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Conserved domains on  [gi|1827946656|ref|NP_001366376|]
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natural resistance-associated macrophage protein 2 isoform 2 [Homo sapiens]

Protein Classification

NRAMP family metal ion transporter( domain architecture ID 10018734)

NRAMP (natural resistance-associated macrophage protein) family metal ion transporter transports divalent cations

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
nramp TIGR01197
NRAMP (natural resistance-associated macrophage protein) metal ion transporters; This model ...
68-467 0e+00

NRAMP (natural resistance-associated macrophage protein) metal ion transporters; This model describes the Nramp metal ion transporter family. Historically, in mammals these proteins have been functionally characterized as proteins involved in the host pathogen resistance, hence the name - NRAMP. At least two isoforms Nramp1 and Nramp2 have been identified. However the exact mechanism of pathogen resistance was unclear, until it was demonstrated by expression cloning and electrophysiological techniques that this protein was a metal ion transporter. It was also independently demonstrated that a microcytic anemia (mk) locus in mouse, encodes a metal ion transporter (DCT1 or Nramp2). The transporter has a broad range of substrate specificity that include Fe+2, Zn+2, Mn+2, Co+2, Cd+2, Cu+2, Ni+2 and Pb+2. The uptake of these metal ions is coupled to proton symport. Metal ions are essential cofactors in a number of biological process including, oxidative phosphorylation, gene regulation and metal ion homeostasis. Nramp1 could confer resistance to infection in one of the two ways. (1) The uptake of Fe+2 can produce toxic hydroxyl radicals via Fenton reaction killing the pathogens in phagosomes or (2) Deplete the metal ion pools in the phagosome and deprive the pathogens of metal ions, which is critical for its survival. [Transport and binding proteins, Cations and iron carrying compounds]


:

Pssm-ID: 162246  Cd Length: 390  Bit Score: 577.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656  68 RKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRV 147
Cdd:TIGR01197   1 RKLWAFIGPGFLMSIAYIDPGNYSTDLQAGAAAGYKLLWVLLLSNIMALLLQRLCARLGVVTGLDLAEVCREHYPKVPRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 148 ILWLMVELAIIGSDMQEVIGSAIAINLLSvgRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYV 227
Cdd:TIGR01197  81 TLWILAELAIIATDMAEVIGTAIALNLLS--HIPLWGGVLITIVDVFLFLFLDKPGLRILEAFVALLVTIVAICFAYELF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 228 TVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIALFVS 307
Cdd:TIGR01197 159 YAKPGQVKVLFGGFVPSCAVFGTDGLLQAVGILGATVMPHSLYLHSALVQSRLVDRDVKEGVSEANMYRPIEAAIALSVS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 308 FIINVFVVSVFAEAFFGKTNEQVVEVCTntssphagLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSST 387
Cdd:TIGR01197 239 FSINEFVIALFTAALFVNTNILVVAGAT--------LFNSNNNADAADLFSIGVLLGCLFSPAAGYIFAVGLLAAGQSSG 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 388 MTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVM 467
Cdd:TIGR01197 311 MVGTYSGQFVMEGFLNWRWSPWLRRLITRAIAIIPCLLVAAFGGREGLTGALNASQVVLSLLLPFALIPLIMFTSSKKIM 390
 
Name Accession Description Interval E-value
nramp TIGR01197
NRAMP (natural resistance-associated macrophage protein) metal ion transporters; This model ...
68-467 0e+00

