|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
42-449 |
0e+00 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 666.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 42 LAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYII 121
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPEHSSSPSVEHNETGKKYDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 122 TQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSI 201
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 202 SYAG-----------------------------TIGIFWFLLWIWLVsdtpqkhkrishyekeyilsslrnqlssqksvp 252
Cdd:cd17381 161 SYAGaqlgtvvslplsglicyyldwtyvfyifgAVGLLWFFLWIWLV--------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 253 wvpilksLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTL 332
Cdd:cd17381 208 -------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNFSTV 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 333 CVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGP 412
Cdd:cd17381 281 CVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMVGP 360
|
410 420 430
....*....|....*....|....*....|....*..
gi 1843419871 413 VIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFA 449
Cdd:cd17381 361 VIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
43-449 |
1.28e-173 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 492.52 E-value: 1.28e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 43 AILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKAcpehsapiKVHHNQTGKKYQWDAETQGWILGSFFYGYIIT 122
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTD--------KDTLPVEAPEFDWSEKTQGIILSSFFYGYILT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 123 QIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSIS 202
Cdd:cd17318 73 QIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 203 YAG-----------------------------TIGIFWFLLWIWLVsdtpqkhkrishyekeyilsslrnqlssqksvpw 253
Cdd:cd17318 153 YSGsqfgtviamplsgflceslgwpsifyifgGLGLLWCLLWFFLV---------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 254 vpilksLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLC 333
Cdd:cd17318 199 ------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTT 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 334 VRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPV 413
Cdd:cd17318 273 VRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPL 352
|
410 420 430
....*....|....*....|....*....|....*..
gi 1843419871 414 IAKSLTPDN-TVGEWQTVFYIAAAINVFGAIFFTLFA 449
Cdd:cd17318 353 IVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
43-449 |
8.51e-111 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 332.00 E-value: 8.51e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 43 AILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTskacpehsapikvhhNQTGKKYQWDAETQGWILGSFFYGYIIT 122
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKV---------------IVHKAEFNWTPETVGLIESSFFWGYLVT 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 123 QIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSIS 202
Cdd:cd17382 66 QIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 203 YAGT-----------------------------IGIFWFLLWIWLvsdtpqkhkrishyekeyilsslrnqlssqksvpw 253
Cdd:cd17382 146 FCGSyagavvgmplsgilvqyvgwsspfyvygvFGIIWYMFWMLV----------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 254 vpilkSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLC 333
Cdd:cd17382 191 -----SMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTA 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 334 VRRIFSLIGMIGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPV 413
Cdd:cd17382 266 VRKIFNCGGFGMEATFLLVVAFSH-SPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPV 344
|
410 420 430
....*....|....*....|....*....|....*.
gi 1843419871 414 IAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFA 449
Cdd:cd17382 345 IVGALTKHKTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
30-462 |
4.02e-106 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 323.23 E-value: 4.02e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 30 EAAPVCCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSnttleDNRTSKACPEHSAPIKVHHNqtgKKYQWDAETQG 109
Cdd:TIGR00894 8 TKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNK-----ENSTDLACLSAENELDNIKN---PNFKWSGALQG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 110 WILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:TIGR00894 80 LILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 190 APPLERSKLLSISYAG------------------------------TIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILS 239
Cdd:TIGR00894 160 APPKERSRLLGMSTSGfqlgtfiflpisgwlceswggwpmifyvfgIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 240 SLRNQ-LSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQ 318
Cdd:TIGR00894 240 SLQGQkGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 319 AADNLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLG 398
Cdd:TIGR00894 320 LADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKG 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843419871 399 ITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKGEVQNWALNDHH 462
Cdd:TIGR00894 400 ITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKD 463
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
44-449 |
1.11e-101 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 307.94 E-value: 1.11e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 44 ILAFFGFFIVYALRVNLSVALVDMVdsnttlednrtskacpehsapikvhhnqtgKKYQWDAETQGWILGSFFYGYIITQ 123
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMA------------------------------KEFGWSKTDQGLVLSSFFWGYALTQ 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 124 IPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSI-- 201
Cdd:cd17380 52 VLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIvt 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 202 --SYAGTIGIFWFLLWIwlvsdtpqkhkrISHYEKE---YILSSLrnqlssqkSVPWVPILKSL--PLWAIVVAHFSYNW 274
Cdd:cd17380 132 agSYLGTLLGGLIGPLL------------LEYYGWPsvfYFFGLL--------GLLWALVWLIYlpPVWAIIVAHFCMNW 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 275 TFYTLLTLLPTYMKEILrFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKwNFSTLCVRRIFSLIGMIGPAVFLVAAG 354
Cdd:cd17380 192 GFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISR-GWTVTSVRKLMQSIGFLGPALFLLLLS 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 355 FIgCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTpdNTVGEWQTVFYIA 434
Cdd:cd17380 270 HT-DSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYIL--EATGSWSLVFVLA 346
|
410
....*....|....*
gi 1843419871 435 AAINVFGAIFFTLFA 449
Cdd:cd17380 347 AVVNLVGAVVFLLFG 361
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
39-443 |
1.02e-40 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 149.26 E-value: 1.02e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 39 RYNLAILAFFGFFIVYALRVNLSVALVDMvdsnttlednrtskacpehsapikvhhnqtGKKYQWDAETQGWILGSFFYG 118
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTI------------------------------MKDLGLSPTQYGLIASAFFLG 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 119 YIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAAdlGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKL 198
Cdd:cd17319 51 YALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT--SLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRA 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 199 LSISYAGT-IGIFWFLL----------WIWLVsdtpqkhkrishyekeYILSSLrnqlssqkSVPWVPI-LKSLP-LWAI 265
Cdd:cd17319 129 TGLFNSGApLGAAIGPPlsgwllllfgWRWAF----------------IIEGLL--------GLLLAVLwWFYLRqVWGL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 266 VVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKwnfstlcVRRIFSLIGMIG 345
Cdd:cd17319 185 ALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG-------ARRLVIIIGLLL 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 346 PAVFLVAAGFIGcDYSLAVAFLTISTTLGGFCSSGFSINHLDIAP-SYAGILLGITNTFATIPGMVGPVIAKSLTpdNTV 424
Cdd:cd17319 258 AAVGLLLAYLTT-SPVVAVILLSLAGFGIGAASPVFWSLPADLLPgEAAATAGGLINSGGNLGGFVAPLLIGYLV--DAT 334
|
410
....*....|....*....
