|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
99-512 |
0e+00 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 620.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 99 ATMACVGFMIAFGMRCNMSAAKLKGEHNGTV-----------FMNWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANK 167
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDayggkvivhkaEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 168 IFGLSIVSSATLHLFVPFAMTlMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPL 247
Cdd:cd17382 81 VFGLAIFVTSTLNMLIPIAAR-VHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 248 SGLLADAVGYQAPFYAYGVFGIIWYMFWIWLcfenprkhpaisipelkyiekslgesahptmpslkttpwremmrSMPVY 327
Cdd:cd17382 160 SGILVQYVGWSSPFYVYGVFGIIWYMFWMLV--------------------------------------------SMPVY 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 328 AIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTNVRKLFNCGGF 407
Cdd:cd17382 196 AIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGF 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 408 GMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQANPT 487
Cdd:cd17382 276 GMEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTR 355
|
410 420
....*....|....*....|....*
gi 386768993 488 GCWTTVFTLAACVHLVGCTFYGIFA 512
Cdd:cd17382 356 EEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
99-512 |
4.16e-124 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 372.34 E-value: 4.16e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 99 ATMACVGFMIAFGMRCNMSAA------------------KLKGEHNGTVFMNWTVAVESHVDSSFFWGYLVTQIPGGFIA 160
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAivamvnstathdnnntstDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 161 SKFPANKIFGLSIVSSATLHLFVPFAMtlmHGHV--VICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSY 238
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAA---RGGYgaLIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 239 AGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCfenprkhpaisipelkyiekslgesahptmpslkttpwr 318
Cdd:cd17318 158 FGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV--------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 319 emmrsMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTNV 398
Cdd:cd17318 199 -----LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 399 RKLFNCGGFGMEGLFFLFVAH-SSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGIIVPYa 477
Cdd:cd17318 274 RKLFTSIGFLGPGVFLIALGYlGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPL- 352
|
410 420 430
....*....|....*....|....*....|....*..
gi 386768993 478 LDGLI--QANPTGCWTTVFTLAACVHLVGCTFYGIFA 512
Cdd:cd17318 353 IVGAIvkNDQTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
98-512 |
4.09e-87 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 277.05 E-value: 4.09e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 98 IATMACVGFMIAFGMRCNMSAAKL-------------------------KGEHNGTVFM-NWTVAVESHVDSSFFWGYLV 151
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVdmvnsnstlpsnnssnacpehssspSVEHNETGKKyDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 152 TQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGHVvICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLAT 231
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYL-IAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 232 LAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCfenprkhpaisipelkyiekslgesahptmps 311
Cdd:cd17381 160 ISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV-------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 312 lkttpwremmrsMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNG 391
Cdd:cd17381 208 ------------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQ 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 392 ILSTTNVRKLFNCGGFGMEGLFFLFVAHSS-TATGAMFALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLA 470
Cdd:cd17381 276 NFSTVCVRKIFTLIGMIGPAVFLLAAGFTGcNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIP 355
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 386768993 471 GIIVPYALDGLIQANPTGCWTTVFTLAACVHLVGCTFYGIFA 512
Cdd:cd17381 356 GMVGPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
101-512 |
5.69e-82 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 262.49 E-value: 5.69e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 101 MACVGFMIAFGMRCNMSAAklkgehngTVFM----NWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSS 176
Cdd:cd17380 3 LLFLATCICYADRVNMPIA--------IVPMakefGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 177 ATLHLFVPFAmTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVG 256
Cdd:cd17380 75 SLATLLTPLL-AYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 257 YQAPFYAYGVFGIIWYMFWIWLcfenprkhpaisipelkyiekslgesahptmpslkttpwremmrSMPVYAIIVANFCR 336
Cdd:cd17380 154 WPSVFYFFGLLGLLWALVWLIY--------------------------------------------LPPVWAIIVAHFCM 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 337 SWNFYLLVLFQSSFLKHKFGfKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGIlSTTNVRKLFNCGGFGMEGLFFLF 416
Cdd:cd17380 190 NWGFYILLSWLPTYFHEVLV-PLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPALFLLL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 417 VAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQAnpTGCWTTVFTL 496
Cdd:cd17380 268 LSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEA--TGSWSLVFVL 345
|
410
....*....|....*.
