:cd00110    77 LNDGQWHSVSVERNGRS--------VTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDL 148

                  ..
gi 226958325  442 VY 443
Cdd:cd00110   149 KV 150
LamG smart00282
Laminin G domain;
928-1061 1.02e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 115.13  E-value: 1.02e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325    928 HLFFQFKTTSLDGLILYN-SGDGNDFIVVELVKGYLHYVFDLGNGANLIKgSSNKPLNDNQWHNVMISRDTSNLhTVKID 1006
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgSKGGGDYLALELRDGRLVLRYDLGSGPARLT-SDPTPLNDGQWHRVAVERNGRSV-TLSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 226958325   1007 --TKITTQITAGARNLDLKSDLYIGGVaKETYKSLPKLVHakEGFQGCLASVDLNGR 1061
Cdd:smart00282   79 ggNRVSGESPGGLTILNLDGPLYLGGL-PEDLKLPPLPVT--PGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
30-190 1.04e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 115.98  E-value: 1.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   30 GLEFPGaeGQWTRFPKW-NACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILtRGGRLQLSFSIFcAEPATLLADTP 108
Cdd:cd00110     1 GVSFSG--SSYVRLPTLpAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALEL-EDGRLVLRYDLG-SGSLVLSSKTP 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  109 VNDGAWHSVRIRRQFRNTTLYIDRaeAKWVEVKSKRRD--MTVFSGLFVGGLPPELRAAALKLtlasvreREPFKGWIRD 186
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDG--ERVVESGSPGGSalLNLDGPLYLGGLPEDLKSPGLPV-------SPGFVGCIRD 147

                  ....
gi 226958325  187 VRVN 190
Cdd:cd00110   148 LKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
312-443 1.74e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 114.44  E-value: 1.74e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   312 FKTLQRNGLMLHTG-KSADYVNLALKNGAVSLVINLGSGAFEALVEPVNgkFNDNAWHDVKVTRNLRqhsgighaMVTIS 390
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKN--LNDGQWHSVRVERNGN--------TLTLS 70
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 226958325   391 VDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 443
Cdd:pfam02210   71 VDGQTVVSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG smart00282
Laminin G domain;
53-191 9.28e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 112.43  E-value: 9.28e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325     53 EMSFQLKTRSARGLVLYFDDEGFCDFLELILtRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDR 132
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALEL-RDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 226958325    133 AEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTlasvrerEPFKGWIRDVRVNS 191
Cdd:smart00282   80 GNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT-------PGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
58-191 9.41e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 103.65  E-value: 9.41e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325    58 LKTRSARGLVLYFDDEGfCDFLELILtRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKW 137
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG-SDFLALEL-VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 226958325   138 VEVKSKRRDMTVFSGLFVGGLPPELRaaalkltLASVREREPFKGWIRDVRVNS 191
Cdd:pfam02210   79 SLPPGESLLLNLNGPLYLGGLPPLLL-------LPALPVRAGFVGCIRDVRVNG 125
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
746-876 1.78e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.41  E-value: 1.78e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   746 FRSQRAYGILMATTSRDSaDTLRLELDAGRVKLTVNLdcirincnSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTV 825
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDL--------GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV 71
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 226958325   826 DDQQAMTGQMAGDHTRLefhNIETGI------ITERRYLSSVPSNFIGHLQSLTFNG 876
Cdd:pfam02210   72 DGQTVVSSLPPGESLLL---NLNGPLylgglpPLLLLPALPVRAGFVGCIRDVRVNG 125
LamG smart00282
Laminin G domain;
741-877 1.40e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.02  E-value: 1.40e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325    741 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCirincnsskGPETLFAGYN-LNDNEWHTVRVVRRGK 819
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---------GPARLTSDPTpLNDGQWHRVAVERNGR 71
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226958325    820 SLKLTVDDQQAMTGQMAGDHTRLEFH-NIETG--IITERRYLSSVPSNFIGHLQSLTFNGM 877
Cdd:smart00282   72 SVTLSVDGGNRVSGESPGGLTILNLDgPLYLGglPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
1156-1304 3.19e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 85.16  E-value: 3.19e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  1156 FSTVQKEAVLVrvDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 1235
Cdd:pfam02210    1 FRTRQPNGLLL--YAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226958325  1236 RYPAGNNDnerlaiarqripyrlgrvvdewlldkgrqltIFNSQATIIIGG---------KEQGQPFQGQLSGLYYNG 1304
Cdd:pfam02210   79 SLPPGESL-------------------------------LLNLNGPLYLGGlppllllpaLPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
1125-1244 1.47e-18

