|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
70-470 |
0e+00 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 674.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDAQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 230 LFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGsgsslfSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKK------RKFKCPPLKKIFNFNIWKSTGYRIWAFGIPAALFGYFV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 310 PYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVC 389
Cdd:cd17464 235 PYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYIPGVKKVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVC 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 390 LIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFI 469
Cdd:cd17464 315 LFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPIIGGIILCFI 394
|
.
gi 18699730 470 P 470
Cdd:cd17464 395 P 395
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
70-470 |
0e+00 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 622.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKLGDPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 230 LFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSlFSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPGRRT-LHSRINLFLRKIFNVEIFKRKRYVIWALGIPLALFGYFV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 310 PYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVC 389
Cdd:cd17420 240 PYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGVKKMYLQVLSFVSIGLMSMMIPLCNSFGILISVC 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 390 LIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFI 469
Cdd:cd17420 320 LVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFFI 399
|
.
gi 18699730 470 P 470
Cdd:cd17420 400 P 400
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
70-470 |
4.28e-162 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 464.27 E-value: 4.28e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17465 1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDQAVQFKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 230 LFYTLRVLCIFMFVLFLAGFTYRplatstkdkesggsgsslfsrkkfsppkkifnfaIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17465 161 LAHTFQVLSLFMFIQIFLSLTYK----------------------------------VFRRKTYRIWAFGIATAVLGYFV 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 310 PYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVC 389
Cdd:cd17465 207 PYVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGKIGDLIPGLKKIYLQVASFLLLGIMSMMIPLCQVFEGVIVVC 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 390 LIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFI 469
Cdd:cd17465 287 LFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIGGTVLFFV 366
|
.
gi 18699730 470 P 470
Cdd:cd17465 367 P 367
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
70-470 |
1.11e-86 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 271.35 E-value: 1.11e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDddkmvFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGEST-----SDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17352 76 LLAALGLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 230 LFYTLRVLCIFMFVLFLAGFTYRplatstkdkesggsgsslfsrkkfsppkkifnfaIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17352 156 WRGALLILGGLCLNLCVCGLLLR----------------------------------LLKDPTFVLLALGVSFAMLGFFV 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 310 PYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYvPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVC 389
Cdd:cd17352 202 PFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADK-PRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFS 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 390 LIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFI 469
Cdd:cd17352 281 VLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
.
gi 18699730 470 P 470
Cdd:cd17352 361 P 361
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
67-487 |
2.02e-50 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 178.78 E-value: 2.02e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 67 GGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDkmvfkTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAV 146
Cdd:TIGR00892 14 GGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSE-----TAWISSIMLAVLYAGGPISSILVNRFGCRPVVI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 147 VGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLID 226
Cdd:TIGR00892 89 AGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFE 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 227 SVGLFYTLRVLCIFMFVLFLAGFTYRPLATS-----TKDKESGGSGSSLFSRKKFSPPKKI---FNFAIFKVTAYAVWAV 298
Cdd:TIGR00892 169 SFGWRGSFLILGGLLLHCCVCGALMRPVGPSqrvskSKSKEGLPPDGSTKKLSKKSTAEKInrfLDFSLFTHRGFLVYLS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 299 GIPLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIAD---YVPGVKkvYLQVLSFFFIGLMSMM 375
Cdd:TIGR00892 249 GNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGlkwIRPHVQ--YLFSFALLFNGLTHLL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 376 IPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLA 455
Cdd:TIGR00892 327 CALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYAS 406
|
410 420 430
....*....|....*....|....*....|..
gi 18699730 456 GVPPLIGGAVLCFIPWIHSKKQREISKTTGKE 487
Cdd:TIGR00892 407 GSIVVSAGLFLAIGNYINYRLLAKEQKAALER 438
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
70-470 |
2.32e-49 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 174.12 E-value: 2.32e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFgskddDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYF-----EESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17423 76 LLSSLGFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 230 LFYTLRVLCIFMFVLFLAGFTYRPLATSTKdkesggsgsslfSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17423 156 WRGALLLLSALSLHLVPCGALLRPLALPGD------------PPAPPRSLSAAFGLSLLTHRAFLRYALATTLINTGYFI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 310 PYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPgVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVC 389
Cdd:cd17423 224 PYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGP-LRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALA 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 390 LIMGLFDGCfisiMAPIAF----ELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAV 465
Cdd:cd17423 303 VAYGFCAGA----LAPLVFsvlpELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLI 378
|
....*
gi 18699730 466 LCFIP 470
Cdd:cd17423 379 LLTLP 383
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
70-468 |
1.32e-37 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 141.79 E-value: 1.32e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDkmvfkTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSD-----TAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17430 76 LLASLGMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 230 LFYTLRVLCIFMFVLFLAGFTYRPLatstkdkesggsgsslfsrkkfsppkkifNFAIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17430 156 WRGGFLILGGLLLNCCTCGAVMRPL-----------------------------DFSVFRDRGFVIYTIAKFIMVLGLFV 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 310 PYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIAdyvpGVKKV-----YLQVLSFFFIGLMSMMIPLCSIFGA 384
Cdd:cd17430 207 PPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVA----GLKWVrprvvYLFSFAMLFNGLTDLCSATAADYGG 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 385 LIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGA 464
Cdd:cd17430 283 LVVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSAL 362
|
....