gi 1843419871 425 GEWQTVFYIAAAINVFGAI 443
Cdd:cd17319 335 GSYTAAFLFLAAVALLAAL 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
39-450 |
1.80e-39 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 145.78 E-value: 1.80e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 39 RYNLAILAFFGFFIVYALRVNLSVALVDMVDSnttlednrtskacpehsapikvhhnqtgkkYQWDAETQGWILGSFFYG 118
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQAD------------------------------LGLSAAQLGLLASAFFLG 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 119 YIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKL 198
Cdd:COG2271 58 YALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQ--LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 199 LSISYAGTI--GIFWFLLWIWLVSDTPQkhkRIShyekeYILSSLRnqlssqkSVPWVPilksLPLWAIVVAHFSYNWTF 276
Cdd:COG2271 136 LGIFNAGGPlgGALAPPLLGWLLAAFGW---RAA-----FLILGLP-------GLLLAL----LRFWLLALAYFLVYFAL 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 277 YTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKwnfstlcvRRIFSLIGMIGPAVFLVAAGFI 356
Cdd:COG2271 197 YGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR--------RKLVLAIGLLLAALALLLLALL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 357 GCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTpdnTVGEWQTVFYIAAA 436
Cdd:COG2271 269 PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL---DATGYQAAFLLLAA 345
|
410
....*....|....
gi 1843419871 437 INVFGAIFFTLFAK 450
Cdd:COG2271 346 LALLAALLALLLLR 359
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
101-445 |
1.12e-36 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 138.71 E-value: 1.12e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 101 YQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFP 180
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWL--LLLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 181 AMHAMWSSWAPPLERSKLLSISYAGT-------------------------------IGIFWFLLWIWLVSDTPQKHKRI 229
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGsvggilgpllggilasslgfgwravfliaaaLALLAAILLLLVVPDPPESARAK 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 230 SHYEKeyilsslrnqlSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGS 309
Cdd:cd06174 184 NEEAS-----------SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 310 WLCMILSGQAADNLRAkwnfstlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIA 389
Cdd:cd06174 253 ALGSLLLGLLSDRLIG---------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1843419871 390 PSYAGILLGITNTFATIPGMVGPVIAKSLTpdNTVGEWQTVFYIAAAINVFGAIFF 445
Cdd:cd06174 324 PEIRGTAFGLLNTFGFLGGAIGPLLAGFLL--AATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
98-412 |
1.31e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 104.42 E-value: 1.31e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 98 GKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGV 177
Cdd:pfam07690 24 AEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWL--LLVLRVLQGLGAGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 178 TFPAMHAMWSSWAPPLERSKLLSISYAGTI--------------------GIFWF-------LLWIWLVSDTPQKHKRIS 230
Cdd:pfam07690 102 LFPAALALIADWFPPEERGRALGLVSAGFGlgaalgpllggllaslfgwrAAFLIlailsllAAVLLLLPRPPPESKRPK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 231 HYEKEYILSslrnqlssqkSVPWVPILKSLPLWAIVVAhFSYNWTFYTLLTLLPTYMkEILRFNVQENGFLSSLPYLGSW 310
Cdd:pfam07690 182 PAEEARLSL----------IVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 311 LCMILSGQAADNLRAKwnfstlcVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAP 390
Cdd:pfam07690 250 IGRLLLGRLSDRLGRR-------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPK 322
|
330 340
....*....|....*....|..
gi 1843419871 391 SYAGILLGITNTFATIPGMVGP 412
Cdd:pfam07690 323 EERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
109-449 |
1.45e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 98.80 E-value: 1.45e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ--LLLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 189 WAPPLERSKLLSISYAG-TIGI-------------------FWF---------LLWIWLVSDTPQKHKRishyekeyils 239
Cdd:cd17325 112 IAPPEERGRAMGIFSSAiGLGFligpllgglladalgyrapFLVcaalallalVLALLLLPEPRPPPNK----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 240 slRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQA 319
Cdd:cd17325 181 --RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 320 ADNLRakwnfstlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGI 399
Cdd:cd17325 259 SDRIG----------RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1843419871 400 TNTFATIPGMVGPVIAKSLTpdnTVGEWQTVFYIAAAINVFGAIFFTLFA 449
Cdd:cd17325 329 FNTAFSLGMVLGPLLGGFLY---DAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
37-448 |
1.27e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 93.41 E-value: 1.27e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 37 SARYNLAILAFFGFFIVYALRVNLSVALVDMvdsnttlednrtskacpehsapikvhhnqtGKKYQWDAETQGWILGSFF 116
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPL------------------------------AEEFGLSAAQLGLLFAIPV 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 117 YGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERS 196
Cdd:COG2223 51 LVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWL--LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRG 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 197 KLLSISYA-----------------------------GTIGIFWFLLWIWLVSDTPQKHKRISHyekeyilSSLRNQLSs 247
Cdd:COG2223 129 LALGLAAGggnlgaavaaflaplliaafgwrnaflilGILLLVVAVLAWLFLRDPPAGAAAAAK-------ASLRDQLE- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 248 qksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRakw 327
Cdd:COG2223 201 --------ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIG--- 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 328 nfstlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLA-VAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATI 406
Cdd:COG2223 270 -------GRRVLLIVFALMALGLLLLALALGSLWLFlVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGL 342
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1843419871 407 PGMVGPVIAKSLTpdNTVGEWQTVFYIAAAINVFGAIFFTLF 448
Cdd:COG2223 343 GGFLGPLLFGALL--DATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
101-406 |
8.35e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 81.56 E-value: 8.35e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 101 YQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFP 180
Cdd:COG2814 40 LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWL--LLAARFLQGLGAGALFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 181 AMHAMWSSWAPPLERSKLLSISYAGT-----IG-------------------------IFWFLLWIWLVSDTPQKHKRIS 230
Cdd:COG2814 118 AALALIADLVPPERRGRALGLLGAGLglgpaLGpllgglladlfgwrwvflvnavlalLALLLLLRLLPESRPAARARLR 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 231 HYEKEyilsslrnqlssqksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSW 310
Cdd:COG2814 198 GSLRE--------------------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGV 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 311 LCMILSGQAADNLRakwnfstlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAP 390
Cdd:COG2814 258 LGALLAGRLADRFG----------RRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPP 327
|
330
....*....|....*.
gi 1843419871 391 SYAGILLGITNTFATI 406
Cdd:COG2814 328 EARGRASGLYNSAFFL 343
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
47-414 |
5.47e-14 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 73.18 E-value: 5.47e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 47 FFGFFIVYALRVNLSVALVDMVDSnttlednrtskacpehsapikvhhnqtgkkYQWDAETQGWILGSFFYGYIITQIPG 126
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEE------------------------------IGLSKTDLGLLLSSFSIAYGISKFVM 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 127 GYVASKIGGKMLLGFGILGTAVLTLFtpIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSI----- 201
Cdd:TIGR00881 51 GSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFwncsh 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 202 -------------------------SYAGTIGIFWFLLWIWLVSDTPQKHKRIS-----HYEKEYILSSLRNQLSSQKSV 251
Cdd:TIGR00881 129 nvgggllpplvlfgiaelyswhwvfIVPGIIAIIVSLICFLLLRDSPQSCGLPPaeempNEEPDGDAEKKEEELTKKQIF 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 252 PWVpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLrakwnfst 331
Cdd:TIGR00881 209 LQY-VLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKL-------- 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 332 lcVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGF----SINHLDIAPSYA-GILLGITNTFATI 406
Cdd:TIGR00881 280 --FNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPqmliGVIASELAPKKAaGTAAGFVGFFAYL 357
|
....*...
