|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
42-458 |
0e+00 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 690.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 42 LAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYII 121
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPEHSSSPSVEHNETGKKYDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 122 TQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSI 201
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 202 SYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVsdtpqkhkrishyekeyilsslrnqlssqksvp 281
Cdd:cd17381 161 SYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV--------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 282 wvpilksLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTL 361
Cdd:cd17381 208 -------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNFSTV 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 362 CVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGP 441
Cdd:cd17381 281 CVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMVGP 360
|
410
....*....|....*...
gi 1843419888 442 VIAKSLTPDAGV-QWRNL 458
Cdd:cd17381 361 VIAKSLTHNNTVeEWQTV 378
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
43-458 |
0e+00 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 521.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 43 AILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKAcpehsapiKVHHNQTGKKYQWDAETQGWILGSFFYGYIIT 122
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTD--------KDTLPVEAPEFDWSEKTQGIILSSFFYGYILT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 123 QIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSIS 202
Cdd:cd17318 73 QIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 203 YAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVsdtpqkhkrishyekeyilsslrnqlssqksvpw 282
Cdd:cd17318 153 YSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV---------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 283 vpilksLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLC 362
Cdd:cd17318 199 ------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTT 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 363 VRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPV 442
Cdd:cd17318 273 VRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPL 352
|
410
....*....|....*...
gi 1843419888 443 IAKSLTPDAGV--QWRNL 458
Cdd:cd17318 353 IVGAIVKNDQTigQWRIV 370
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
43-448 |
4.28e-116 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 348.17 E-value: 4.28e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 43 AILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTskacpehsapikvhhNQTGKKYQWDAETQGWILGSFFYGYIIT 122
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKV---------------IVHKAEFNWTPETVGLIESSFFWGYLVT 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 123 QIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSIS 202
Cdd:cd17382 66 QIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 203 YAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLvsdtpqkhkrishyekeyilsslrnqlssqksvpw 282
Cdd:cd17382 146 FCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV----------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 283 vpilkSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLC 362
Cdd:cd17382 191 -----SMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTA 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 363 VRRIFSLIGMIGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPV 442
Cdd:cd17382 266 VRKIFNCGGFGMEATFLLVVAFSH-SPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPV 344
|
....*.
gi 1843419888 443 IAKSLT 448
Cdd:cd17382 345 IVGALT 350
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
30-448 |
5.37e-110 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 335.56 E-value: 5.37e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 30 EAAPVCCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSnttleDNRTSKACPEHSAPIKVHHNqtgKKYQWDAETQG 109
Cdd:TIGR00894 8 TKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNK-----ENSTDLACLSAENELDNIKN---PNFKWSGALQG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 110 WILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:TIGR00894 80 LILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 190 APPLERSKLLSISYAGAQLGTVISLPLSGIIC-YYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILS 268
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 269 SLRNQ-LSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQ 347
Cdd:TIGR00894 240 SLQGQkGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 348 AADNLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLG 427
Cdd:TIGR00894 320 LADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKG 399
|
410 420
....*....|....*....|.
gi 1843419888 428 ITNtfatIPGMVGPVIAKSLT 448
Cdd:TIGR00894 400 ITG----LPGFIGGLIASTLA 416
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
44-444 |
7.08e-106 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 321.04 E-value: 7.08e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 44 ILAFFGFFIVYALRVNLSVALVDMVdsnttlednrtskacpehsapikvhhnqtgKKYQWDAETQGWILGSFFYGYIITQ 123
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMA------------------------------KEFGWSKTDQGLVLSSFFWGYALTQ 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 124 IPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISY 203
Cdd:cd17380 52 VLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVT 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 204 AGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSdtpqkhkrishyekeyilsslrnqlssqksvpwv 283
Cdd:cd17380 132 AGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP---------------------------------- 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 284 pilkslPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILrFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKwNFSTLCV 363
Cdd:cd17380 178 ------PVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISR-GWTVTSV 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 364 RRIFSLIGMIGPAVFLVAAGFIgCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVI 443
Cdd:cd17380 250 RKLMQSIGFLGPALFLLLLSHT-DSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYL 328
|
.
gi 1843419888 444 A 444
Cdd:cd17380 329 T 329
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
39-444 |
1.21e-51 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 180.07 E-value: 1.21e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 39 RYNLAILAFFGFFIVYALRVNLSVALVDMvdsnttlednrtskacpehsapikvhhnqtGKKYQWDAETQGWILGSFFYG 118
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTI------------------------------MKDLGLSPTQYGLIASAFFLG 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 119 YIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAAdlGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKL 198
Cdd:cd17319 51 YALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT--SLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRA 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 199 LSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVsdtPQkhkrishyekeyilsslrnqlssqk 278
Cdd:cd17319 129 TGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL---RQ------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 279 svpwvpilkslpLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKwnf 358
Cdd:cd17319 181 ------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG--- 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 359 stlcVRRIFSLIGMIGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFCSSGFSINHLDIAP-SYAGILLGITNTFATIPG 437
Cdd:cd17319 246 ----ARRLVIIIGLLLAAVGLLLAYLTT-SPVVAVILLSLAGFGIGAASPVFWSLPADLLPgEAAATAGGLINSGGNLGG 320
|
....*..
gi 1843419888 438 MVGPVIA 444
Cdd:cd17319 321 FVAPLLI 327
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
39-444 |
2.56e-45 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 163.12 E-value: 2.56e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 39 RYNLAILAFFGFFIVYALRVNLSVALVDMVDSnttlednrtskacpehsapikvhhnqtgkkYQWDAETQGWILGSFFYG 118
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQAD------------------------------LGLSAAQLGLLASAFFLG 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 119 YIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKL 198
Cdd:COG2271 58 YALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQ--LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 199 LSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLvsdtpqkhkrishyekeyilsslrnqlssqk 278
Cdd:COG2271 136 LGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFWL------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 279 svpwvpilkslplwaIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKwnf 358
Cdd:COG2271 185 ---------------LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR--- 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 359 stlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGM 438
Cdd:COG2271 247 -----RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGA 321
|
....*.
gi 1843419888 439 VGPVIA 444
Cdd:COG2271 322 LGPLLV 327
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
101-452 |
7.39e-45 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 162.21 E-value: 7.39e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 101 YQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFP 180
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWL--LLLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 181 AMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYY--MNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRI 258
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 259 SHYEKeyilsslrnqlSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGS 338
Cdd:cd06174 184 NEEAS-----------SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 339 WLCMILSGQAADNLRAkwnfstlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIA 418
Cdd:cd06174 253 ALGSLLLGLLSDRLIG---------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP 323
|
330 340 350
....*....|....*....|....*....|....