gi 386768993 497 AACVHLVGCTFYGIFA 512
Cdd:cd17380 346 AAVVNLVGAVVFLLFG 361
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
132-527 |
1.15e-79 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 259.68 E-value: 1.15e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 132 NWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGHVVICvRVLQGLFEGVTYP 211
Cdd:TIGR00894 72 KWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFC-RVIQGLAQGSVSP 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 212 ACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADA-VGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAIS 290
Cdd:TIGR00894 151 ATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCIS 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 291 IPELKYIEKSLGESAHPTMPSLkttPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPH 370
Cdd:TIGR00894 231 KFEKKYINSSLQGQKGSTRQSL---PIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPY 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 371 LIMTTIVPFGGMLADHLRKNGILSTTNVRKLFNCGGFGMEGLFFLFVAH-SSTATGAMFALTCGVAFSGFAISGYNVNHL 449
Cdd:TIGR00894 308 LFAWLCSIFAGYLADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYlSAAFYLTIIILTLANAVSSGPLAGVLINSL 387
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386768993 450 DIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQANPTGCWTTVFTLAACVHLVGCTFYGIFASGELQPWAEPPAEEQ 527
Cdd:TIGR00894 388 DLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
95-508 |
3.79e-45 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 164.28 E-value: 3.79e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 95 RYTIATMACVGFMIAFGMRCNMSAAKLKGEHNgtvfMNWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIV 174
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKD----LGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSML 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 175 SSATLHLFVPFAMTLMHGHVVicvRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADA 254
Cdd:cd17319 77 LWSLFTALTGFATSLTSLYVL---RFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 255 VGYQAPFYAYGVFGIIWYMFWIWLcfenprkhpaisipelkyiekslgesahptmpsLKTtpwremmrsmpVYAIIVANF 334
Cdd:cd17319 154 FGWRWAFIIEGLLGLLLAVLWWFY---------------------------------LRQ-----------VWGLALGYF 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 335 CRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRkngilstTNVRKLFNCGGFGMEGLFF 414
Cdd:cd17319 190 GINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLL-------RGARRLVIIIGLLLAAVGL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 415 LFVAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPR-YASILMGLSNGIGTLAGIIVPYALDGLIQAnpTGCWTTV 493
Cdd:cd17319 263 LLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGGNLGGFVAPLLIGYLVDA--TGSYTAA 340
|
410
....*....|....*
gi 386768993 494 FTLAACVHLVGCTFY 508
Cdd:cd17319 341 FLFLAAVALLAALLV 355
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
95-512 |
1.07e-38 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 146.55 E-value: 1.07e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 95 RYTIATMACVGFMIAFGMRCNMSAAK--LKGEhngtvfMNWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLS 172
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAppLQAD------LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 173 IVSSATLHLFVPFAMTLMhghVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLA 252
Cdd:COG2271 82 LLLWGLATLLFGFATSFW---QLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 253 DAVGYQAPFYAYGVFGIIWYMFWIWLcfenprkhpaisipelkyiekslgesahptmpslkttpwremmrsmpvyaIIVA 332
Cdd:COG2271 159 AAFGWRAAFLILGLPGLLLALLRFWL--------------------------------------------------LALA 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 333 NFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKngilsttnVRKLFNCGGFGMEGL 412
Cdd:COG2271 189 YFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR--------RRKLVLAIGLLLAAL 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 413 FFLFVAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAP-RYASILMGLSNGIGTLAGIIVPYALDGLIQAnpTGcWT 491
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDA--TG-YQ 337
|
410 420
....*....|....*....|.
gi 386768993 492 TVFTLAACVHLVGCTFYGIFA 512
Cdd:COG2271 338 AAFLLLAALALLAALLALLLL 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
101-475 |
5.57e-31 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 124.07 E-value: 5.57e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 101 MACVGFMIAFGMRCNMSAAKLkgeHNGTVFmNWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLH 180
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPL---LLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 181 LFVPFAmtlmHGHVVICV-RVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQA 259