gi 18699730 465 VLCF 468
Cdd:cd17430 363 FLAL 366
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
70-470 |
1.80e-36 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 138.43 E-value: 1.80e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFgskddDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEF-----QQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17429 76 ILTSLGWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 230 LFYTLRVLCIFMFVLFLAGFTYRplatstkdkesggsgssLFSRKKFsppkkifnfaifkvTAYAVWAVgipLALFGYFV 309
Cdd:cd17429 156 WRNAMFIQGAVSLNLCVCGALMR-----------------LFTNKVF--------------VAFIFWAL---FAYCSFVI 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 310 PYVHLMKHVNE-RFQDEKNKEVVLMCIGVTSGVGRLLFGRIADyVPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAV 388
Cdd:cd17429 202 PFIHLPEIVKLyGLSEQNDKFPLTSIIAIVHIFGKVILGIICD-LPCISVWNVFILANFTLGVCILILPLMHTYTGLAIV 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 389 CLIMGLFDGCFiSIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCF 468
Cdd:cd17429 281 CALIGFSSGYF-SLMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIICLLL 359
|
..
gi 18699730 469 IP 470
Cdd:cd17429 360 KP 361
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
70-466 |
1.06e-32 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 128.01 E-value: 1.06e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDdkmvfKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKG-----MTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17428 76 FMVAGGLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 230 LFYTLRVLCIFMFVLFLAGFTYRplatstkdkesggsgssLFSRKKFSPpkkiFNFAIFkvtayavwavgipLALFGYFV 309
Cdd:cd17428 156 LDGCLLIVGALALNLLACGSLMR-----------------LFKNRVFSA----LFIAIL-------------LFDIGAFP 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 310 PyVHLMKHV--NERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYvPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIA 387
Cdd:cd17428 202 P-SLLMEDVarSENIIEEIALIPLVSIIGITTAIGKLILGVLADF-KWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAV 279
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18699730 388 VCLIMGLFDGCFiSIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVL 466
Cdd:cd17428 280 LSAILGFLSGNW-SIFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLL 357
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
70-470 |
1.98e-32 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 127.63 E-value: 1.98e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDdkmvfKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSE-----QISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVfTILLPLLLRVLIDSVG 229
Cdd:cd17421 76 FLVSAGFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGL-TFALAPFTQLLLDEYD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 230 LFYTLRVLCIFMFVLFLAGFTYRPLatstkdkesggsgsslfsrkkfsppkkifNFAIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17421 155 WQGALLIFGGIMLNLVASGMLLRPI-----------------------------DFSLLKDPFFCIYTWSFVFSQLAYFI 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 310 PYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYvPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVC 389
Cdd:cd17421 206 PYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQ-NWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYA 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 390 LIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFI 469
Cdd:cd17421 285 VFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFLE 364
|
.
gi 18699730 470 P 470
Cdd:cd17421 365 P 365
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
70-469 |
1.57e-30 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 122.16 E-value: 1.57e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFgskddDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYF-----NETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17422 76 LLISLGMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 230 LFYTLRVLCIFMFVLFLAGFTYRPLatstKDKESGGSGSslfsrkkfsppkkifnFAIFkvtayavwavgiplALFGYFV 309
Cdd:cd17422 156 WRYCLLVVGALQLNIVVCGALLRVL----KEPGFICYAL----------------FGLF--------------ATLGFFA 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 310 PYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPgVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVC 389
Cdd:cd17422 202 PQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCP-IRKIYIELICVILLCVVLLLFPFAYGFWSLLVCS 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 390 LIMGLFDGCFISIMAPIAFE--LVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLC 467
Cdd:cd17422 281 IFYGFMFGTVAGTHIPLLAEddVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLA 360
|
..
gi 18699730 468 FI 469
Cdd:cd17422 361 LV 362
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
70-453 |
6.76e-29 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 117.57 E-value: 6.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDkmvfkTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSE-----TSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17425 76 LLSGVGMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 230 LFYTLRVLCIFMFVLFLAGFTYRPLatstkdkesggsgsslfsrkkfsppkkifnfaiFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17425 156 WRGSFLVFGGVLLNCCVCGAVMRPF---------------------------------CSNTRYQIYTLGVTWMVLGFVL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 310 PYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADY-VPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAV 388
Cdd:cd17425 203 PLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLpVFKGRRIYLFSLALLLNGLSNLICAISASFPVLLVY 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18699730 389 CLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFY 453
Cdd:cd17425 283 CLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFY 347
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
70-466 |
1.72e-28 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 116.52 E-value: 1.72e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDdkmvfKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSS-----EVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17426 76 CLSGAGLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 230 LFYTLRVLCIFMFVLFLAGFTYRPLAtstkdkesggsgsslfsrkkfspPKKIFNFAIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17426 156 WRGSFLILGGLLLNCCVAGSLMRPIG-----------------------PKPFLDLTLFTHRGFLLYLSGNVIMFFGLFA 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 310 PYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKV-YLQVLSFFFIGLMSMMIPLCSIFGALIAV 388
Cdd:cd17426 213 PLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIqYFFAASVLYNGVCHLLAPLSTSYVGFCIY 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18699730 389 CLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVL 466
Cdd:cd17426 293 AIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYL 370
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
113-468 |
3.16e-28 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 115.68 E-value: 3.16e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 113 KTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILG 192
Cdd:cd17424 39 RTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLASTGLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 193 HYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATSTkdkesggsgsslfs 272
Cdd:cd17424 119 KYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRFLLMPD-------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 273 rkkfsppkkifnfaifkvtaYAVWAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADY 352
Cdd:cd17424 185 --------------------FLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 353 vpGVKKVYLQVLSFFFI---GLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSI 429
Cdd:cd17424 245 --RCLKKYRYFCYLFAVgmdGLCCLFLPILKTFPLLVPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAV 322
|
330 340 350
....*....|....*....|....*....|....*....
gi 18699730 430 PMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCF 468
Cdd:cd17424 323 PYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLLGS 361
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
70-457 |
7.12e-27 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 111.83 E-value: 7.12e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFgskddDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIF-----HTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17427 76 LLCSLGMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 230 LFYTLRVLCIFMFVLFLAGFTYRPLAtstkdkesggsgsslfsrkkfsppkkifnfAIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17427 156 WRGSFLILGGLLLNCCVAGSLMRPLG------------------------------PLFKHRGFLIYLSGNVIMFLGFFA 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 310 PYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKV-YLQVLSFFFIGLMSMMIPLCSIFGALIAV 388
Cdd:cd17427 206 PIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIqYFFSFAVMYNGVCHLLCPLAEDYTGLVIY 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18699730 389 CLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGV 457
Cdd:cd17427 286 AVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGA 354
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
71-470 |
2.56e-25 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 107.66 E-value: 2.56e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 71 WLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKmvfktAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAA 150
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQL-----GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 151 VGFVGLMSSSFVSSIePLYLTYGIIFACGCSFAYQPSLVILGHYF-KKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:COG2223 79 LLGIGLLLLALAVSY-WLLLLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 230 LFYTLRVLCIFMFVLFLAGFTY---RPLATSTKDKESGGSGSSLFSRKKFsppkkifnfaiFKVTAYAVWAVGIPLALFG 306
Cdd:COG2223 158 WRNAFLILGILLLVVAVLAWLFlrdPPAGAAAAAKASLRDQLEALRDPRF-----------WLLSLLYFGTFGSFIGFSS 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 307 YFVPYVHLMKHVnerfqDEKNKEVVLMCIGVTSGVGRLLFGRIADYVpGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALI 386
Cdd:COG2223 227 WLPPYLVDQFGL-----SAATAGLLAALFALLGALGRPLGGWLSDRI-GGRRVLLIVFALMALGLLLLALALGSLWLFLV 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 387 AVCLIMGLFDGCFISIMAPIAfELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVL 466
Cdd:COG2223 301 LFLLLGLALGGGNGAVFALVP-DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLT 379
|
....
gi 18699730 467 CFIP 470
Cdd:COG2223 380 LLLY 383
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
71-469 |
2.99e-23 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 101.53 E-value: 2.99e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 71 WLVMLAAMWCNGsVFGIQNACGVLFVSMLETFGSKdddkmVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAA 150
Cdd:cd17353 3 WLVLLGAVLMHL-ILGYQYAWSVFNPPLSSALGWS-----LASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 151 VGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGL 230
Cdd:cd17353 77 LFGLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 231 FYTLRVL-CIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKFSPPKKIFNFAIFkvtaYAVW-----AVGIPLAL 304
Cdd:cd17353 157 PTTFLILgIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPTF----WLLWlmfflNATAGLML 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 305 FGYFVPYVHLMKHVnerfqdekNKEVVLMCIGVTS---GVGRLLFGRIADYVpGVKKVYLqvLSFFFIGLMSMMIPLC-S 380
Cdd:cd17353 233 IGQAKPIGQEFAGL--------DAGIAALAVSILSifnGGGRPFWGWLSDKI-GRKNTLS--IAFLIQGVAMFLLPFIgS 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 381 IFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLrDKLGSYDVAFYLAGVPPL 460
Cdd:cd17353 302 VAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYV-LYTGGYNAAFIIAAALSL 380
|
....*....
gi 18699730 461 IGGAVLCFI 469
Cdd:cd17353 381 VALALALLL 389
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
70-468 |
1.07e-22 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 99.79 E-value: 1.07e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKdddkmVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYS-----SSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17314 76 IMVLAGYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 230 LFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKkfsppkkifnfAIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17314 156 LALVYTILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMG-----------EIFRDKVFWILFIAIFLVLIGGFL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 310 PYVHLMKHVNERFQDEKNKEVVLMCI-GVTSGVGRLLFGRIADYVPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAV 388
Cdd:cd17314 225 FIANMASLVRSLQLDAPSFVTKLMSIyGLFNAFGRLLWGIVADFFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLT 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 389 CLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCF 468
Cdd:cd17314 305 GSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLA 384
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
67-470 |
2.42e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 86.46 E-value: 2.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 67 GGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDkmvfkTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAV 146
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQ-----LGLLASAFFLGYALGQIPAGLLADRFGRRRVLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 147 VGAAVGFVGLMSSSFVSSIEPLYLTYgIIFACGCSFAYQPSLVILGHYF-KKRLGLVNGIVTAGSSVFTILLPLLLRVLI 225
Cdd:COG2271 80 IGLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 226 DSVGLFYTLRVLCIFMFVLFLAGFTYrplatstkdkesggsgsslfsrkkfsppkkifnFAIFKVTAYAVWavgipLALF 305
Cdd:COG2271 159 AAFGWRAAFLILGLPGLLLALLRFWL---------------------------------LALAYFLVYFAL-----YGFL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 306 GYFVPYVHLMKHVnerfqDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVYLqVLSFFFIGLMSMMIPLCSIFGAL 385
Cdd:COG2271 201 TWLPTYLVEVRGL-----SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL-AIGLLLAALALLLLALLPSPALA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 386 IAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGsYDVAFYLAGVPPLIGGAV 465
Cdd:COG2271 275 IALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALL 353
|
....*
gi 18699730 466 LCFIP 470
Cdd:COG2271 354 ALLLL 358
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
114-466 |
2.40e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 80.55 E-value: 2.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 114 TAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYgIIFACGCSFAYQPSLVILGH 193
Cdd:cd06174 33 LGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGR-FLLGLGSGLIDPAVLALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 194 YFKKR-LGLVNGIVTAGSSVFTILLPLLLRVLIDSVGlfYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFS 272
Cdd:cd06174 112 LFPEReRGRALGLLQAFGSVGGILGPLLGGILASSLG--FGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 273 RKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYvHLMKHVNERFQDEKnkeVVLMCIGVTSGVGRLLFGRIADY 352
Cdd:cd06174 190 KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPL-FLLDLGGLSVAVAG---LLLSLFGLAGALGSLLLGLLSDR 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 353 VPGVKkvYLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMT 432
Cdd:cd06174 266 LIGRK--PLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGA 343
|
330 340 350
....*....|....*....|....*....|....
gi 18699730 433 VGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVL 466
Cdd:cd06174 344 IGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
116-435 |
5.58e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 76.30 E-value: 5.58e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 116 WVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTyGIIFACGCSFAYQPSLVILGHYF 195
Cdd:pfam07690 36 LLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVL-RVLQGLGAGALFPAALALIADWF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 196 -KKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRK 274
Cdd:pfam07690 115 pPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 275 KfsppkkifnfaIFKVTAYAVWAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVP 354
Cdd:pfam07690 195 K-----------ALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 355 GVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVG 434
Cdd:pfam07690 264 RRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
.
gi 18699730 435 P 435
Cdd:pfam07690 344 P 344
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
70-469 |
1.89e-14 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 75.00 E-value: 1.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGskdddkmvFKTAWVG---SLSMGMIFFCCPIVSVFTDLFGCRKTAV 146
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFG--------WSRAVISlafTVGLLAFGLAQPFVGRLLDRFGPRRVML 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 147 VGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPS-LVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLI 225
Cdd:cd17355 73 LGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 226 DSVGLFYTLRVLCIFM----FVLFLAGFTYRPLATSTKDKESGGSGSSLFSRkkfsppkkifnfAIFKVTAYAVWAVGIP 301
Cdd:cd17355 153 EAFGWRTALLVLALLAllvlVPVLLLLRRRPADLALRAYDDASPASPGSTLK------------EALRSASFWLLALAFF 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 302 LALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVkkvyLQVLSFFFIGLMSMMIPLCSI 381
Cdd:cd17355 221 LCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPR----RLLAASYALRALGLALLLLLP 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 382 FG--ALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPP 459
Cdd:cd17355 297 FPplALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALG 376
|
410
....*....|
gi 18699730 460 LIGGAVLCFI 469
Cdd:cd17355 377 LIAALLVLPI 386
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
114-469 |
5.91e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 73.37 E-value: 5.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 114 TAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFAcGCSFAYQPSLVILGH 193
Cdd:COG2807 55 AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA-GIAVGNVLLPGLIKR 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 194 YFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFV--LFLAGFTYRPLATSTKDKESGGSGSSLF 271
Cdd:COG2807 134 WFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLalLLWLPLLRRRPAAAAAAPAAASLRSLWR 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 272 SRkkfsppkkifnfaifkvtayAVWAVGIPLAL--FGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRI 349
Cdd:COG2807 214 SP--------------------LAWLLTLFFGLqsLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 350 ADYVPGVKKVYLQVLSFFFIGLMSMMIplcSIFGALIAVCLIMGL-FDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMS 428
Cdd:COG2807 274 ADRLGDRRPLLLLLGLLGLAGLLGLLL---APGSLPWLWAVLLGLgQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGY 350
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 18699730 429 IPMTVGPPIAGLLRDKLGSYDVAFYLagvppLIGGAVLCFI 469
Cdd:COG2807 351 LLAALGPLLVGALHDATGSWTAALLL-----LAALAVLMLV 386
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
115-429 |
4.24e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 70.39 E-value: 4.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 115 AWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLtYGIIFACGCSFAYQPSLVILGHY 194
Cdd:COG2814 48 GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 195 F-KKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSR 273
Cdd:COG2814 127 VpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRR 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 274 KKFSPPkkIFNFAIFKVTAYAVWAvgiplalfgYFVPYVHLMKHVnerfqDEKNKEVVLMCIGVTSGVGRLLFGRIADYV 353
Cdd:COG2814 207 PRLLLL--LLLAFLLGFGFFALFT---------YLPLYLQEVLGL-----SASAAGLLLALFGLGGVLGALLAGRLADRF 270
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18699730 354 pGVKKVYlqVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSI 429
Cdd:COG2814 271 -GRRRLL--LIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
117-466 |
4.87e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 61.44 E-value: 4.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 117 VGSLSMGMIFFCcPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFK 196
Cdd:cd17325 37 VAAYALAQLLFS-PPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 197 KRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKF 276
Cdd:cd17325 116 EERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 277 SPPKKIFnfaifkVTAYAVWAVGIPLALFGYFVPYvhlmkHVNERFQ-DEKNKEVVLMCIGVTSGVGRLLFGRIADYVPG 355
Cdd:cd17325 196 LRDRRLL------ALFLAIFVLAFAFGALEPFLPL-----YAAELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRIGR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 356 VKkvyLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGP 435
Cdd:cd17325 265 KP---LILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGP 341
|
330 340 350
....*....|....*....|....*....|.
gi 18699730 436 PIAGLLRDKLGsYDVAFYLAGVPPLIGGAVL 466
Cdd:cd17325 342 LLGGFLYDAFG-FATPFLAAAALLLLAAVLF 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
331-468 |
6.00e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 60.76 E-value: 6.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 331 VLMCIGVTSGVGRLLFGRIADYVpGVKKVYLqvLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFEL 410
Cdd:COG2814 50 VVTAYLLGAALGAPLAGRLADRF-GRRRVLL--LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 18699730 411 VGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGsYDVAFYLAGVPPLIGGAVLCF 468
Cdd:COG2814 127 VPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVFLVNAVLALLALLLLLR 183
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
115-479 |
1.30e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 59.87 E-value: 1.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 115 AWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIePLYLTYGIIFACGCSF---AYQPSLVIL 191
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY-PLLLLALFLLGLGLGLldvAANPYVAAL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 192 GH-YFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIdSVGLFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSL 270
Cdd:COG0738 125 GPeTAASRLNLLHAFFSLGALLGPLLGGLLILLGL-SLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 271 FSRKKFsppkKIFNFAIFKVTAYavwaVGIPLALFGYFVPYVHLMKHVNErfqdeknkEVVLMCIGVTSG---VGRLLFG 347
Cdd:COG0738 204 KSLLKN----PRLLLGGLAIFLY----VGAEGAIGDWLPLYLKDVLGLSE--------ATAALGLSLFWGgmtIGRFLGG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 348 RIADYVPGVKkvYLQVLSFFFIGLMSMMIPLCSIFGALIAVCLImglfdGCFISIMAPIAFELVGAQ---DVSQAIGFLL 424
Cdd:COG0738 268 FLLKRFGPVR--LLRLSALLAAVGLLLALLAPGPWLALIGLALV-----GLGLSLMFPTIFSLALDGlgkRTAAAVSAVL 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 18699730 425 GFMSIPMTVGPPIAGLLRDKLGsYDVAFYLAGVPPLIggaVLCFIPWIHSKKQRE 479
Cdd:COG0738 341 IMGIVGGAIGPPLIGFLADAFG-LRAAFLVPLVCYLL---ILLLALALKRKRRKK 391
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
330-486 |
1.27e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.82 E-value: 1.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 330 VVLMCIGVTSGVGRLLFGRIADYVpGVKKVYlqVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFE 409
Cdd:cd17325 35 LIVAAYALAQLLFSPPAGRLSDRF-GRKRLL--LLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18699730 410 LVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGsYDVAFYLAGVPPLIGGAVLCFIPWIHSKKQREISKTTGK 486
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAAR 187
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
331-468 |
5.12e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 54.73 E-value: 5.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 331 VLMCIGVTSGVGRLLFGRIADYVpGVKKVYLqvLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFEL 410
Cdd:pfam07690 37 LLTLFSLGYALAQPLAGRLSDRF-GRRRVLL--IGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 18699730 411 VGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLrDKLGSYDVAFYLAGVPPLIGGAVLCF 468
Cdd:pfam07690 114 FPPEERGRALGLVSAGFGLGAALGPLLGGLL-ASLFGWRAAFLILAILSLLAAVLLLL 170
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
236-467 |
6.82e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 54.55 E-value: 6.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 236 VLCIFMFVLFLAGFTYRPLATSTKDKEsggsgsslfSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLM 315
Cdd:cd17475 158 LVSILAAVLFWLFYREPPAASAATESA---------STLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDH 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 316 KHVNErfqdeKNKEVVLMCIGVTSGVGRLLFGRIADYV-PGVKKVYLQVLSFF---FIGLMSMMIPLcSIFGALIAVCLI 391
Cdd:cd17475 229 LGLSV-----VAAGALLAVAQLGGALGRIGLGRVSDRVfGGRRRPVLVITAAIaaaALLVLSLLSPG-TPLWLLVLLLIL 302
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18699730 392 MGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLC 467
Cdd:cd17475 303 LGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
124-470 |
2.13e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.96 E-value: 2.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 124 MIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLyLTYGIIFACGCSFAYQPSLVILGHYF-----KKR 198
Cdd:cd17473 47 FIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYAL-LASRALLGIGVAGIMTLATALIGDYFegeerAKM 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 199 LGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLagftYRPLATSTKDKESGGsgsslfSRKKFSP 278
Cdd:cd17473 126 LGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLLFL----PEPARKSKSAASPGA------ATAAALP 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 279 PKKIFnfaifkvtayaVWAVGIPLALFGYFVPYVHLMKHVNERF-QDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPgvk 357
Cdd:cd17473 196 WKRVL-----------PIYFLAFLAMLLFYVIPIQLPFLLQERGgGSAALIGLALAIASLAGAIGALLFGRLKRRLG--- 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 358 KVYLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPI 437
Cdd:cd17473 262 KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLV 341
|
330 340 350
....*....|....*....|....*....|...
gi 18699730 438 AGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFIP 470
Cdd:cd17473 342 LGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
337-490 |
5.57e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 51.83 E-value: 5.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 337 VTSGVGRLLFGRIADYVpGVKKVYLqvLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDV 416
Cdd:cd17489 42 LAALLARPFAGRLLDRF-GRKRLLL--IGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRR 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18699730 417 SQAIGFLLGFMSIPMTVGPPIAGLLRDKLGsYDVAFYLAGVPPLIgGAVLCFIPWIHSKKQREISKTTGKEKME 490
Cdd:cd17489 119 GEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVAAVLALL-ALLLVFLVKDPPPVAAEEAEAGTRAFRR 190
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
340-469 |
9.00e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 47.93 E-value: 9.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 340 GVGRLLFGRIADYVpGVKKVYLQVLSFFFIGLMsmMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQA 419
Cdd:cd17324 48 ALGALLLGPLSDRI-ERRRLLLVLLLLFILGNL--LAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRA 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 18699730 420 IGFLLGFMSIPMTVGPPIAGLLRDKLGsYDVAFYLAGVPPLIGGAVLCFI 469
Cdd:cd17324 125 IGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAIAVLALLAALLLWRL 173
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
115-469 |
2.43e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.39 E-value: 2.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 115 AWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIePLYLTYGIIFACGCSFAYQPSLVILGHY 194
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF-ALLLLARALAGLAHGGFWAIAAAYAADL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 195 F-KKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG---LFYTLRVLCIFMFVLFLAGFTYRPLATSTKdkesggsgssl 270
Cdd:cd17324 116 VpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGwraAFLAIAVLALLAALLLWRLLPSLPPKKPGS----------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 271 fSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLMKHVNERFQDeknkeVVLMCIGVTSGVGRLLFGRIA 350
Cdd:cd17324 185 -LGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAII-----GLLLLFGVAGVVGSPLAGRLA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 351 DYVPGvkkvylQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAP--IAFELVGAQDVSQAIGFLLGFMS 428
Cdd:cd17324 259 DRGGR------RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSAlqTRVLRLAPEARGLASSLYLAAYN 332
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 18699730 429 IPMTVGPPIAGLLRDKLGSYDVAFYLAGvppLIGGAVLCFI 469
Cdd:cd17324 333 LGGALGAALGGLVLDHGGWAGVGWVGAA---LLLLALLLAL 370
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
130-467 |
2.50e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.40 E-value: 2.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 130 PIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLtyGIIFACGCSFAYQP-SLVILGHYFKKRLGLVNGIVTA 208
Cdd:cd17478 49 PLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL--LVALAGIGSAAFHPeGARLASQAAGGRRGLAMSIFSV 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 209 GSSVFTILLPLLLRVLIDSVGLFYTLRVLCI-FMFVLFLAGFTYRPLATSTKDKEsggsgsslfSRKKFSPPKKIFNFAI 287
Cdd:cd17478 127 GGNLGFALGPLIAAALVALFGGLGLLILLIIpGLAVALLLLRLRPLKKPEAKKAA---------AKSSARSTLKGVWRAL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 288 FKVTAYAVWAVGIPLALFGYFVPYVHlmkhvnERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVpGVKKVYLQ--VLS 365
Cdd:cd17478 198 LLLLIIVFLRSWVLSSLTTFLPFYLV------QRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRF-GRRRVIIAslLLA 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 366 FFFIGLMsMMIPLCSIFGALIavclIMGLFdgcfisIMAPIAFELVGAQD-----VSQAIGFLLGFMSIPMTVGPPIAGL 440
Cdd:cd17478 271 APFLLLF-LLTPGIWSYILLV----LAGFL------LFASFPVTVVLAQEllpgnVGLASGLMMGLSFGLGGIGAPVLGA 339
|
330 340
....*....|....*....|....*..
gi 18699730 441 LRDKLGsYDVAFYLAGVPPLIGGAVLC 467
Cdd:cd17478 340 LADAFG-LESVLLILALLPLLGALLAF 365
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
117-469 |
4.06e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.02 E-value: 4.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 117 VGSLSMGMIFFCcPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLyLTYGIIFACGCSFAYQPSLVILGHYFK 196
Cdd:cd17474 40 ITAFTLPAAVLM-PVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIGAAGLGPLALTLIGDLFE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 197 -----KRLGLVNGIVTAGSSVFTIllpllLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPlatSTKDKESGGSGSSLF 271
Cdd:cd17474 118 ggeraKAMGLYEAALGLGIAVGPL-----LGGLLAAISWRYPFFLLAALIPVAFLAILFLLP---EPKEKAKSSSATKLR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 272 SRKKFSPPKKIFNFaifkvtayavwAVGIPLALFGYFVPYVHLMKHVNERF-QDEKNKEVVLMCIGVTSGVGRLLFGRIA 350
Cdd:cd17474 190 DLKKALRGRGLLTF-----------LVSAFLYFFLYFAFLTYLPFLLELLYgISPIIIGLLFAGWSVLLALGSLFVGRLL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 351 DYVPGVKKVYlqVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIP 430
Cdd:cd17474 259 KKRFGARRIL--VIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLG 336
|
330 340 350
....*....|....*....|....*....|....*....
gi 18699730 431 MTVGPPIAGLLRDKLGsYDVAFYLAGVPPLIGGAVLCFI 469
Cdd:cd17474 337 QAVGPLLFGLLLEIFG-LSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
112-469 |
2.99e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.99 E-value: 2.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 112 FKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVV-----GAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSF---- 182
Cdd:cd06173 34 LLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFgpar 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 183 -AYQPSLVIlghyfKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLF--YTLRVLCIFMFVLFLAGFTYRPLATSTK 259
Cdd:cd06173 114 qALLPELVP-----KEQLVRANALNSLATQLARIIGPALGGLLVALLGPGgaFAINALSFLLSALLLLFIRRPPPAAPGE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 260 DKESGGSGSSLFSRKKFSPPKKIFnfAIFKVTAYAVWAVGIpLALFGYFVPYVHLMkhvnerfqDEKNKEVVLMCIGVTS 339
Cdd:cd06173 189 SSSLLLRDLREGLRYLRRSPLLRL--LLLALALFALLGGAL-TVLLPLLAKEVLGG--------GAAGYGLLLAAFGVGA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 340 GVGRLLFGRIADYVPGVKKVylqVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQA 419
Cdd:cd06173 258 LLGALLLGRLSKRRRRGRLL---LIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRV 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 18699730 420 IGFLLGFMSIPMTVGPPIAGLLRDKLGsYDVAFYLAGVPPLIGGAVLCFI 469
Cdd:cd06173 335 FSVYNALNSGAMPLGALLAGLLADALG-LSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
335-469 |
8.11e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.79 E-value: 8.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 335 IGVTSGVGRLLFGRIADYVPGVKKVYLQVLSFFFIGLMSMMIPL-CSIFGALIAVCLIMGLFDGCFISIMApIAFELVGA 413
Cdd:cd17319 224 PFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLtTSPVVAVILLSLAGFGIGAASPVFWS-LPADLLPG 302
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 18699730 414 QDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFI 469
Cdd:cd17319 303 EAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
136-465 |
8.95e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.43 E-value: 8.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 136 TDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLY---LTYGIIFACGCSFAyqpSLVILGHYFKKRLGLV---NGIVTAG 209
Cdd:cd17489 55 LDRFGRKRLLLIGLLIFALATLLYLLATSVALLLvlrLIHGIGWGAFTTAA---ATLVADIIPPSRRGEGigyYGLATTL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 210 SSVFtillPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKEsggsgsslfSRKKFSPPKKIFNFAIFK 289
Cdd:cd17489 132 AMAL----GPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEE---------AEAGTRAFRRLVEKKVLP 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 290 VtayavwAVGIPLALFGYFVPYVHLMKHVNERFQDekNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVYLQVLsFFFI 369
Cdd:cd17489 199 P------ALILFLASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLL-LLAL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 370 GLMsMMIPLCSIFGALIAVcLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGsYD 449
Cdd:cd17489 270 GLL-LLSFAGSPWMLLLAA-VLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YR 346
|
330
....*....|....*.
