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Conserved domains on  [gi|20149594|ref|NP_031381|]
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heat shock protein HSP 90-beta isoform a [Homo sapiens]

Protein Classification

HSP90 family protein( domain architecture ID 1903338)

HSP90 (heat shock protein 90) family protein functions as a molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HSP90 super family cl46693
Hsp90 protein;
14-724 0e+00

Hsp90 protein;


The actual alignment was detected with superfamily member PTZ00272:

Pssm-ID: 481033  Cd Length: 701  Bit Score: 934.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   14 TFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGM 93
Cdd:PTZ00272   4 TFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGESPRLCIRVVPDKENKTLTVEDNGIGM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   94 TKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGE 173
Cdd:PTZ00272  84 TKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVTSKNNSDESYVWESSAGGTFTITSTPES 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  174 PIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDeekpkIEDV 253
Cdd:PTZ00272 164 DMKRGTRITLHLKEDQMEYLEPRRLKELIKKHSEFIGYDIELMVEKTTEKEVTDEDEEDTKKADEDGEEPK-----VEEV 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  254 gsDEEDDSGKDKKKKTKKIKEKYIDQeelNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALL 333
Cdd:PTZ00272 239 --KEGDEGKKKKTKKVKEVTKEYEVQ---NKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLEFRSIM 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  334 FIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCL 413
Cdd:PTZ00272 314 FVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKCL 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  414 ELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQ 493
Cdd:PTZ00272 394 EMFDEVAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKAGQKSIYYITGDSKKK 473
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  494 VANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDK 573
Cdd:PTZ00272 474 LETSPFIEQARRRGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKQQREEEKAACEKLCKTMKEVLGD 553
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  574 KVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKD 653
Cdd:PTZ00272 554 KVEKVIVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMELNPRHPIIKELRRRVGADENDKAVKD 633
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20149594  654 LVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEvaaEEPNAAVPDEIPPLEGDEDASRMEEVD 724
Cdd:PTZ00272 634 LVFLLFDTSLLTSGFQLEDPTGYAERINRMIKLGLSLDEEE---EEAAEAPVAETAPAEVTAGTSSMEQVD 701
 
Name Accession Description Interval E-value
PTZ00272 PTZ00272
heat shock protein 83 kDa (Hsp83); Provisional
14-724 0e+00

heat shock protein 83 kDa (Hsp83); Provisional


Pssm-ID: 240341  Cd Length: 701  Bit Score: 934.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   14 TFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGM 93
Cdd:PTZ00272   4 TFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGESPRLCIRVVPDKENKTLTVEDNGIGM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   94 TKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGE 173
Cdd:PTZ00272  84 TKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVTSKNNSDESYVWESSAGGTFTITSTPES 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  174 PIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDeekpkIEDV 253
Cdd:PTZ00272 164 DMKRGTRITLHLKEDQMEYLEPRRLKELIKKHSEFIGYDIELMVEKTTEKEVTDEDEEDTKKADEDGEEPK-----VEEV 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  254 gsDEEDDSGKDKKKKTKKIKEKYIDQeelNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALL 333
Cdd:PTZ00272 239 --KEGDEGKKKKTKKVKEVTKEYEVQ---NKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLEFRSIM 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  334 FIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCL 413
Cdd:PTZ00272 314 FVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKCL 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  414 ELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQ 493
Cdd:PTZ00272 394 EMFDEVAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKAGQKSIYYITGDSKKK 473
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  494 VANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDK 573
Cdd:PTZ00272 474 LETSPFIEQARRRGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKQQREEEKAACEKLCKTMKEVLGD 553
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  574 KVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKD 653
Cdd:PTZ00272 554 KVEKVIVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMELNPRHPIIKELRRRVGADENDKAVKD 633
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20149594  654 LVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEvaaEEPNAAVPDEIPPLEGDEDASRMEEVD 724
Cdd:PTZ00272 634 LVFLLFDTSLLTSGFQLEDPTGYAERINRMIKLGLSLDEEE---EEAAEAPVAETAPAEVTAGTSSMEQVD 701
HSP90 pfam00183
Hsp90 protein;
191-712 0e+00

