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Conserved domains on  [gi|24430146|ref|NP_005115|]
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nuclear pore complex protein Nup153 isoform 2 [Homo sapiens]

Protein Classification

Nup153 and Nup_retrotrp_bd domain-containing protein( domain architecture ID 13755483)

protein containing domains Nup153, zf-RanBP, Nucleoporin_FG2, and Nup_retrotrp_bd

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nup153 pfam08604
Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and ...
 113-621 0e+00

Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and Nup154 from fission yeast. These have been demonstrated to be functionally equivalent.


:

Pssm-ID: 462533 [Multi-domain]  Cd Length: 507  Bit Score: 740.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    113 PSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 192
Cdd:pfam08604    1 PSTSRSALNFQDVLTRPSLHRSHLNFTVLDSPALFCQPSTSTAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    193 DKDITVSKNTSLPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGaAAA 272
Cdd:pfam08604   81 DKDIPVSKTVSLPLLWSPEAERSHSLSQHSASSSKKPAFNLSAFGTLSPSLGNSSVLNTSQLGDSPFYPGKTTYGG-AAA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    273 VRQSKLRNTPYQAPVRRQMKAKQLSAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSIVSSPLNSPLDRSGIDITDFQA 352
Cdd:pfam08604  160 VRSSRVRGTPYQAPVRRQIKAKPANAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSTVSSPLSSPLDRSDLDITNFQS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    353 KREKVDSQYPPVQRLMTPKPVSIATNRSVYFKPSLTPSGEFRKTNQRIDNKCSTgYEKNMTPGQNREQRESGFSYPNFSL 432
Cdd:pfam08604  240 KRKKVDSQYPPVQKLVTPKAISVSGNRSVYFKPSLTPSGQSNKTSRRVDKDHRE-TEVRQSPEQAVEPSESSLSYPKFST 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    433 PAANGLSSGVGGGGGKMRRERTRFVASKPLEEEE-MEVPVLPKISLPITSSSLPTFNFSSPEITTSSPSPINSSQALTNK 511
Cdd:pfam08604  319 PASNSLSSGGNGGGGKMRRERGRRPSSKPAEEDEvVEVPVLPKISLPISTASLPTFNFSSPTSSTSSSSPPSVTKSAENK 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    512 VQMTSPSSTGSPMFKFSSPIVKSTEANVLPP-SSIGFTFSVPVAKTAELSGSSSTLEPIISSSAHhvTTVNSTNCKKTPP 590
Cdd:pfam08604  399 AQKQPPSTSGSPAFTFSSPIVKSTEASVPPPsPSIGFTFSVPVAKTAELSGSSGTSVVSVVSTET--TTVNSTSNKKEEE 476

                          490       500       510
                   ....*....|....*....|....*....|.
gi 24430146    591 EDCEGPFRPAEILKEGSVLDILKSPGFASPK 621
Cdd:pfam08604  477 EEFEGPFKPAKVLKQGSVLDILKSPGFASPK 507
Nup_retrotrp_bd pfam10599
Retro-transposon transporting motif; This is the highly conserved C-terminal motif ...
 1386-1475 2.90e-18

Retro-transposon transporting motif; This is the highly conserved C-terminal motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organizms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localization signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity.


:

Pssm-ID: 371156  Cd Length: 86  Bit Score: 80.88  E-value: 2.90e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146   1386 GTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGANSSTPAASAQPSGSGGFPFNQSPAAFTVGSNGKNvfsssGTSFSGR 1465
Cdd:pfam10599    2 EGTPDPASVFGFGSSNTNFNFTNNNPSTPFGFGASPSTPQAANPPSAFTPPAFSQSPASFNVGSNGSN-----MFSVSGR 76

                           90
                   ....*....|
gi 24430146   1466 KIKTAVRRRK 1475
Cdd:pfam10599   77 KIAQMRRRRR 86
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
723-751 2.17e-09

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 53.90  E-value: 2.17e-09
                           10        20
                   ....*....|....*....|....*....
gi 24430146    723 IGTWDCDTCLVQNKPEAIKCVACETPKPG 751
Cdd:pfam00641    2 EGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
851-880 8.69e-09

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 52.35  E-value: 8.69e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 24430146    851 PEGSWDCELCLVQNKADSTKCLACESAKPG 880
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
793-822 9.87e-09

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 51.97  E-value: 9.87e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 24430146    793 PIGSWECSVCCVSNNAEDNKCVSCMSEKPG 822
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
661-687 3.58e-07