gi 1843419888 419 PSYAGILLGITNTFATIPGMVGPVIAKSLTPDAG 452
Cdd:cd06174 324 PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
98-441 |
8.86e-39 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 144.87 E-value: 8.86e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 98 GKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGV 177
Cdd:pfam07690 24 AEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWL--LLVLRVLQGLGAGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 178 TFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLwiWLVSDTPQKHKR 257
Cdd:pfam07690 102 LFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL--LLLPRPPPESKR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 258 ISHYEKEYILSslrnqlssqkSVPWVPILKSLPLWAIVVAhFSYNWTFYTLLTLLPTYMkEILRFNVQENGFLSSLPYLG 337
Cdd:pfam07690 180 PKPAEEARLSL----------IVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 338 SWLCMILSGQAADNLRAKwnfstlcVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDI 417
Cdd:pfam07690 248 GAIGRLLLGRLSDRLGRR-------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 1843419888 418 APSYAGILLGITNTFATIPGMVGP 441
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
109-455 |
6.02e-30 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 120.76 E-value: 6.02e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ--LLLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 189 WAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRishyekeyils 268
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 269 slRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQA 348
Cdd:cd17325 181 --RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 349 ADNLRakwnfstlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGI 428
Cdd:cd17325 259 SDRIG----------RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL 328
|
330 340
....*....|....*....|....*..
gi 1843419888 429 TNTFATIPGMVGPVIAKSLTPDAGVQW 455
Cdd:cd17325 329 FNTAFSLGMVLGPLLGGFLYDAFGFAT 355
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
37-447 |
4.42e-29 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 118.83 E-value: 4.42e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 37 SARYNLAILAFFGFFIVYALRVNLSVALVDMvdsnttlednrtskacpehsapikvhhnqtGKKYQWDAETQGWILGSFF 116
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPL------------------------------AEEFGLSAAQLGLLFAIPV 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 117 YGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERS 196
Cdd:COG2223 51 LVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWL--LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRG 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 197 KLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHyekeyilSSLRNQLSs 276
Cdd:COG2223 129 LALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK-------ASLRDQLE- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 277 qksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRakw 356
Cdd:COG2223 201 --------ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIG--- 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 357 nfstlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLA-VAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATI 435
Cdd:COG2223 270 -------GRRVLLIVFALMALGLLLLALALGSLWLFlVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGL 342
|
410
....*....|..
gi 1843419888 436 PGMVGPVIAKSL 447
Cdd:COG2223 343 GGFLGPLLFGAL 354
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
101-435 |
8.66e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 117.00 E-value: 8.66e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 101 YQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFP 180
Cdd:COG2814 40 LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWL--LLAARFLQGLGAGALFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 181 AMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIG-IFWFLLWIWLVSDTPQKHKRIS 259
Cdd:COG2814 118 AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLAlLALLLLLRLLPESRPAARARLR 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 260 HYEKEyilsslrnqlssqksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSW 339
Cdd:COG2814 198 GSLRE--------------------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGV 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 340 LCMILSGQAADNLRakwnfstlcvRRIFSLIGMIGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFCSSGFSINHLDIAP 419
Cdd:COG2814 258 LGALLAGRLADRFG----------RRRLLLIGLLLLALGLLLLALAG-SLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326
|
330
....*....|....*..
gi 1843419888 420 -SYAGILLGITNTFATI 435
Cdd:COG2814 327 pEARGRASGLYNSAFFL 343
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
47-443 |
8.02e-21 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 94.36 E-value: 8.02e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 47 FFGFFIVYALRVNLSVALVDMVDSnttlednrtskacpehsapikvhhnqtgkkYQWDAETQGWILGSFFYGYIITQIPG 126
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEE------------------------------IGLSKTDLGLLLSSFSIAYGISKFVM 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 127 GYVASKIGGKMLLGFGILGTAVLTLFtpIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGA 206
Cdd:TIGR00881 51 GSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSH 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 207 QLGTVISLPLSGI-ICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRIS-----HYEKEYILSSLRNQLSSQKSV 280
Cdd:TIGR00881 129 NVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPaeempNEEPDGDAEKKEEELTKKQIF 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 281 PWVpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLrakwnfst 360
Cdd:TIGR00881 209 LQY-VLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKL-------- 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 361 lcVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGF----SINHLDIAPSYA-GILLGITNTFATI 435
Cdd:TIGR00881 280 --FNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPqmliGVIASELAPKKAaGTAAGFVGFFAYL 357
|
....*...
gi 1843419888 436 PGMVGPVI 443
Cdd:TIGR00881 358 GGILAGLP 365
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
110-446 |
1.65e-20 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 93.85 E-value: 1.65e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 110 WILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTpiAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLT--AAVKNFGGLIALRFFLGLFESGVFPGFILYLGMW 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 190 APPLERSKLLSISYAGAQLGTVislpLSGII---CYYM-------NWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRIS 259
Cdd:cd17327 123 YKREEQAKRIAFFYAAAGLGSI----FGGLLaygVFKIlgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLT 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 260 HYEKEYILSSLR-NQ--LSSQKSVP--WVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENgFLSSLP 334
Cdd:cd17327 199 EEEKELAVERLRaNQtgKGDQKFKWkqIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQTN-LLSVPI 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 335 YLGSWLCMILSGQAADNLRAKWNFSTlcvrrIFSLIGMIGPAVfLVAAGFIGCDYsLAVAFLTISTTLGGFCSSGFSINh 414
Cdd:cd17327 278 GALGAVSLLIAALLSDRFKKRGLFAI-----FACVLALVGSII-LLAAPNPPGAY-FAAYILGGGSYAGFPILLSWISS- 349
|
330 340 350
....*....|....*....|....*....|....
gi 1843419888 415 ldIAPSYAG--ILLGITNTFATIPGMVGPVIAKS 446
Cdd:cd17327 350 --NCAGYTKraTVLAIMLIFYNVGNIVAPQIFRA 381
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
104-447 |
5.76e-16 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 79.71 E-value: 5.76e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADlgVGPLIVLRALEGLGEGVTFPAMH 183
Cdd:TIGR00895 50 DPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATN--VTQLLILRFLAGLGLGGLMPNLN 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 184 AMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWI--------WLVSDTPQKH 255
Cdd:TIGR00895 128 ALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMrflpesidFLVSKRPETV 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 256 KRISHYEKEYILSSLRNQLSSQKSVP--WVPILK----------SLPLWaivVAHFSYNWTFYTLLTLLPTYMKEiLRFN 323
Cdd:TIGR00895 208 RRIVNAIAPQMQAEAQSALPEQKSTQgtKRSVFKalfqgktariTVLLW---LLYFMLLVGVYFLTNWLPKLMVE-LGFS 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 324 VQENGFLSSLPYLGSWLCMILSGQAADNLRAKwnfstlcvrriFSLIGMIGPAVFLVAAGFigcDYSLAVAFLTISTTLG 403
Cdd:TIGR00895 284 LSLAATGGALFNFGGVIGSIIFGWLADRLGPR-----------VTALLLLLGAVFAVLVGS---TLFSPTLLLLLGAIAG 349
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1843419888 404 GFCSSGFSINHLDIAPSYA--------GILLGITNTFAtipgMVGPVIAKSL 447
Cdd:TIGR00895 350 FFVNGGQSGLYALMALFYPtairatgvGWAIGIGRLGA----IIGPILAGYL 397
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
109-444 |
6.69e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 79.52 E-value: 6.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL--LLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 189 WAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILs 268
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLL- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 269 slrnqlssqksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQA 348
Cdd:cd17324 194 ----------------LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 349 ADNLRAkwnfstlcvRRIFSLIGMIgpAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGI 428
Cdd:cd17324 258 ADRGGR---------RALLIALLLL--AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSL 326
|
330
....*....|....*.
