NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|304434531|ref|NP_001182122|]
View 

nuclear autoantigenic sperm protein isoform 4 [Homo sapiens]

Protein Classification

TPR_12 and SHNi-TPR domain-containing protein( domain architecture ID 12139966)

TPR_12 and SHNi-TPR domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SHNi-TPR pfam10516
SHNi-TPR; SHNi-TPR family members contain a reiterated sequence motif that is an interrupted ...
 478-515 5.34e-09

SHNi-TPR; SHNi-TPR family members contain a reiterated sequence motif that is an interrupted form of TPR repeat.


:

Pssm-ID: 402238 [Multi-domain]  Cd Length: 38  Bit Score: 52.07  E-value: 5.34e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 304434531  478 AQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAH 515
Cdd:pfam10516   1 ADVYDLLGEISLENENFPQAVTDLRKALELREELLPPE 38
TPR_12 pfam13424
Tetratricopeptide repeat;
476-552 3.39e-08

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 50.85  E-value: 3.39e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 304434531  476 YAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIEN 552
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 152-452 3.81e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.83  E-value: 3.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   152 GAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQ--EECREKGGQEKQGEVivsieekPKEVSEEQPVVTlEKQGTAV 229
Cdd:TIGR00927  633 GDVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEqeGETETKGENESEGEI-------PAERKGEQEGEG-EIEAKEA 704

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   230 EVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEvppAEESPEVTTEAAEASAVEAGSEVSEKPGQEApv 309
Cdd:TIGR00927  705 DHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGE---AEGKHEVETEGDRKETEHEGETEAEGKEDED-- 779

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   310 lpkdgavngpsvvgdqtpiEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPE 389
Cdd:TIGR00927  780 -------------------EGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAE 840

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 304434531   390 DKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMpndsvlENKSLQENEEEEIGNLE 452
Cdd:TIGR00927  841 NQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEE------EEEEEEEEENEEPLSLE 897
 
Name Accession Description Interval E-value
SHNi-TPR pfam10516
SHNi-TPR; SHNi-TPR family members contain a reiterated sequence motif that is an interrupted ...
 478-515 5.34e-09

SHNi-TPR; SHNi-TPR family members contain a reiterated sequence motif that is an interrupted form of TPR repeat.


Pssm-ID: 402238 [Multi-domain]  Cd Length: 38  Bit Score: 52.07  E-value: 5.34e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 304434531  478 AQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAH 515
Cdd:pfam10516   1 ADVYDLLGEISLENENFPQAVTDLRKALELREELLPPE 38
TPR_12 pfam13424
Tetratricopeptide repeat;
476-552 3.39e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 50.85  E-value: 3.39e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 304434531  476 YAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIEN 552
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
478-580 7.07e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 50.68  E-value: 7.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531 478 AQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRllaethyqLGLAYGYNSQYDEAVAQFSKSIEVIEN-RMAV 556
Cdd:COG4785  107 AEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLN--------RGIALYYLGRYELAIADLEKALELDPNdPERA 178

                         90       100
                 ....*....|....*....|....
gi 304434531 557 LNEQVKEAEgssAEYKKEIEELKE 580
Cdd:COG4785  179 LWLYLAERK---LDPEKALALLLE 199
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 478-548 7.78e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.22  E-value: 7.78e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 304434531 478 AQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAhdrllaetHYQLGLAYGYNSQYDEAVAQFSKSIE 548
Cdd:COG3914  146 AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEA--------LNNLGNALQDLGRLEEAIAAYRRALE 208
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 152-452 3.81e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.83  E-value: 3.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   152 GAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQ--EECREKGGQEKQGEVivsieekPKEVSEEQPVVTlEKQGTAV 229
Cdd:TIGR00927  633 GDVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEqeGETETKGENESEGEI-------PAERKGEQEGEG-EIEAKEA 704

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   230 EVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEvppAEESPEVTTEAAEASAVEAGSEVSEKPGQEApv 309
Cdd:TIGR00927  705 DHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGE---AEGKHEVETEGDRKETEHEGETEAEGKEDED-- 779

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   310 lpkdgavngpsvvgdqtpiEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPE 389
Cdd:TIGR00927  780 -------------------EGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAE 840

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 304434531   390 DKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMpndsvlENKSLQENEEEEIGNLE 452
Cdd:TIGR00927  841 NQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEE------EEEEEEEEENEEPLSLE 897
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 520-552 1.86e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 1.86e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 304434531   520 AETHYQLGLAYGYNSQYDEAVAQFSKSIEVIEN 552
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
PRK02603 PRK02603
photosystem I assembly protein Ycf3; Provisional
 460-558 3.26e-03

photosystem I assembly protein Ycf3; Provisional


Pssm-ID: 179448 [Multi-domain]  Cd Length: 172  Bit Score: 39.27  E-value: 3.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531 460 LAKIIFK----RQETKEAQLY-----AAQAHlklGEvsvesenYVQAVEEFQSCLNLQEqylEAHDRllAETHYQLGLAY 530
Cdd:PRK02603  18 MADLILKilpiNKKAKEAFVYyrdgmSAQAD---GE-------YAEALENYEEALKLEE---DPNDR--SYILYNMGIIY 82