Hsp90 protein;


Pssm-ID: 459703  Cd Length: 516  Bit Score: 804.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   191 EYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEekpkIEDVGSDEEDdsgkdkkKKTK 270
Cdd:pfam00183   1 EYLEEKKIKELVKKYSEFINFPIYLWVEKEEEVEVPDEEEEEEEEEEEEEDDDPK----VEEEDEEEEK-------KKTK 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   271 KIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKK 350
Cdd:pfam00183  70 KVKETVWEWELLNKTKPIWTRNPKEVTEEEYAEFYKSLSKDWEDPLAVKHFSVEGEVEFKSLLFIPKRAPFDLFENKKKK 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   351 NNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFY 430
Cdd:pfam00183 150 NNIKLYVRRVFITDDFEDLIPEYLNFVKGVVDSDDLPLNVSRETLQQNKILKVIKKKLVRKALDMFKEIAEEKEDYKKFW 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   431 EAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEV 510
Cdd:pfam00183 230 KEFGKNLKLGIIEDSSNRNKLAKLLRFYSSKSGDELTSLDDYVSRMKEGQKHIYYITGESKEEVENSPFLERLKKKGYEV 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   511 VYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCC 590
Cdd:pfam00183 310 LYLTDPIDEYAVQQLKEFDGKKLVNVAKEGLELEEDEEEKKKDEELKKEFEPLTKWLKDVLGDKVEKVVVSNRLVDSPCV 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   591 IVTSTYGWTANMERIMKAQALR-DNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFS 669
Cdd:pfam00183 390 LVTSQYGWSANMERIMKAQALRkDSSMSSYMSSKKTLEINPRHPIIKELLKRVEADKDDKTAKDLALLLYETALLRSGFS 469
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 20149594   670 LEDPQTHSNRIYRMIKLGLGIDEDEVAAEEP----NAAVPDEIPPLE 712
Cdd:pfam00183 470 LEDPASFASRIYRMLKLGLGIDEDEIVEEEDeieeEEEEEEEEPEEE 516
HtpG COG0326
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
14-689 0e+00

Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440095 [Multi-domain]  Cd Length: 616  Bit Score: 729.23  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  14 TFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGM 93
Cdd:COG0326   5 TGEFQAEVKQLLDLMIHSLYSNKEIFLRELISNASDAIDKLRFLALTDPELKEEDGDLKIRIEVDKEAKTLTISDNGIGM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  94 TKADLINNLGTIAKSGTKAFMEALQ--AGADISMIGQFGVGFYSAYLVAEKVVVITKH--NDDEQYAWESSAGGSFTVRA 169
Cdd:COG0326  85 TREEVIENLGTIAKSGTREFLEKLKgdQKKDSDLIGQFGVGFYSAFMVADKVEVVTRSagEDAEAVRWESDGDGEYTIEE 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594 170 dhGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPItlYLEKEREKEISDdeaeeekgekeeedkddeekpk 249
Cdd:COG0326 165 --AEKAERGTEITLHLKEDAEEFLEEWRLREIIKKYSDFIPVPI--KMEGEEEETEED---------------------- 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594 250 iedvgsdeeddsgkdkkkktkkikekyidqEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEF 329
Cdd:COG0326 219 ------------------------------ETINSATALWTRSKSEITDEEYKEFYKHLFHDFEDPLFWIHLNVEGPFEY 268
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594 330 RALLFIPRRAPFDLFENKKKKNNIkLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIV 409
Cdd:COG0326 269 TGLLYIPKKAPFDLYDRDRKGGIK-LYVKRVFIMDDAEDLLPEYLRFVRGVVDSPDLPLNVSREILQEDRQLKKIRKAIT 347
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594 410 KKCLELFSELAE-DKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSqSGDEMTSLSEYVSRMKETQKSIYYITG 488
Cdd:COG0326 348 KKVLDELEKLAKnDREKYEKFWKEFGLVLKEGALEDFKNREKIADLLRFEST-KEGGYVTLAEYVERMKEGQKKIYYITG 426
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594 489 ESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKeGLELPEDEEEKKKMEESKAKFENLCKLMK 568
Cdd:COG0326 427 ESREAAEQSPHLEIFKAKGIEVLLLTDPIDEFLISHLEEFDGKKFKSVDS-GDLDLDKLEEKKESEEEEEEFKPLLERFK 505
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594 569 EILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAqalrdnstMGYMM--AKKHLEINPDHPIVETLRqkaeADK 646
Cdd:COG0326 506 EALGDKVKDVRVSARLTDSPACLVADEGDMSRRMEKMLKA--------MGQDMpeAKPILEINPNHPLVKKLA----AEE 573
                       650       660       670       680
                ....*....|....*....|....*....|....*....|...
gi 20149594 647 NDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLG 689
Cdd:COG0326 574 DEELFKDLAELLYDQALLAEGGLLEDPAAFVKRLNKLLEKALG 616
HATPase_Hsp90-like cd16927
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
23-209 1.58e-110

Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.


Pssm-ID: 340404 [Multi-domain]  Cd Length: 189  Bit Score: 332.56  E-value: 1.58e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  23 QLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNL 102
Cdd:cd16927   2 QLLDLIIHSLYSNKEIFLRELISNASDALDKLRYLSLTDPSLLDDDPELEIRISPDKENRTLTISDTGIGMTKEELINNL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594 103 GTIAKSGTKAFMEALQAGA-DISMIGQFGVGFYSAYLVAEKVVVITKHN-DDEQYAWESSAGGSFTVRADHGEPiGRGTK 180
Cdd:cd16927  82 GTIARSGTKAFLEALQEGAkDSDLIGQFGVGFYSAFMVADKVTVTTKSAgDDEGYRWESDGGGSYTIEEAEGEL-GRGTK 160
                       170       180
                ....*....|....*....|....*....
gi 20149594 181 VILHLKEDQTEYLEERRVKEVVKKHSQFI 209
Cdd:cd16927 161 ITLHLKEDAKEFLEEARIKELVKKYSDFI 189
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
35-186 2.99e-10

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 58.04  E-value: 2.99e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594     35 NKEIFLRELISNASDALDKIRYEsltdpskldsGKELKIDIIPNPQERTLTLVDTGIGMTKADLinnlgtiaksgTKAFM 114
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPE----------GGRITVTLERDGDHVEITVEDNGPGIPPEDL-----------EKIFE 59
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20149594    115 EALQAGADISMIGQFGVGFYSAYLVAEKVvvitkhnddeqyawessaGGSFTVRadhGEPiGRGTKVILHLK 186
Cdd:smart00387  60 PFFRTDKRSRKIGGTGLGLSIVKKLVELH------------------GGEISVE---SEP-GGGTTFTITLP 109
 
Name Accession Description Interval E-value
PTZ00272 PTZ00272
heat shock protein 83 kDa (Hsp83); Provisional
14-724 0e+00