gi 1843419888 429 TNTFATIPGMVGPVIA 444
Cdd:cd17324 327 YLAAYNLGGALGAALG 342
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
109-444 |
3.14e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 74.14 E-value: 3.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYIITQIPGGYVASKIGGK--MLLGFGILGTA-VLTLFTPiaadlGVGPLIVLRALEGLGEGVTFPAMHAM 185
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKkvLLPGLLLFGIGgLLCGLSD-----SFALLLAGRALQGIGAAGLGPLALTL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 186 WSSWAPPLERSKLLSISYAGAQLGTVISlPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYekeY 265
Cdd:cd17474 112 IGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSAT---K 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 266 ILSSLRnqlssqksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSwlcMILS 345
Cdd:cd17474 188 LRDLKK-------------ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL---ALGS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 346 GQAADNLRAKWNFSTLCVrrifslIGMIGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYA-GI 424
Cdd:cd17474 252 LFVGRLLKKRFGARRILV------IGLLLYALSLLLLGFVP-SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEErGT 324
|
330 340
....*....|....*....|
gi 1843419888 425 LLGITNTFATIPGMVGPVIA 444
Cdd:cd17474 325 ASSLYNFVRFLGQAVGPLLF 344
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
104-247 |
1.27e-13 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 71.38 E-value: 1.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMH 183
Cdd:COG0477 47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPEL--LIAARALQGIGAGGLMPGAL 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843419888 184 AMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWL 247
Cdd:COG0477 125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
109-443 |
1.88e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 72.19 E-value: 1.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMwSS 188
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPL--LLLALFLLGLGLGLLDVAANPY-VA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 189 WAPPLERSKLLSISYAGAQLGTVISlPLSGIICYYMNWT-YVFYFFGTIGIFWFLLWIWLVsdtPQKHKRISHYEKEyil 267
Cdd:COG0738 123 ALGPETAASRLNLLHAFFSLGALLG-PLLGGLLILLGLSlSWHLPYLILAVLLLLLALLFL---RSKLPEIEEEEEE--- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 268 sslrnqlSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLpylgSWLCMILSGQ 347
Cdd:COG0738 196 -------AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL----FWGGMTIGRF 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 348 AADNLRAKWNFSTLCvrRIFSLIGMIGPAVFLVAAGFIgcdysLAVAFLTIsttLGGFCSSGFS-INHL--DIAPSYAGI 424
Cdd:COG0738 265 LGGFLLKRFGPVRLL--RLSALLAAVGLLLALLAPGPW-----LALIGLAL---VGLGLSLMFPtIFSLalDGLGKRTAA 334
|
330
....*....|....*....
gi 1843419888 425 LLGITNTFATIPGMVGPVI 443
Cdd:COG0738 335 AVSAVLIMGIVGGAIGPPL 353
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
127-401 |
2.13e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 71.84 E-value: 2.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 127 GYVASKIGGKMLLGFGILGTAVLTLfTPIAADlGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGA 206
Cdd:cd17473 56 GWLADRFGRKRLLIAGLLLYGIGGV-AGLFLD-SLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAM 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 207 QLGTVISLPLSGIICYyMNWTYVFYFFGtIGIFWFLLWIWLVSDTPQKHKRISHYEKEyilsslrnqlsSQKSVPWVPIl 286
Cdd:cd17473 134 SLGGVVFLLLGGALAE-IGWRAPFLVYL-LALPVLILVLLFLPEPARKSKSAASPGAA-----------TAAALPWKRV- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 287 kslplWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSwlcmILSGQAADNLRAKWNFSTLcVRRI 366
Cdd:cd17473 200 -----LPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAG----AIGALLFGRLKRRLGKRRL-LAIG 269
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1843419888 367 FSL--IGMI------GPAVFLVAAGFIGCDYSLAVAFLTISTT 401
Cdd:cd17473 270 FALmaLGFLllalasGLWVVLLGAILAGLGFGLLLPTLNSWAM 312
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
109-443 |
2.66e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 68.42 E-value: 2.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPV--LLVLLFLVGAGYGSVQPGGGRAIMR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 189 WAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLL-WIWLV-SDTPQKHKRISHYEKEYI 266
Cdd:cd17475 112 WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLfWLFYRePPAASAATESASTLLRSL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 267 LSSLRNqlssqksvpwvpilksLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSG 346
Cdd:cd17475 192 KEVLRN----------------RDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 347 QAADNLRAKwnfstlcvRRIFSLIGMIGPAVfLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGF-SINHLDIA----PSY 421
Cdd:cd17475 256 RVSDRVFGG--------RRRPVLVITAAIAA-AALLVLSLLSPGTPLWLLVLLLILLGLFAIGWnGLYLTLVAesagPEQ 326
|
330 340
....*....|....*....|..