                         90       100
                 ....*....|....*....|....*...
gi 304434531 531 GYNSQYDEAVAQFSKSIEVIENRMAVLN 558
Cdd:PRK02603  83 ASNGEHDKALEYYHQALELNPKQPSALN 110
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 312-612 5.14e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.43  E-value: 5.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   312 KDGAVNGPSVVGDQTPIEPQTSIERLTETKDgsGLEEKVRAKlvpSQEETKLSVEESEAAGDGVDT-KVAQGATEKSPED 390
Cdd:TIGR02168  657 PGGVITGGSAKTNSSILERRREIEELEEKIE--ELEEKIAEL---EKALAELRKELEELEEELEQLrKELEELSRQISAL 731

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   391 KVQIAANEETQEREEQMKEGEETEGSEEDDK--ENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWdmldlakiifkrq 468
Cdd:TIGR02168  732 RKDLARLEAEVEQLEERIAQLSKELTELEAEieELEERLEEAEEELAEAEAEIEELEAQIEQLKEEL------------- 798

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   469 ETKEAQLYAAQAhlKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIE 548
Cdd:TIGR02168  799 KALREALDELRA--ELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELE 876

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 304434531   549 VIENRMAVLNEQVKEAEgssAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVE 612
Cdd:TIGR02168  877 ALLNERASLEEALALLR---SELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVR 937
PTZ00121 PTZ00121
MAEBL; Provisional
 77-452 6.07e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 6.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   77 EELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREdmdISKSAEEPQEKvdltlDWLTETSEEAKGGA--- 153
Cdd:PTZ00121 1339 EEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADA---AKKKAEEKKKA-----DEAKKKAEEDKKKAdel 1410

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531  154 --APEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEV 231
Cdd:PTZ00121 1411 kkAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKK 1490

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531  232 EAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEvtTEAAEASAVEAGSEVSEKPGQEAPVLP 311
Cdd:PTZ00121 1491 KAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKK--AEEKKKADELKKAEELKKAEEKKKAEE 1568

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531  312 KDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEE----------SEAAGDGVDTKVAQ 381
Cdd:PTZ00121 1569 AKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEElkkaeeekkkVEQLKKKEAEEKKK 1648

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 304434531  382 GATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLE 452
Cdd:PTZ00121 1649 AEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAE 1719
 
Name Accession Description Interval E-value
SHNi-TPR pfam10516
SHNi-TPR; SHNi-TPR family members contain a reiterated sequence motif that is an interrupted ...
 478-515 5.34e-09

SHNi-TPR; SHNi-TPR family members contain a reiterated sequence motif that is an interrupted form of TPR repeat.


Pssm-ID: 402238 [Multi-domain]  Cd Length: 38  Bit Score: 52.07  E-value: 5.34e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 304434531  478 AQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAH 515
Cdd:pfam10516   1 ADVYDLLGEISLENENFPQAVTDLRKALELREELLPPE 38
TPR_12 pfam13424
Tetratricopeptide repeat;
476-552 3.39e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 50.85  E-value: 3.39e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 304434531  476 YAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIEN 552
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
478-580 7.07e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 50.68  E-value: 7.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531 478 AQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRllaethyqLGLAYGYNSQYDEAVAQFSKSIEVIEN-RMAV 556
Cdd:COG4785  107 AEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLN--------RGIALYYLGRYELAIADLEKALELDPNdPERA 178

                         90       100
                 ....*....|....*....|....
gi 304434531 557 LNEQVKEAEgssAEYKKEIEELKE 580
Cdd:COG4785  179 LWLYLAERK---LDPEKALALLLE 199
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
435-548 3.77e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 48.76  E-value: 3.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531 435 LENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYlea 514
Cdd:COG4785   30 LFAAVLALAIALADLALALAAAALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDL--- 106