NRAMP (natural resistance-associated macrophage protein) metal ion transporters; This model describes the Nramp metal ion transporter family. Historically, in mammals these proteins have been functionally characterized as proteins involved in the host pathogen resistance, hence the name - NRAMP. At least two isoforms Nramp1 and Nramp2 have been identified. However the exact mechanism of pathogen resistance was unclear, until it was demonstrated by expression cloning and electrophysiological techniques that this protein was a metal ion transporter. It was also independently demonstrated that a microcytic anemia (mk) locus in mouse, encodes a metal ion transporter (DCT1 or Nramp2). The transporter has a broad range of substrate specificity that include Fe+2, Zn+2, Mn+2, Co+2, Cd+2, Cu+2, Ni+2 and Pb+2. The uptake of these metal ions is coupled to proton symport. Metal ions are essential cofactors in a number of biological process including, oxidative phosphorylation, gene regulation and metal ion homeostasis. Nramp1 could confer resistance to infection in one of the two ways. (1) The uptake of Fe+2 can produce toxic hydroxyl radicals via Fenton reaction killing the pathogens in phagosomes or (2) Deplete the metal ion pools in the phagosome and deprive the pathogens of metal ions, which is critical for its survival. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162246  Cd Length: 390  Bit Score: 577.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656  68 RKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRV 147
Cdd:TIGR01197   1 RKLWAFIGPGFLMSIAYIDPGNYSTDLQAGAAAGYKLLWVLLLSNIMALLLQRLCARLGVVTGLDLAEVCREHYPKVPRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 148 ILWLMVELAIIGSDMQEVIGSAIAINLLSvgRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYV 227
Cdd:TIGR01197  81 TLWILAELAIIATDMAEVIGTAIALNLLS--HIPLWGGVLITIVDVFLFLFLDKPGLRILEAFVALLVTIVAICFAYELF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 228 TVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIALFVS 307
Cdd:TIGR01197 159 YAKPGQVKVLFGGFVPSCAVFGTDGLLQAVGILGATVMPHSLYLHSALVQSRLVDRDVKEGVSEANMYRPIEAAIALSVS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 308 FIINVFVVSVFAEAFFGKTNEQVVEVCTntssphagLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSST 387
Cdd:TIGR01197 239 FSINEFVIALFTAALFVNTNILVVAGAT--------LFNSNNNADAADLFSIGVLLGCLFSPAAGYIFAVGLLAAGQSSG 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 388 MTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVM 467
Cdd:TIGR01197 311 MVGTYSGQFVMEGFLNWRWSPWLRRLITRAIAIIPCLLVAAFGGREGLTGALNASQVVLSLLLPFALIPLIMFTSSKKIM 390
PRK00701 PRK00701
divalent metal cation transporter MntH;
66-496 1.04e-100

divalent metal cation transporter MntH;


Pssm-ID: 234815  Cd Length: 439  Bit Score: 311.78  E-value: 1.04e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656  66 SFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVP 145
Cdd:PRK00701   29 FWKRLLAFLGPAFLVAVGYMDPGNWATNIQGGSQFGYTLLWVILLSNLMAMLLQSLSAKLGIATGRDLAQACRDRYPRPV 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 146 RVILWLMVELAIIGSDMQEVIGSAIAINLLSvgRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYE 225
Cdd:PRK00701  109 VWFLWIQAELAIMATDLAEVIGAAIALKLLF--GIPLLQGALITALDTFLILMLQRRGFRPLEAIIGGLLLVIAAAFIVE 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 226 YVTVKPSQSQVLKGmFVPSCSGCRTPQ-IEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKqEVREANKYFFIESCIAL 304
Cdd:PRK00701  187 LFLAQPDWAAVLKG-FIPSSEILPNPEaLYLAAGILGATVMPHNLYLHSSLVQTRVVGRTGE-EKREALRFTRIDSAIAL 264
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 305 FVSFIINVFVVSVFAEAFFGKTNEQVVEVctntssphaglfpkdnstlaVDIYKGgvvLGCYFGPAALYIWAVGILAAGQ 384
Cdd:PRK00701  265 TIAGFVNAAMLILAAAAFHASGHTDVADI--------------------EDAYLL---LSPLLGAAAATLFGIALLASGL 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 385 SSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVF---QDVEHLTGMNdflNVLQSLQLPFALIPILTFT 461
Cdd:PRK00701  322 SSTVVGTLAGQIVMEGFLRLRIPLWVRRLITRGLAMVPALIVILLggeLDPTRLLVLS---QVVLSFGLPFALIPLLLFT 398
                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1827946656 462 SLRPVMSDFANGLGWRIAGGILVLIICSINMYFVV 496
Cdd:PRK00701  399 SDRKLMGELVNPRWVKIIAWIIAVLIVALNIYLLY 433
Nramp pfam01566
Natural resistance-associated macrophage protein; The natural resistance-associated macrophage ...
126-474 1.96e-100

Natural resistance-associated macrophage protein; The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis. Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals. The yeast proteins Smf1 and Smf2 may also transport divalent cations.


