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Conserved domains on  [gi|1677538581|ref|NP_001334352|]
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alpha-2-macroglobulin isoform a precursor [Homo sapiens]

Protein Classification

A2M and A2M_2 domain-containing protein( domain architecture ID 13392383)

protein containing domains YfaS, A2M, A2M_2, and A2M_recep

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
A2M_2 cd02897
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ...
958-1264 3.75e-157

Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.


:

Pssm-ID: 239227  Cd Length: 292  Bit Score: 476.69  E-value: 3.75e-157
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  958 AMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGrnQG 1037
Cdd:cd02897      1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDK--SG 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1038 NTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVT 1117
Cdd:cd02897     79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1118 HPVVRNALFCLESAWKTAqegdhgSHVYTKALLAYAFALAGnQDKRKEVLKSLNEEAVKKDNSVHWERPqkPKAPVGHFY 1197
Cdd:cd02897    159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1677538581 1198 EPQAPSAEVEMTSYVLLAYLTAQPaptsEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKY 1264
Cdd:cd02897    230 YWQAPSAEVEMTAYALLALLSAGG----EDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
A2M pfam00207
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ...
738-828 2.01e-41

Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.


:

Pssm-ID: 459711 [Multi-domain]  Cd Length: 91  Bit Score: 146.96  E-value: 2.01e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  738 TWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNY 817
Cdd:pfam00207    1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
                           90
                   ....*....|.
gi 1677538581  818 LPKCIRVSVQL 828
Cdd:pfam00207   81 LDKCLKVRVRL 91
YfaS super family cl34462
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
129-1338 1.53e-38

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


The actual alignment was detected with superfamily member COG2373:

Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 157.94  E-value: 1.53e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  129 VFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELiPL-VYIQDPKGNRIAQwQSFQL-EGGLKQFSFPLSSEPFQGSYKVV 206
Cdd:COG2373    371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPDGKEVRR-QTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  207 VQ-KKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPG-HVTVSICRK------------- 271
Cdd:COG2373    449 LYvDPKPALGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGlKVEGEVTLRpartafpgypgyr 528
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  272 YSDASDCHGEDSQAFcekFSGQLNSHGCFyqQVKTKVFQLKRKEYEMKLHTEAQIQEEGtvveltGRqssEITRTITkls 351
Cdd:COG2373    529 FGDPDEEFEPEELDL---GEGTLDADGKA--SLSLPLPDAPDAPGPLRATVEASVFESG------GR---PVTRSAT--- 591
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  352 fvkvdshfrqgIPFFGQVRLVdgkGVPIPNkvifirgneanyysNATTDEHGLVQFSINTTN-----VMGTSLTVRVNYK 426
Cdd:COG2373    592 -----------VPVHPADFYV---GIRLPL--------------FDGDPEGAPATFEVVAVDpdgkpVAGKGLKVELYRE 643
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  427 DRSpcY--------GYQWVSEEHEEAHHTAYLVFSPSK----SFVHLEPMSHEL----PCGHTQTVQAHYI-------LN 483
Cdd:COG2373    644 EWR--YvwyksddgGWRYESQEKEEPVAEGTLTTGADGpaslSLTPVEWGRYRLevkdPDGGLATSVRFYAggnaswgAE 721
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  484 GGTLLGLK------------KLSFY------YLIMakggIVRTGThgLLVKQEDMK-GHFSISIPVKSDIAPVARLLIYA 544
Cdd:COG2373    722 RPDRLELSldkesykpgetaKLLIQspfagrALVT----VERDGV--LETQWVDVKgGGTTVEIPVTEDWAPNAYVSATL 795
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  545 VLPTGDVIGDSAKY-------DVENcLANKVDLSFSPSQSL-PASHAHLRVTAA-----PQSVcALRAVDQSVLlmkpda 611
Cdd:COG2373    796 VRPGDSTANDMPARaygvaplPVDP-PARRLKVELTAPEKLrPGETLTVTVKVKgaagkAAEV-TLAAVDEGIL------ 867
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  612 elsassvynllpekDLTGF--PGPLNdqdnedcinrhnvYINGITYTPVSSTnekDMYSFLEDmglkaftnskirkpkmc 689
Cdd:COG2373    868 --------------NLTGYktPDPLD-------------FFYGKRALGVETR---DLYGRLIG----------------- 900
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  690 pqlqqyEMHGPEG-LRVGfyesdvmGRGHARLVHVEEPhtetVRKYFPETWIWD-LVVVNSAGVAEVGVTVPDTITEWKA 767
Cdd:COG2373    901 ------AFGGAAGaLRSG-------GDGALGRGGNPKP----PRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRV 963
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  768 GAFCLSEDAgLGiSSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPAfLAVPVEKEQAPHc 847
Cdd:COG2373    964 MAVAWSDDR-FG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGG-LTLEGEATQTVT- 1039
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  848 ICANGRQTVSWAVTPKSLGNVNFTVSAEALesqelcgtevpsvpehGRKDTVIKPLLVEP-EGLEKETTFNSLlcpSGGE 926
Cdd:COG2373   1040 LAAGGRATVRFPLKAPDAGDAKVTVTATGG----------------GESDAREVELPVRPaNPLVTRATSGVL---APGE 1100
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  927 vSEELSLKLPPNVVEESARASVSV----LGDILGSAMQntqnLLQMPYGCGEQNMVLFAPNIYVLDyLNETQQLTPEIKS 1002
Cdd:COG2373   1101 -SWTLPLDLPGGLRPGTGSLTLSLssspPLDLAGLLRY----LLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDA 1174
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1003 KAIGYLNTGYQRQLNYKHYDGSYSTFGeryGRNQGNTWLTAFVLKTFAQARAY-IFIDEAHITQALIWLSQRQKDNGcfr 1081
Cdd:COG2373   1175 ELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPW--- 1248
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1082 ssgsllnnAIKGGVEDEVTLSAYITIALleipltvthpvvrnALfclesawktAQEGDHGSHVYTKALLAYAF------- 1154
Cdd:COG2373   1249 --------EIEYDDAYRLAVRAYALYVL--------------AR---------AGKADLGDLRYLYDRRKDALsplakaq 1297
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1155 -----ALAGNQDKRKEVLKSLNEEAVKKDNSVHWerpqkpkapvGHFYepqapSAEVEMTSYVLLAYLTAQPAPtsedlT 1229
Cdd:COG2373   1298 laaalALLGDKARAEELLAAALARLRETGARDYW----------YGDY-----GSPLRDQALALALLAELGPDA-----P 1357
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1230 SATNIVKWITKQQNaQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIqsSGTfssKFQVDNNNRLLLQQVSLPEL- 1308
Cdd:COG2373   1358 LAPKLARWLAKALK-SGRWLSTQETAWALLALAAYARAAGASPDFTATLTL--DGK---TLPLTGRGPLARVTLPAAELl 1431
                         1290      1300      1310
                   ....*....|....*....|....*....|
gi 1677538581 1309 PGEYSMKVTGEGCVYLQTSLKYNILPEKEE 1338
Cdd:COG2373   1432 AGPLTITNTGDGPLYYTLTLSGYPAEGPPP 1461
A2M_recep pfam07677
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ...
1374-1464 8.91e-34

A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.


:

Pssm-ID: 462226  Cd Length: 92  Bit Score: 125.37  E-value: 8.91e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1374 SASNMAIVDVKMVSGFIPLKPTVKMLERSNHVSRTE-VSSNHVLIYLDKVSNQTLSLFFTVLQDVPVRDLKPAIVKVYDY 1452
Cdd:pfam07677    1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
                           90
                   ....*....|..
gi 1677538581 1453 YETDEFAIAEYN 1464
Cdd:pfam07677   81 YEPERRATTFYS 92
 
Name Accession Description Interval E-value
A2M_2 cd02897
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ...
958-1264 3.75e-157

Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.


