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Conserved domains on  [gi|167466169|ref|NP_002039|]
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growth arrest-specific protein 1 precursor [Homo sapiens]

Protein Classification

GDNF domain-containing protein( domain architecture ID 10658247)

GDNF domain-containing protein similar to Homo sapiens growth arrest-specific protein 1 (GAS-1), which is a specific growth arrest protein involved in growth suppression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 48-143 2.46e-04

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 197975  Cd Length: 86  Bit Score: 39.55  E-value: 2.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466169    48 CWQALLQCQGEPECSYAYNQYAEACAPVLaqhgggdapgaaaaafpasaaSFSSRWRCPSHCISALIQLNHTR----RGP 123
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSP---------------------SSSCPGENSEACLRAYCGLALRPfyddNSS 59

                           90       100
                   ....*....|....*....|..
gi 167466169   124 ALEDCDCA--QDENCKSTKRAI 143
Cdd:smart00907  60 VLLFCTCAgnRDEECLEFRRLF 81
 
Name Accession Description Interval E-value
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 48-143 2.46e-04

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 39.55  E-value: 2.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466169    48 CWQALLQCQGEPECSYAYNQYAEACAPVLaqhgggdapgaaaaafpasaaSFSSRWRCPSHCISALIQLNHTR----RGP 123
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSP---------------------SSSCPGENSEACLRAYCGLALRPfyddNSS 59

                           90       100
                   ....*....|....*....|..
gi 167466169   124 ALEDCDCA--QDENCKSTKRAI 143
Cdd:smart00907  60 VLLFCTCAgnRDEECLEFRRLF 81
 
Name Accession Description Interval E-value
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 48-143 2.46e-04

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 39.55  E-value: 2.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466169    48 CWQALLQCQGEPECSYAYNQYAEACAPVLaqhgggdapgaaaaafpasaaSFSSRWRCPSHCISALIQLNHTR----RGP 123
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSP---------------------SSSCPGENSEACLRAYCGLALRPfyddNSS 59

                           90       100
                   ....*....|....*....|..
gi 167466169   124 ALEDCDCA--QDENCKSTKRAI 143
Cdd:smart00907  60 VLLFCTCAgnRDEECLEFRRLF 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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