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 47.73  E-value: 3.58e-07
                           10        20
                   ....*....|....*....|....*..
gi 24430146    661 SWQCDTCLLQNKVTDNKCIACQAAKLS 687
Cdd:pfam00641    4 DWDCSKCLVQNFATSTKCVACQAPKPD 30
Chi1 super family cl43877
Chitinase [Carbohydrate transport and metabolism];
1261-1437 3.78e-05

Chitinase [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG3469:

Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 48.21  E-value: 3.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146 1261 ATTSSTGTAVTPFVFGPGASSNNTTTSGFGFGATTTSSSAGSSFVFGTGPSAPSASPAFGANQTPTFGQSQGASQPNPPG 1340
Cdd:COG3469   37 ATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTS 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146 1341 FGSISSSTALFPTGSQPAPPTFGTVSSSSQPPVFGQQPSQSAFGSGTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGAN 1420
Cdd:COG3469  117 TGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTP 196

                        170
                 ....*....|....*..
gi 24430146 1421 SSTPAASAQPSGSGGFP 1437
Cdd:COG3469  197 SATTTATTTGPPTPGLP 213
 
Name Accession Description Interval E-value
Nup153 pfam08604
Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and ...
 113-621 0e+00

Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and Nup154 from fission yeast. These have been demonstrated to be functionally equivalent.


Pssm-ID: 462533 [Multi-domain]  Cd Length: 507  Bit Score: 740.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    113 PSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 192
Cdd:pfam08604    1 PSTSRSALNFQDVLTRPSLHRSHLNFTVLDSPALFCQPSTSTAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    193 DKDITVSKNTSLPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGaAAA 272
Cdd:pfam08604   81 DKDIPVSKTVSLPLLWSPEAERSHSLSQHSASSSKKPAFNLSAFGTLSPSLGNSSVLNTSQLGDSPFYPGKTTYGG-AAA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    273 VRQSKLRNTPYQAPVRRQMKAKQLSAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSIVSSPLNSPLDRSGIDITDFQA 352
Cdd:pfam08604  160 VRSSRVRGTPYQAPVRRQIKAKPANAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSTVSSPLSSPLDRSDLDITNFQS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    353 KREKVDSQYPPVQRLMTPKPVSIATNRSVYFKPSLTPSGEFRKTNQRIDNKCSTgYEKNMTPGQNREQRESGFSYPNFSL 432
Cdd:pfam08604  240 KRKKVDSQYPPVQKLVTPKAISVSGNRSVYFKPSLTPSGQSNKTSRRVDKDHRE-TEVRQSPEQAVEPSESSLSYPKFST 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    433 PAANGLSSGVGGGGGKMRRERTRFVASKPLEEEE-MEVPVLPKISLPITSSSLPTFNFSSPEITTSSPSPINSSQALTNK 511
Cdd:pfam08604  319 PASNSLSSGGNGGGGKMRRERGRRPSSKPAEEDEvVEVPVLPKISLPISTASLPTFNFSSPTSSTSSSSPPSVTKSAENK 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    512 VQMTSPSSTGSPMFKFSSPIVKSTEANVLPP-SSIGFTFSVPVAKTAELSGSSSTLEPIISSSAHhvTTVNSTNCKKTPP 590
Cdd:pfam08604  399 AQKQPPSTSGSPAFTFSSPIVKSTEASVPPPsPSIGFTFSVPVAKTAELSGSSGTSVVSVVSTET--TTVNSTSNKKEEE 476

                          490       500       510
                   ....*....|....*....|....*....|.
gi 24430146    591 EDCEGPFRPAEILKEGSVLDILKSPGFASPK 621
Cdd:pfam08604  477 EEFEGPFKPAKVLKQGSVLDILKSPGFASPK 507
Nup_retrotrp_bd pfam10599
Retro-transposon transporting motif; This is the highly conserved C-terminal motif ...
 1386-1475 2.90e-18

Retro-transposon transporting motif; This is the highly conserved C-terminal motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organizms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localization signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity.