gi 1843419871 407 PGMVGPVI 414
Cdd:TIGR00881 358 GGILAGLP 365
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
110-417 |
8.43e-14 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 72.67 E-value: 8.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 110 WILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTpiAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLT--AAVKNFGGLIALRFFLGLFESGVFPGFILYLGMW 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 190 APPLERSKLLSISYA-----------------------------------GTIGIFWFLLWIWLVSDTPQKHKRISHYEK 234
Cdd:cd17327 123 YKREEQAKRIAFFYAaaglgsifggllaygvfkilgvgglagwrwlfiieGLITIIIGLVIFFWLPDNPSKAWFLTEEEK 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 235 EYILSSLR-NQ--LSSQKSVP--WVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENgFLSSLPYLGS 309
Cdd:cd17327 203 ELAVERLRaNQtgKGDQKFKWkqIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQTN-LLSVPIGALG 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 310 WLCMILSGQAADNLRAKWNFSTlcvrrIFSLIGMIGPAVfLVAAGFIGCDYsLAVAFLTISTTLGGFCSSGFSINhldIA 389
Cdd:cd17327 282 AVSLLIAALLSDRFKKRGLFAI-----FACVLALVGSII-LLAAPNPPGAY-FAAYILGGGSYAGFPILLSWISS---NC 351
|
330 340 350
....*....|....*....|....*....|
gi 1843419871 390 PSYAG--ILLGITNTFATIPGMVGPVIAKS 417
Cdd:cd17327 352 AGYTKraTVLAIMLIFYNVGNIVAPQIFRA 381
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
104-443 |
7.37e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 63.39 E-value: 7.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMH 183
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPIL--LLVLRFLQGIGIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 184 AMWSSWAPPLERSKLLSISYAG-TIGIFWFLLWIWLVSDTPQKHK--RIShyekeYILSSLrnqlssqksvpwvPILKSL 260
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGwALGALLAALVASLLIPLLSGDWgwRIL-----FLIGAL-------------PALLAL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 261 PL----WAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADnlraKWNfstlcvRR 336
Cdd:cd17316 174 LLrrrtLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD----RIG------RK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 337 IFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTIstTLGGFCSSGFSINHLDIAPSYA----GILLGITNTFATIPGMVGP 412
Cdd:cd17316 244 KTLVIGLILSGILALPLFYLLSGSPTLLLLLLF--ILSFFVGGVWGALYAYLAELFPtevrATGVGLSYNLGRLGGGGAP 321
|
330 340 350
....*....|....*....|....*....|.
gi 1843419871 413 VIAKSLTPdnTVGEWQTVFYIAAAINVFGAI 443
Cdd:cd17316 322 PLIALLLA--STGGTGVPALILALLAIVALI 350
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
109-414 |
4.23e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 61.41 E-value: 4.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVT---------- 178
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPL--LLLALFLLGLGLGLLdvaanpyvaa 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 179 ---------FPAMHAMWS----------SWAPPLERSKLLSISYAGTIGIFWFLLWIWLVSDTPQKHKRISHyekeyils 239
Cdd:COG0738 124 lgpetaasrLNLLHAFFSlgallgpllgGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEE-------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 240 slrnqlSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLpylgSWLCMILSGQA 319
Cdd:COG0738 196 ------AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL----FWGGMTIGRFL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 320 ADNLRAKWNFSTLCvrRIFSLIGMIGPAVFLVAAGFIgcdysLAVAFLTIsttLGGFCSSGFS-INHL--DIAPSYAGIL 396
Cdd:COG0738 266 GGFLLKRFGPVRLL--RLSALLAAVGLLLALLAPGPW-----LALIGLAL---VGLGLSLMFPtIFSLalDGLGKRTAAA 335
|
330
....*....|....*...
gi 1843419871 397 LGITNTFATIPGMVGPVI 414
Cdd:COG0738 336 VSAVLIMGIVGGAIGPPL 353
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
104-418 |
5.18e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 61.22 E-value: 5.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADlgVGPLIVLRALEGLGEGVTFPAMH 183
Cdd:TIGR00895 50 DPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATN--VTQLLILRFLAGLGLGGLMPNLN 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 184 AMWSSWAPPLERSKLLSISYAG-TIGI-------------------FW-------FLLWI----------WLVSDTPQKH 226
Cdd:TIGR00895 128 ALVSEYAPKRFRGTAVGLMFCGyPIGAavggflagwlipvfgwrslFYvggiaplLLLLLlmrflpesidFLVSKRPETV 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 227 KRISHYEKEYILSSLRNQLSSQKSVP--WVPILK----------SLPLWaivVAHFSYNWTFYTLLTLLPTYMKEiLRFN 294
Cdd:TIGR00895 208 RRIVNAIAPQMQAEAQSALPEQKSTQgtKRSVFKalfqgktariTVLLW---LLYFMLLVGVYFLTNWLPKLMVE-LGFS 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 295 VQENGFLSSLPYLGSWLCMILSGQAADNLRAKwnfstlcvrriFSLIGMIGPAVFLVAAGFigcDYSLAVAFLTISTTLG 374
Cdd:TIGR00895 284 LSLAATGGALFNFGGVIGSIIFGWLADRLGPR-----------VTALLLLLGAVFAVLVGS---TLFSPTLLLLLGAIAG 349
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1843419871 375 GFCSSGFSINHLDIAPSYA--------GILLGITNTFAtipgMVGPVIAKSL 418
Cdd:TIGR00895 350 FFVNGGQSGLYALMALFYPtairatgvGWAIGIGRLGA----IIGPILAGYL 397
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
106-445 |
1.07e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 56.93 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 106 ETQGWILGSFF-YGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHA 184
Cdd:cd17371 33 EAEAGLLGTVTlAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ--LLILRALAGLGFGGEWAAGAA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 185 MWSSWAPPLERSKLLSISYAG-TIG-IFWFLLWIWLVSDTPQKH-------------------KRISHYEKEYILSSLRN 243
Cdd:cd17371 111 LMAEYVPARHRGKALGYVQSGwAVGwLLATLLAALLFPLLPPEIawrvlfllgalpallvlfiRRFVKEPPQWQAARAAR 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 244 QLSSQKSVPWV---PILKSLPLWAIVVAHFSYnWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAA 320
Cdd:cd17371 191 RHFADRPSLRElfsPPLLRTTLLASLLATGAL-GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 321 DNLRAKWNFstlcvrrifsLIGMIGPAVFLVAAGFIGCDYSLavafLTISTTLGGFCSSG-FSINHLDIAPSYA----GI 395
Cdd:cd17371 270 DRIGRRNNF----------ALFALGSAISILLYFFLPLSPTL----ILILGFPLGFFASGpFSGMGAYLTELFPtavrAT 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1843419871 396 LLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFF 445
Cdd:cd17371 336 AQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALL 385
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
109-448 |
1.14e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.81 E-value: 1.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 109 GWILGSFFYGYIITQIPGGYVASKIGGK--MLLGFGILGTA-VLTLFTPiaadlGVGPLIVLRALEGLGEGVTFPAMHAM 185