Pssm-ID: 426327 [Multi-domain]  Cd Length: 356  Bit Score: 308.34  E-value: 1.96e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 126 GVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLsvGRIPLWGGVLITIADTFVFLFlDKYGLR 205
Cdd:pfam01566  37 GLVTGKGLAELIRERFPRKVSWLLWILAELAIIATDLAEVIGGAIALNLL--FGIPLWIGVLITAVLVLLLLF-QKGGYR 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 206 KLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTpqIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNN 285
Cdd:pfam01566 114 KLEKVIIGLVLVIALSFIAELFLVKPDWGAVAAGLVVPSFPGSGS--LLLAVGILGATVMPHNLFLHSSLVQERGWTIDR 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 286 KQEvREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEvctntssphaglfpkdnstlAVDIYKggvVLGC 365
Cdd:pfam01566 192 DEE-DEALRYSRIDTIIALIVAGLVNAAILIVAAAAFHGSGGIDVAT--------------------LADAAA---ALEP 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 366 YFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVL 445
Cdd:pfam01566 248 LLGKAAAVLFALGLLAAGLSSTITGTLAGQYVMEGFLGWRIPLWLRRLITRAIAFYPALAVILLGGAPGVVQLLVLSQVV 327
                         330       340
                  ....*....|....*....|....*....
gi 1827946656 446 QSLQLPFALIPILTFTSLRPVMSDFANGL 474
Cdd:pfam01566 328 LSLQLPFALIPLLLLTSDRKLMGEFVNSR 356
MntH COG1914
Mn2+ or Fe2+ transporter, NRAMP family [Inorganic ion transport and metabolism];
66-496 7.60e-76

Mn2+ or Fe2+ transporter, NRAMP family [Inorganic ion transport and metabolism];


Pssm-ID: 441518 [Multi-domain]  Cd Length: 405  Bit Score: 246.21  E-value: 7.60e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656  66 SFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVP 145
Cdd:COG1914     6 RLRRLLALLGPGLLVAAAYIDPGNLATYTQAGAQFGYSLLWVILLSNLLAIVLQEMSARLGIVTGKGLAELIRERLGRWL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 146 RVILWLMVELAIIGSDMQEVIGSAIAINLLSvgRIPLWGGVLITIADTFVFLFLDKYglRKLEAFFGFLITIMALTFGYE 225
Cdd:COG1914    86 GWLLLILLELANLATDAAEIAGAALALNLLF--GIPLLLGAVITALLAILLLLRGGY--RRLERVLKVLVALMLLAFVVT 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 226 YVTVKPSQSQVLKGMFVPScsgcrTPQIEQ---AVGIVGAVIMPHNMYLHSALVKSRQVNRnnkqevREANKYFFIESCI 302
Cdd:COG1914   162 AFLAHPDWGEVAKGTLVPS-----LPGSGSlllAIAILGATVMPYNLFLHSSLVQEKGWTG------KEDLRYARLDTVV 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 303 ALFVSFIINVFVVSVFAEAFFGkTNEQVVEvctntssphaglfpkdnstlAVDIYKggvVLGCYFGPAALYIWAVGILAA 382
Cdd:COG1914   231 GMLLAGLVNLAILLLAAAVLHG-TGIGVDS--------------------AAQAAQ---ALEPLLGEWAAILFALGLLAA 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 383 GQSSTMTGTYSGQFVMEGFLNLKWSRFARV--VLTRSIAIIPTLLVAVFQDveHLTGMNDFLNVLQSLQLPFALIPILTF 460
Cdd:COG1914   287 GFSSTITATLAGAYVMAGFLGWRIGLWLRRfyLVTRLLTLIGALIVLLLGG--DPVKLLVLSQVLNGLLLPFALIPLLLL 364
                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1827946656 461 TSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVV 496
Cdd:COG1914   365 TNDKDLMGEYRNGRWLNVLGWLIVLLIVVLNLYLLV 400
Nramp_1 NF037982
Nramp family divalent metal transporter; Nramp (natural resistance-associated macrophage ...
75-464 6.11e-17

Nramp family divalent metal transporter; Nramp (natural resistance-associated macrophage protein) family divalent metal transporters are widely conserved divalent metal transporters, which enables manganese import in bacteria and dietary iron uptake in mammals.


