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Conserved domains on  [gi|73760403|ref|NP_001027453|]
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Krueppel-like factor 10 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 23-358 4.64e-84

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


:

Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 258.76  E-value: 4.64e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403  23 AEKSDFEAVEALMSMSCSWKSDFKKYVENRPVTPVSDLSEEEnLLPGTPDFHTIPAFCLTPPYSPSDFEPSQVSNLMAPA 102
Cdd:cd21572   1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDD-DLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAATLH 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403 103 PSTVHfkslsdtakphiaaPFKEEEKSPVSAPKLPKAQATSVIRHTADAQLCNHQTCPmkaasilnyqnnsfrrrthlnv 182
Cdd:cd21572  80 PPAAQ--------------PPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP---------------------- 123

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403 183 eaarknipcaavspnrskcerntvadvdekasaalydfsvpssetvicrsqpapvspqQKSVLVSPPAVSAGGVPPMPVI 262
Cdd:cd21572 124 ----------------------------------------------------------SSPSVVPSVPAGVAGVSPVPVY 145

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403 263 CQMVPLPANNP-VVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQS--SKPPVVSPNGTRLSPIAPAPGF 339
Cdd:cd21572 146 CQILPVSSSSTtVVAAQAPLPQPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTlyVQPTLVTPGGTKLAAIAPAPGH 225

                       330       340
                ....*....|....*....|
gi 73760403 340 SPSAA-KVTPQIDSSRIRSH 358
Cdd:cd21572 226 TPSEQrKSPPQPEVSRVRSH 245
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 418-440 1.89e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 1.89e-04
                          10        20
                  ....*....|....*....|...
gi 73760403   418 FACPMCDRRFMRSDHLTKHARRH 440
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
363-413 1.67e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.67e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 73760403 363 PGCGKTYFKSSHLKAHTRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHT 413
Cdd:COG5048  37 PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
 
Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 23-358 4.64e-84

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 258.76  E-value: 4.64e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403  23 AEKSDFEAVEALMSMSCSWKSDFKKYVENRPVTPVSDLSEEEnLLPGTPDFHTIPAFCLTPPYSPSDFEPSQVSNLMAPA 102
Cdd:cd21572   1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDD-DLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAATLH 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403 103 PSTVHfkslsdtakphiaaPFKEEEKSPVSAPKLPKAQATSVIRHTADAQLCNHQTCPmkaasilnyqnnsfrrrthlnv 182
Cdd:cd21572  80 PPAAQ--------------PPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP---------------------- 123

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403 183 eaarknipcaavspnrskcerntvadvdekasaalydfsvpssetvicrsqpapvspqQKSVLVSPPAVSAGGVPPMPVI 262
Cdd:cd21572 124 ----------------------------------------------------------SSPSVVPSVPAGVAGVSPVPVY 145

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403 263 CQMVPLPANNP-VVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQS--SKPPVVSPNGTRLSPIAPAPGF 339
Cdd:cd21572 146 CQILPVSSSSTtVVAAQAPLPQPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTlyVQPTLVTPGGTKLAAIAPAPGH 225

                       330       340
                ....*....|....*....|
gi 73760403 340 SPSAA-KVTPQIDSSRIRSH 358
Cdd:cd21572 226 TPSEQrKSPPQPEVSRVRSH 245
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 124-353 9.23e-05

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 44.81  E-value: 9.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403  124 KEEEKSPVSAPKLPKAQATSVIRHTADAQLCNHQTCPMKA-ASILNYQNNSFRRRTHLnveaarknipcaavspnRSKCE 202
Cdd:PRK13729  37 DMSGNGEAVAEQEPVPDMTGVVDTTFDDKVRQHATTEMQVtAAQMQKQYEEIRRELDV-----------------LNKQR 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403  203 RNTVADVDEKAS--AALYDfsvpssetvicrsqpapvspQQKSVLVSPPAVSAGGVPPMPVICQMvplPANNPVVTTVVP 280
Cdd:PRK13729 100 GDDQRRIEKLGQdnAALAE--------------------QVKALGANPVTATGEPVPQMPASPPG---PEGEPQPGNTPV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403  281 STPPSQPPAVCPPVVF---MGTQVPKGAVMFVVPQPVVQSSKPPVVSP--NGTRLsPIAPAPGFSPSA--------AKVT 347
Cdd:PRK13729 157 SFPPQGSVAVPPPTAFypgNGVTPPPQVTYQSVPVPNRIQRKTFTYNEgkKGPSL-PYIPSGSFAKAMliegadanASVT 235