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKkvLLPGLLLFGIGgLLCGLSD-----SFALLLAGRALQGIGAAGLGPLALTL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 186 WSSWAPPLERSKLLSIsYAGTIGI--------------------FW---------FLLWIWLVSDTPQKHKRISHYEKEY 236
Cdd:cd17474 112 IGDLFEGGERAKAMGL-YEAALGLgiavgpllggllaaiswrypFFllaalipvaFLAILFLLPEPKEKAKSSSATKLRD 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 237 ILSSLRNQLssqksvpwvpilkslpLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSwlcMILS 316
Cdd:cd17474 191 LKKALRGRG----------------LLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL---ALGS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 317 GQAADNLRAKWNFSTLCVrrifslIGMIGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYA-GI 395
Cdd:cd17474 252 LFVGRLLKKRFGARRILV------IGLLLYALSLLLLGFVP-SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEErGT 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1843419871 396 LLGITNTFATIPGMVGPVIAKSLTpdnTVGEWQTVFYIAAAINVFGAIFFTLF 448
Cdd:cd17474 325 ASSLYNFVRFLGQAVGPLLFGLLL---EIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
265-448 |
2.81e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 55.50 E-value: 2.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 265 IVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRakwnfstlcvRRIFSLIGMI 344
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG----------RRRVLLIGLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 345 GPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTpdnTV 424
Cdd:pfam07690 71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA---SL 147
|
170 180
....*....|....*....|....
gi 1843419871 425 GEWQTVFYIAAAINVFGAIFFTLF 448
Cdd:pfam07690 148 FGWRAAFLILAILSLLAAVLLLLP 171
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
104-213 |
2.11e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.51 E-value: 2.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMH 183
Cdd:COG0477 47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPEL--LIAARALQGIGAGGLMPGAL 124
|
90 100 110
....*....|....*....|....*....|
gi 1843419871 184 AMWSSWAPPLERSKLLSIsYAGTIGIFWFL 213
Cdd:COG0477 125 ALIAELFPARERGRALGL-WGAAIGLGLAL 153
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
99-201 |
2.04e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.88 E-value: 2.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 99 KKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAAdlGVGPLIVLRALEGLGEGVT 178
Cdd:cd17325 228 ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGLV 305
|
90 100
....*....|....*....|...
gi 1843419871 179 FPAMHAMWSSWAPPLERSKLLSI 201
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGL 328
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
109-446 |
2.09e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 49.86 E-value: 2.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL--LLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 189 WAPPLERSKLLSISYAG-TIGI-------------------FWF--------LLWIW-LVSDTPQKHKRISHYEKEYILs 239
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGlTLGLvlgrplggllgqllgwraaFLAiavlallaALLLWrLLPSLPPKKPGSLGLLSSLLL- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 240 slrnqlssqksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQA 319
Cdd:cd17324 194 ----------------LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 320 ADNLRAkwnfstlcvRRIFSLIGMIgpAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGI 399
Cdd:cd17324 258 ADRGGR---------RALLIALLLL--AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSL 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1843419871 400 TNTFATIPGMVGPVIAKSLTpdnTVGEWQTVFYIAAAINVFGAIFFT 446
Cdd:cd17324 327 YLAAYNLGGALGAALGGLVL---DHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
39-448 |
2.23e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 49.58 E-value: 2.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 39 RYNLAILAFFGFFIVYALRVNLSVALVDMVDsnttlednrtskacpehsapikvhhnqtgkKYQWDAETQGWILGSFFYG 118
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVE------------------------------EIGLSKDDLGIIGSAFLIA 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 119 YIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKL 198
Cdd:cd17312 51 YAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWF--FAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTV 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 199 LSI----SYAGTIGIFWFLLWIwlvsdtpqkhkrISHYEKEYILsslrnqlssqKSVPWVPILKSLPLWAIVVAHFSYNW 274
Cdd:cd17312 129 YGIwstsHNFGGILAPILAASL------------ASYYGWRAAF----------LVPGIVGLVVAIILFFFLRDSPPYVW 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 275 TF-----------YTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLrakWNFSTLCVRRIFSLIGM 343
Cdd:cd17312 187 VLslayafvyivrYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKL---FGGRRAPIAVIYMLLMT 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 344 IGPAVFLVAAGFIgcdYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYA-GILLGITNTFATIPGMVGPVIAKSLTPDN 422
Cdd:cd17312 264 LSLALFWFFPHNK---LLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAaGTATGFVGLFGYLGASLAGLPLGYIIDHY 340
|
410 420
....*....|....*....|....*.
gi 1843419871 423 TvgeWQTVFYIAAAINVFGAIFFTLF 448
Cdd:cd17312 341 G---WSTVFYFLISAALLSVLLLLSL 363
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
127-449 |
2.76e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.49 E-value: 2.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 127 GYVASKIGGKMLLGFGILGTAVLTLfTPIAADlGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYA-- 204
Cdd:cd17473 56 GWLADRFGRKRLLIAGLLLYGIGGV-AGLFLD-SLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAam 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 205 GTIGIFWFLL--------W-----------------IWLVSDTPQKHKRISHYEKEyilsslrnqlsSQKSVPWVPIlks 259
Cdd:cd17473 134 SLGGVVFLLLggalaeigWrapflvyllalpvlilvLLFLPEPARKSKSAASPGAA-----------TAAALPWKRV--- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 260 lplWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSwlcmILSGQAADNLRAKWNFSTLcVRRIFS 339
Cdd:cd17473 200 ---LPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAG----AIGALLFGRLKRRLGKRRL-LAIGFA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 340 L--IGMI------GPAVFLVAAGFIGCDYSLAVAFLTISTTlggfcssgfsinhLDIAPSYAGILLGITNTFATIPGMVG 411
Cdd:cd17473 272 LmaLGFLllalasGLWVVLLGAILAGLGFGLLLPTLNSWAM-------------SLVPPELRGRAMGIVTSAFFLGQFLS 338
|
330 340 350
....*....|....*....|....*....|....*...