Pssm-ID: 239227  Cd Length: 292  Bit Score: 476.69  E-value: 3.75e-157
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  958 AMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGrnQG 1037
Cdd:cd02897      1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDK--SG 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1038 NTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVT 1117
Cdd:cd02897     79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1118 HPVVRNALFCLESAWKTAqegdhgSHVYTKALLAYAFALAGnQDKRKEVLKSLNEEAVKKDNSVHWERPqkPKAPVGHFY 1197
Cdd:cd02897    159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1677538581 1198 EPQAPSAEVEMTSYVLLAYLTAQPaptsEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKY 1264
Cdd:cd02897    230 YWQAPSAEVEMTAYALLALLSAGG----EDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
TED_complement pfam07678
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ...
948-1264 8.89e-153

A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.


Pssm-ID: 462227 [Multi-domain]  Cd Length: 311  Bit Score: 465.62  E-value: 8.89e-153
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  948 VSVLGDILGSAMQ----NTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDG 1023
Cdd:pfam07678    1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1024 SYSTFGERygrnQGNTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSA 1103
Cdd:pfam07678   81 SYSAFGHS----PGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1104 YITIALLEI-----PLTVTHPVVRNALFCLESAwktaqEGDHGSHVYTKALLAYAFALAGNQDKRKEVLKSLNEEAVKKD 1178
Cdd:pfam07678  157 YVTIALLEAldingLLQRVHPSIRKALTYLEQA-----QLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1179 NSVHWERPQKPKAPVGHFYEPQAPSAEVEMTSYVLLAYLtaqpapTSEDLTSATNIVKWITKQQNAQGGFSSTQDTVVAL 1258
Cdd:pfam07678  232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYL------LLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305

                   ....*.
gi 1677538581 1259 HALSKY 1264
Cdd:pfam07678  306 QALAEY 311
A2M pfam00207
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ...
738-828 2.01e-41

Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.


Pssm-ID: 459711 [Multi-domain]  Cd Length: 91  Bit Score: 146.96  E-value: 2.01e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  738 TWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNY 817
Cdd:pfam00207    1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
                           90
                   ....*....|.
gi 1677538581  818 LPKCIRVSVQL 828
Cdd:pfam00207   81 LDKCLKVRVRL 91
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
129-1338 1.53e-38