Pssm-ID: 371156  Cd Length: 86  Bit Score: 80.88  E-value: 2.90e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146   1386 GTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGANSSTPAASAQPSGSGGFPFNQSPAAFTVGSNGKNvfsssGTSFSGR 1465
Cdd:pfam10599    2 EGTPDPASVFGFGSSNTNFNFTNNNPSTPFGFGASPSTPQAANPPSAFTPPAFSQSPASFNVGSNGSN-----MFSVSGR 76

                           90
                   ....*....|
gi 24430146   1466 KIKTAVRRRK 1475
Cdd:pfam10599   77 KIAQMRRRRR 86
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
723-751 2.17e-09

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 53.90  E-value: 2.17e-09
                           10        20
                   ....*....|....*....|....*....
gi 24430146    723 IGTWDCDTCLVQNKPEAIKCVACETPKPG 751
Cdd:pfam00641    2 EGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
851-880 8.69e-09

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 52.35  E-value: 8.69e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 24430146    851 PEGSWDCELCLVQNKADSTKCLACESAKPG 880
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
793-822 9.87e-09

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 51.97  E-value: 9.87e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 24430146    793 PIGSWECSVCCVSNNAEDNKCVSCMSEKPG 822
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
661-687 3.58e-07

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 47.73  E-value: 3.58e-07
                           10        20
                   ....*....|....*....|....*..
gi 24430146    661 SWQCDTCLLQNKVTDNKCIACQAAKLS 687
Cdd:pfam00641    4 DWDCSKCLVQNFATSTKCVACQAPKPD 30
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 724-748 7.86e-06

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 43.85  E-value: 7.86e-06
                            10        20
                    ....*....|....*....|....*
gi 24430146     724 GTWDCDTCLVQNKPEAIKCVACETP 748
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1261-1437 3.78e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 48.21  E-value: 3.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146 1261 ATTSSTGTAVTPFVFGPGASSNNTTTSGFGFGATTTSSSAGSSFVFGTGPSAPSASPAFGANQTPTFGQSQGASQPNPPG 1340
Cdd:COG3469   37 ATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTS 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146 1341 FGSISSSTALFPTGSQPAPPTFGTVSSSSQPPVFGQQPSQSAFGSGTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGAN 1420
Cdd:COG3469  117 TGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTP 196

                        170
                 ....*....|....*..
gi 24430146 1421 SSTPAASAQPSGSGGFP 1437
Cdd:COG3469  197 SATTTATTTGPPTPGLP 213
Nucleoporin_FG2 pfam15967
Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of ...
 1265-1441 2.14e-04

Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of chordate nucleoporins. The proteins carry many repeats of the FG sequence motif.


Pssm-ID: 435043 [Multi-domain]  Cd Length: 586  Bit Score: 45.81  E-value: 2.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146   1265 STGTAVTPFVFGPGASSNNTTTSGFGFGATTTSSSAGSS--------------------FVFGTgPSAPSASPAFGANQT 1324
Cdd:pfam15967   12 STATAGGGFSFGAAAASNPGSTGGFSFGTLGAAPAATATtttatlglggglfgqkpatgFTFGT-PASSTAATGPTGLTL 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146   1325 PTFGQSQGASQPNPPGFGSISSST---ALFPTGSQPAPPTFGTVSSSSQPPvfgQQPSQSAFGSGTTPNSSSAFQFG--- 1398
Cdd:pfam15967   91 GTPAATTAASTGFSLGFNKPAASAtpfSLPASSTSGGGLSLGSVLTSTAAQ---QGATGFTLNLGGTPATTTAVSTGlsl 167

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 24430146   1399 ----SSTTNFNFTNNSPSGV------FTFGANSSTPAASAQPS-GSGGFPFNQS 1441
Cdd:pfam15967  168 gstlTSLGGSLFQNTNSTGLgqttlgLTLLATSTAPVSAPAASeGLGGLDFSTS 221
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 660-683 2.63e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 39.61  E-value: 2.63e-04
                            10        20
                    ....*....|....*....|....
gi 24430146     660 SSWQCDTCLLQNKVTDNKCIACQA 683
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGA 24
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 853-875 3.26e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 39.22  E-value: 3.26e-04
                            10        20
                    ....*....|....*....|...
gi 24430146     853 GSWDCELCLVQNKADSTKCLACE 875
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACG 23
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 795-816 1.49e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 37.30  E-value: 1.49e-03
                            10        20
                    ....*....|....*....|..
gi 24430146     795 GSWECSVCCVSNNAEDNKCVSC 816
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFAC 22
 
Name Accession Description Interval E-value
Nup153 pfam08604
Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and ...
 113-621 0e+00

Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and Nup154 from fission yeast. These have been demonstrated to be functionally equivalent.