gi 1843419888 422 AGILLGITNTFATIPGMVGPVI 443
Cdd:cd17475 327 AGTALGLANTINFIGIAIGPPL 348
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
106-409 |
5.47e-12 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 67.33 E-value: 5.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 106 ETQGWILGSFF-YGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHA 184
Cdd:cd17371 33 EAEAGLLGTVTlAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ--LLILRALAGLGFGGEWAAGAA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 185 MWSSWAPPLERSKLLSISYAGAQLG----TVISLPLSGIICYYMNWTYVFYFfgtiGIFWFLLWIWL---VSDTPQkhkr 257
Cdd:cd17371 111 LMAEYVPARHRGKALGYVQSGWAVGwllaTLLAALLFPLLPPEIAWRVLFLL----GALPALLVLFIrrfVKEPPQ---- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 258 ishyekeYILSSLRNQLSSQKSVPWV---PILKSLPLWAIVVAHFSYnWTFYTLLTLLPTYMKEILRFNVQENGFLSSLP 334
Cdd:cd17371 183 -------WQAARAARRHFADRPSLRElfsPPLLRTTLLASLLATGAL-GGYYGITTWLPSYLTGERGLSFEGSAGYLVVT 254
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1843419888 335 YLGSWLCMILSGQAADNLRAKWNFstlcvrrifsLIGMIGPAVFLVAAGFIGCDYSLavafLTISTTLGGFCSSG 409
Cdd:cd17371 255 ILGGFLGYLAGGFLADRIGRRNNF----------ALFALGSAISILLYFFLPLSPTL----ILILGFPLGFFASG 315
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
104-411 |
5.68e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 64.16 E-value: 5.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMH 183
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPIL--LLVLRFLQGIGIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 184 AMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYM----NWTYVFYFFGTIGIFWFLLWIWlvsdtpqkhkris 259
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRILFLIGALPALLALLLRRR------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 260 hyekeyilsslrnqlssqksvpwvpilkslpLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSW 339
Cdd:cd17316 179 -------------------------------TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGAL 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1843419888 340 LCMILSGQAADnlraKWNfstlcvRRIFSLIGMIGPAVFLVAAGFIGcdySLAVAFLTISTTLGGFCSSGFS 411
Cdd:cd17316 228 VGALIAGLLSD----RIG------RKKTLVIGLILSGILALPLFYLL---SGSPTLLLLLLFILSFFVGGVW 286
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
99-248 |
2.17e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.59 E-value: 2.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 99 KKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAAdlGVGPLIVLRALEGLGEGVT 178
Cdd:cd17325 228 ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 179 FPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLV 248
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
141-444 |
2.29e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 62.61 E-value: 2.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 141 FGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAP-----PLERSKLLSISYAGAQLGTVISLP 215
Cdd:COG2211 86 IGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAeltpdYEERTRLSSWRFAFAGLGGLLASV 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 216 LSGIICYYM------NWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKrishyEKEYILSSLRNqlssqksvpwvpILKSL 289
Cdd:COG2211 166 LPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE-----EKVSLKESLKA------------LLKNR 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 290 PLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFstlcvrrifsL 369
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAF----------I 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 370 IGMIGPAVFLVAAGFIGcdySLAVAFLTISTTLGGFCSSGFSINHL----DIAP--------SYAGILLGITNTFATIPG 437
Cdd:COG2211 299 IGLLLAALGLLLLFFLG---PGNLWLLLVLAALAGIGLGAILVLPWamlaDVVDydewktgrRREGLYFGIFTFAIKLGQ 375
|
....*..
gi 1843419888 438 MVGPVIA 444
Cdd:COG2211 376 ALAGALA 382
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
104-406 |
3.06e-10 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 61.82 E-value: 3.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 104 DAETQGWILGSFFYGYIITqIP-GGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAM 182
Cdd:cd17503 29 SLDTVQWVITSYLLALAIM-IPlSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--LIIFRILQGFGGGVLIPLA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 183 HAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLwiwlvsdTPqkhkrishye 262
Cdd:cd17503 106 QTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL-------AP---------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 263 keyiLSSLRnqlssqksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCM 342
Cdd:cd17503 169 ----LLDLR-------------LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILS 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843419888 343 ILSGQAADnlraKWNFstlcvrRIFSLIGMIGPAVFLVAAGFIGCDYSlaVAFLTISTTLGGFC 406
Cdd:cd17503 232 PLVGRLLD----KFGP------RLLLLAGLLLLALGTLLLAFLTPDTS--LWLIILPLFIRGLG 283
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
109-333 |
5.05e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 61.47 E-value: 5.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADlgVGPLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS--PWLFAIALVLTGFGGGLFEPASEAMIAD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 189 WAPPLERSKLLSISYAGAQLGTVISlPLSGIICYYMNWTYVFYF-FGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEyil 267
Cdd:cd17329 116 VTTPENRTRAFSLLYWAINLGVAIG-PLLGGLLLLYSFRLLFLAaAVLFLLAALVLLFLLPETRPKRRAAEKTEILR--- 191
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1843419888 268 sslrnqlssqksvPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSL 333
Cdd:cd17329 192 -------------GYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLAL 244
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
109-397 |
7.08e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 60.69 E-value: 7.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAAdlGVGPLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT--SVALLLVLRLIHGIGWGAFTTAAATLVAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 189 WAPPLERSKLLSISYAGAQLGTVISLPLSGIIcyYMNWTYVFYFFGTIGI-FWFLLWIWLVSDTPQKHKRIShyekeyil 267
Cdd:cd17489 112 IIPPSRRGEGIGYYGLATTLAMALGPALGLFL--YQHLGFAVLFIVAAVLaLLALLLVFLVKDPPPVAAEEA-------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 268 sslrnqlSSQKSVPWVPILKSLPLWAIVVAHFSYnwTFYTLLTLLPTYMKEILRFNVqenGFLSSLPYLGSWLCMILSGQ 347
Cdd:cd17489 182 -------EAGTRAFRRLVEKKVLPPALILFLASI--AYGAISTFLPLYAAERGISNA---GLFFTVYAIALLLSRPFSGK 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1843419888 348 AADNLRAKWnFSTLCVrrIFSLIGMI------GPAVFLVAAGFIGCDYSLAVAFLT 397
Cdd:cd17489 250 LSDRKGPKT-VIIPGL--LLLALGLLllsfagSPWMLLLAAVLYGLGFGLLFPALQ 302
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
99-253 |
3.32e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.73 E-value: 3.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 99 KKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIG--GKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEG 176
Cdd:COG2271 209 EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPAL--AIALLFLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1843419888 177 VTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQ 253
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
104-447 |
3.40e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 58.72 E-value: 3.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMH 183
Cdd:cd17321 29 SPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAF--LIAARALQGIGAAAIMPASL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 184 AMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLwiwlvsdtpqkhkrishyek 263
Cdd:cd17321 107 ALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL-------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 264 eyilsslrnqlssqksvpwvpilkSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMI 343
Cdd:cd17321 167 ------------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 344 LSGQAADNLRAkwnfstlcvrRIFSLIGMIgpavfLVAAGFIG---CDYSLAVAFLTISTTLGGFCsSGFSINHLDIA-- 418
Cdd:cd17321 223 LAGRLADRFGP----------RLVLVAGLL-----LTAVGLLLlalLGADSSVWLLLPGLVLLGLG-LGLFATPLTNAal 286
|
330 340 350
....*....|....*....|....*....|...