                 ....*.
gi 73760403  348 PQIDSS 353
Cdd:PRK13729 236 GNESTV 241
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 418-440 1.89e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 1.89e-04
                          10        20
                  ....*....|....*....|...
gi 73760403   418 FACPMCDRRFMRSDHLTKHARRH 440
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
363-413 1.67e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.67e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 73760403 363 PGCGKTYFKSSHLKAHTRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHT 413
Cdd:COG5048  37 PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 82-347 2.95e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 39.94  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403    82 TPPYSPSDFEPSQVSNLMAPAPSTVhfKSLSDTAKPHIAAPFKEEEKSPVSApkLPKAQATSVIRHTADAQLCNHQTCPM 161
Cdd:pfam17823  99 EPATREGAADGAASRALAAAASSSP--SSAAQSLPAAIAALPSEAFSAPRAA--ACRANASAAPRAAIAAASAPHAASPA 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403   162 KAASILNYQNNSFRRRTHLNVEAARKNIPcAAVSPNRSKCErNTVADVDEKASAALYdfSVPSSetvicrsQPAPVSPQQ 241
Cdd:pfam17823 175 PRTAASSTTAASSTTAASSAPTTAASSAP-ATLTPARGIST-AATATGHPAAGTALA--AVGNS-------SPAAGTVTA 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403   242 KSVLVSPPAVSAGGVPPMPVICQMVPLPANNPVVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQSSKPP 321
Cdd:pfam17823 244 AVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTDQPVHNTAGEP 323

                         250       260
                  ....*....|....*....|....*.
gi 73760403   322 VVSPNGTRLSPIAPAPGFSPSAAKVT 347
Cdd:pfam17823 324 TPSPSNTTLEPNTPKSVASTNLAVVT 349
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 358-382 4.81e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.81e-03
                          10        20
                  ....*....|....*....|....*
gi 73760403   358 HICSHpgCGKTYFKSSHLKAHTRTH 382
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 23-358 4.64e-84

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 258.76  E-value: 4.64e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403  23 AEKSDFEAVEALMSMSCSWKSDFKKYVENRPVTPVSDLSEEEnLLPGTPDFHTIPAFCLTPPYSPSDFEPSQVSNLMAPA 102
Cdd:cd21572   1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDD-DLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAATLH 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403 103 PSTVHfkslsdtakphiaaPFKEEEKSPVSAPKLPKAQATSVIRHTADAQLCNHQTCPmkaasilnyqnnsfrrrthlnv 182
Cdd:cd21572  80 PPAAQ--------------PPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP---------------------- 123

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403 183 eaarknipcaavspnrskcerntvadvdekasaalydfsvpssetvicrsqpapvspqQKSVLVSPPAVSAGGVPPMPVI 262
Cdd:cd21572 124 ----------------------------------------------------------SSPSVVPSVPAGVAGVSPVPVY 145

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403 263 CQMVPLPANNP-VVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQS--SKPPVVSPNGTRLSPIAPAPGF 339
Cdd:cd21572 146 CQILPVSSSSTtVVAAQAPLPQPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTlyVQPTLVTPGGTKLAAIAPAPGH 225

                       330       340
                ....*....|....*....|
gi 73760403 340 SPSAA-KVTPQIDSSRIRSH 358
Cdd:cd21572 226 TPSEQrKSPPQPEVSRVRSH 245
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 24-358 7.14e-74

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 232.13  E-value: 7.14e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403  24 EKSDFEAVEALMSMSCSWKSDFKKYVENRPVTPVSDLSEEENLLPGTPDFHTIPAFCLTPPYSPSDFEPSQVSNLMAPAP 103
Cdd:cd21974   1 EQGDLEAVEALVSMSSWWKRRQKRLRKPRPLTPSSDSSDEDDAPESPKDFHSLSSLCMTPPYSPPFFEASHSPSVASLHP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403 104 STvhfkslsdtakPHIAAPFKEEEKSPVSAPKLPKAQATSVIRHTADAqlcnhqtcpmkaasilnyqnnsfrrrthlnve 183
Cdd:cd21974  81 PS-----------AASSQPPPEPESSEPPAASPQRAQATSVIRHTADP-------------------------------- 117

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403 184 aarknipcaavspnrskcerntvadvdekasaalydfsvpssetvicrsqpapvspqqksvlvsppavsaGGVPPMPVIC 263
Cdd:cd21974 118 ----------------------------------------------------------------------VPVSPPPVLC 127

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403 264 QMVPLPANNPVV-----TTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQS--SKPPVVSPNGTRLSPIAPA 336
Cdd:cd21974 128 QMLPVSSSSGVIvaflkAPQQPSPQPQKPALPQPQVVLVGGQVPQGPVMLVVPQPAVPQpyVQPTVVTPGGTKLLPIAPA 207

                       330       340
                ....*....|....*....|..
gi 73760403 337 PGFSPSAAKVTPQIDSSRIRSH 358
Cdd:cd21974 208 PGFIPSGQSSAPQPDFSRRRNH 229
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 24-356 1.80e-26

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 106.62  E-value: 1.80e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403  24 EKSDFEAVEALMSMScSW--KSDFKKYVENRPVTPVSDLSEEENLLPGTP----DFHTIPAFCLTPPYSPSDFEPSqvsn 97
Cdd:cd21584   2 EQNDLEAVEALVCMS-SWgqRSQKGDLLKIRPLTPASDSCDSLTLHPAAPelpkDFHSLSSLCMTPPHSPSFAEPS---- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403  98 lmapapstvhfkslsdtakphiaapfkeeeksPVSAPKLPKAQATSVIRHTADAQLCnhqtcpmkaasilnyqnnsfrrr 177
Cdd:cd21584  77 --------------------------------TTAPPPPCRAMATSVIRHTADSSPP----------------------- 101

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403 178 thlnveaarknipcaavspnrskcerntvadvdekasaalydFSVPSSeTVICRSQPAPVSPQQKSVLVSPPAVSAGGVP 257
Cdd:cd21584 102 ------------------------------------------VPVPSP-PVLCQMIPVSGQSGMISAFLQPPALSAGTVK 138

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403 258 PMPvicqmvplpannpvvttvvPSTPPSQPPavcppvVFMGTQVPKGAVMFVVPQPVV---QSSKPPVVSPNGTRLSPIA 334
Cdd:cd21584 139 PIL-------------------PQTAPASQP------LLVGSPVPQGTVMLVLPQASVpqpPQCPQTVMTLGNTKLLPLA 193

                       330       340
                ....*....|....*....|..
gi 73760403 335 PAPGFSPSAAKVTPQIDSSRIR 356
Cdd:cd21584 194 PAPVFIPSGQSCAPQVDFSRRR 215
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 124-353 9.23e-05

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 44.81  E-value: 9.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403  124 KEEEKSPVSAPKLPKAQATSVIRHTADAQLCNHQTCPMKA-ASILNYQNNSFRRRTHLnveaarknipcaavspnRSKCE 202
Cdd:PRK13729  37 DMSGNGEAVAEQEPVPDMTGVVDTTFDDKVRQHATTEMQVtAAQMQKQYEEIRRELDV-----------------LNKQR 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403  203 RNTVADVDEKAS--AALYDfsvpssetvicrsqpapvspQQKSVLVSPPAVSAGGVPPMPVICQMvplPANNPVVTTVVP 280
Cdd:PRK13729 100 GDDQRRIEKLGQdnAALAE--------------------QVKALGANPVTATGEPVPQMPASPPG---PEGEPQPGNTPV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403  281 STPPSQPPAVCPPVVF---MGTQVPKGAVMFVVPQPVVQSSKPPVVSP--NGTRLsPIAPAPGFSPSA--------AKVT 347
Cdd:PRK13729 157 SFPPQGSVAVPPPTAFypgNGVTPPPQVTYQSVPVPNRIQRKTFTYNEgkKGPSL-PYIPSGSFAKAMliegadanASVT 235


                 ....*.
gi 73760403  348 PQIDSS 353
Cdd:PRK13729 236 GNESTV 241
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 418-440 1.89e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 1.89e-04
                          10        20
                  ....*....|....*....|...
gi 73760403   418 FACPMCDRRFMRSDHLTKHARRH 440
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 235-348 9.36e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 9.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403  235 APVSPQQKSVLVSPPAVSAGGVPPMPVICQMVPLPANNPVVttvVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPV 314
Cdd:PRK14951 380 TPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAA---APPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAA 456

                         90       100       110
                 ....*....|....*....|....*....|....
gi 73760403  315 VQSSKPPVVSPNGTRLSPIAPAPGFSPSAAKVTP 348
Cdd:PRK14951 457 PETVAIPVRVAPEPAVASAAPAPAAAPAAARLTP 490
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
363-413 1.67e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.67e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 73760403 363 PGCGKTYFKSSHLKAHTRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHT 413
Cdd:COG5048  37 PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 82-347 2.95e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 39.94  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403    82 TPPYSPSDFEPSQVSNLMAPAPSTVhfKSLSDTAKPHIAAPFKEEEKSPVSApkLPKAQATSVIRHTADAQLCNHQTCPM 161
Cdd:pfam17823  99 EPATREGAADGAASRALAAAASSSP--SSAAQSLPAAIAALPSEAFSAPRAA--ACRANASAAPRAAIAAASAPHAASPA 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403   162 KAASILNYQNNSFRRRTHLNVEAARKNIPcAAVSPNRSKCErNTVADVDEKASAALYdfSVPSSetvicrsQPAPVSPQQ 241
Cdd:pfam17823 175 PRTAASSTTAASSTTAASSAPTTAASSAP-ATLTPARGIST-AATATGHPAAGTALA--AVGNS-------SPAAGTVTA 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403   242 KSVLVSPPAVSAGGVPPMPVICQMVPLPANNPVVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQSSKPP 321
Cdd:pfam17823 244 AVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTDQPVHNTAGEP 323