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 84.01  E-value: 1.47e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325 1125 TYIFSkGGGQITYKWPPNDRPSTRadrLAIGFSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDIAIEeSN 1204
Cdd:cd00110     1 GVSFS-GSSYVRLPTLPAPRTRLS---ISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLS-SK 74
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 226958325 1205 AIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDN 1244
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSAL 114
LamG smart00282
Laminin G domain;
1151-1304 4.96e-18

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 82.00  E-value: 4.96e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   1151 RLAIGFSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVD- 1229
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDg 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   1230 SWPVIERYPAGnndnerlaiarqripyrlgrvvdewlldkgrqLTIFNSQATIIIGG---------KEQGQPFQGQLSGL 1300
Cdd:smart00282   80 GNRVSGESPGG--------------------------------LTILNLDGPLYLGGlpedlklppLPVTPGFRGCIRNL 127

                    ....
gi 226958325   1301 YYNG 1304
Cdd:smart00282  128 KVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
718-875 1.66e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 80.93  E-value: 1.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  718 VLSYDGSMFMKIQLPVVMHTEaEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLdcirincnsSKGPET 797
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDL---------GSGSLV 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  798 LFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLefhNIETGI------ITERRYLSSVPSNFIGHLQS 871
Cdd:cd00110    71 LSSKTPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALL---NLDGPLylgglpEDLKSPGLPVSPGFVGCIRD 147

                  ....
gi 226958325  872 LTFN 875
Cdd:cd00110   148 LKVN 151
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
680-713 2.14e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 2.14e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 226958325  680 CLS-NPCKNNGMCRDGWNRYVCDCSgTGYLGRSCE 713
Cdd:cd00054     5 CASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
680-707 9.05e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 9.05e-06
                           10        20
                   ....*....|....*....|....*...
gi 226958325   680 CLSNPCKNNGMCRDGWNRYVCDCSgTGY 707
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGY 27
4.1m smart00294
putative band 4.1 homologues' binding motif;
1452-1470 3.03e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.13  E-value: 3.03e-05
                            10
                    ....*....|....*....
gi 226958325   1452 MYKYRNRDEGSYHVDESRN 1470
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
EGF_CA smart00179
Calcium-binding EGF-like domain;
680-713 4.31e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.31e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 226958325    680 CLS-NPCKNNGMCRDGWNRYVCDCSgTGY-LGRSCE 713
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECP-PGYtDGRNCE 39
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
503-652 2.03e-39

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 142.86  E-value: 2.03e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325    503 SISFDFRTTEPNGLILFSHGKPRHqkdakhpqmikvDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQR 582
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGG------------DYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226958325    583 DGRSGTISVN-TLRTPYTAPGESEILDLDDELYLGGLPENKaglvfptEVWTALLNYGYVGCIRDLFIDGQ 652
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDL-------KLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
481-650 1.08e-38

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 141.79  E-value: 1.08e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  481 PITFETPeSFISLPKWNAKKT-GSISFDFRTTEPNGLILFSHGKPRHqkdakhpqmikvDFFAIEMLDGHLYLLLDMGSG 559
Cdd:cd00110     1 GVSFSGS-SYVRLPTLPAPRTrLSISFSFRTTSPNGLLLYAGSQNGG------------DFLALELEDGRLVLRYDLGSG 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  560 TIKIKAlQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPY-TAPGESEILDLDDELYLGGLPENKaglvfptEVWTALLNY 638
Cdd:cd00110    68 SLVLSS-KTPLNDGQWHSVSVERNGRSVTLSVDGERVVEsGSPGGSALLNLDGPLYLGGLPEDL-------KSPGLPVSP 139
                         170
                  ....*....|..
gi 226958325  639 GYVGCIRDLFID 650
Cdd:cd00110   140 GFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
508-652 4.09e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.54  E-value: 4.09e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   508 FRTTEPNGLILFSHGKPRhqkdakhpqmikvDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSG 587
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-------------DFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTL 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226958325   588 TISVNTLRT-PYTAPGESEILDLDDELYLGGLPEnkaglvfPTEVWTALLNYGYVGCIRDLFIDGQ 652
Cdd:pfam02210   68 TLSVDGQTVvSSLPPGESLLLNLNGPLYLGGLPP-------LLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
933-1061 1.29e-33