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 157.94  E-value: 1.53e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  129 VFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELiPL-VYIQDPKGNRIAQwQSFQL-EGGLKQFSFPLSSEPFQGSYKVV 206
Cdd:COG2373    371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPDGKEVRR-QTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  207 VQ-KKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPG-HVTVSICRK------------- 271
Cdd:COG2373    449 LYvDPKPALGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGlKVEGEVTLRpartafpgypgyr 528
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  272 YSDASDCHGEDSQAFcekFSGQLNSHGCFyqQVKTKVFQLKRKEYEMKLHTEAQIQEEGtvveltGRqssEITRTITkls 351
Cdd:COG2373    529 FGDPDEEFEPEELDL---GEGTLDADGKA--SLSLPLPDAPDAPGPLRATVEASVFESG------GR---PVTRSAT--- 591
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  352 fvkvdshfrqgIPFFGQVRLVdgkGVPIPNkvifirgneanyysNATTDEHGLVQFSINTTN-----VMGTSLTVRVNYK 426
Cdd:COG2373    592 -----------VPVHPADFYV---GIRLPL--------------FDGDPEGAPATFEVVAVDpdgkpVAGKGLKVELYRE 643
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  427 DRSpcY--------GYQWVSEEHEEAHHTAYLVFSPSK----SFVHLEPMSHEL----PCGHTQTVQAHYI-------LN 483
Cdd:COG2373    644 EWR--YvwyksddgGWRYESQEKEEPVAEGTLTTGADGpaslSLTPVEWGRYRLevkdPDGGLATSVRFYAggnaswgAE 721
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  484 GGTLLGLK------------KLSFY------YLIMakggIVRTGThgLLVKQEDMK-GHFSISIPVKSDIAPVARLLIYA 544
Cdd:COG2373    722 RPDRLELSldkesykpgetaKLLIQspfagrALVT----VERDGV--LETQWVDVKgGGTTVEIPVTEDWAPNAYVSATL 795
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  545 VLPTGDVIGDSAKY-------DVENcLANKVDLSFSPSQSL-PASHAHLRVTAA-----PQSVcALRAVDQSVLlmkpda 611
Cdd:COG2373    796 VRPGDSTANDMPARaygvaplPVDP-PARRLKVELTAPEKLrPGETLTVTVKVKgaagkAAEV-TLAAVDEGIL------ 867
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  612 elsassvynllpekDLTGF--PGPLNdqdnedcinrhnvYINGITYTPVSSTnekDMYSFLEDmglkaftnskirkpkmc 689
Cdd:COG2373    868 --------------NLTGYktPDPLD-------------FFYGKRALGVETR---DLYGRLIG----------------- 900
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  690 pqlqqyEMHGPEG-LRVGfyesdvmGRGHARLVHVEEPhtetVRKYFPETWIWD-LVVVNSAGVAEVGVTVPDTITEWKA 767
Cdd:COG2373    901 ------AFGGAAGaLRSG-------GDGALGRGGNPKP----PRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRV 963
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  768 GAFCLSEDAgLGiSSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPAfLAVPVEKEQAPHc 847
Cdd:COG2373    964 MAVAWSDDR-FG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGG-LTLEGEATQTVT- 1039
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  848 ICANGRQTVSWAVTPKSLGNVNFTVSAEALesqelcgtevpsvpehGRKDTVIKPLLVEP-EGLEKETTFNSLlcpSGGE 926
Cdd:COG2373   1040 LAAGGRATVRFPLKAPDAGDAKVTVTATGG----------------GESDAREVELPVRPaNPLVTRATSGVL---APGE 1100
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  927 vSEELSLKLPPNVVEESARASVSV----LGDILGSAMQntqnLLQMPYGCGEQNMVLFAPNIYVLDyLNETQQLTPEIKS 1002
Cdd:COG2373   1101 -SWTLPLDLPGGLRPGTGSLTLSLssspPLDLAGLLRY----LLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDA 1174
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1003 KAIGYLNTGYQRQLNYKHYDGSYSTFGeryGRNQGNTWLTAFVLKTFAQARAY-IFIDEAHITQALIWLSQRQKDNGcfr 1081
Cdd:COG2373   1175 ELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPW--- 1248
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1082 ssgsllnnAIKGGVEDEVTLSAYITIALleipltvthpvvrnALfclesawktAQEGDHGSHVYTKALLAYAF------- 1154
Cdd:COG2373   1249 --------EIEYDDAYRLAVRAYALYVL--------------AR---------AGKADLGDLRYLYDRRKDALsplakaq 1297
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1155 -----ALAGNQDKRKEVLKSLNEEAVKKDNSVHWerpqkpkapvGHFYepqapSAEVEMTSYVLLAYLTAQPAPtsedlT 1229
Cdd:COG2373   1298 laaalALLGDKARAEELLAAALARLRETGARDYW----------YGDY-----GSPLRDQALALALLAELGPDA-----P 1357
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1230 SATNIVKWITKQQNaQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIqsSGTfssKFQVDNNNRLLLQQVSLPEL- 1308
Cdd:COG2373   1358 LAPKLARWLAKALK-SGRWLSTQETAWALLALAAYARAAGASPDFTATLTL--DGK---TLPLTGRGPLARVTLPAAELl 1431
                         1290      1300      1310
                   ....*....|....*....|....*....|
gi 1677538581 1309 PGEYSMKVTGEGCVYLQTSLKYNILPEKEE 1338
Cdd:COG2373   1432 AGPLTITNTGDGPLYYTLTLSGYPAEGPPP 1461
MG4 pfam17789
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
350-445 2.14e-35

Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.