gi 1843419888 419 ----PSYAGILLGITNTFATIPGMVGPVIAKSL 447
Cdd:cd17321 287 ssvpKEKAGAASGILNTARQLGGALGVALLGAL 319
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
124-396 |
3.57e-09 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 58.73 E-value: 3.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 124 IPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAAdlGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPpLERSKLLSISY 203
Cdd:COG2807 71 PLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP--SVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYT 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 204 AGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRishyekeyilsslrnqlsSQKSVPWV 283
Cdd:COG2807 148 AAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAA------------------APAAASLR 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 284 PILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEiLRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLCV 363
Cdd:COG2807 210 SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLG 288
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1843419888 364 rrIFSLIGMIG--------PAVFLVAAGF-IGCDYSLAVAFL 396
Cdd:COG2807 289 --LLGLAGLLGlllapgslPWLWAVLLGLgQGGLFPLALTLI 328
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
44-447 |
3.65e-09 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 58.79 E-value: 3.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 44 ILAFFGFFIVYALRVNLSVALVDMVDSnttlednrtskacpehsapikvhhnqtgkkYQWDAETQGWILGSFFYGYIITQ 123
Cdd:cd17345 6 LGIFIGYAGYYLVRNNFSLAQPYLIEQ------------------------------YGLSKTEIGLIGSALSIAYGLSK 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 124 IPGGYVASKIGGKMLLGFGILGTAVLTLFTPIA--ADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSI 201
Cdd:cd17345 56 FVMGNLSDRSNPKRFLAIGLILSAIINILIGFVpsATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSI 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 202 SYAGAQLGTVISLPLSGIICYYM---NWTYVFYFFGTIGIFWFLLWIWLVSDTPQKH--KRISHYEKEYILSSLRNQLSS 276
Cdd:cd17345 136 WNISHNVGGGLVGPLAGLGLAIFgdgWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEglPPIEEYKGDYPEEADGEEEEQ 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 277 QKSVP---WVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLR 353
Cdd:cd17345 216 ELSAWeifVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLF 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 354 AKwnfstlcvRRifSLIGMIgpAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSG----FSINHLDIAPSYA-GILLGI 428
Cdd:cd17345 296 KG--------RR--APTGII--FMILVIVALIVYWLAPNVLVDLIALIALGFLIYGpvmlIGLQALELVPKKAaGTAAGL 363
|
410
....*....|....*....
gi 1843419888 429 TNTFATIpgmVGPVIAKSL 447
Cdd:cd17345 364 TGLFGYL---GGSVLATAL 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
39-452 |
7.67e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 57.67 E-value: 7.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 39 RYNLAILAFFGFFIVYALRVNLSVALVDMVDsnttlednrtskacpehsapikvhhnqtgkKYQWDAETQGWILGSFFYG 118
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVE------------------------------EIGLSKDDLGIIGSAFLIA 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 119 YIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKL 198
Cdd:cd17312 51 YAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWF--FAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTV 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 199 LSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGI-FWFLLWIWLVSDtpqkhkrishyekeyilsslrnqlssq 277
Cdd:cd17312 129 YGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLvVAIILFFFLRDS--------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 278 ksvPWVpilkslpLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLrakWN 357
Cdd:cd17312 182 ---PPY-------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKL---FG 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 358 FSTLCVRRIFSLIGMIGPAVFLVAAGFIgcdYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYA-GILLGITNTFATIP 436
Cdd:cd17312 249 GRRAPIAVIYMLLMTLSLALFWFFPHNK---LLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAaGTATGFVGLFGYLG 325
|
410
....*....|....*.
gi 1843419888 437 GMVGPVIAKSLTPDAG 452
Cdd:cd17312 326 ASLAGLPLGYIIDHYG 341
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
107-398 |
2.44e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 56.09 E-value: 2.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 107 TQGWILGSFF-YGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAM 185
Cdd:cd17328 34 SLAGLLQTVFiISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ--LLLFRALVGIGEASYSPIAPTI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 186 WSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIIC-YYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKE 264
Cdd:cd17328 112 IADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 265 YILSSLRNqlssqksvpWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSlpYLGSWLCM-- 342
Cdd:cd17328 192 TATSFLAD---------LKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGL--IFGAITCIag 260
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1843419888 343 ----ILSGQAADNLRAKwnfstlcVRRIFSLIGMIG--PAVFLVAAGFIGCDYSLAVAFLTI 398
Cdd:cd17328 261 vlgvLLGGILADRLRRK-------TPRADPLVCAVGllAAAPFLFLALVLALSNLLLAWVLL 315
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
109-455 |
3.38e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 55.70 E-value: 3.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGP---LIVLRALEGLGEGVTFPAMHAM 185
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSlwlLLVLAFLLGIASAFFGPARQAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 186 WSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYF-FGTIGIFWFLLWIWLVSDTPQKHKRISHYEKE 264
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAInALSFLLSALLLLFIRRPPPAAPGESSSLLLRD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 265 YILSSLRnqlssqksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMIL 344
Cdd:cd06173 197 LREGLRY-------------LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 345 SGQAADNLRakwnfstlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGI 424
Cdd:cd06173 264 LGRLSKRRR----------RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGR 333
|
330 340 350
....*....|....*....|....*....|.
gi 1843419888 425 LLGITNTFATIPGMVGPVIAKSLTPDAGVQW 455
Cdd:cd06173 334 VFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
109-444 |
5.02e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 55.02 E-value: 5.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYIITQIPGGYVASKIG-GKMLLGFGILGTAVLTLFTPiAADLGVgpLIVLRALEGLGEGVTFPAM----H 183
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGrRRTLILGLLLISLALALIFA-TPSIYL--FVVLMFLAGLGAGILDTGAntfvG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 184 AMWSSwapplERSKLLSISYAGAQLGTVISLPLSG-IICYYMNWTYVFYFFGTIGIFWFLLWIWLVSdtpqkhkrishye 262
Cdd:cd17333 111 ALFEE-----SSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYLLLAILILLTLF------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 263 KEYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCM 342
Cdd:cd17333 173 PELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGR 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 343 ILSGQAADNLRAKwnfsTLCVrrIFSLIGMIGPAVFLVAAGFIGcdysLAVAFLTISTTLGGFCSSGFSINhLDIAPSYA 422
Cdd:cd17333 253 LLGGPISRRIKPH----TLLV--LSGSGALLGLLILLLAPTLVV----GLVATALLGLFMAALFPTILSLG-ISNLPYAK 321
|
330 340
....*....|....*....|..
gi 1843419888 423 GILLGITNTFATIPGMVGPVIA 444
Cdd:cd17333 322 GKGTSVLLAAGSIGGAIIPFIM 343
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
127-445 |
1.65e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 53.33 E-value: 1.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 127 GYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSWAPPlERSKLLSISYAGA 206
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWL--LLLLVALAGIGSAAFHPEGARLASQAAGG-RRGLAMSIFSVGG 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 207 QLGTVISlPLSGIICYYMNWTYVFYFFGTI-GIFWFLLWIWLVSDTPQKHKRishyekeyilsslRNQLSSQKSVPWVPI 285
Cdd:cd17478 129 NLGFALG-PLIAAALVALFGGLGLLILLIIpGLAVALLLLRLRPLKKPEAKK-------------AAAKSSARSTLKGVW 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 286 LKSLPLWAIVvahFSYNWTFYTLLTLLPTYMKEILrFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFstlcvrr 365
Cdd:cd17478 195 RALLLLLIIV---FLRSWVLSSLTTFLPFYLVQRG-YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVI------- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 366 ifsLIGMIGPAVFLVAAGFIGCDYSLAVAFLTisttlGGFCSSGFSINHL---DIAPSYAGILLGITNTFA-TIPGMVGP 441
Cdd:cd17478 264 ---IASLLLAAPFLLLFLLTPGIWSYILLVLA-----GFLLFASFPVTVVlaqELLPGNVGLASGLMMGLSfGLGGIGAP 335
|
....