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 126.00  E-value: 1.29e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   933 FKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKgSSNKPLNDNQWHNVMISRDTSNLhTVKIDTKITTQ 1012
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL-SSGKNLNDGQWHSVRVERNGNTL-TLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 226958325  1013 ITAGARN--LDLKSDLYIGGVAketYKSLPKLVHAKEGFQGCLASVDLNGR 1061
Cdd:pfam02210   79 SLPPGESllLNLNGPLYLGGLP---PLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
307-446 1.30e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 117.83  E-value: 1.30e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325    307 EITLSFKTLQRNGLMLHTGKSA--DYVNLALKNGAVSLVINLGSGAFEalVEPVNGKFNDNAWHDVKVTRNLRQhsgigh 384
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSGPAR--LTSDPTPLNDGQWHRVAVERNGRS------ 72
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226958325    385 amVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 446
Cdd:smart00282   73 --VTLSVDGGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
906-1059 2.23e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.90  E-value: 2.23e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  906 PVTFkTKSSYVALATLQA-YTSMHLFFQFKTTSLDGLILYN-SGDGNDFIVVELVKGYLHYVFDLGNGANLIkgSSNKPL 983
Cdd:cd00110     1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALELEDGRLVLRYDLGSGSLVL--SSKTPL 77
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226958325  984 NDNQWHNVMISRDTSNLhTVKIDTK--ITTQITAGARNLDLKSDLYIGGVAkETYKSLPKLVHakEGFQGCLASVDLN 1059
Cdd:cd00110    78 NDGQWHSVSVERNGRSV-TLSVDGErvVESGSPGGSALLNLDGPLYLGGLP-EDLKSPGLPVS--PGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
284-443 5.29e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 116.75  E-value: 5.29e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  284 ATFKGSEYfcYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTG--KSADYVNLALKNGAVSLVINLGSGafEALVEPVNgK 361
Cdd:cd00110     2 VSFSGSSY--VRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGsqNGGDFLALELEDGRLVLRYDLGSG--SLVLSSKT-P 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  362 FNDNAWHDVKVTRNLRQhsgighamVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEV 441
Cdd:cd00110    77 LNDGQWHSVSVERNGRS--------VTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDL 148

                  ..
gi 226958325  442 VY 443
Cdd:cd00110   149 KV 150
LamG smart00282
Laminin G domain;
928-1061 1.02e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 115.13  E-value: 1.02e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325    928 HLFFQFKTTSLDGLILYN-SGDGNDFIVVELVKGYLHYVFDLGNGANLIKgSSNKPLNDNQWHNVMISRDTSNLhTVKID 1006
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgSKGGGDYLALELRDGRLVLRYDLGSGPARLT-SDPTPLNDGQWHRVAVERNGRSV-TLSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 226958325   1007 --TKITTQITAGARNLDLKSDLYIGGVaKETYKSLPKLVHakEGFQGCLASVDLNGR 1061
Cdd:smart00282   79 ggNRVSGESPGGLTILNLDGPLYLGGL-PEDLKLPPLPVT--PGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
30-190 1.04e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 115.98  E-value: 1.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   30 GLEFPGaeGQWTRFPKW-NACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILtRGGRLQLSFSIFcAEPATLLADTP 108
Cdd:cd00110     1 GVSFSG--SSYVRLPTLpAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALEL-EDGRLVLRYDLG-SGSLVLSSKTP 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  109 VNDGAWHSVRIRRQFRNTTLYIDRaeAKWVEVKSKRRD--MTVFSGLFVGGLPPELRAAALKLtlasvreREPFKGWIRD 186
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDG--ERVVESGSPGGSalLNLDGPLYLGGLPEDLKSPGLPV-------SPGFVGCIRD 147