Pssm-ID: 465507  Cd Length: 95  Bit Score: 130.06  E-value: 2.14e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  350 LSFVKVDSHFRQGIPFFGQVRLVDGKGVPIPNKVIFIRGNEANYYSNATTDEHGLVQFSINTTNvMGTSLTVRVNYKDRS 429
Cdd:pfam17789    1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPG-NAASLSITVKTKDPD 79
                           90
                   ....*....|....*.
gi 1677538581  430 PCYGYQWVSEEHEEAH 445
Cdd:pfam17789   80 LCPEHQALAEMYAEAY 95
A2M_recep pfam07677
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ...
1374-1464 8.91e-34

A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.


Pssm-ID: 462226  Cd Length: 92  Bit Score: 125.37  E-value: 8.91e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1374 SASNMAIVDVKMVSGFIPLKPTVKMLERSNHVSRTE-VSSNHVLIYLDKVSNQTLSLFFTVLQDVPVRDLKPAIVKVYDY 1452
Cdd:pfam07677    1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
                           90
                   ....*....|..
gi 1677538581 1453 YETDEFAIAEYN 1464
Cdd:pfam07677   81 YEPERRATTFYS 92
 
Name Accession Description Interval E-value
A2M_2 cd02897
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ...
958-1264 3.75e-157

Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.


Pssm-ID: 239227  Cd Length: 292  Bit Score: 476.69  E-value: 3.75e-157
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  958 AMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGrnQG 1037
Cdd:cd02897      1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDK--SG 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1038 NTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVT 1117
Cdd:cd02897     79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1118 HPVVRNALFCLESAWKTAqegdhgSHVYTKALLAYAFALAGnQDKRKEVLKSLNEEAVKKDNSVHWERPqkPKAPVGHFY 1197
Cdd:cd02897    159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1677538581 1198 EPQAPSAEVEMTSYVLLAYLTAQPaptsEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKY 1264
Cdd:cd02897    230 YWQAPSAEVEMTAYALLALLSAGG----EDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
TED_complement pfam07678
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ...
948-1264 8.89e-153

A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.


Pssm-ID: 462227 [Multi-domain]  Cd Length: 311  Bit Score: 465.62  E-value: 8.89e-153
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  948 VSVLGDILGSAMQ----NTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDG 1023
Cdd:pfam07678    1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1024 SYSTFGERygrnQGNTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSA 1103
Cdd:pfam07678   81 SYSAFGHS----PGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1104 YITIALLEI-----PLTVTHPVVRNALFCLESAwktaqEGDHGSHVYTKALLAYAFALAGNQDKRKEVLKSLNEEAVKKD 1178
Cdd:pfam07678  157 YVTIALLEAldingLLQRVHPSIRKALTYLEQA-----QLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1179 NSVHWERPQKPKAPVGHFYEPQAPSAEVEMTSYVLLAYLtaqpapTSEDLTSATNIVKWITKQQNAQGGFSSTQDTVVAL 1258
Cdd:pfam07678  232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYL------LLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305

                   ....*.
gi 1677538581 1259 HALSKY 1264
Cdd:pfam07678  306 QALAEY 311
A2M_like cd02891
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ...
958-1264 7.33e-107

Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.


Pssm-ID: 239221 [Multi-domain]  Cd Length: 282  Bit Score: 340.52  E-value: 7.33e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  958 AMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGeryGRNQG 1037
Cdd:cd02891      1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWG---NSDSG 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1038 NTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVt 1117
Cdd:cd02891     78 STWLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKAC- 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1118 HPVVRNALFCLESAWktaqegDHGSHVYTKALLAYAFALAGNQDKRKEVLKSLNEEAVKKDNSVHWERpqkpkapvgHFY 1197
Cdd:cd02891    157 DASIEKALAYLETQL------DGLLDPYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHWSL---------SWP 221
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1677538581 1198 EPQAPSAEVEMTSYVLLAYLTAqpaptsEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKY 1264
Cdd:cd02891    222 GDYGSSLRVEATAYALLALLKL------GDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
complement_C3_C4_C5 cd02896
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ...
961-1264 4.35e-71

Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.