Cdd:pfam07690 77 LLLLFA----SSLWLLLVlRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 260 PFYAYGVFGIIWymFWIWLCFENPRKHPAISIPELKYIekslgesahptmpsLKTTPWREmMRSMPVYAIIVANFCRSWN 339
Cdd:pfam07690 153 AFLILAILSLLA--AVLLLLPRPPPESKRPKPAEEARL--------------SLIVAWKA-LLRDPVLWLLLALLLFGFA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 340 FYLLVLFQSSFLKHkFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKngilsttNVRKLFNCGGFGMEGLFFLFVAH 419
Cdd:pfam07690 216 FFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGR-------RRRLLLALLLLILAALGLLLLSL 287
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 386768993 420 SSTATGAMFALTCGVAFSGFAISGYNVNHLDIAP-RYASILMGLSNGIGTLAGIIVP 475
Cdd:pfam07690 288 TLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPkEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
143-508 |
3.13e-28 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 116.76 E-value: 3.13e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 143 SSFFWGYLVTQIPGGFIASKFPANKIFGLSIVssatLHLFVPFAMTLMHGHVVICV-RVLQGLFEGVTYPACHGIWRFWA 221
Cdd:cd06174 38 ALFSLGYALLQPLAGLLADRFGRRPVLLLGLL----LFALGALLFAFAPSFWLLLLgRFLLGLGSGLIDPAVLALIADLF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 222 PPMERSRLATLAFSGSYAGVVVGLPLSGLLADA--VGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIek 299
Cdd:cd06174 114 PERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKS-- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 300 slgesahptmpslKTTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPF 379
Cdd:cd06174 192 -------------VLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 380 GGMLADHLRKngilsttnVRKLFNCGGFGMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPRYASIL 459
Cdd:cd06174 259 LGLLSDRLIG--------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTA 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 386768993 460 MGLSNGIGTLAGIIVPYALDGLIQAnpTGCWTTVFTLAACVHLVGCTFY 508
Cdd:cd06174 331 FGLLNTFGFLGGAIGPLLAGFLLAA--TFGLTGAFLVLAVLLLLAAILL 377
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
95-504 |
6.04e-26 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 110.36 E-value: 6.04e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 95 RYTIATMACVGFMIAFGMRCNMS--AAKLKGEhngtvfMNWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLS 172
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSvlAPPLAEE------FGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 173 IVSSATLHLFVPFAMTLMhghVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLA 252
Cdd:COG2223 77 LLLLGIGLLLLALAVSYW---LLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 253 DAVGYQAPFYAYGVFGIIWyMFWIWLCFENPRKHPAISIPElkyiekslgesahptmpSLKTtpWREMMRSMPVYAIIVA 332
Cdd:COG2223 154 AAFGWRNAFLILGILLLVV-AVLAWLFLRDPPAGAAAAAKA-----------------SLRD--QLEALRDPRFWLLSLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 333 NFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHL-RKNGILsttnvrklfncGGFGMEG 411
Cdd:COG2223 214 YFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIgGRRVLL-----------IVFALMA 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 412 LFFLFVAHSSTATGAMFALTCGVafsGFAISGYNVNHLDIAP-----RYASILMGLSNGIGTLAGIIVPYALDGLIQAnp 486
Cdd:COG2223 283 LGLLLLALALGSLWLFLVLFLLL---GLALGGGNGAVFALVPdifptKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA-- 357
|
410
....*....|....*...
gi 386768993 487 TGCWTTVFTLAACVHLVG 504
Cdd:COG2223 358 TGSYTAAFLVFAVLALVA 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
94-471 |
1.95e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 108.14 E-value: 1.95e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 94 ARYTIATMACVGFMIAFGMRCNMSAAKLKGEHngtvfMNWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSI 173
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAAD-----LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 174 VSSATLHLFVPFAMTLmhgHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLAD 253
Cdd:COG2814 83 LLFALGSLLCALAPSL---WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 254 AVGYQAPFYAYGVFGII-WYMFWIWLcfenprkhpaisiPElkyiekslgesAHPTMPSLKTTPWREMMRSMPVYAIIVA 332
Cdd:COG2814 160 LFGWRWVFLVNAVLALLaLLLLLRLL-------------PE-----------SRPAARARLRGSLRELLRRPRLLLLLLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 333 NFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSttnvrklfncGGFGMEGL 412
Cdd:COG2814 216 AFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL----------IGLLLLAL 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 413 FFLFVAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAP-RYASILMGLSNGIGTLAG 471
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPpEARGRASGLYNSAFFLGG 345
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
143-512 |
1.23e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 94.18 E-value: 1.23e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 143 SSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLmhgHVVICVRVLQGLFEGVTYPACHGIWRFWAP 222
Cdd:cd17325 38 AAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY---WQLLLARFLQGLASAAVWPAAMALIADIAP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 223 PMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIwYMFWIWLCFENPRKHPAisipelkyiekslg 302
Cdd:cd17325 115 PEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL-ALVLALLLLPEPRPPPN-------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 303 esAHPTMPSLKTTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGM 382
Cdd:cd17325 180 --KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 383 LADHLRKNGILSTtnvrklfncgGFGMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPRYA-SILMG 461
Cdd:cd17325 258 LSDRIGRKPLILI----------GLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGrGTAMG 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 386768993 462 LSNGIGTLAGIIVPYALDGLIQANPtgcWTTVFTLAACVHLVGCTFYGIFA 512
Cdd:cd17325 328 LFNTAFSLGMVLGPLLGGFLYDAFG---FATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
199-512 |
3.39e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 68.37 E-value: 3.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 199 RVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADaVGYQAPFYAYGVFGIIWYMFWIWL 278
Cdd:cd17473 95 RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLFL 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 279 cFENPRKHpaisipelkyiekslGESAHPTMPSLKTTPWRemmrsmPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFK 358
Cdd:cd17473 174 -PEPARKS---------------KSAASPGAATAAALPWK------RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGS 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 359 VEEAGFVGSlphlIMTTIVPFGGMLADHLRKNgiLSttnvRKLFNCGGFGMEGLFFLFVAHSSTAtgAMFALTCGVAFSG 438
Cdd:cd17473 232 AALIGLALA----IASLAGAIGALLFGRLKRR--LG----KRRLLAIGFALMALGFLLLALASGL--WVVLLGAILAGLG 299
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386768993 439 FAISGYNVNHLdIAPRYASILMGLSNGIGTLAGII----VPYALDGLIQANPTGcwTTVFTLAACVHLVGCTFYGIFA 512
Cdd:cd17473 300 FGLLLPTLNSW-AMSLVPPELRGRAMGIVTSAFFLgqflSPLVLGPLVNLTGGL--SGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
96-478 |
3.13e-11 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 65.73 E-value: 3.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 96 YTIATMACVGFMIAFGMRCNMSAAKLKG-----EHNGTVFmNWTVAVeshvdssFFWGYLVTQIPGGFIASKFPANKIFG 170
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMGmkedlKLVGNQY-NWGNTV-------FYVGYIIFELPGNLLLQRFPPSKWLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 171 LSIVSSAtlhlfvpfAMTLMHGHV-----VICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGl 245
Cdd:cd17327 76 VFIVLWG--------LLTLLTAAVknfggLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFG- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 246 plsGLLADAV----------GYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSLGESaHPTMPSLKTT 315
Cdd:cd17327 147 ---GLLAYGVfkilgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRAN-QTGKGDQKFK 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 316 P--WREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKhKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGIL 393
Cdd:cd17327 223 WkqIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILK-SLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLF 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 394 STTnvrklFNCggFGMEGlfFLFVAHSSTATGAMFAL--TCGVAFSGFAISGYNVNhlDIAPRYAS--ILMGLSNGIGTL 469
Cdd:cd17327 302 AIF-----ACV--LALVG--SIILLAAPNPPGAYFAAyiLGGGSYAGFPILLSWIS--SNCAGYTKraTVLAIMLIFYNV 370
|
....*....
gi 386768993 470 AGIIVPYAL 478
Cdd:cd17327 371 GNIVAPQIF 379
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
143-471 |
3.51e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 65.26 E-value: 3.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 143 SSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLmhgHVVICVRVLQGLFEGVtypachgiwrFWA- 221
Cdd:cd17324 41 SAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF---ALLLLARALAGLAHGG----------FWAi 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 222 ---------PPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIwYMFWIWLCFENPRKHPAISIP 292
Cdd:cd17324 108 aaayaadlvPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALL-AALLLWRLLPSLPPKKPGSLG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 293 ELKyiekslGESAHPTMPSLkttpwremmrsMPVYAIIVANFCrswNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLI 372
Cdd:cd17324 187 LLS------SLLLLLRNPRL-----------RLAYLITFLLFG---GFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 373 MTTIVPFGGMLADHLRKNGILSTtnvrkLFNCGGFGMegLFFLFVAHSSTATGAMFALTCGVAFSGFAISGYNvnhLDIA 452
Cdd:cd17324 247 GVVGSPLAGRLADRGGRRALLIA-----LLLLAAALL--LLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRV---LRLA 316
|
330 340
....*....|....*....|....*.