Pssm-ID: 462533 [Multi-domain]  Cd Length: 507  Bit Score: 740.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    113 PSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 192
Cdd:pfam08604    1 PSTSRSALNFQDVLTRPSLHRSHLNFTVLDSPALFCQPSTSTAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    193 DKDITVSKNTSLPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGaAAA 272
Cdd:pfam08604   81 DKDIPVSKTVSLPLLWSPEAERSHSLSQHSASSSKKPAFNLSAFGTLSPSLGNSSVLNTSQLGDSPFYPGKTTYGG-AAA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    273 VRQSKLRNTPYQAPVRRQMKAKQLSAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSIVSSPLNSPLDRSGIDITDFQA 352
Cdd:pfam08604  160 VRSSRVRGTPYQAPVRRQIKAKPANAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSTVSSPLSSPLDRSDLDITNFQS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    353 KREKVDSQYPPVQRLMTPKPVSIATNRSVYFKPSLTPSGEFRKTNQRIDNKCSTgYEKNMTPGQNREQRESGFSYPNFSL 432
Cdd:pfam08604  240 KRKKVDSQYPPVQKLVTPKAISVSGNRSVYFKPSLTPSGQSNKTSRRVDKDHRE-TEVRQSPEQAVEPSESSLSYPKFST 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    433 PAANGLSSGVGGGGGKMRRERTRFVASKPLEEEE-MEVPVLPKISLPITSSSLPTFNFSSPEITTSSPSPINSSQALTNK 511
Cdd:pfam08604  319 PASNSLSSGGNGGGGKMRRERGRRPSSKPAEEDEvVEVPVLPKISLPISTASLPTFNFSSPTSSTSSSSPPSVTKSAENK 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146    512 VQMTSPSSTGSPMFKFSSPIVKSTEANVLPP-SSIGFTFSVPVAKTAELSGSSSTLEPIISSSAHhvTTVNSTNCKKTPP 590
Cdd:pfam08604  399 AQKQPPSTSGSPAFTFSSPIVKSTEASVPPPsPSIGFTFSVPVAKTAELSGSSGTSVVSVVSTET--TTVNSTSNKKEEE 476

                          490       500       510
                   ....*....|....*....|....*....|.
gi 24430146    591 EDCEGPFRPAEILKEGSVLDILKSPGFASPK 621
Cdd:pfam08604  477 EEFEGPFKPAKVLKQGSVLDILKSPGFASPK 507
Nup_retrotrp_bd pfam10599
Retro-transposon transporting motif; This is the highly conserved C-terminal motif ...
 1386-1475 2.90e-18

Retro-transposon transporting motif; This is the highly conserved C-terminal motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organizms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localization signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity.


Pssm-ID: 371156  Cd Length: 86  Bit Score: 80.88  E-value: 2.90e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146   1386 GTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGANSSTPAASAQPSGSGGFPFNQSPAAFTVGSNGKNvfsssGTSFSGR 1465
Cdd:pfam10599    2 EGTPDPASVFGFGSSNTNFNFTNNNPSTPFGFGASPSTPQAANPPSAFTPPAFSQSPASFNVGSNGSN-----MFSVSGR 76

                           90
                   ....*....|
gi 24430146   1466 KIKTAVRRRK 1475
Cdd:pfam10599   77 KIAQMRRRRR 86
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
723-751 2.17e-09

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 53.90  E-value: 2.17e-09
                           10        20
                   ....*....|....*....|....*....
gi 24430146    723 IGTWDCDTCLVQNKPEAIKCVACETPKPG 751
Cdd:pfam00641    2 EGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
851-880 8.69e-09

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 52.35  E-value: 8.69e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 24430146    851 PEGSWDCELCLVQNKADSTKCLACESAKPG 880
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
793-822 9.87e-09

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 51.97  E-value: 9.87e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 24430146    793 PIGSWECSVCCVSNNAEDNKCVSCMSEKPG 822
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
661-687 3.58e-07

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 47.73  E-value: 3.58e-07
                           10        20
                   ....*....|....*....|....*..
gi 24430146    661 SWQCDTCLLQNKVTDNKCIACQAAKLS 687
Cdd:pfam00641    4 DWDCSKCLVQNFATSTKCVACQAPKPD 30
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 724-748 7.86e-06

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 43.85  E-value: 7.86e-06
                            10        20
                    ....*....|....*....|....*
gi 24430146     724 GTWDCDTCLVQNKPEAIKCVACETP 748
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1261-1437 3.78e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 48.21  E-value: 3.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146 1261 ATTSSTGTAVTPFVFGPGASSNNTTTSGFGFGATTTSSSAGSSFVFGTGPSAPSASPAFGANQTPTFGQSQGASQPNPPG 1340
Cdd:COG3469   37 ATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTS 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146 1341 FGSISSSTALFPTGSQPAPPTFGTVSSSSQPPVFGQQPSQSAFGSGTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGAN 1420
Cdd:COG3469  117 TGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTP 196

                        170
                 ....*....|....*..
gi 24430146 1421 SSTPAASAQPSGSGGFP 1437
Cdd:COG3469  197 SATTTATTTGPPTPGLP 213
Nucleoporin_FG2 pfam15967
Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of ...
 1265-1441 2.14e-04

Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of chordate nucleoporins. The proteins carry many repeats of the FG sequence motif.