Pssm-ID: 468301  Cd Length: 404  Bit Score: 83.18  E-value: 6.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656  75 GPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYpKVPRVILWLMVE 154
Cdd:NF037982    1 GPGVIAAAAGVGSGEFILWPYIGSQFGYTLLWAALVGVLMQMFLNMEIERYTLATGETLFTGFRRLW-KPWGWFFWVQAE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 155 LAIIGSDMQEVIGSAIAINLLSVGRIPLWggVLITIADTFVFLFLDKYGLRKLEAFFGFLI--TIMALTFGYEYVTVKPS 232
Cdd:NF037982   80 LVNIWPGWATFSAAALTYLLGFGIPILWI--AIATLVLIGLILTLAPVVYRALEKVIGVKVglLVVFVAVAVVAVIAAPD 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 233 QSQVLKGMFVPSCSGCRTPQIEQAV----GIVGAVIMPHNMYLHSA---------LVKSRQVNRN--------------- 284
Cdd:NF037982  158 WGALGAGVLFPQLPDGDLFAVLLGAiafaGAGGAQNMVQSNWLRDKgfgmgshvpRLTSRVTGETeaepstgymfptdee 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 285 NKQEVREANKYFFIESCIALFVSFIINVFVVSVFA-EAFFGktneqvvevctntsSPHAGLFPKdnstlavDIYKGGVVL 363
Cdd:NF037982  238 NLARWRGWWRVANFDQLIAFWLIGFINISMLSVLAaATFFG--------------SGSLANDVA-------FLDVEGQTL 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 364 GCYFGPAALYIWAVGILAAGQSSTM-----TGTYSGQFVMEGFL--NLKWSRFA-RVVLTRSIAIIPTLLVAVFQDVEhl 435
Cdd:NF037982  297 AALVGPWFGTLFWLGGAASGLSSALgivdyVSRLAADVVKQGFLggASRWSESRiYLYLVWGLTMFGIVILLAGGDQP-- 374
                         410       420
                  ....*....|....*....|....*....
gi 1827946656 436 TGMNDFLNVLQSLQLpFALIPILTFTSLR 464
Cdd:NF037982  375 LVLLVISAVLLGFGM-FAYSILLLLLNRR 402
 
Name Accession Description Interval E-value
nramp TIGR01197
NRAMP (natural resistance-associated macrophage protein) metal ion transporters; This model ...
68-467 0e+00

NRAMP (natural resistance-associated macrophage protein) metal ion transporters; This model describes the Nramp metal ion transporter family. Historically, in mammals these proteins have been functionally characterized as proteins involved in the host pathogen resistance, hence the name - NRAMP. At least two isoforms Nramp1 and Nramp2 have been identified. However the exact mechanism of pathogen resistance was unclear, until it was demonstrated by expression cloning and electrophysiological techniques that this protein was a metal ion transporter. It was also independently demonstrated that a microcytic anemia (mk) locus in mouse, encodes a metal ion transporter (DCT1 or Nramp2). The transporter has a broad range of substrate specificity that include Fe+2, Zn+2, Mn+2, Co+2, Cd+2, Cu+2, Ni+2 and Pb+2. The uptake of these metal ions is coupled to proton symport. Metal ions are essential cofactors in a number of biological process including, oxidative phosphorylation, gene regulation and metal ion homeostasis. Nramp1 could confer resistance to infection in one of the two ways. (1) The uptake of Fe+2 can produce toxic hydroxyl radicals via Fenton reaction killing the pathogens in phagosomes or (2) Deplete the metal ion pools in the phagosome and deprive the pathogens of metal ions, which is critical for its survival. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162246  Cd Length: 390  Bit Score: 577.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656  68 RKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRV 147
Cdd:TIGR01197   1 RKLWAFIGPGFLMSIAYIDPGNYSTDLQAGAAAGYKLLWVLLLSNIMALLLQRLCARLGVVTGLDLAEVCREHYPKVPRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 148 ILWLMVELAIIGSDMQEVIGSAIAINLLSvgRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYV 227
Cdd:TIGR01197  81 TLWILAELAIIATDMAEVIGTAIALNLLS--HIPLWGGVLITIVDVFLFLFLDKPGLRILEAFVALLVTIVAICFAYELF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 228 TVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIALFVS 307
Cdd:TIGR01197 159 YAKPGQVKVLFGGFVPSCAVFGTDGLLQAVGILGATVMPHSLYLHSALVQSRLVDRDVKEGVSEANMYRPIEAAIALSVS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 308 FIINVFVVSVFAEAFFGKTNEQVVEVCTntssphagLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSST 387
Cdd:TIGR01197 239 FSINEFVIALFTAALFVNTNILVVAGAT--------LFNSNNNADAADLFSIGVLLGCLFSPAAGYIFAVGLLAAGQSSG 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 388 MTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVM 467
Cdd:TIGR01197 311 MVGTYSGQFVMEGFLNWRWSPWLRRLITRAIAIIPCLLVAAFGGREGLTGALNASQVVLSLLLPFALIPLIMFTSSKKIM 390
PRK00701 PRK00701
divalent metal cation transporter MntH;
66-496 1.04e-100

divalent metal cation transporter MntH;