gi 1843419888 442 VIAK 445
Cdd:cd17478 336 VLGA 339
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
100-209 |
3.98e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 52.28 E-value: 3.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 100 KYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTF 179
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWL--LLLALFLLGFGFGLLF 314
|
90 100 110
....*....|....*....|....*....|
gi 1843419888 180 PAMHAMWSSWAPPLERSKLLSISYAGAQLG 209
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
109-444 |
5.41e-07 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 51.83 E-value: 5.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGeGVTFPAMhAMWSS 188
Cdd:cd17472 35 GLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYG--LILGRALQGSG-AISSVVM-ALLAD 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 189 WAPPLERSKllSISYAGAQLGT--VISLPLSGIICYYMNWTYVFYFFGTIGIFWFLlWIWLVSDTPQKHKRISHYEKEYI 266
Cdd:cd17472 111 LTREENRTK--AMALIGASIGIafAISMVLGPLLAAHLGVSGLFLITAILSLVSLL-ILLFFVPDPPKIVQISEKEKKKL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 267 LSSLRNqlssqksvpwvPILKSLPLwAIVVAHFSYNWTFYtlltLLPTYMKEILRFNVQEngFLSSLP-YLGSWLCMILS 345
Cdd:cd17472 188 KKLLKN-----------KRLLRLDF-SIFILHFVLMAFFY----ILPLLLTQLGGGKGQL--WKVYLPaILIGFILMVPF 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 346 GQAADNLRAKWN---FSTLCVRRIFSLIGMIGPAVFLVAAGFIGcdysLAVAFLTISTTLGGFcssgfsINHLdIAPSYA 422
Cdd:cd17472 250 VIYAEKKGKMKQvfvSSILLIAVGFLLLLFAATSLWLLIIGLII----FFIGFNLLEALLPSL------VSKI-APKEYR 318
|
330 340
....*....|....*....|..
gi 1843419888 423 GILLGITNTFATIPGMVGPVIA 444
Cdd:cd17472 319 GTAMGIYNTSQFLGSFLGGALG 340
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
108-253 |
8.36e-07 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 51.11 E-value: 8.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 108 QGWILGSffygYIITQ----IPGGYVASKIGGKMLLgfgILGTAVLTLFTPIAadlGVGP----LIVLRALEGLGEGVTF 179
Cdd:cd17476 35 LSWLAAS----YSLTVgtfiLIFGRLGDIYGHKKMF---VIGSFWFAIWSLIA---GFSPnfifFIICRALQGLGPAFLL 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1843419888 180 P-AMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLL-WIWLVSDTPQ 253
Cdd:cd17476 105 PnAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAaIFWTSPSFIA 180
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
104-249 |
1.03e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.66 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMH 183
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ--LALLRFLTGLGLGAAMPNAI 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1843419888 184 AMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFL-----LWIWLVS 249
Cdd:cd17365 110 TLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPllrgtLLLWVTF 180
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
110-258 |
1.09e-06 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 51.23 E-value: 1.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 110 WILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:TIGR00711 41 WVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLEL--MIIFRVIQGFGGGPLIPLSFSTLLNI 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 190 APPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLL-WIWLVSDTPQKHKRI 258
Cdd:TIGR00711 119 YPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVaFFILPRDKPAASENF 188
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
111-253 |
1.67e-06 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 50.10 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 111 ILGSFFY-GYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:cd17488 42 ILGSLFYiTYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWA--FAVLWTLNAFFQGWGWPPCARLLTHW 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843419888 190 APPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQ 253
Cdd:cd17488 120 YSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIAILMGIVLCWRLRDRPP 183
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
101-243 |
2.52e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 49.73 E-value: 2.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 101 YQWDAETQGWILGSFFYGYIITQIPGGYVASK-IGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLraLEGLGEGVTF 179
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLL--LLGFGLGGLL 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1843419888 180 PAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYM-NWTYVFYFFGTIGIFWFLL 243
Cdd:cd06174 312 PLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATfGLTGAFLVLAVLLLLAAIL 376
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
109-253 |
3.08e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 49.58 E-value: 3.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:PRK11551 53 GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--LLVARLLTGVGLGGALPNLIALTSE 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1843419888 189 WAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQ 253
Cdd:PRK11551 131 AVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRA 195
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
102-247 |
1.10e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.61 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 102 QWDAETQGWILGSFFYGYIItqipGGYVASKIGGKMLLG-FGILGTAVLTLFTPIAADLGVGPL-IVLRALEGLGEGVTF 179
Cdd:cd06173 240 GGGAAGYGLLLAAFGVGALL----GALLLGRLSKRRRRGrLLLIGALLLGLALLVLGLSPSLWLlLAALFLLGLAGGLFN 315
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1843419888 180 PAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWL 247
Cdd:cd06173 316 VPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
109-396 |
1.16e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.55 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17477 34 GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWV--WFLLRFVMGIGLAGLFVVSESWLNA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 189 WAPPLERSKLLSISYAGAQLGTVISlPLSGIICYYMNWTyvfyFFGTIGIFwFLLWIWLVSDTPQKHKRISHYEKeyils 268
Cdd:cd17477 112 LATNENRGRVLGLYSTVLGLGFALG-PLLLALVGTAGAL----PFLIAAVL-LLLALVPLLLTRRAAPEIEEAES----- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 269 slrnqlssqksVPWVPILKSLPLwaIVVAHFSYNWTFYTLLTLLPTYMKEILrFNVQENGFLSSLPYLGSWLCMILSGQA 348
Cdd:cd17477 181 -----------ISLRRLLRIAPL--ALLGAFVAGFLEGAFYSLLPLYGLRLG-LSVAQAALLLAAFVLGGLLLQWPLGWL 246
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1843419888 349 ADNLRAKWnfstlcVRRIFSLIGMIGP--------------AVFLVAAGFIGCDYSLAVAFL 396
Cdd:cd17477 247 ADRFDRRR------VLLGCALLGALAAlllplvpglplallVLLFLWGGAAGPLYTLALALA 302
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
104-405 |
1.32e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 47.57 E-value: 1.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMH 183
Cdd:cd17320 32 SASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--LLIARFLQGLGAAAGSVVAR 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 184 AMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRIshyek 263
Cdd:cd17320 110 AIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRK----- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 264 eyilSSLRNQLSSQKSVpwvpiLKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGswlcMI 343
Cdd:cd17320 185 ----PLLSSLLRAYKRV-----LKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIA----LI 251
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1843419888 344 LSGQAADNLRAKWNFSTLCvrrIFSLIGMIGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGF 405
Cdd:cd17320 252 LGSLLNGRLVRRFGPRRLL---RLGLLLLLAAALVLLLAALLG-GLSLWPLVAPLFLIFFGF 309
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
291-455 |
2.63e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.40 E-value: 2.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 291 LWAIVVAHFSYNWTFYTLLTLLPTYMKEiLRFNVQENGFLSSLPYLGSWLCMILSGQAADnlraKWNfstlcvRRIFSLI 370
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQAD-LGLSAAQLGLLASAFFLGYALGQIPAGLLAD----RFG------RRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 371 GMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPD 450
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
....*
gi 1843419888 451 AGVQW 455
Cdd:COG2271 161 FGWRA 165
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
109-242 |
4.02e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.02 E-value: 4.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYIITQipggyvasKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17474 246 LLALGSLFVGRLLKK--------RFGARRILVIGLLLYALSLLLLGFVPSLAL--LLIAIVLFGLGLGLNLPLLTTLVTE 315
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1843419888 189 WAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFY-----FFGTIGIFWFL 242
Cdd:cd17474 316 LAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLvgaaiALAAAVLLALL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
294-455 |
5.38e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.49 E-value: 5.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 294 IVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRakwnfstlcvRRIFSLIGMI 373
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG----------RRRVLLIGLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 374 GPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPDAGV 453
Cdd:pfam07690 71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGW 150
|
..