gi 386768993 453 PRYASILMGLS-------NGIGTLAG 471
Cdd:cd17324 317 PEARGLASSLYlaaynlgGALGAALG 342
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
143-368 |
2.50e-09 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 59.70 E-value: 2.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 143 SSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMhghVVICVRVLQGLFEGVTYPACHGIWRFWAP 222
Cdd:TIGR00881 37 SSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLW---VMAALWALNGIFQGMGWPPCGRTVTKWFS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 223 PMERSR-LATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSL 301
Cdd:TIGR00881 114 RSERGTwVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEEPDG 193
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386768993 302 GESAHPTMPSLKTTPWREMMRSMPVYAIIVANF--------CRSW-NFYLLVLFQSSFLKHKFGFKVEE-AGFVGSL 368
Cdd:TIGR00881 194 DAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVfvyvvrtgILDWsPLYLTQEKGFSKEKASWAFTLYElGGLVGTL 270
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
143-504 |
6.49e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 58.00 E-value: 6.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 143 SSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMhghVVICVRVLQGLFEGVTYPACHGIWRFWAP 222
Cdd:cd17316 43 AAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPI---LLLVLRFLQGIGIGGEYPGASTYVAEFAP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 223 PMERSRLATLAFSGSYAGVVVGLPLSGLL----ADAVGYQAPFYAYGVFGIIwyMFWIWlcfenprkhpaisipelkyie 298
Cdd:cd17316 120 SKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGWRILFLIGALPALL--ALLLR--------------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 299 kslgesahptmpslkttpwremmrsMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVP 378
Cdd:cd17316 177 -------------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGAL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 379 FGGMLADHLRkngilsttnvRKLFNCGGFGMEGLF--FLFVAHSSTATGAMFaltCGVAFSGFAISGYNVNHLDIA---- 452
Cdd:cd17316 232 IAGLLSDRIG----------RKKTLVIGLILSGILalPLFYLLSGSPTLLLL---LLFILSFFVGGVWGALYAYLAelfp 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 386768993 453 PRYASILMGLSNGIGTLAGIIVPYALDGLIQAnpTGCWTTVFTLAACVHLVG 504
Cdd:cd17316 299 TEVRATGVGLSYNLGRLGGGGAPPLIALLLAS--TGGTGVPALILALLAIVA 348
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
143-384 |
4.84e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 54.82 E-value: 4.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 143 SSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLmhgHVVICVRVLQGLFEGVTYPACHGIWRFWAP 222
Cdd:COG0477 56 SAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSP---ELLIAARALQGIGAGGLMPGALALIAELFP 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 223 PMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIwymfWIWLCFENPRKHPAISIPELKYIEKSLG 302
Cdd:COG0477 133 ARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLL----ALVLRLRLPESRGLLLALLALALAALLL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 303 ESAHPTMPSLKTTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGM 382
Cdd:COG0477 209 AALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLL 288
|
..
gi 386768993 383 LA 384
Cdd:COG0477 289 LL 290
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
131-504 |
8.01e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 54.92 E-value: 8.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 131 MNWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANK-------IFGLSIVSSAtlhlFVPFAMTLmhghvVICVRVLQG 203
Cdd:cd17353 33 LGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKailiggiLFGLGFILSA----FAISLPLL-----FLGYGVLGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 204 LFEGVTYPACHGIWRFWAPpmERSRLAT-LAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGV-FGIIWYMFWIWLCFE 281
Cdd:cd17353 104 IGAGIGYITPVSTAVKWFP--DKRGLATgIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIiFLIIIVIGAFLIRDP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 282 NPRKHPAISIPelkyiekslgeSAHPTMPSLKTTPWREMMRSMPVYAIIVANFCRSwnFYLLVLFQSS--FLKHKFGFKV 359
Cdd:cd17353 182 PKGWVPPGVDP-----------LANNAENSPRDYTPREMLRTPTFWLLWLMFFLNA--TAGLMLIGQAkpIGQEFAGLDA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 360 EEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTnvrklfncggFGMEGLFFLFVAHSSTATGAMFALTCGVAF--- 436
Cdd:cd17353 249 GIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIA----------FLIQGVAMFLLPFIGSVAVLFVLGVALIGFcyg 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386768993 437 SGFAISGYNVNHLdIAPRYASILMGL---SNGIGTLAGIIVPYALDGliqanpTGCWTTVFTLAACVHLVG 504
Cdd:cd17353 319 GGFALFPALTADF-FGTKNAGTNYGLlytAKGVGGLIGPIIAAYVLY------TGGYNAAFIIAAALSLVA 382
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
225-510 |
1.27e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.52 E-value: 1.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 225 ERSRLATLAFSGSYAGVVVGLPLSGLLAD------AVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAisipelkyiE 298
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLVAafggdaALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE---------K 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 299 KSLGESahptmpslkttpWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVP 378
Cdd:COG2211 215 VSLKES------------LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAP 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 379 FGGMLADHLRKngilsttnvRKLFnCGGFGMEGLFFLFVAHSSTATGAMFALTCgvAFSGFAISGYNVNHL----DIAP- 453