gi 1843419871 412 PVIAKSLTpdNTVGEWQTVFYIAAAINVFGAIFFTLFA 449
Cdd:cd17473 339 PLVLGPLV--NLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
109-448 |
4.15e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 48.74 E-value: 4.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAAdlGVGPLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT--SVALLLVLRLIHGIGWGAFTTAAATLVAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 189 WAPPLERSKLLSI-SYAGTIGI---------------FWFLLWI------------WLVSDTPQKHKRIShyekeyilss 240
Cdd:cd17489 112 IIPPSRRGEGIGYyGLATTLAMalgpalglflyqhlgFAVLFIVaavlallalllvFLVKDPPPVAAEEA---------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 241 lrnqlSSQKSVPWVPILKSLPLWAIVVAHFSYnwTFYTLLTLLPTYMKEILRFNVqenGFLSSLPYLGSWLCMILSGQAA 320
Cdd:cd17489 182 -----EAGTRAFRRLVEKKVLPPALILFLASI--AYGAISTFLPLYAAERGISNA---GLFFTVYAIALLLSRPFSGKLS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 321 DNLRAK---WNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTtlggfcssgfsinhLDIAPSYA-GIL 396
Cdd:cd17489 252 DRKGPKtviIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALA--------------VDLVPPHRrGAA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1843419871 397 LGITNTFATIPGMVGPVIAKSLTPdntVGEWQTVFYIAAAINVFGAIFFTLF 448
Cdd:cd17489 318 NGTFFIFFDLGIGLGGLLLGLVAE---LFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
264-448 |
7.24e-06 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 48.39 E-value: 7.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 264 AIVVAHFSYNWTFYTLLTLLPTYMKEILrfNVQENGFLSSLPYLGSWLCMILSGQAADnlrakwnfstLCVRRIFsligM 343
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLG--PSSNSTWISTAWSLAQAVLGPIVGRLSD----------LFGRRWF----F 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 344 IGPAVFLVAAGFIGCD----YSLAVAFLTISTTLGGFCSSGFSINHLdIAPSYAGILLGITNTFATIPGMVGPVIAKSLT 419
Cdd:cd06179 66 IGGNLLGVVGSIVAGTaksvNMLIGGQALIGIGAGTQGLGAAVASEL-VPNKYRGLVQGVVNLVASPGSALGPLIAGALV 144
|
170 180
....*....|....*....|....*....
gi 1843419871 420 PDNTVGeWQTVFYIAAAINVFGAIFFTLF 448
Cdd:cd06179 145 EANAAG-WRWIFYINAIFNALALILLFFF 172
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
39-448 |
9.20e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 47.62 E-value: 9.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 39 RYNLAILAFFGFFIVYALRVNLSVALVDMVDSnttlednrtskacpehsapikvhhnqtgkkYQWDAETQGWILGSFFYG 118
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQ------------------------------YGLSKTEIGLIGSALSIA 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 119 YIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIA--ADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERS 196
Cdd:cd17345 51 YGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVpsATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERG 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 197 KLLSI--------------------SYAGT---IGIFWF---------LLWIWLVSDTPQKH--KRISHYEKEYILSSLR 242
Cdd:cd17345 131 TWTSIwnishnvggglvgplaglglAIFGDgwwRGAFIFpaiiaiivaVIVLFLGKDTPESEglPPIEEYKGDYPEEADG 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 243 NQLSSQKSVP---WVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQA 319
Cdd:cd17345 211 EEEEQELSAWeifVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 320 ADNLRAKwnfstlcvRRifSLIGMIgpAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSG----FSINHLDIAPSYA-G 394
Cdd:cd17345 291 SDKLFKG--------RR--APTGII--FMILVIVALIVYWLAPNVLVDLIALIALGFLIYGpvmlIGLQALELVPKKAaG 358
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1843419871 395 ILLGITNTFATIPGMVGPVIAKSLTPDNTvgEWQTVFYIaAAINVFGAIFFTLF 448
Cdd:cd17345 359 TAAGLTGLFGYLGGSVLATALIGIIVDHF--GWNGGFIV-LLASCILAIIFLAL 409
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
124-454 |
1.03e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 47.56 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 124 IPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAAdlGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPplERSKLLSISY 203
Cdd:COG2807 71 PLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP--SVALLLAGTALIGAGIAVGNVLLPGLIKRWFP--DRVGLMTGLY 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 204 AGTIGI-----------------------FW-------FLLWIWLVSDTPQKHKRishyekeyilsslrnqlsSQKSVPW 253
Cdd:COG2807 147 TAAMGLgaalaagltvplaaalgwrgalaVWallallaLLLWLPLLRRRPAAAAA------------------APAAASL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 254 VPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEiLRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLC 333
Cdd:COG2807 209 RSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLL 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 334 vrrifSLIGMIGPAVFLVAAGfigcdySLAVAFLTIsttLGGFCSSGFS-----INHLDIAPSYAGILLGITNTFATIPG 408
Cdd:COG2807 288 -----GLLGLAGLLGLLLAPG------SLPWLWAVL---LGLGQGGLFPlaltlIGLRARTPAEAAALSGMAQSVGYLLA 353
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1843419871 409 MVGPVIA---KSLTpdntvGEWQTVFYIAAAINVFGAIFFTLFAKGEVQ 454
Cdd:COG2807 354 ALGPLLVgalHDAT-----GSWTAALLLLAALAVLMLVAGLLAGRPYVE 397
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
109-445 |
1.05e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 47.62 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPV--LLVLLFLVGAGYGSVQPGGGRAIMR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 189 WAPPLERSKLLSI-----------------------------SYAGTIGIFWFLL-WIWLV-SDTPQKHKRISHYEKEYI 237
Cdd:cd17475 112 WFPPRERGLAMGIrqtgvplggalaaallpplalhygwraafVVAGLVSILAAVLfWLFYRePPAASAATESASTLLRSL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 238 LSSLRNqlssqksvpwvpilksLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSG 317
Cdd:cd17475 192 KEVLRN----------------RDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 318 QAADNLRAKwnfstlcvRRIFSLIGMIGPAVfLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGF-SINHLDIA----PSY 392
Cdd:cd17475 256 RVSDRVFGG--------RRRPVLVITAAIAA-AALLVLSLLSPGTPLWLLVLLLILLGLFAIGWnGLYLTLVAesagPEQ 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1843419871 393 AGILLGITNTFATIPGMVGPVIAKSLTpdNTVGEWQTVFYIAAAINVFGAIFF 445
Cdd:cd17475 327 AGTALGLANTINFIGIAIGPPLFGLLV--DATHSYAPAWLALALLLVLAALLL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
100-204 |
1.11e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.28 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 100 KYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTF 179
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWL--LLLALFLLGFGFGLLF 314
|
90 100
....*....|....*....|....*
gi 1843419871 180 PAMHAMWSSWAPPLERSKLLSISYA 204
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNS 339
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
252-448 |
1.14e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.28 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 252 PWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEiLRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAkwnfst 331
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGR------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 332 lcvRRIFsLIGMIGPAVFLVAAGFigcdySLAVAFLTISTTLGGFCSSGFSINHLDIAPSYA-----GILLGITNTFATI 406
Cdd:COG2814 75 ---RRVL-LLGLLLFALGSLLCAL-----APSLWLLLAARFLQGLGAGALFPAALALIADLVpperrGRALGLLGAGLGL 145
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1843419871 407 PGMVGPVIAKSLTpdnTVGEWQTVFYIAAAINVFGAIFFTLF 448
Cdd:COG2814 146 GPALGPLLGGLLA---DLFGWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
265-448 |
1.43e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 47.04 E-value: 1.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 265 IVVAHFSYNWTFYTLLTLLPTYMKEiLRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRakwnfstlcvRRIFSLIGMI 344
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFG----------RRPVLLLGLL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 345 GPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAkSLTPDNTV 424
Cdd:cd06174 70 LFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLG-GILASSLG 148
|
170 180
....*....|....*....|....