                         90       100       110
                 ....*....|....*....|....*....|....
gi 304434531 515 hdrllAETHYQLGLAYGYNSQYDEAVAQFSKSIE 548
Cdd:COG4785  107 -----AEAYNNRGLAYLLLGDYDAALEDFDRALE 135
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 478-548 7.78e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.22  E-value: 7.78e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 304434531 478 AQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAhdrllaetHYQLGLAYGYNSQYDEAVAQFSKSIE 548
Cdd:COG3914  146 AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEA--------LNNLGNALQDLGRLEEAIAAYRRALE 208
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 449-582 5.60e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.49  E-value: 5.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531 449 GNLELAWDMLDLAKIIFkrQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHdRLLAETHYQLGl 528
Cdd:COG2956   49 GNLYRRRGEYDRAIRIH--QKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEAL-RLLAEIYEQEG- 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 304434531 529 aygynsQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSaEYKKEIEELKELL 582
Cdd:COG2956  125 ------DWEKAIEVLERLLKLGPENAHAYCELAELYLEQG-DYDEAIEALEKAL 171
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 452-584 5.63e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.64  E-value: 5.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531 452 ELAWDMLDLAKIIFKRQETKEAQLYA----------AQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAhdrllae 521
Cdd:COG4783    2 ACAEALYALAQALLLAGDYDEAEALLekaleldpdnPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEA------- 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 304434531 522 tHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNE--QVKEAEGSSAEYKKEIEELKELLPE 584
Cdd:COG4783   75 -RLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRlaRAYRALGRPDEAIAALEKALELDPD 138
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
478-548 6.73e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.00  E-value: 6.73e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 304434531 478 AQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYleahdrllAETHYQLGLAYGYNSQYDEAVAQFSKSIE 548
Cdd:COG0457    8 AEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDD--------AEALYNLGLAYLRLGRYEEALADYEQALE 70
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 437-582 2.34e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.56  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531 437 NKSLQENEEEEIGNLELAWD-----MLDLAKIIFKRQETKEAqlYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQY 511
Cdd:COG2956   66 QKLLERDPDRAEALLELAQDylkagLLDRAEELLEKLLELDP--DDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN 143

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 304434531 512 leahdrllAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNE--QVKEAEGssaEYKKEIEELKELL 582
Cdd:COG2956  144 --------AHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLlaELYLEQG---DYEEAIAALERAL 205
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
450-597 3.28e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.07  E-value: 3.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531 450 NLELAWDMLDLAKIIFKRQETKEA-QLYA---------AQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYleahdrll 519
Cdd:COG0457   72 DPDDAEALNNLGLALQALGRYEEAlEDYDkaleldpddAEALYNLGLALLELGRYDEAIEAYERALELDPDD-------- 143

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 304434531 520 AETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQR 597
Cdd:COG0457  144 ADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAE 221
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 152-452 3.81e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.83  E-value: 3.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   152 GAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQ--EECREKGGQEKQGEVivsieekPKEVSEEQPVVTlEKQGTAV 229
Cdd:TIGR00927  633 GDVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEqeGETETKGENESEGEI-------PAERKGEQEGEG-EIEAKEA 704

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   230 EVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEvppAEESPEVTTEAAEASAVEAGSEVSEKPGQEApv 309
Cdd:TIGR00927  705 DHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGE---AEGKHEVETEGDRKETEHEGETEAEGKEDED-- 779

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   310 lpkdgavngpsvvgdqtpiEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPE 389
Cdd:TIGR00927  780 -------------------EGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAE 840

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 304434531   390 DKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMpndsvlENKSLQENEEEEIGNLE 452
Cdd:TIGR00927  841 NQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEE------EEEEEEEEENEEPLSLE 897
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 478-582 4.34e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 4.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531 478 AQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHdRLLAETHYQLGLaygynsqYDEAVAQFSKSIEVIENRMAVL 557
Cdd:COG2956   42 VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEAL-LELAQDYLKAGL-------LDRAEELLEKLLELDPDDAEAL 113

                         90       100
                 ....*....|....*....|....*..
gi 304434531 558 NEQVK--EAEGssaEYKKEIEELKELL 582
Cdd:COG2956  114 RLLAEiyEQEG---DWEKAIEVLERLL 137
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 427-558 6.15e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.06  E-value: 6.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531 427 EEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEA-QLYA---------AQAHLKLGEVSVESENYVQ 496
Cdd:COG3914   51 LAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEAlALYRralalnpdnAEALFNLGNLLLALGRLEE 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 304434531 497 AVEEFQSCLNLQEQYLEAHdrllaethYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLN 558
Cdd:COG3914  131 ALAALRRALALNPDFAEAY--------LNLGEALRRLGRLEEAIAALRRALELDPDNAEALN 184
TPR_1 pfam00515
Tetratricopeptide repeat;
520-552 1.15e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.02  E-value: 1.15e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 304434531  520 AETHYQLGLAYGYNSQYDEAVAQFSKSIEVIEN 552
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 454-564 1.62e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.22  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531 454 AWDMLdlAKIIFKRQETKEA-QLYA---------AQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAhdrllaetH 523
Cdd:COG4235   19 GWLLL--GRAYLRLGRYDEAlAAYEkalrldpdnADALLDLAEALLAAGDTEEAEELLERALALDPDNPEA--------L 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 304434531 524 YQLGLAYGYNSQYDEAVAQFSKSIEVIEN--RMAVLNEQVKEA 564
Cdd:COG4235   89 YLLGLAAFQQGDYAEAIAAWQKLLALLPAdaPARLLEASIAEA 131
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 520-552 1.86e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 1.86e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 304434531   520 AETHYQLGLAYGYNSQYDEAVAQFSKSIEVIEN 552
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 460-580 2.25e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.48  E-value: 2.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531 460 LAKIIFKRQETKEAQLYAAQA----------HLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRlLAETHYQLGla 529
Cdd:COG2956  150 LAELYLEQGDYDEAIEALEKAlkldpdcaraLLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPR-LAELYEKLG-- 226