Cdd:COG2211 283 LWPRLAKRFGK---------KKAF-IIGLLLAALGLLLLFFLGPGNLWLLLVLA--ALAGIGLGAILVLPWamlaDVVDy 350
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386768993 454 -------RYASILMGLSNGI----GTLAGIIVPYALDGL-IQANPTGCWTTVFTLAACVHLVGCTFYGI 510
Cdd:COG2211 351 dewktgrRREGLYFGIFTFAiklgQALAGALAGLLLALFgYVAGAAQSPSALTGIRLLFFLLPAVLLLL 419
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
143-507 |
1.50e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 50.70 E-value: 1.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 143 SSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMhghVVICVRVLQGLFEGVTYPA-CHGIWRfWA 221
Cdd:cd17475 38 SALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYP---VLLVLLFLVGAGYGSVQPGgGRAIMR-WF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 222 PPMERS-----RLATLAFSGSYAGVVvgLPLsglLADAVGYQAPFYAYGVFGIIW-YMFWIWLcfenpRKHPAIsipelk 295
Cdd:cd17475 114 PPRERGlamgiRQTGVPLGGALAAAL--LPP---LALHYGWRAAFVVAGLVSILAaVLFWLFY-----REPPAA------ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 296 yieKSLGESAHPTMPSLKttpwrEMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTT 375
Cdd:cd17475 178 ---SAATESASTLLRSLK-----EVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 376 IVPFGGMLADHLRKNgilsttNVRKLFNCGGFGMEGLFFLF-VAHSSTATGAMFALTCGVAFSGFAISGYNVNHL-DIAP 453
Cdd:cd17475 250 GRIGLGRVSDRVFGG------RRRPVLVITAAIAAAALLVLsLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVaESAG 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 386768993 454 -RYASILMGLSNGIGTLAGIIVPYALDGLIQAnpTGCWTTV-FTLAACVHLVGCTF 507
Cdd:cd17475 324 pEQAGTALGLANTINFIGIAIGPPLFGLLVDA--THSYAPAwLALALLLVLAALLL 377
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
223-513 |
1.64e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 47.56 E-value: 1.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 223 PMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAisipelkyiekslg 302
Cdd:COG2807 136 PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAA-------------- 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 303 esahptmpSLKTTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLkHKFGFKVEEAGFVGSLphLIMTTIVP--FG 380
Cdd:COG2807 202 --------APAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSL--FQLAGIPGslLV 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 381 GMLADHLRKNGILSTTnvrklfnCGGFGMEGLFFLFVAHSSTATGAMFALTCGVAfSGFAISGYNVNHLDIAPRYASILM 460
Cdd:COG2807 271 PLLADRLGDRRPLLLL-------LGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG-GLFPLALTLIGLRARTPAEAAALS 342
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 386768993 461 GLSNGIGTLAGIIVPYALDGLIQAnpTGCWTTVFTLAACVhLVGCTFYGIFAS 513
Cdd:COG2807 343 GMAQSVGYLLAALGPLLVGALHDA--TGSWTAALLLLAAL-AVLMLVAGLLAG 392
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
141-284 |
6.57e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 45.73 E-value: 6.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 141 VDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMhghVVICVRVLQGLFEGVTYPACHGIWRFW 220
Cdd:cd17312 43 IGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLW---FFAVLWGLNGLFQSMGWPPCVKLLGNW 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386768993 221 APPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYG----VFGIIwymFWIWLCFENPR 284
Cdd:cd17312 120 FSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGivglVVAII---LFFFLRDSPPY 184
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
200-498 |
9.81e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.95 E-value: 9.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 200 VLQGLFEGVTY-PACHGIWRFWAPPmERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIwYMFWIWL 278
Cdd:cd17355 100 LLGGGGAGTLAaVAFATVAAWWFER-RRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALL-VLVPVLL 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 279 CfenPRKHPAisipelkyieKSLGESAHPTMPSLKTTPWREMMRSmPVYAIIVANF---CRSWNFYLLVLFqsSFLKHkF 355
Cdd:cd17355 178 L---LRRRPA----------DLALRAYDDASPASPGSTLKEALRS-ASFWLLALAFflcGFAVVGLIVHLV--PYLAD-R 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 356 GFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTtnvrklfncgGFGMEGLFFLFVAHSSTATGAMFALTCGVA 435
Cdd:cd17355 241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAA----------SYALRALGLALLLLLPFPPLALLLFAALFG 310
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386768993 436 FSGFA---ISGYNVNHLdIAPRYASILMGLSNGIGTLAGIIVPYALdGLIqANPTGCWTTVFTLAA 498
Cdd:cd17355 311 LGWGAtvpLTAALAARY-FGARSYGTLFGLVFAPHQLGSALGPWLG-GLL-YDRTGSYTAAWALAV 373
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
143-284 |
1.09e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.86 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 143 SSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLhLFVPFAMTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAP 222
Cdd:COG2271 223 SLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAA-LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP 301
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386768993 223 PMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPR 284
Cdd:COG2271 302 KKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
144-277 |
2.43e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 43.69 E-value: 2.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 144 SFFW-GYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGhvVICVrVLQGLFEGVTYPAchgIWRFWA- 221