                         250       260
                  ....*....|....*....|....*.
gi 73760403   322 VVSPNGTRLSPIAPAPGFSPSAAKVT 347
Cdd:pfam17823 324 TPSPSNTTLEPNTPKSVASTNLAVVT 349
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 232-356 3.37e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.08  E-value: 3.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403  232 SQPAPVSPQQKSVLVSPPAVSAGGVPPMPVIcqmVPLPANNPVVTTVVPSTPP--SQPPAVCPPVvfmgtQVPKGAVMFV 309
Cdd:PRK14951 369 AAEAAAPAEKKTPARPEAAAPAAAPVAQAAA---APAPAAAPAAAASAPAAPPaaAPPAPVAAPA-----AAAPAAAPAA 440

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 73760403  310 VPQPVVQSSKPPVVSPNGTRLSP--IAPAPGFSPSAAKVTPQIDSSRIR 356
Cdd:PRK14951 441 APAAVALAPAPPAQAAPETVAIPvrVAPEPAVASAAPAPAAAPAAARLT 489
PHA03247 PHA03247
large tegument protein UL36; Provisional
 176-348 4.77e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 4.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403   176 RRTHLNVEAARKNIPCAAVSPN---RSKCERNTVADVDEKASAALYDFSVPSSETVICRSQPAPVSPQqkSVLVSPPAVS 252
Cdd:PHA03247 2659 GRVSRPRRARRLGRAAQASSPPqrpRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPA--AARQASPALP 2736

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403   253 AGGVPPMPVICQMVPL----PANNPVVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQSSKPPVVSPNGT 328
Cdd:PHA03247 2737 AAPAPPAVPAGPATPGgparPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA 2816

                         170       180
                  ....*....|....*....|...
gi 73760403   329 RLSPIA-PAPGFSP--SAAKVTP 348
Cdd:PHA03247 2817 ALPPAAsPAGPLPPptSAQPTAP 2839
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 358-382 4.81e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.81e-03
                          10        20
                  ....*....|....*....|....*
gi 73760403   358 HICSHpgCGKTYFKSSHLKAHTRTH 382
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 51-342 4.81e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 4.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403    51 NRPVTPVSDLSEEENLLPGT---PDFHTIPAfcltPPYSPSD--FEPSQVSNLMAPAPSTVHFKSLSDTAKPHIAAPFKE 125
Cdd:PHA03247 2596 ARPRAPVDDRGDPRGPAPPSplpPDTHAPDP----PPPSPSPaaNEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLG 2671

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403   126 EEKSPVSAPKLPKAQAT--SVIRHTADAQLCNHQTCPMKAASILnyqnnSFRRRTHLNVEAARKNIPCAAVSPNRSKCER 203
Cdd:PHA03247 2672 RAAQASSPPQRPRRRAArpTVGSLTSLADPPPPPPTPEPAPHAL-----VSATPLPPGPAAARQASPALPAAPAPPAVPA 2746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403   204 NTVADVDEKASAALYDFSVPSSETVIC-------RSQPAPVSPQQKSVLVSPPAVSAGGVPPMPVICQMVPLPANN---- 272
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAapaagppRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAspag 2826

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 73760403   273 --PVVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPqpvvqsSKPPVVSPNGTRLSPIA--PAPGFSPS 342
Cdd:PHA03247 2827 plPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPP------SRSPAAKPAAPARPPVRrlARPAVSRS 2894
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 360-436 6.59e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 36.24  E-value: 6.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760403   360 CSHPGCGKTYFKSSHLKAHTRTHTGE------KPFSCSWKGCERRFARSDELSRHRRTHTGEKK-FACPMCDRRFMRSDH 432
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHYKPNRyFKCENCLLRFRTHRS 81


                  ....
gi 73760403   433 LTKH 436
Cdd:pfam15909  82 LFKH 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
352-425 8.32e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 8.32e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 73760403 352 SSRIRSHICSHPGCGKTYFKSSHLKAHTRT--HTGE--KPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDR 425
Cdd:COG5048 282 SEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNS 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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