                  ....
gi 226958325  187 VRVN 190
Cdd:cd00110   148 LKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
312-443 1.74e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 114.44  E-value: 1.74e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   312 FKTLQRNGLMLHTG-KSADYVNLALKNGAVSLVINLGSGAFEALVEPVNgkFNDNAWHDVKVTRNLRqhsgighaMVTIS 390
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKN--LNDGQWHSVRVERNGN--------TLTLS 70
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 226958325   391 VDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 443
Cdd:pfam02210   71 VDGQTVVSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG smart00282
Laminin G domain;
53-191 9.28e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 112.43  E-value: 9.28e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325     53 EMSFQLKTRSARGLVLYFDDEGFCDFLELILtRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDR 132
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALEL-RDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 226958325    133 AEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTlasvrerEPFKGWIRDVRVNS 191
Cdd:smart00282   80 GNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT-------PGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
58-191 9.41e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 103.65  E-value: 9.41e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325    58 LKTRSARGLVLYFDDEGfCDFLELILtRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKW 137
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG-SDFLALEL-VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 226958325   138 VEVKSKRRDMTVFSGLFVGGLPPELRaaalkltLASVREREPFKGWIRDVRVNS 191
Cdd:pfam02210   79 SLPPGESLLLNLNGPLYLGGLPPLLL-------LPALPVRAGFVGCIRDVRVNG 125
Laminin_G_1 pfam00054
Laminin G domain;
508-655 9.57e-26

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 103.94  E-value: 9.57e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   508 FRTTEPNGLILFSHGKPRHqkdakhpqmikvDFFAIEMLDGHLYLLLDMGSGTIKIKALQkKVNDGEWYHVDFQRDGRSG 587
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTER------------DFLALELRDGRLEVSYDLGSGAAVVRSGD-KLNDGKWHSVELERNGRSG 67
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   588 TISVNTLRTP-YTAP-GESEILDLDDELYLGGLPENKAGLvfptevWTALLNYGYVGCIRDLFIDGQSKD 655
Cdd:pfam00054   68 TLSVDGEARPtGESPlGATTDLDVDGPLYVGGLPSLGVKK------RRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
746-876 1.78e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.41  E-value: 1.78e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   746 FRSQRAYGILMATTSRDSaDTLRLELDAGRVKLTVNLdcirincnSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTV 825
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDL--------GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV 71
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 226958325   826 DDQQAMTGQMAGDHTRLefhNIETGI------ITERRYLSSVPSNFIGHLQSLTFNG 876
Cdd:pfam02210   72 DGQTVVSSLPPGESLLL---NLNGPLylgglpPLLLLPALPVRAGFVGCIRDVRVNG 125
LamG smart00282
Laminin G domain;
741-877 1.40e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.02  E-value: 1.40e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325    741 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCirincnsskGPETLFAGYN-LNDNEWHTVRVVRRGK 819
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---------GPARLTSDPTpLNDGQWHRVAVERNGR 71
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226958325    820 SLKLTVDDQQAMTGQMAGDHTRLEFH-NIETG--IITERRYLSSVPSNFIGHLQSLTFNGM 877
Cdd:smart00282   72 SVTLSVDGGNRVSGESPGGLTILNLDgPLYLGglPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
933-1061 5.46e-20

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 87.37  E-value: 5.46e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   933 FKTTSLDGLILYN-SGDGNDFIVVELVKGYLHYVFDLGNGANLIkgSSNKPLNDNQWHNVMISRDTSNLhTVKID---TK 1008
Cdd:pfam00054    1 FRTTEPSGLLLYNgTQTERDFLALELRDGRLEVSYDLGSGAAVV--RSGDKLNDGKWHSVELERNGRSG-TLSVDgeaRP 77
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 226958325  1009 ITTQITAGARNLDLKSDLYIGGvAKETYKSLPKLVHAKeGFQGCLASVDLNGR 1061
Cdd:pfam00054   78 TGESPLGATTDLDVDGPLYVGG-LPSLGVKKRRLAISP-SFDGCIRDVIVNGK 128
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
1156-1304 3.19e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 85.16  E-value: 3.19e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  1156 FSTVQKEAVLVrvDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 1235
Cdd:pfam02210    1 FRTRQPNGLLL--YAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226958325  1236 RYPAGNNDnerlaiarqripyrlgrvvdewlldkgrqltIFNSQATIIIGG---------KEQGQPFQGQLSGLYYNG 1304
Cdd:pfam02210   79 SLPPGESL-------------------------------LLNLNGPLYLGGlppllllpaLPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
1125-1244 1.47e-18

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 84.01  E-value: 1.47e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325 1125 TYIFSkGGGQITYKWPPNDRPSTRadrLAIGFSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDIAIEeSN 1204
Cdd:cd00110     1 GVSFS-GSSYVRLPTLPAPRTRLS---ISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLS-SK 74
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 226958325 1205 AIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDN 1244
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSAL 114
LamG smart00282
Laminin G domain;
1151-1304 4.96e-18