gi 1843419888 454 QW 455
Cdd:pfam07690 151 RA 152
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
102-452 |
7.81e-05 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 44.99 E-value: 7.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 102 QWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTpiAADLGVGPLIVLRALEGLGEGVTFPA 181
Cdd:cd06180 30 GLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAM--ALTSGFAALLALRFLAGAASAFVFVF 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 182 MHAMWSSWAPPLERSKLLSISYAGAQLGTVIS-LPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISh 260
Cdd:cd06180 108 GSNLVLHHATAAGRGHLIGLLFAGVGLGIALSgLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEAS- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 261 yekeyilsslrnqlSSQKSVPWVpilksLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQEnGFLSSLPYLGSWL 340
Cdd:cd06180 187 --------------AAESAPGLN-----RPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLA-GLLWSLFGLAAVP 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 341 CMILSGQAADNLRAKWNFS-TLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLaVAFLTISTTLGGfcssgfsinhlDIAP 419
Cdd:cd06180 247 SCFLWGALSDRWGTRRALAaNLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTF-MAITALVMALAR-----------ELAP 314
|
330 340 350
....*....|....*....|....*....|...
gi 1843419888 420 SYAGILLGITNTFATIPGMVGPVIAKSLTPDAG 452
Cdd:cd06180 315 PAAPRALALMTASFGVGQILGPLLAGWLADATG 347
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
109-256 |
1.45e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.07 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILG-SFFYGYIItQIPGGYVASKIGG-KMLLGFGILGTAVLTLFtpIAADLGVGPLIVLRALEGLGEGVTFPAMHAMW 186
Cdd:cd17370 37 GLIEGlAEALGSLL-RLFSGYLSDRTGKrKPLVILGYGLSALAKPL--LALAGSWQLVLLLRILERLGKGIRTPPRDALL 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1843419888 187 SSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTY--VFYFFGTIGIFWFLLWIWLVSDTPQKHK 256
Cdd:cd17370 114 ADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNYrtIFLLAAIPALLALLILLFVVKEYPRPPK 185
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
124-443 |
2.05e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 43.78 E-value: 2.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 124 IPGGYVASKIGGKMLlgfGILGTAVLTLFTPIAADLGVGP--LIVLRALEGLGeGVTFPAMHAMWSSWAPPLERSKLLSI 201
Cdd:cd17341 52 LPYGFLCDRFGGRRV---FIASLLLLLIPLLALALAVSSYwgLLVLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 202 SYAGAQLGTVIS----LPLSGIICY---YMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKhkrishyeKEYILSSLRnql 274
Cdd:cd17341 128 IAGAGNMGVAVSqllaPLIAGAIVFdggFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTG--------KASALEFLK--- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 275 ssqksvPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADnlra 354
Cdd:cd17341 197 ------VQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSD---- 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 355 KWNFStlcVRRIFSLIGMIGPAVFLVAAGFIgcDYSLAVAFLTISTTLGGFCSSGF-SINHL--DIAPSYAGILLGITNT 431
Cdd:cd17341 267 RFGGR---RRLWWLFIVMTIGAALLSLSLPT--SGTNLVLFLALFVALGLGAGAGNgSVFRMvpFIFRRELGAVTGLVGA 341
|
330
....*....|..
gi 1843419888 432 FATIPGMVGPVI 443
Cdd:cd17341 342 IGGLGGFFLPLL 353
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
112-326 |
2.38e-04 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 43.52 E-value: 2.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 112 LGSFFYGYIITQIPG---GYVASKIGGK--MLLGFGILGTAVLTL-FTPIAADLGV-GPLIVL--RALEGLGEGVTFPAM 182
Cdd:cd17368 43 FATFGVGFFMRPIGAivlGAYADRIGRKpaMTLTLAIMALGTLLIaLAPTYATIGIaAPLLVLlaRLLQGFAAGGEVGGV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 183 HAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMN------WTYVFYFFGTIGIFWFLLWIWL-VSDTPQKH 255
Cdd:cd17368 123 TAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSLTLTaealaeWGWRIPFFIGLLIIPLGLWLRRsLEETEAFL 202
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1843419888 256 KRISHYEKEYILSSLRNqlssqksvPWVPILKSLPLWAIVVAhfsynwTFYTLLTLLPTYMKEILRFNVQE 326
Cdd:cd17368 203 ERKARPTRRELFALLAN--------NRRIILLGMLLVAGSTV------TFYFTTVYTPTYAKTVLGLSARD 259
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
100-243 |
2.92e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.95 E-value: 2.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 100 KYQWDAETQGWILGSFFYGYIITQIP-GGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVlrALEGLGEGVT 178
Cdd:cd17330 204 RFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAA--AILAFGTGIV 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1843419888 179 FPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIIcYYMNWTYVFYFFG----TIGIFWFLL 243
Cdd:cd17330 282 FPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL-YSFLGPGVPFLLAagllLIALFLLSL 349
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
113-248 |
5.55e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.20 E-value: 5.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 113 GSFFYGYIITQIPGGYVASKI----GGKMLLGFGILgtaVLTLFTPIAADLGVGPLIVLRA-LEGLGEGVTFPAMHAMWS 187
Cdd:cd17489 230 GLFFTVYAIALLLSRPFSGKLsdrkGPKTVIIPGLL---LLALGLLLLSFAGSPWMLLLAAvLYGLGFGLLFPALQALAV 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1843419888 188 SWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLV 248
Cdd:cd17489 307 DLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
99-330 |
7.02e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 41.99 E-value: 7.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 99 KKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVT 178
Cdd:TIGR00710 33 ADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIET--LLVLRFVQAFGASAG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 179 FPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRI 258
Cdd:TIGR00710 111 SVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLPYEARI 190
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1843419888 259 ShyekeyilsslrnqlSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFL 330
Cdd:TIGR00710 191 Q---------------ISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLL 247
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
109-245 |
9.90e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.54 E-value: 9.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLgFGILGTAVLTLFTPIAADLGVGpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17333 238 GYLLSGFWVGITIGRLLGGPISRRIKPHTLL-VLSGSGALLGLLILLLAPTLVV-GLVATALLGLFMAALFPTILSLGIS 315
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1843419888 189 WAPpLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWI 245
Cdd:cd17333 316 NLP-YAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLAL 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
101-247 |
1.02e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.40 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 101 YQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGK--MLLGFGILGTAVLTL-FTPIAADLGVGPLIVLRALEGLGEGV 177
Cdd:COG2223 236 FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRrvLLIVFALMALGLLLLaLALGSLWLFLVLFLLLGLALGGGNGA 315
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1843419888 178 TFPAMHAMWsswaPPLERSKLLSISYAGAQLGTVISLPLSG-IICYYMNWTYVFYFFGTIGIFWFLLWIWL 247
