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Conserved domains on  [gi|5729875|ref|NP_006658|]
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membrane-associated progesterone receptor component 1 isoform 1 [Homo sapiens]

Protein Classification

cytochrome b5-like heme/steroid binding domain-containing protein( domain architecture ID 10445738)

cytochrome b5-like heme/steroid binding domain-containing protein such as cytochrome b5, a membrane-bound hemoprotein that functions as an electron carrier for several membrane-bound oxygenases and Arabidopsis thaliana steroid-binding proteins

CATH:  3.10.120.10
Gene Ontology:  GO:0097159|GO:0016020
PubMed:  12537557|7893819

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 74-137 7.08e-13

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


:

Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 61.10  E-value: 7.08e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 5729875     74 TPAELRRFDGvqDPRILMAINGKVFDVTKGRKFY-GPEGPYGVFAGRDASRGLATFCLDKEALKD 137
Cdd:pfam00173   1 TLEELSKHNG--DGDCWVAINGKVYDVTKFLKEHpGGEDVILSAAGKDATDAFEAIGHSEDAAEK 63
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 74-137 7.08e-13

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 61.10  E-value: 7.08e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 5729875     74 TPAELRRFDGvqDPRILMAINGKVFDVTKGRKFY-GPEGPYGVFAGRDASRGLATFCLDKEALKD 137
Cdd:pfam00173   1 TLEELSKHNG--DGDCWVAINGKVYDVTKFLKEHpGGEDVILSAAGKDATDAFEAIGHSEDAAEK 63
COG4892 COG4892
Predicted heme/steroid binding protein [General function prediction only];
71-120 4.28e-05

Predicted heme/steroid binding protein [General function prediction only];


Pssm-ID: 443920 [Multi-domain]  Cd Length: 75  Bit Score: 40.19  E-value: 4.28e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 5729875   71 RDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGpeGP-YGVFAGRD 120
Cdd:COG4892   2 KEFTLEELAKYNGKDGNPAYVAVNGKVYDVTNSRLWKN--GThYGHWAGQD 50
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 74-137 7.08e-13

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 61.10  E-value: 7.08e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 5729875     74 TPAELRRFDGvqDPRILMAINGKVFDVTKGRKFY-GPEGPYGVFAGRDASRGLATFCLDKEALKD 137
Cdd:pfam00173   1 TLEELSKHNG--DGDCWVAINGKVYDVTKFLKEHpGGEDVILSAAGKDATDAFEAIGHSEDAAEK 63
COG4892 COG4892
Predicted heme/steroid binding protein [General function prediction only];
71-120 4.28e-05

Predicted heme/steroid binding protein [General function prediction only];


Pssm-ID: 443920 [Multi-domain]  Cd Length: 75  Bit Score: 40.19  E-value: 4.28e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 5729875   71 RDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGpeGP-YGVFAGRD 120
Cdd:COG4892   2 KEFTLEELAKYNGKDGNPAYVAVNGKVYDVTNSRLWKN--GThYGHWAGQD 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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