gi 1843419871 425 GEWQTVFYIAAAINVFGAIFFTLF 448
Cdd:cd06174 149 FGWRAVFLIAAALALLAAILLLLV 172
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
109-448 |
7.17e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.91 E-value: 7.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGP---LIVLRALEGLGEGVTFPAMHAM 185
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSlwlLLVLAFLLGIASAFFGPARQAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 186 WSSWAPPLERSKLLS--------------------ISYAGTIGIFW-----FLLWIWLVSDTPQKHKRISHYEKEYILSS 240
Cdd:cd06173 117 LPELVPKEQLVRANAlnslatqlariigpalggllVALLGPGGAFAinalsFLLSALLLLFIRRPPPAAPGESSSLLLRD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 241 LRNQLSsqksvpwvpILKSLPLWAIVVAHFSYNWTFYT-LLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQA 319
Cdd:cd06173 197 LREGLR---------YLRRSPLLRLLLLALALFALLGGaLTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 320 ADNLRakwnfstlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGI 399
Cdd:cd06173 268 SKRRR----------RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSV 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1843419871 400 TNTFATIPGMVGPVIAKSLTPdntVGEWQTVFYIAAAINVFGAIFFTLF 448
Cdd:cd06173 338 YNALNSGAMPLGALLAGLLAD---ALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
109-304 |
8.23e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.53 E-value: 8.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADlgVGPLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS--PWLFAIALVLTGFGGGLFEPASEAMIAD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 189 WAPPLERSKLLSISY-----------------------------AGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEyils 239
Cdd:cd17329 116 VTTPENRTRAFSLLYwainlgvaigpllggllllysfrllflaaAVLFLLAALVLLFLLPETRPKRRAAEKTEILR---- 191
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1843419871 240 slrnqlssqksvPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSL 304
Cdd:cd17329 192 ------------GYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLAL 244
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
127-445 |
1.16e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.08 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 127 GYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSWAPPlERSKLLSI-SYAG 205
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWL--LLLLVALAGIGSAAFHPEGARLASQAAGG-RRGLAMSIfSVGG 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 206 TIG----------------------------IFWFLLWIWLVSDTPQKHKRishyekeyilsslRNQLSSQKSVPWVPIL 257
Cdd:cd17478 129 NLGfalgpliaaalvalfgglgllilliipgLAVALLLLRLRPLKKPEAKK-------------AAAKSSARSTLKGVWR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 258 KSLPLWAIVvahFSYNWTFYTLLTLLPTYMKEILrFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFstlcvrri 337
Cdd:cd17478 196 ALLLLLIIV---FLRSWVLSSLTTFLPFYLVQRG-YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVI-------- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 338 fsLIGMIGPAVFLVAAGFIGCDYSLAVAFLTisttlGGFCSSGFSINHL---DIAPSYAGILLGITNTFA-TIPGMVGPV 413
Cdd:cd17478 264 --IASLLLAAPFLLLFLLTPGIWSYILLVLA-----GFLLFASFPVTVVlaqELLPGNVGLASGLMMGLSfGLGGIGAPV 336
|
330 340 350
....*....|....*....|....*....|....*
gi 1843419871 414 IAKsltpdntVGEW---QTVFYIAAAINVFGAIFF 445
Cdd:cd17478 337 LGA-------LADAfglESVLLILALLPLLGALLA 364
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
109-437 |
1.27e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 44.13 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGeGVTFPAMhAMWSS 188
Cdd:cd17472 35 GLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYG--LILGRALQGSG-AISSVVM-ALLAD 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 189 WAPPLERSK---LLSISYAGTI-----------------GIFWF--------LLWIWLVSDTPQKHKRISHYEKEYILSS 240
Cdd:cd17472 111 LTREENRTKamaLIGASIGIAFaismvlgpllaahlgvsGLFLItailslvsLLILLFFVPDPPKIVQISEKEKKKLKKL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 241 LRNqlssqksvpwvPILKSLPLwAIVVAHFSYNWTFYtlltLLPTYMKEILRFNVQEngFLSSLP-YLGSWLCMILSGQA 319
Cdd:cd17472 191 LKN-----------KRLLRLDF-SIFILHFVLMAFFY----ILPLLLTQLGGGKGQL--WKVYLPaILIGFILMVPFVIY 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 320 ADNLRAKWN---FSTLCVRRIFSLIGMIGPAVFLVAAGFIGcdysLAVAFLTISTTLGGFcssgfsINHLdIAPSYAGIL 396
Cdd:cd17472 253 AEKKGKMKQvfvSSILLIAVGFLLLLFAATSLWLLIIGLII----FFIGFNLLEALLPSL------VSKI-APKEYRGTA 321
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1843419871 397 LGITNTFATIPGMVGPVIAKSLtpdNTVGEWQTVFYIAAAI 437
Cdd:cd17472 322 MGIYNTSQFLGSFLGGALGGLL---WGLLGYSSVFLTILIL 359
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
107-445 |
1.95e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 43.76 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 107 TQGWILGSFF-YGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAM 185
Cdd:cd17328 34 SLAGLLQTVFiISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ--LLLFRALVGIGEASYSPIAPTI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 186 WSSWAPPLERSKLLSISYAGT------------------------------IGIFWFLLWIWLVSDTPQKHKRISHYEKE 235
Cdd:cd17328 112 IADLFPKEKRTRALGVFYFAIplgsglgyvvgglvaqatggwrwafrvtgvLGVLLAILLLLFVREPPRGAAEGGVMAKS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 236 YILSSLRNqlssqksvpWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSlpYLGSWLCM-- 313
Cdd:cd17328 192 TATSFLAD---------LKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGL--IFGAITCIag 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 314 ----ILSGQAADNLRAKwnfstlcVRRIFSLIGMIG--PAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCS----SGFSI 383
Cdd:cd17328 261 vlgvLLGGILADRLRRK-------TPRADPLVCAVGllAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLnwapVFAIL 333
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1843419871 384 NHLDI----APSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGE-----WQTVFYIAAAINVFGAIFF 445
Cdd:cd17328 334 LYVVIptrrSTASAIQILLSHLLGDAGSPYLIGLISDLLRQNKDSPLaeaasLQYALLLCSFVLVLGGFFF 404
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
104-444 |
1.98e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 43.32 E-value: 1.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMH 183
Cdd:cd17321 29 SPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAF--LIAARALQGIGAAAIMPASL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 184 AMWSSWAPPLERSKLLSI--SYAGTIGIFWFLLWIWLVsdtpqkhkrishyekeyilsslrnQLSSQKSVPWVPILKSL- 260
Cdd:cd17321 107 ALIAATFPGERRGRALGLwgAVVGIGAALGPLLGGLLL------------------------ELFGWRWIFLINVPIGLv 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 261 ------PLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAkwnfstlcv 334
Cdd:cd17321 163 alllarTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGP--------- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 335 rRIFSLIGMIgpavfLVAAGFIG---CDYSLAVAFLTISTTLGGFCsSGFSINHLDIA------PSYAGILLGITNTFAT 405
Cdd:cd17321 234 -RLVLVAGLL-----LTAVGLLLlalLGADSSVWLLLPGLVLLGLG-LGLFATPLTNAalssvpKEKAGAASGILNTARQ 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1843419871 406 IPGMVGPVIAKSL--------------------TPDNTVGEWQTVFYIAAAINVFGAIF 444
Cdd:cd17321 307 LGGALGVALLGALltaglsanlgdsgvaallsaAAAAFAAGFHLAFLVAAALALLAALL 365
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
262-450 |
2.22e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.35 E-value: 2.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 262 LWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWnfstlCVRRIFSLI 341
Cdd:COG2211 12 KLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRW-----GRRRPWILI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 342 GMIGPAVFLVAAGFI-GCDYSLAVAFLTISTTLGGFCSSGFSINHL----DIAPSYA--GILLGITNTFATIPGMVGPVI 414
Cdd:COG2211 87 GAIPLALSFVLLFTApDLSPTGKLIYALVTYLLLGLAYTLVNIPYSalgaELTPDYEerTRLSSWRFAFAGLGGLLASVL 166
|
170 180 190
....*....|....*....|....*....|....*....
gi 1843419871 415 AKSLTP---DNTVGEWQTVFYIAAAINVFGAIFFTLFAK 450
Cdd:COG2211 167 PPPLVAafgGDAALGYRLTALIFAVLGLLAFLLTFFGTK 205
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
265-450 |
2.33e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 43.33 E-value: 2.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 265 IVVAHFSYNWTFYTLLTLLPTYMKEiLRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRakwnfstlcvRRIFSLIGMI 344
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFG----------RKRLLLLGLL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 345 GPAVFLVAAGFIGcdyslAVAFLTISTTLGGFCSSGFSINHL----DIAPS-YAGILLGITNTFATIPGMVGPVIAKSLT 419
Cdd:cd17325 70 LLAVSTLLFAFAT-----SYWQLLLARFLQGLASAAVWPAAMaliaDIAPPeERGRAMGIFSSAIGLGFLIGPLLGGLLA 144
|
170 180 190
....*....|....*....|....*....|.
gi 1843419871 420 pdnTVGEWQTVFYIAAAINVFGAIFFTLFAK 450
Cdd:cd17325 145 ---DALGYRAPFLVCAALALLALVLALLLLP 172
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
104-205 |
2.52e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.96 E-value: 2.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMH 183
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ--LALLRFLTGLGLGAAMPNAI 109
|
90 100
....*....|....*....|..
gi 1843419871 184 AMWSSWAPPLERSKLLSISYAG 205
Cdd:cd17365 110 TLVSEYAPARRRSLAVTLMFCG 131
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
109-447 |
4.17e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 42.31 E-value: 4.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 109 GWILGSFFYGYIITQIPGGYVASKIG-GKMLLGFGILGTAVLTLFTPiAADLGVgpLIVLRALEGLGEGVTFPA------ 181
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGrRRTLILGLLLISLALALIFA-TPSIYL--FVVLMFLAGLGAGILDTGantfvg 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 182 -------------MHAMWSSWA--------PPLERSKLLSISYAGTIGIFWFLLWIWLVSDTPQKHKrishyekeyilSS 240
Cdd:cd17333 111 alfeessatrlnvLHGFFGLGAligpliatSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPS-----------AR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 241 LRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAA 320
Cdd:cd17333 180 NPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPIS 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 321 DNLRAKwnfsTLCVrrIFSLIGMIGPAVFLVAAGFIGcdysLAVAFLTISTTLGGFCSSGFSINhLDIAPSYAGILLGIT 400
Cdd:cd17333 260 RRIKPH----TLLV--LSGSGALLGLLILLLAPTLVV----GLVATALLGLFMAALFPTILSLG-ISNLPYAKGKGTSVL 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1843419871 401 NTFATIPGMVGPVIAKSLtpDNTVGEwQTVFYIaaaINVFGAIFFTL 447
Cdd:cd17333 329 LAAGSIGGAIIPFIMGFI--AEAVGI-QTAMLL---ITILYAIIFVL 369
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
276-448 |
4.50e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 4.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 276 FYTLLTLLPTYMKEILRFNVQ--ENGFLSSLPYLGSWLCMILSGQAADnlraKWNfstlcvRRIFSLIGMIGpavflVAA 353
Cdd:cd17330 12 FGIVFPVLPFYVREFNKLGASgyYVGLLQSSYSLGQFLASPLWGRLSD----RYG------RKPVLLLSLAG-----SAV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 354 GFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIA----PSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVgewQT 429
Cdd:cd17330 77 SYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIAditdEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGY---AL 153
|
170
....*....|....*....
gi 1843419871 430 VFYIAAAINVFGAIFFTLF 448
Cdd:cd17330 154 PFLVAAALALLNLVLVLFF 172
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
109-205 |
8.36e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 41.49 E-value: 8.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:PRK11551 53 GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--LLVARLLTGVGLGGALPNLIALTSE 130
|
90
....*....|....*..
gi 1843419871 189 WAPPLERSKLLSISYAG 205
Cdd:PRK11551 131 AVGPRLRGTAVSLMYCG 147
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
260-448 |
1.11e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.99 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 260 LPLWAIVVAHFSYNWTFYTLLTLLPtYMKEILRFNVQENGFLSSLPYLGSWLCMILSGqaadnlrakwnfstLCVRRIFS 339
Cdd:COG0738 8 RALIAIYLLFFLWGFATALWGPLIP-ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAG--------------RLIDRFGY 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 340 LIGMIGpAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGF--SINHL--DIAPSYAGILLGITNTFATIPGMVGPVIA 415
Cdd:COG0738 73 KRGLLL-GLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLdvAANPYvaALGPETAASRLNLLHAFFSLGALLGPLLG 151
|
170 180 190
....*....|....*....|....*....|...