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 304434531 530 ygynsQYDEAVAQFSKSIEVIENRMAVLN--EQVKEAEGSSAEYKKEIEELKE 580
Cdd:COG2956  227 -----DPEEALELLRKALELDPSDDLLLAlaDLLERKEGLEAALALLERQLRR 274
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 476-545 2.36e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 38.43  E-value: 2.36e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531 476 YAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQyleahDRLLAETHYQLGLAYGYNSQYDEAVAQFSK 545
Cdd:COG1729   28 LAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPD-----SPKAPDALLKLGLSYLELGDYDKARATLEE 92
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 434-576 3.05e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.79  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531 434 VLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYle 513
Cdd:COG5010   10 LPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNN-- 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 304434531 514 ahdrllAETHYQLGLAYGYNSQYDEAVAQFSKSIE------VIENRMAVLNEQVKEAEGSSAEYKKEIE 576
Cdd:COG5010   88 ------PELYYNLALLYSRSGDKDEAKEYYEKALAlspdnpNAYSNLAALLLSLGQDDEAKAALQRALG 150
PRK02603 PRK02603
photosystem I assembly protein Ycf3; Provisional
 460-558 3.26e-03

photosystem I assembly protein Ycf3; Provisional


Pssm-ID: 179448 [Multi-domain]  Cd Length: 172  Bit Score: 39.27  E-value: 3.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531 460 LAKIIFK----RQETKEAQLY-----AAQAHlklGEvsvesenYVQAVEEFQSCLNLQEqylEAHDRllAETHYQLGLAY 530
Cdd:PRK02603  18 MADLILKilpiNKKAKEAFVYyrdgmSAQAD---GE-------YAEALENYEEALKLEE---DPNDR--SYILYNMGIIY 82

                         90       100
                 ....*....|....*....|....*...
gi 304434531 531 GYNSQYDEAVAQFSKSIEVIENRMAVLN 558
Cdd:PRK02603  83 ASNGEHDKALEYYHQALELNPKQPSALN 110
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 312-612 5.14e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.43  E-value: 5.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   312 KDGAVNGPSVVGDQTPIEPQTSIERLTETKDgsGLEEKVRAKlvpSQEETKLSVEESEAAGDGVDT-KVAQGATEKSPED 390
Cdd:TIGR02168  657 PGGVITGGSAKTNSSILERRREIEELEEKIE--ELEEKIAEL---EKALAELRKELEELEEELEQLrKELEELSRQISAL 731

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   391 KVQIAANEETQEREEQMKEGEETEGSEEDDK--ENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWdmldlakiifkrq 468
Cdd:TIGR02168  732 RKDLARLEAEVEQLEERIAQLSKELTELEAEieELEERLEEAEEELAEAEAEIEELEAQIEQLKEEL------------- 798

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   469 ETKEAQLYAAQAhlKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIE 548
Cdd:TIGR02168  799 KALREALDELRA--ELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELE 876

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 304434531   549 VIENRMAVLNEQVKEAEgssAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVE 612
Cdd:TIGR02168  877 ALLNERASLEEALALLR---SELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVR 937
PTZ00121 PTZ00121
MAEBL; Provisional
 77-452 6.07e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 6.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531   77 EELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREdmdISKSAEEPQEKvdltlDWLTETSEEAKGGA--- 153
Cdd:PTZ00121 1339 EEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADA---AKKKAEEKKKA-----DEAKKKAEEDKKKAdel 1410

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531  154 --APEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEV 231
Cdd:PTZ00121 1411 kkAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKK 1490

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531  232 EAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEvtTEAAEASAVEAGSEVSEKPGQEAPVLP 311
Cdd:PTZ00121 1491 KAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKK--AEEKKKADELKKAEELKKAEEKKKAEE 1568

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304434531  312 KDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEE----------SEAAGDGVDTKVAQ 381
Cdd:PTZ00121 1569 AKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEElkkaeeekkkVEQLKKKEAEEKKK 1648

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 304434531  382 GATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLE 452
Cdd:PTZ00121 1649 AEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAE 1719
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH