alpha-2-macroglobulin, partial [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| TED_complement super family | cl26240 | A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
1-60 | 8.42e-06 | ||
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved. The actual alignment was detected with superfamily member pfam07678: Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 40.74 E-value: 8.42e-06
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| Name | Accession | Description | Interval | E-value | ||
| TED_complement | pfam07678 | A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
1-60 | 8.42e-06 | ||
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved. Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 40.74 E-value: 8.42e-06
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| A2M_2 | cd02897 | Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
1-60 | 5.83e-03 | ||
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation. Pssm-ID: 239227 Cd Length: 292 Bit Score: 32.55 E-value: 5.83e-03
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| Name | Accession | Description | Interval | E-value | ||
| TED_complement | pfam07678 | A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
1-60 | 8.42e-06 | ||
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved. Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 40.74 E-value: 8.42e-06
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| A2M_2 | cd02897 | Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
1-60 | 5.83e-03 | ||
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation. Pssm-ID: 239227 Cd Length: 292 Bit Score: 32.55 E-value: 5.83e-03
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| Blast search parameters | ||||
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