Pssm-ID: 234815  Cd Length: 439  Bit Score: 311.78  E-value: 1.04e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656  66 SFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVP 145
Cdd:PRK00701   29 FWKRLLAFLGPAFLVAVGYMDPGNWATNIQGGSQFGYTLLWVILLSNLMAMLLQSLSAKLGIATGRDLAQACRDRYPRPV 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 146 RVILWLMVELAIIGSDMQEVIGSAIAINLLSvgRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYE 225
Cdd:PRK00701  109 VWFLWIQAELAIMATDLAEVIGAAIALKLLF--GIPLLQGALITALDTFLILMLQRRGFRPLEAIIGGLLLVIAAAFIVE 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 226 YVTVKPSQSQVLKGmFVPSCSGCRTPQ-IEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKqEVREANKYFFIESCIAL 304
Cdd:PRK00701  187 LFLAQPDWAAVLKG-FIPSSEILPNPEaLYLAAGILGATVMPHNLYLHSSLVQTRVVGRTGE-EKREALRFTRIDSAIAL 264
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 305 FVSFIINVFVVSVFAEAFFGKTNEQVVEVctntssphaglfpkdnstlaVDIYKGgvvLGCYFGPAALYIWAVGILAAGQ 384
Cdd:PRK00701  265 TIAGFVNAAMLILAAAAFHASGHTDVADI--------------------EDAYLL---LSPLLGAAAATLFGIALLASGL 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 385 SSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVF---QDVEHLTGMNdflNVLQSLQLPFALIPILTFT 461
Cdd:PRK00701  322 SSTVVGTLAGQIVMEGFLRLRIPLWVRRLITRGLAMVPALIVILLggeLDPTRLLVLS---QVVLSFGLPFALIPLLLFT 398
                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1827946656 462 SLRPVMSDFANGLGWRIAGGILVLIICSINMYFVV 496
Cdd:PRK00701  399 SDRKLMGELVNPRWVKIIAWIIAVLIVALNIYLLY 433
Nramp pfam01566
Natural resistance-associated macrophage protein; The natural resistance-associated macrophage ...
126-474 1.96e-100

Natural resistance-associated macrophage protein; The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis. Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals. The yeast proteins Smf1 and Smf2 may also transport divalent cations.


Pssm-ID: 426327 [Multi-domain]  Cd Length: 356  Bit Score: 308.34  E-value: 1.96e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 126 GVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLsvGRIPLWGGVLITIADTFVFLFlDKYGLR 205
Cdd:pfam01566  37 GLVTGKGLAELIRERFPRKVSWLLWILAELAIIATDLAEVIGGAIALNLL--FGIPLWIGVLITAVLVLLLLF-QKGGYR 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 206 KLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTpqIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNN 285
Cdd:pfam01566 114 KLEKVIIGLVLVIALSFIAELFLVKPDWGAVAAGLVVPSFPGSGS--LLLAVGILGATVMPHNLFLHSSLVQERGWTIDR 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 286 KQEvREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEvctntssphaglfpkdnstlAVDIYKggvVLGC 365
Cdd:pfam01566 192 DEE-DEALRYSRIDTIIALIVAGLVNAAILIVAAAAFHGSGGIDVAT--------------------LADAAA---ALEP 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 366 YFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVL 445
Cdd:pfam01566 248 LLGKAAAVLFALGLLAAGLSSTITGTLAGQYVMEGFLGWRIPLWLRRLITRAIAFYPALAVILLGGAPGVVQLLVLSQVV 327
                         330       340
                  ....*....|....*....|....*....
gi 1827946656 446 QSLQLPFALIPILTFTSLRPVMSDFANGL 474
Cdd:pfam01566 328 LSLQLPFALIPLLLLTSDRKLMGEFVNSR 356
MntH COG1914
Mn2+ or Fe2+ transporter, NRAMP family [Inorganic ion transport and metabolism];
66-496 7.60e-76

Mn2+ or Fe2+ transporter, NRAMP family [Inorganic ion transport and metabolism];