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 82.00  E-value: 4.96e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   1151 RLAIGFSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVD- 1229
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDg 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   1230 SWPVIERYPAGnndnerlaiarqripyrlgrvvdewlldkgrqLTIFNSQATIIIGG---------KEQGQPFQGQLSGL 1300
Cdd:smart00282   80 GNRVSGESPGG--------------------------------LTILNLDGPLYLGGlpedlklppLPVTPGFRGCIRNL 127

                    ....
gi 226958325   1301 YYNG 1304
Cdd:smart00282  128 KVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
718-875 1.66e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 80.93  E-value: 1.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  718 VLSYDGSMFMKIQLPVVMHTEaEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLdcirincnsSKGPET 797
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDL---------GSGSLV 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325  798 LFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLefhNIETGI------ITERRYLSSVPSNFIGHLQS 871
Cdd:cd00110    71 LSSKTPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALL---NLDGPLylgglpEDLKSPGLPVSPGFVGCIRD 147

                  ....
gi 226958325  872 LTFN 875
Cdd:cd00110   148 LKVN 151
Laminin_G_1 pfam00054
Laminin G domain;
312-445 1.87e-15

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 74.28  E-value: 1.87e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   312 FKTLQRNGLMLHTGKSA--DYVNLALKNGAVSLVINLGSGAfeaLVEPVNGKFNDNAWHDVKVTRNLRQhsgighamVTI 389
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTerDFLALELRDGRLEVSYDLGSGA---AVVRSGDKLNDGKWHSVELERNGRS--------GTL 69
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 226958325   390 SVDGILTTTGYTQEDYTMLGS-DDFFYVGGSPSTADLP-GSPVSNNFMGCLKEVVYKN 445
Cdd:pfam00054   70 SVDGEARPTGESPLGATTDLDvDGPLYVGGLPSLGVKKrRLAISPSFDGCIRDVIVNG 127
Laminin_G_1 pfam00054
Laminin G domain;
59-195 1.43e-14

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 71.96  E-value: 1.43e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325    59 KTRSARGLVLYFDDEGFCDFLELILtRGGRLQLSFSiFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKWV 138
Cdd:pfam00054    2 RTTEPSGLLLYNGTQTERDFLALEL-RDGRLEVSYD-LGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTG 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 226958325   139 EVKSKRRDMTVFSG-LFVGGLPPElraAALKLTLASVRerePFKGWIRDVRVNSSQAL 195
Cdd:pfam00054   80 ESPLGATTDLDVDGpLYVGGLPSL---GVKKRRLAISP---SFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
746-879 5.41e-10

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 58.87  E-value: 5.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958325   746 FRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLdcirincnsSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTV 825
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDL---------GSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSV 71
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226958325   826 DDQQAMTGQMagDHTRLEFHNIETGI--------ITERRYLSSVPSnFIGHLQSLTFNGMAY 879
Cdd:pfam00054   72 DGEARPTGES--PLGATTDLDVDGPLyvgglpslGVKKRRLAISPS-FDGCIRDVIVNGKPL 130
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
680-713 2.14e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 2.14e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 226958325  680 CLS-NPCKNNGMCRDGWNRYVCDCSgTGYLGRSCE 713
Cdd:cd00054     5 CASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
Laminin_G_1 pfam00054
Laminin G domain;
1156-1229 3.02e-06

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 48.08  E-value: 3.02e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226958325  1156 FSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDiAIEESNAIINDGKYHVVRFTRSGGNATLQVD 1229
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTE-RDFLALELRDGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSVD 72
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
680-707 9.05e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 9.05e-06
                           10        20
                   ....*....|....*....|....*...
gi 226958325   680 CLSNPCKNNGMCRDGWNRYVCDCSgTGY 707
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGY 27
4.1m smart00294
putative band 4.1 homologues' binding motif;
1452-1470 3.03e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.13  E-value: 3.03e-05
                            10
                    ....*....|....*....
gi 226958325   1452 MYKYRNRDEGSYHVDESRN 1470
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
EGF_CA smart00179
Calcium-binding EGF-like domain;
680-713 4.31e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.31e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 226958325    680 CLS-NPCKNNGMCRDGWNRYVCDCSgTGY-LGRSCE 713
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECP-PGYtDGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
679-713 1.18e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 40.54  E-value: 1.18e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 226958325  679 PC-LSNPCKNNGMCRDGWNRYVCDCSgTGYLG-RSCE 713
Cdd:cd00053     1 ECaASNPCSNGGTCVNTPGSYRCVCP-PGYTGdRSCE 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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