gi 18699730 450 VAFYLAGVPPLIGGAV 465
Cdd:cd17489 347 AMFLLAAVVVLLALVL 362
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
258-466 |
1.78e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 258 TKDKESGGSGSSLFSRKKFSPPKKIFNFAIFkvtayavwavgipLALFGYFvPYVHLMKHVNERFQDEKNKEVVLMCIGV 337
Cdd:cd17370 180 YPRPPKLRKKSKKTSLKKLPKAFWLYLLAVA-------------LFALGNF-SFAFLILRAQELGLSAALIPLLYALFNL 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 338 TSGVGRLLFGRIADYVpGVKKVYLQVLSFFFIGLMSMMipLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVS 417
Cdd:cd17370 246 VYALAAYPAGRLSDRI-GRKKLLILGYLSLALAYLGFA--LGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRG 322
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 18699730 418 QAIGFLLGFMSIPMTVGPPIAGLLRDKLgSYDVAFYLAGVPPLIGGAVL 466
Cdd:cd17370 323 TAYGLFNTVVGIGWLLASLIAGYLWDLI-SPSAAFLFSAVLALIALLLL 370
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
297-468 |
3.67e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.59 E-value: 3.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 297 AVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVpGVKKVYLQVLSfffIGLMSMMI 376
Cdd:cd06180 202 ALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRW-GTRRALAANLL---VQAVGVLL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 377 PLCSIFGALIAVCLImgLFDGCFISIMA---PIAFELvGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFY 453
Cdd:cd06180 278 PLLSPGPAGLVLSAV--LFGGTFMAITAlvmALAREL-APPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALI 354
|
170
....*....|....*
gi 18699730 454 LAGVpPLIGGAVLCF 468
Cdd:cd06180 355 LAAA-ALVVAALLAL 368
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
331-470 |
3.80e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.41 E-value: 3.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 331 VLMCIGVTSGVGRLLFGRIADYVpGVKKVYLqvLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFEL 410
Cdd:COG0477 54 IVSAYLLGRAIGLLLFGRLGDRY-GRKRVLL--IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAEL 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 411 VGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGsYDVAFYLAGVPPLIGGAVLCFIP 470
Cdd:COG0477 131 FPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG-WRWIFLINAPLGLLALVLRLRLP 189
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
331-493 |
4.70e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 4.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 331 VLMCIGVTSGVG-RLLFGRIADYVPGVKKVYLQVLSFFFIGLMSMMIpLCSIFGALIAVCLIMGLFDGCF--ISIMAPIA 407
Cdd:cd17471 36 IFMTLSALSGIVvSQWLGRLSDRGGDRKPLILLALLAGALGYLLFAF-LRNYWVLLLVGVVLLSLGAAAFpqLFALAREY 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 408 FELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGsYDVAFYLAGvppLIGGAVLCFIPWIHSKKQREISKTTGKE 487
Cdd:cd17471 115 ADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLG-FTGLFLLAA---LLYLVVALLVLFLLPSVKPPAQKATPAS 190
|
....*.
gi 18699730 488 KMEKML 493
Cdd:cd17471 191 SLVKAP 196
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
330-459 |
7.57e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.71 E-value: 7.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 330 VVLMCIGVTSGVGRLLFGRIADYVpGVKKVYLQVLSFFFIGLMSMMIPLCSIFgALIAVCLIMGLFDGCFISIMAPIAFE 409
Cdd:cd17504 221 LLLLPGALVMLIAGPLAGRLIARV-GPRRVLLIGLVISAVGLLLLALLHSSLW-ALVVALLLIGIGLGLAFASLPNIVVE 298
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 18699730 410 LVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLrdkLGSYDVAFYLAGVPP 459
Cdd:cd17504 299 SVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI---LTTYTVSITSGGVPT 345
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
69-253 |
8.53e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.31 E-value: 8.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 69 WGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDddkmVFKTAWVGSLSMGMIFFCCPIVSVFTDLFG--CRKTAV 146
Cdd:COG2271 177 LALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLS----LAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLA 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18699730 147 VGAAVGFVGLMSSSFVSSIePLYLTYGIIFACGCSFAYQPSLVILGHYF-KKRLGLVNGIVTAGSSVFTILLPLLLRVLI 225
Cdd:COG2271 253 IGLLLAALALLLLALLPSP-ALAIALLFLAGFGLGGAFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYLL 331
|
170 180
....*....|....*....|....*...
gi 18699730 226 DSVGLFYTLRVLCIFMFVLFLAGFTYRP 253
Cdd:COG2271 332 DATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| |