Cdd:COG0738 253 SLFWgGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLA--LIGL-ALVGLGLSLMFPT---IFSLALd 326
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 386768993 222 -PPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFG--IIWYMFWIW 277
Cdd:COG0738 327 gLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYllILLLALALK 385
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
147-278 |
2.53e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.76 E-value: 2.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 147 WGYLVTQIP-----GGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGH-VVICVRVLQGLFEGVTYPACHGIWRFW 220
Cdd:cd06173 246 YGLLLAAFGvgallGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLwLLLAALFLLGLAGGLFNVPLNTLLQLR 325
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 386768993 221 APPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWL 278
Cdd:cd06173 326 VPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
141-482 |
2.91e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 43.69 E-value: 2.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 141 VDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMhghVVICVRVLQGLFEGVTYPACHGIWRFW 220
Cdd:COG0738 48 LLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP---LLLLALFLLGLGLGLLDVAANPYVAAL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 221 APPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVG--YQAPFYAYGVFGIIwYMFWIWLcfenprkhpaISIPELKYIE 298
Cdd:COG0738 125 GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSlsWHLPYLILAVLLLL-LALLFLR----------SKLPEIEEEE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 299 KSLGESAHPTmpslkttpwREMMRSMPVYAIIVANFCrswnfYLLV-----LFQSSFLKHKFGFKVEEAGFVGSLPHLIM 373
Cdd:COG0738 194 EEAAGSAASL---------KSLLKNPRLLLGGLAIFL-----YVGAegaigDWLPLYLKDVLGLSEATAALGLSLFWGGM 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 374 TTIVPFGGMLADHLRKNGILSTtnvrklfnCGGFGMEGLFFLFVAHSSTATGAMFALtCGVAFSG-----FAISGynvnh 448
Cdd:COG0738 260 TIGRFLGGFLLKRFGPVRLLRL--------SALLAAVGLLLALLAPGPWLALIGLAL-VGLGLSLmfptiFSLAL----- 325
|
330 340 350
....*....|....*....|....*....|....
gi 386768993 449 lDIAPRYASILMGLSNGIGTLAGIIVPYALdGLI 482
Cdd:COG0738 326 -DGLGKRTAAAVSAVLIMGIVGGAIGPPLI-GFL 357
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
199-478 |
6.08e-04 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 42.67 E-value: 6.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 199 RVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLAD--------AVGYQAPFYAYGVFGII 270
Cdd:cd17367 108 RLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHtlgedqmaAWGWRIPFLLGGVLAVV 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 271 wyMFWIwlcfenpRKhpaiSIPE-LKYIEKSLGESAhptmpslKTTPWREMMRSmPVYAIIVANFCR--SWNFYLLVLFQ 347
Cdd:cd17367 188 --VLWL-------RR----GLEEtESFEAIAESNEA-------SAGTLRELRRH-PRELLLVVGLTAggTLAFYTWTTYL 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 348 SSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTnvrklfncGGFGMEGLFFLFVA--HSSTATG 425
Cdd:cd17367 247 QKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFF--------GIGGTLATVPLLSAldHTDSPYT 318
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 386768993 426 AMFALTCGVAFSGFAISGYNVNHLDIAPRYASILmglsngigtlaGIIVPYAL 478
Cdd:cd17367 319 AFALVLVGLVFLSGYTSINAVVKAELFPTHVRAL-----------GVGLPYAL 360
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
142-504 |
7.66e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 7.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 142 DSSFFWGYLVTQIP-GGFIAS--------KFPANKIFGLSIVSSATLHLFVPFAMTLMhghVVICVRVLQGLFeGVTYPA 212
Cdd:cd17330 31 ASGYYVGLLQSSYSlGQFLASplwgrlsdRYGRKPVLLLSLAGSAVSYVLLGLSRNLW---LLFLARFLDGLT-GGNVSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 213 CHGIWRFWAPPMERSR---LATLAFSgsyAGVVVGLPLSGLLADAVGYQAPFYAYGVFGII--WYMFWIwlcfenprkhp 287
Cdd:cd17330 107 AQAYIADITDEEERAKafgIISAAFG---LGFILGPALGGFLSTPYGYALPFLVAAALALLnlVLVLFF----------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 288 aisipelkyiekslgesahptMPSLkttpwremMRSMPVYAIIvanfcrswnFYLLVLFQSSF---LKHKFGFKVEEAGF 364
Cdd:cd17330 173 ---------------------LPPL--------RRLLLVYFLI---------ALAFAGLESVFslfLKDRFGFSPSQIGL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 365 VGSLPHLIMTTI-VPFGGMLADHLrkngilsttNVRKLFnCGGFGMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAISG 443
Cdd:cd17330 215 LLALVGIAGILAqLLLIPRLAKRL---------GERKLL-RLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPA 284
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386768993 444 YN-VNHLDIAPRYASILMGLSNGIGTLAGIIVPyALDGLIQANPTGCWttVFTLAACVHLVG 504
Cdd:cd17330 285 LSaLLSKSVPSKEQGKAQGIIQSLQSLARIIGP-LLAGPLYSFLGPGV--PFLLAAGLLLIA 343
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
294-474 |
1.08e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.77 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 294 LKYIEKSLGESAHPTMPSLKTTPWREMMRsmPVYAIIVANFCRSWNFYLLVLFQSSFLKHKfGFKVEEAGFVGSLpHLIM 373
Cdd:cd17478 167 LRLRPLKKPEAKKAAAKSSARSTLKGVWR--ALLLLLIIVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLLLSL-FLFA 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 374 TTI-VPFGGMLADHL-RKNGILSTTnvrklfncggFGMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAISGynVNHLDI 451
Cdd:cd17478 243 GAIgTLIGGPLSDRFgRRRVIIASL----------LLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTV--VLAQEL 310
|
170 180
....*....|....*....|....*..