Pssm-ID: 239226 [Multi-domain]  Cd Length: 297  Bit Score: 240.25  E-value: 4.35e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  961 NTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQ---LTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERygrnQG 1037
Cdd:cd02896      4 GLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQwekLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNR----PS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1038 NTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGV---EDEVTLSAYITIALLEIpL 1114
Cdd:cd02896     80 STWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVegsEGDVSLTAFVLIALQEA-R 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1115 TVTHPVVRNalfcLESAWKTAQE-----GDHGSHVYTKALLAYAFALAgNQDKRKEVLKSLNEEAVKKDNSVHWERPQKP 1189
Cdd:cd02896    159 SICPPEVQN----LDQSIRKAISylenqLPNLQRPYALAITAYALALA-DSPLSHAANRKLLSLAKRDGNGWYWWTIDSP 233
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1677538581 1190 kapvgHFYEPQAPSAEVEMTSYVLLAYLtaqpapTSEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKY 1264
Cdd:cd02896    234 -----YWPVPGPSAITVETTAYALLALL------KLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
958-1264 6.97e-61

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 211.26  E-value: 6.97e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  958 AMQNTQNLLQMPYG--------CGEQNMVLFAPNIYVLDYLNETqqltpEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFG 1029
Cdd:cd00688      1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAAT-----GIRDKADENIEKGIQRLLSYQLSDGGFSGWG 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1030 eryGRNQGNTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNaiKGGVEDEVTLSAYITIAL 1109
Cdd:cd00688     76 ---GNDYPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHR--IGGDESDVRLTAYALIAL 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1110 LEIPLTVTHPVVRNALFCLESawktAQEGDHG------SHVYTKALLAYAFALAG--NQDKRKEVLKSLNEEAVKKDNSV 1181
Cdd:cd00688    151 ALLGKLDPDPLIEKALDYLLS----CQNYDGGfgpggeSHGYGTACAAAALALLGdlDSPDAKKALRWLLSRQRPDGGWG 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1182 HWERPqkpkapvghfYEPQAPSAEVEMTSYVLLAYLTAqpaptsEDLTSATNIVKWITKQQNAQGGFSS-------TQDT 1254
Cdd:cd00688    227 EGRDR----------TNKLSDSCYTEWAAYALLALGKL------GDLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHT 290
                          330
                   ....*....|
gi 1677538581 1255 VVALHALSKY 1264
Cdd:cd00688    291 VFALLALSLY 300
A2M pfam00207
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ...
738-828 2.01e-41

Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.


Pssm-ID: 459711 [Multi-domain]  Cd Length: 91  Bit Score: 146.96  E-value: 2.01e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  738 TWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNY 817
Cdd:pfam00207    1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
                           90
                   ....*....|.
gi 1677538581  818 LPKCIRVSVQL 828
Cdd:pfam00207   81 LDKCLKVRVRL 91
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
129-1338 1.53e-38