Pssm-ID: 435043 [Multi-domain]  Cd Length: 586  Bit Score: 45.81  E-value: 2.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146   1265 STGTAVTPFVFGPGASSNNTTTSGFGFGATTTSSSAGSS--------------------FVFGTgPSAPSASPAFGANQT 1324
Cdd:pfam15967   12 STATAGGGFSFGAAAASNPGSTGGFSFGTLGAAPAATATtttatlglggglfgqkpatgFTFGT-PASSTAATGPTGLTL 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146   1325 PTFGQSQGASQPNPPGFGSISSST---ALFPTGSQPAPPTFGTVSSSSQPPvfgQQPSQSAFGSGTTPNSSSAFQFG--- 1398
Cdd:pfam15967   91 GTPAATTAASTGFSLGFNKPAASAtpfSLPASSTSGGGLSLGSVLTSTAAQ---QGATGFTLNLGGTPATTTAVSTGlsl 167

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 24430146   1399 ----SSTTNFNFTNNSPSGV------FTFGANSSTPAASAQPS-GSGGFPFNQS 1441
Cdd:pfam15967  168 gstlTSLGGSLFQNTNSTGLgqttlgLTLLATSTAPVSAPAASeGLGGLDFSTS 221
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 660-683 2.63e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 39.61  E-value: 2.63e-04
                            10        20
                    ....*....|....*....|....
gi 24430146     660 SSWQCDTCLLQNKVTDNKCIACQA 683
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGA 24
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 853-875 3.26e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 39.22  E-value: 3.26e-04
                            10        20
                    ....*....|....*....|...
gi 24430146     853 GSWDCELCLVQNKADSTKCLACE 875
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACG 23
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 795-816 1.49e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 37.30  E-value: 1.49e-03
                            10        20
                    ....*....|....*....|..
gi 24430146     795 GSWECSVCCVSNNAEDNKCVSC 816
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFAC 22
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1208-1394 3.83e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 41.66  E-value: 3.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146 1208 GGGIFGSSTSSSNPPVATFVFGQSSNPVSSSAFGNTAESSTSQSLL----FSQDSKLATTSSTGTAVTPFVFGPGASSNN 1283
Cdd:COG3469   24 GAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTaatsSTTSTTATATAAAAAATSTSATLVATSTAS 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146 1284 TTTSGFGFGATTTSSSAGssfvfGTGPSAPSASPAFGANQTPTFGQSQGASQPNPPG--FGSISSSTALFPTGSQPAPPT 1361
Cdd:COG3469  104 GANTGTSTVTTTSTGAGS-----VTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGteTATGGTTTTSTTTTTTSASTT 178

                        170       180       190
                 ....*....|....*....|....*....|...
gi 24430146 1362 FGTVSSSSQPPVFGQQPSQSAFGSGTTPNSSSA 1394
Cdd:COG3469  179 PSATTTATATTASGATTPSATTTATTTGPPTPG 211
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1174-1372 7.52e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 40.51  E-value: 7.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146 1174 GAQTSTTADQGAAKPVFSFLNNSSSSSSTPATSAGG-GIFGSSTSSSNPPVATFVFGQSSNPVSSSAFG-NTAESSTSQS 1251
Cdd:COG3469   12 AGGASATAVTLLGAAATAASVTLTAATATTVVSTTGsVVVAASGSAGSGTGTTAASSTAATSSTTSTTAtATAAAAAATS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24430146 1252 LLFSQDSKLATTSSTGTAVTPFVFGPGASSNNTTTSGFGFGATTTSSSAGSSFVFGTGPSAPSASPAF--GANQTPTFGq 1329
Cdd:COG3469   92 TSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETAtgGTTTTSTTT- 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 24430146 1330 sQGASQPNPPGFGSISSSTALFPTGSQPAPPTFGTVSSSSQPP 1372
Cdd:COG3469  171 -TTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGL 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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