gi 386768993 452 APRYA----SILMGLSNGIGTLAGIIV 474
Cdd:cd17478 311 LPGNVglasGLMMGLSFGLGGIGAPVL 337
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
225-508 |
1.55e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 225 ERSRLATLAFSGSYAGVVVGLPLSGLLAdAVGYQAPFYAYGVFGIIwyMFWIWLCFENPRKHPAISIPELKyiekslges 304
Cdd:cd17474 120 ERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPV--AFLAILFLLPEPKEKAKSSSATK--------- 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 305 aHPTMPSLKTTPWremmrsmpVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGmla 384
Cdd:cd17474 188 -LRDLKKALRGRG--------LLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVG--- 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 385 dHLRKNGILSttnvRKLFNCGGFGMEGLFFLFVAHSSTATGAMFALTCGVAfSGFAISGYNVNHLDIAPRYA-SILMGLS 463
Cdd:cd17474 256 -RLLKKRFGA----RRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLG-LGLNLPLLTTLVTELAPEEErGTASSLY 329
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 386768993 464 NGIGTLAGIIVPYALDGLIQANPtgcWTTVFTLAACVHLVGCTFY 508
Cdd:cd17474 330 NFVRFLGQAVGPLLFGLLLEIFG---LSAPFLVGAAIALAAAVLL 371
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
199-472 |
1.84e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.19 E-value: 1.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 199 RVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGII---WYMFW 275
Cdd:TIGR00895 112 RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLlllLLMRF 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 276 -----IWLCFENPRKHPAIsipeLKYIEKSLGESAHPTMPSLKTTP--WR---------EMMRSMPVyaIIVANFCRSWN 339
Cdd:TIGR00895 192 lpesiDFLVSKRPETVRRI----VNAIAPQMQAEAQSALPEQKSTQgtKRsvfkalfqgKTARITVL--LWLLYFMLLVG 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 340 FYLLVLFqSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGIlsttnvrklfncGGFGMEGLFFLFVAh 419
Cdd:TIGR00895 266 VYFLTNW-LPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVT------------ALLLLLGAVFAVLV- 331
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 386768993 420 SSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPRYASILMGlsNGIGTLAGI 472
Cdd:TIGR00895 332 GSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRA--TGVGWAIGI 382
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
145-508 |
9.15e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.75 E-value: 9.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 145 FFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGHV--VICVRVLQGLFEGVTYPACHGIWRFWAP 222
Cdd:cd06173 43 FFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLwlLLVLAFLLGIASAFFGPARQALLPELVP 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 223 PMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGV---FGIIWYMFWiwlcfenPRKHPAISIPELKYIEK 299
Cdd:cd06173 123 KEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALsflLSALLLLFI-------RRPPPAAPGESSSLLLR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 300 SLGESahptmpslkttpWREMMRSMPVYAIIVANFcrsWNFYLLVLFQS---SFLKHKFGFKVEEAGFvgslphliMTTI 376
Cdd:cd06173 196 DLREG------------LRYLRRSPLLRLLLLALA---LFALLGGALTVllpLLAKEVLGGGAAGYGL--------LLAA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768993 377 VPFGGMLADHLrkNGILSTTNVRKLFNCGGFGMEGLFFLFVAHSSTATGAMFALTC-GVAFSGFAISGYNVNHLDIAPRY 455
Cdd:cd06173 253 FGVGALLGALL--LGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLlGLAGGLFNVPLNTLLQLRVPDEL 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 386768993 456 ASILMGLSNGIGTLAgIIVPYALDGLIqANPTGCWTTVFTLAACVHLVGCTFY 508
Cdd:cd06173 331 RGRVFSVYNALNSGA-MPLGALLAGLL-ADALGLSAVFLLAGALLLLAALLLL 381
|
|
| |