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 157.94  E-value: 1.53e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  129 VFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELiPL-VYIQDPKGNRIAQwQSFQL-EGGLKQFSFPLSSEPFQGSYKVV 206
Cdd:COG2373    371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPDGKEVRR-QTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  207 VQ-KKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPG-HVTVSICRK------------- 271
Cdd:COG2373    449 LYvDPKPALGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGlKVEGEVTLRpartafpgypgyr 528
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  272 YSDASDCHGEDSQAFcekFSGQLNSHGCFyqQVKTKVFQLKRKEYEMKLHTEAQIQEEGtvveltGRqssEITRTITkls 351
Cdd:COG2373    529 FGDPDEEFEPEELDL---GEGTLDADGKA--SLSLPLPDAPDAPGPLRATVEASVFESG------GR---PVTRSAT--- 591
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  352 fvkvdshfrqgIPFFGQVRLVdgkGVPIPNkvifirgneanyysNATTDEHGLVQFSINTTN-----VMGTSLTVRVNYK 426
Cdd:COG2373    592 -----------VPVHPADFYV---GIRLPL--------------FDGDPEGAPATFEVVAVDpdgkpVAGKGLKVELYRE 643
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  427 DRSpcY--------GYQWVSEEHEEAHHTAYLVFSPSK----SFVHLEPMSHEL----PCGHTQTVQAHYI-------LN 483
Cdd:COG2373    644 EWR--YvwyksddgGWRYESQEKEEPVAEGTLTTGADGpaslSLTPVEWGRYRLevkdPDGGLATSVRFYAggnaswgAE 721
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  484 GGTLLGLK------------KLSFY------YLIMakggIVRTGThgLLVKQEDMK-GHFSISIPVKSDIAPVARLLIYA 544
Cdd:COG2373    722 RPDRLELSldkesykpgetaKLLIQspfagrALVT----VERDGV--LETQWVDVKgGGTTVEIPVTEDWAPNAYVSATL 795
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  545 VLPTGDVIGDSAKY-------DVENcLANKVDLSFSPSQSL-PASHAHLRVTAA-----PQSVcALRAVDQSVLlmkpda 611
Cdd:COG2373    796 VRPGDSTANDMPARaygvaplPVDP-PARRLKVELTAPEKLrPGETLTVTVKVKgaagkAAEV-TLAAVDEGIL------ 867
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  612 elsassvynllpekDLTGF--PGPLNdqdnedcinrhnvYINGITYTPVSSTnekDMYSFLEDmglkaftnskirkpkmc 689
Cdd:COG2373    868 --------------NLTGYktPDPLD-------------FFYGKRALGVETR---DLYGRLIG----------------- 900
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  690 pqlqqyEMHGPEG-LRVGfyesdvmGRGHARLVHVEEPhtetVRKYFPETWIWD-LVVVNSAGVAEVGVTVPDTITEWKA 767
Cdd:COG2373    901 ------AFGGAAGaLRSG-------GDGALGRGGNPKP----PRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRV 963
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  768 GAFCLSEDAgLGiSSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPAfLAVPVEKEQAPHc 847
Cdd:COG2373    964 MAVAWSDDR-FG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGG-LTLEGEATQTVT- 1039
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  848 ICANGRQTVSWAVTPKSLGNVNFTVSAEALesqelcgtevpsvpehGRKDTVIKPLLVEP-EGLEKETTFNSLlcpSGGE 926
Cdd:COG2373   1040 LAAGGRATVRFPLKAPDAGDAKVTVTATGG----------------GESDAREVELPVRPaNPLVTRATSGVL---APGE 1100
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  927 vSEELSLKLPPNVVEESARASVSV----LGDILGSAMQntqnLLQMPYGCGEQNMVLFAPNIYVLDyLNETQQLTPEIKS 1002
Cdd:COG2373   1101 -SWTLPLDLPGGLRPGTGSLTLSLssspPLDLAGLLRY----LLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDA 1174
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1003 KAIGYLNTGYQRQLNYKHYDGSYSTFGeryGRNQGNTWLTAFVLKTFAQARAY-IFIDEAHITQALIWLSQRQKDNGcfr 1081
Cdd:COG2373   1175 ELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPW--- 1248
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1082 ssgsllnnAIKGGVEDEVTLSAYITIALleipltvthpvvrnALfclesawktAQEGDHGSHVYTKALLAYAF------- 1154
Cdd:COG2373   1249 --------EIEYDDAYRLAVRAYALYVL--------------AR---------AGKADLGDLRYLYDRRKDALsplakaq 1297
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1155 -----ALAGNQDKRKEVLKSLNEEAVKKDNSVHWerpqkpkapvGHFYepqapSAEVEMTSYVLLAYLTAQPAPtsedlT 1229
Cdd:COG2373   1298 laaalALLGDKARAEELLAAALARLRETGARDYW----------YGDY-----GSPLRDQALALALLAELGPDA-----P 1357
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1230 SATNIVKWITKQQNaQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIqsSGTfssKFQVDNNNRLLLQQVSLPEL- 1308
Cdd:COG2373   1358 LAPKLARWLAKALK-SGRWLSTQETAWALLALAAYARAAGASPDFTATLTL--DGK---TLPLTGRGPLARVTLPAAELl 1431
                         1290      1300      1310
                   ....*....|....*....|....*....|
gi 1677538581 1309 PGEYSMKVTGEGCVYLQTSLKYNILPEKEE 1338
Cdd:COG2373   1432 AGPLTITNTGDGPLYYTLTLSGYPAEGPPP 1461
MG4 pfam17789
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
350-445 2.14e-35

Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.