gi 1843419871 416 KSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLF 448
Cdd:COG0738 152 GLLILLGLSLSWHLPYLILAVLLLLLALLFLRS 184
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
204-448 |
2.41e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.27 E-value: 2.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 204 AGTIGIFWFLLWIWLVSDTPQKHKRIShyEKEYILSSLRNqlssqksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLL 283
Cdd:COG2211 186 ALIFAVLGLLAFLLTFFGTKERPVPEE--EKVSLKESLKA------------LLKNRPFLLLLLAYLLFFLALALVAALL 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 284 PTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFstlcvrrifsLIGMIGPAVFLVAAGFIGcdySLA 363
Cdd:COG2211 252 LYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAF----------IIGLLLAALGLLLLFFLG---PGN 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 364 VAFLTISTTLGGFCSSGFSINHL----DIAP--------SYAGILLGITNTFATIPGMVGPVI-----------AKSLTP 420
Cdd:COG2211 319 LWLLLVLAALAGIGLGAILVLPWamlaDVVDydewktgrRREGLYFGIFTFAIKLGQALAGALaglllalfgyvAGAAQS 398
|
250 260
....*....|....*....|....*...
gi 1843419871 421 DNTVGEWQTVFYIAAAINVFGAIFFTLF 448
Cdd:COG2211 399 PSALTGIRLLFFLLPAVLLLLAALLLLF 426
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
262-450 |
4.01e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.48 E-value: 4.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 262 LWAIVVAhFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLCvrrIFSLI 341
Cdd:COG2223 7 LLLATLA-FFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGL---LLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 342 GMIG------PAVFLVAAGFIGCdySLAVAFLTISTTLGGFcssgfsinhldIAPSYAGILLGITNTFatipGMVGPVIA 415
Cdd:COG2223 83 GLLLlalavsYWLLLLLGLLLGI--GGGGSFAVGIALVSKW-----------FPPDRRGLALGLAAGG----GNLGAAVA 145
|
170 180 190
....*....|....*....|....*....|....*..
gi 1843419871 416 KSLTP--DNTVGeWQTVFYIAAAINVFGAIFFTLFAK 450
Cdd:COG2223 146 AFLAPllIAAFG-WRNAFLILGILLLVVAVLAWLFLR 181
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
109-367 |
4.02e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.46 E-value: 4.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17477 34 GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWV--WFLLRFVMGIGLAGLFVVSESWLNA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 189 WAPPLERSKLLSI----------------SYAGTIGIFWF-------LLWIWLVSDTPQKHKRISHYEKeyilsslrnql 245
Cdd:cd17477 112 LATNENRGRVLGLystvlglgfalgplllALVGTAGALPFliaavllLLALVPLLLTRRAAPEIEEAES----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 246 ssqksVPWVPILKSLPLwaIVVAHFSYNWTFYTLLTLLPTYMKEILrFNVQENGFLSSLPYLGSWLCMILSGQAADNLRA 325
Cdd:cd17477 181 -----ISLRRLLRIAPL--ALLGAFVAGFLEGAFYSLLPLYGLRLG-LSVAQAALLLAAFVLGGLLLQWPLGWLADRFDR 252
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1843419871 326 KWnfstlcVRRIFSLIGMIGP--------------AVFLVAAGFIGCDYSLAVAFL 367
Cdd:cd17477 253 RR------VLLGCALLGALAAlllplvpglplallVLLFLWGGAAGPLYTLALALA 302
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
104-377 |
5.93e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.71 E-value: 5.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 104 DAETQGWILGSFFYGYIITqIP-GGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAM 182
Cdd:cd17503 29 SLDTVQWVITSYLLALAIM-IPlSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--LIIFRILQGFGGGVLIPLA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 183 HAMWSSWAPPLERSKL-----LSISYAGTIG---------------IFWFLLWIWLVSdtpqkhkrishyekeYILSSLR 242
Cdd:cd17503 106 QTILLRIYPPEKRGAAmglvgLVILLAPAIGptlggwltdnlswrwIFYINLPIGILA---------------LLLAPLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 243 NqlssqksvpwVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADn 322
Cdd:cd17503 171 D----------LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLD- 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1843419871 323 lraKWNFstlcvrRIFSLIGMIGPAVFLVAAGFIGCDYSlaVAFLTISTTLGGFC 377
Cdd:cd17503 240 ---KFGP------RLLLLAGLLLLALGTLLLAFLTPDTS--LWLIILPLFIRGLG 283
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
276-447 |
8.15e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 38.30 E-value: 8.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 276 FYTLLTLLPTYMKEiLRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNfstlcvRRIFSLIGMIGPAVFLVAagf 355
Cdd:cd17352 199 FFVPFVYLPSYAKS-LGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRL------YLYIFTLLILGLSLLAFP--- 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 356 IGCDYSLAVAFltisTTLGGFCSSGFSINHLDIAPSYAGI-----LLGITNTFATIPGMVGPVIAKSLTpdNTVGEWQTV 430
Cdd:cd17352 269 LATTYVGLIVF----SVLFGFCSGSYSSLTPVILADLVGLeklsnAYGLVLLFQGLAALVGPPIAGLLR--DYTGDYDAA 342
|
170
....*....|....*..
gi 1843419871 431 FYIAAAINVFGAIFFTL 447
Cdd:cd17352 343 FYFCGACLLLSGVLLFL 359
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
102-210 |
8.37e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.44 E-value: 8.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 102 QWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTpiAADLGVGPLIVLRALEGLGEGVTFPA 181
Cdd:cd06180 30 GLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAM--ALTSGFAALLALRFLAGAASAFVFVF 107
|
90 100 110
....*....|....*....|....*....|
gi 1843419871 182 MHAMWSSWAPPLERSKLLSISYAGT-IGIF 210
Cdd:cd06180 108 GSNLVLHHATAAGRGHLIGLLFAGVgLGIA 137
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
270-452 |
8.58e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.46 E-value: 8.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 270 FSYNWTFYTLLTLLPTyMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWnfsTLcvrRIFSLIGMIGPAVF 349
Cdd:cd17333 6 FSNGLTDALLGILGPS-LEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRR---TL---ILGLLLISLALALI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419871 350 LVAAgfigcDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTpdNTVGEWQT 429
Cdd:cd17333 79 FATP-----SIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLL--TSELSWSW 151
|
170 180
....*....|....*....|...
gi 1843419871 430 VFYIAAAINVFGAIFFTLFAKGE 452
Cdd:cd17333 152 AYLIIGLIYLLLAILILLTLFPE 174
|
|
| |