Cdd:COG2223 316 VFALVPDIF----PTKNAGAVYGLVGAAGGLGGFLGPLLFGaLLDATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
109-249 |
1.11e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.41 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGeGVTFPAMHAMWSS 188
Cdd:cd17330 37 GLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWL--LFLARFLDGLT-GGNVSVAQAYIAD 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1843419888 189 WAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVS 249
Cdd:cd17330 114 ITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP 174
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
281-455 |
1.13e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.11 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 281 PWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEiLRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAkwnfst 360
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGR------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 361 lcvRRIFsLIGMIGPAVFLVAAGFigcdySLAVAFLTISTTLGGFCSSGFSINHLDIAPSYA-----GILLGITNTFATI 435
Cdd:COG2814 75 ---RRVL-LLGLLLFALGSLLCAL-----APSLWLLLAARFLQGLGAGALFPAALALIADLVpperrGRALGLLGAGLGL 145
|
170 180
....*....|....*....|
gi 1843419888 436 PGMVGPVIAKSLTPDAGVQW 455
Cdd:COG2814 146 GPALGPLLGGLLADLFGWRW 165
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
103-385 |
1.17e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.49 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 103 WDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRAL-EGLGEGVTFPA 181
Cdd:cd17355 35 WSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQ--LYLLWGLlGGGGAGTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 182 MHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGT-IGIFWFLLWIWLVSDTPQKHKRISH 260
Cdd:cd17355 113 AFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALlALLVLVPVLLLLRRRPADLALRAYD 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 261 YEKEYILSSLRNQlssqksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEIlRFNVQENGFLSSLPYLGSWL 340
Cdd:cd17355 193 DASPASPGSTLKE-----------ALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR-GISPAAAAVALALIGLFNIV 260
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1843419888 341 CMILSGQAADNLRAKWNFSTLCVRRIFSLIG-MIGPAVFLVAAGFI 385
Cdd:cd17355 261 GRLLSGWLGDRYSPRRLLAASYALRALGLALlLLLPFPPLALLLFA 306
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
109-272 |
1.25e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.05 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYIITQIPGGYVASKIGG-KMLLGFGILGTAVLTLFTPIAADlgVGPLIVLRALEGLGEG--VTFPAMHAm 185
Cdd:cd17490 34 GIILGAYGISQMLLRIPLGILSDRIGKrKLFIIIGLLFTVLASLIMILFPS--PWGLLIARFLSGIAAAtwVSFTVLYA- 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 186 wsSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRIShyEKEY 265
Cdd:cd17490 111 --SYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLT--ELKE 186
|
....*..
gi 1843419888 266 ILSSLRN 272
Cdd:cd17490 187 LLSVLKD 193
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
109-243 |
1.48e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.05 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 109 GWILGSFFYGYII-TQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWS 187
Cdd:cd17490 233 GLLSIIYLLPNALaSLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTL--LYLLQALNGFGTGILFPLLMSLSI 310
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 188 SWAPPLERSKLL----SISYAGAQLGTVISlplsGIICYYMNWTYVFYFFGTIGIFWFLL 243
Cdd:cd17490 311 EGVPAEQRSTAMgffqAIYALGMFLGPVLV----GIISEAFGLQTGFFVIGVIALLAAIL 366
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
136-444 |
2.19e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 40.25 E-value: 2.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 136 KMLLGFGILgTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVtFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLP 215
Cdd:cd17504 62 KVLLIVLAI-YTAGSLLAAFAPNLPV--LIAGRALQGIGGAV-FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLP 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 216 LSGIICYYMNWTYVFYFFGTIGIFWFLLwiwlvsdtpqkhkrishyekeyilsslrnqlssqksVPWVPI--LKSLPLWA 293
Cdd:cd17504 138 LGGWIVQHLGWRWIFWTAAPVAVLLAAL------------------------------------VPLIDLrlLRRRNVLL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 294 IVVAHFSYNWTFYTLLTLLPTYMKE----ILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFstlcvrrifsL 369
Cdd:cd17504 182 ANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL----------L 251
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1843419888 370 IGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFsINHLDIA--PSYAGILLGITNTFATIPGMVGPVIA 444
Cdd:cd17504 252 IGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASL-PNIVVESvpPDRTGIATGMNTVLRTIGSAIGPAIA 327
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
110-443 |
2.40e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 40.47 E-value: 2.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 110 WILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIaADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:cd17314 42 TAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSY-VFNSFPLSYACFVFIGAGTGILYGSAVLVTTQY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 190 APPlERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSS 269
Cdd:cd17314 121 FPD-TKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTM 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 270 LRnqlssqksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEIlrfNVQENGFLS---SLPYLGSWLCMILSG 346
Cdd:cd17314 200 GE-------------IFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSL---QLDAPSFVTklmSIYGLFNAFGRLLWG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 347 QAADNLRAKwnFSTLCVRRIFSLIGMIgpaVFLVAAGFIGCDYSLAVAFLTISTtlGGFCSSGFSINHLDIAPSYAGILL 426
Cdd:cd17314 264 IVADFFGGR--LSTLSILLTILGLGLC---AFLFLLKMTPVGLVLTGSLLGFSY--GGLFTVYPATVSTVFGTESFATLY 336
|
330
....*....|....*..
gi 1843419888 427 GITNTFATIPGMVGPVI 443
Cdd:cd17314 337 GILLFAPAIGSILGPML 353
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
104-245 |
4.63e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.51 E-value: 4.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMH 183
Cdd:cd17316 211 SPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALY 290
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1843419888 184 AMWSSWAPPLERSKLLSISYAGAQLGTVISLPL-SGIICYYMNWTYVFYFFGTIGIFWFLLWI 245
Cdd:cd17316 291 AYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLiALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
104-245 |
6.43e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.07 E-value: 6.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419888 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGegvtFPAMH 183
Cdd:cd17324 232 SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLL--LLVGLVLWGLG----FFAAH 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1843419888 184 AMWSSWA---PPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWI 245
Cdd:cd17324 306 SALQTRVlrlAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| |