Pssm-ID: 441518 [Multi-domain]  Cd Length: 405  Bit Score: 246.21  E-value: 7.60e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656  66 SFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVP 145
Cdd:COG1914     6 RLRRLLALLGPGLLVAAAYIDPGNLATYTQAGAQFGYSLLWVILLSNLLAIVLQEMSARLGIVTGKGLAELIRERLGRWL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 146 RVILWLMVELAIIGSDMQEVIGSAIAINLLSvgRIPLWGGVLITIADTFVFLFLDKYglRKLEAFFGFLITIMALTFGYE 225
Cdd:COG1914    86 GWLLLILLELANLATDAAEIAGAALALNLLF--GIPLLLGAVITALLAILLLLRGGY--RRLERVLKVLVALMLLAFVVT 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 226 YVTVKPSQSQVLKGMFVPScsgcrTPQIEQ---AVGIVGAVIMPHNMYLHSALVKSRQVNRnnkqevREANKYFFIESCI 302
Cdd:COG1914   162 AFLAHPDWGEVAKGTLVPS-----LPGSGSlllAIAILGATVMPYNLFLHSSLVQEKGWTG------KEDLRYARLDTVV 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 303 ALFVSFIINVFVVSVFAEAFFGkTNEQVVEvctntssphaglfpkdnstlAVDIYKggvVLGCYFGPAALYIWAVGILAA 382
Cdd:COG1914   231 GMLLAGLVNLAILLLAAAVLHG-TGIGVDS--------------------AAQAAQ---ALEPLLGEWAAILFALGLLAA 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 383 GQSSTMTGTYSGQFVMEGFLNLKWSRFARV--VLTRSIAIIPTLLVAVFQDveHLTGMNDFLNVLQSLQLPFALIPILTF 460
Cdd:COG1914   287 GFSSTITATLAGAYVMAGFLGWRIGLWLRRfyLVTRLLTLIGALIVLLLGG--DPVKLLVLSQVLNGLLLPFALIPLLLL 364
                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1827946656 461 TSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVV 496
Cdd:COG1914   365 TNDKDLMGEYRNGRWLNVLGWLIVLLIVVLNLYLLV 400
Nramp_1 NF037982
Nramp family divalent metal transporter; Nramp (natural resistance-associated macrophage ...
75-464 6.11e-17

Nramp family divalent metal transporter; Nramp (natural resistance-associated macrophage protein) family divalent metal transporters are widely conserved divalent metal transporters, which enables manganese import in bacteria and dietary iron uptake in mammals.


Pssm-ID: 468301  Cd Length: 404  Bit Score: 83.18  E-value: 6.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656  75 GPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYpKVPRVILWLMVE 154
Cdd:NF037982    1 GPGVIAAAAGVGSGEFILWPYIGSQFGYTLLWAALVGVLMQMFLNMEIERYTLATGETLFTGFRRLW-KPWGWFFWVQAE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 155 LAIIGSDMQEVIGSAIAINLLSVGRIPLWggVLITIADTFVFLFLDKYGLRKLEAFFGFLI--TIMALTFGYEYVTVKPS 232
Cdd:NF037982   80 LVNIWPGWATFSAAALTYLLGFGIPILWI--AIATLVLIGLILTLAPVVYRALEKVIGVKVglLVVFVAVAVVAVIAAPD 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 233 QSQVLKGMFVPSCSGCRTPQIEQAV----GIVGAVIMPHNMYLHSA---------LVKSRQVNRN--------------- 284
Cdd:NF037982  158 WGALGAGVLFPQLPDGDLFAVLLGAiafaGAGGAQNMVQSNWLRDKgfgmgshvpRLTSRVTGETeaepstgymfptdee 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 285 NKQEVREANKYFFIESCIALFVSFIINVFVVSVFA-EAFFGktneqvvevctntsSPHAGLFPKdnstlavDIYKGGVVL 363
Cdd:NF037982  238 NLARWRGWWRVANFDQLIAFWLIGFINISMLSVLAaATFFG--------------SGSLANDVA-------FLDVEGQTL 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827946656 364 GCYFGPAALYIWAVGILAAGQSSTM-----TGTYSGQFVMEGFL--NLKWSRFA-RVVLTRSIAIIPTLLVAVFQDVEhl 435
Cdd:NF037982  297 AALVGPWFGTLFWLGGAASGLSSALgivdyVSRLAADVVKQGFLggASRWSESRiYLYLVWGLTMFGIVILLAGGDQP-- 374
                         410       420
                  ....*....|....*....|....*....
gi 1827946656 436 TGMNDFLNVLQSLQLpFALIPILTFTSLR 464
Cdd:NF037982  375 LVLLVISAVLLGFGM-FAYSILLLLLNRR 402
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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