Pssm-ID: 465507  Cd Length: 95  Bit Score: 130.06  E-value: 2.14e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  350 LSFVKVDSHFRQGIPFFGQVRLVDGKGVPIPNKVIFIRGNEANYYSNATTDEHGLVQFSINTTNvMGTSLTVRVNYKDRS 429
Cdd:pfam17789    1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPG-NAASLSITVKTKDPD 79
                           90
                   ....*....|....*.
gi 1677538581  430 PCYGYQWVSEEHEEAH 445
Cdd:pfam17789   80 LCPEHQALAEMYAEAY 95
A2M_recep pfam07677
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ...
1374-1464 8.91e-34

A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.


Pssm-ID: 462226  Cd Length: 92  Bit Score: 125.37  E-value: 8.91e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581 1374 SASNMAIVDVKMVSGFIPLKPTVKMLERSNHVSRTE-VSSNHVLIYLDKVSNQTLSLFFTVLQDVPVRDLKPAIVKVYDY 1452
Cdd:pfam07677    1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
                           90
                   ....*....|..
gi 1677538581 1453 YETDEFAIAEYN 1464
Cdd:pfam07677   81 YEPERRATTFYS 92
A2M_BRD pfam07703
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ...
459-607 9.33e-34

Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.


Pssm-ID: 462235 [Multi-domain]  Cd Length: 139  Bit Score: 127.08  E-value: 9.33e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  459 VHLEPMSHELPCGHTQTVQAHYILNGGTLLGlkklSFYYLIMAKGGIVRTGTHGllvkqedmkGHFSISIPVKSDIAPVA 538
Cdd:pfam07703    1 LHLSTDKTEYKPGETATVTVKSPFDGTVERD----GFTYLVLSKGQIVVVGRGG---------VTTSFSLPVTAEMAPSA 67
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1677538581  539 RLLIYAV---LPTGDVIGDSAKYDVENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAVDQSVLLM 607
Cdd:pfam07703   68 RVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
MG3 pfam17791
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ...
223-313 9.06e-31

Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.


Pssm-ID: 465509  Cd Length: 83  Bit Score: 116.22  E-value: 9.06e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  223 EFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPGHVTVSICRKYSDASDCHgedsqafcEKFSGQLNSHGCFYQ 302
Cdd:pfam17791    1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDDSKRKCF--------ESFSKELDKDGCGSA 72
                           90
                   ....*....|.
gi 1677538581  303 QVKTKVFQLKR 313
Cdd:pfam17791   73 SLSTEEFQLTF 83
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
129-221 2.70e-25

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 101.24  E-value: 2.70e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538581  129 VFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELIPLVYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSSEPFQGSYKVVVQ 208
Cdd:pfam01835    2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLR 81
                           90
                   ....*....|....
gi 1677538581  209 K-KSGGRTEHPFTV 221
Cdd:pfam01835   82 DgAGGSLGSGSFRV 95
Big_1 pfam02369
Bacterial Ig-like domain (group 1); This family consists of bacterial domains with an Ig-like ...
368-423 2.97e-03

Bacterial Ig-like domain (group 1); This family consists of bacterial domains with an Ig-like fold. Members of this family are found in bacterial surface proteins such as intimins and invasins involved in pathogenicity.


Pssm-ID: 460541 [Multi-domain]  Cd Length: 64  Bit Score: 37.53  E-value: 2.97e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1677538581  368 QVRLVDGKGVPIPNK-VIFIRGNEANYYSNATTDEHGLVQFSInTTNVMGTSlTVRV 423
Cdd:pfam02369   10 TATVTDANGNPVPGAtVTFSASGGTLSASSGTTDANGQATVTL-TSTKAGTV-TVTA 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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