heat shock protein 83 kDa (Hsp83); Provisional


Pssm-ID: 240341  Cd Length: 701  Bit Score: 934.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   14 TFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGM 93
Cdd:PTZ00272   4 TFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGESPRLCIRVVPDKENKTLTVEDNGIGM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   94 TKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGE 173
Cdd:PTZ00272  84 TKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVTSKNNSDESYVWESSAGGTFTITSTPES 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  174 PIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDeekpkIEDV 253
Cdd:PTZ00272 164 DMKRGTRITLHLKEDQMEYLEPRRLKELIKKHSEFIGYDIELMVEKTTEKEVTDEDEEDTKKADEDGEEPK-----VEEV 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  254 gsDEEDDSGKDKKKKTKKIKEKYIDQeelNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALL 333
Cdd:PTZ00272 239 --KEGDEGKKKKTKKVKEVTKEYEVQ---NKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLEFRSIM 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  334 FIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCL 413
Cdd:PTZ00272 314 FVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKCL 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  414 ELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQ 493
Cdd:PTZ00272 394 EMFDEVAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKAGQKSIYYITGDSKKK 473
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  494 VANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDK 573
Cdd:PTZ00272 474 LETSPFIEQARRRGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKQQREEEKAACEKLCKTMKEVLGD 553
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  574 KVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKD 653
Cdd:PTZ00272 554 KVEKVIVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMELNPRHPIIKELRRRVGADENDKAVKD 633
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20149594  654 LVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEvaaEEPNAAVPDEIPPLEGDEDASRMEEVD 724
Cdd:PTZ00272 634 LVFLLFDTSLLTSGFQLEDPTGYAERINRMIKLGLSLDEEE---EEAAEAPVAETAPAEVTAGTSSMEQVD 701
HSP90 pfam00183
Hsp90 protein;
191-712 0e+00

Hsp90 protein;


Pssm-ID: 459703  Cd Length: 516  Bit Score: 804.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   191 EYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEekpkIEDVGSDEEDdsgkdkkKKTK 270
Cdd:pfam00183   1 EYLEEKKIKELVKKYSEFINFPIYLWVEKEEEVEVPDEEEEEEEEEEEEEDDDPK----VEEEDEEEEK-------KKTK 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   271 KIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKK 350
Cdd:pfam00183  70 KVKETVWEWELLNKTKPIWTRNPKEVTEEEYAEFYKSLSKDWEDPLAVKHFSVEGEVEFKSLLFIPKRAPFDLFENKKKK 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   351 NNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFY 430
Cdd:pfam00183 150 NNIKLYVRRVFITDDFEDLIPEYLNFVKGVVDSDDLPLNVSRETLQQNKILKVIKKKLVRKALDMFKEIAEEKEDYKKFW 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   431 EAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEV 510
Cdd:pfam00183 230 KEFGKNLKLGIIEDSSNRNKLAKLLRFYSSKSGDELTSLDDYVSRMKEGQKHIYYITGESKEEVENSPFLERLKKKGYEV 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   511 VYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCC 590
Cdd:pfam00183 310 LYLTDPIDEYAVQQLKEFDGKKLVNVAKEGLELEEDEEEKKKDEELKKEFEPLTKWLKDVLGDKVEKVVVSNRLVDSPCV 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   591 IVTSTYGWTANMERIMKAQALR-DNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFS 669
Cdd:pfam00183 390 LVTSQYGWSANMERIMKAQALRkDSSMSSYMSSKKTLEINPRHPIIKELLKRVEADKDDKTAKDLALLLYETALLRSGFS 469
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 20149594   670 LEDPQTHSNRIYRMIKLGLGIDEDEVAAEEP----NAAVPDEIPPLE 712
Cdd:pfam00183 470 LEDPASFASRIYRMLKLGLGIDEDEIVEEEDeieeEEEEEEEEPEEE 516
PRK05218 PRK05218
heat shock protein 90; Provisional
14-689 0e+00

heat shock protein 90; Provisional


Pssm-ID: 235366 [Multi-domain]  Cd Length: 613  Bit Score: 746.55  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   14 TFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGM 93
Cdd:PRK05218   5 TGEFQAEVKQLLHLMIHSLYSNKEIFLRELISNASDAIDKLRFEALTDPALYEGDGDLKIRISFDKEARTLTISDNGIGM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   94 TKADLINNLGTIAKSGTKAFMEALQ--AGADISMIGQFGVGFYSAYLVAEKVVVITKH--NDDEQYAWESSAGGSFTVra 169
Cdd:PRK05218  85 TREEVIENLGTIAKSGTKEFLEKLKgdQKKDSQLIGQFGVGFYSAFMVADKVTVITRSagPAAEAVRWESDGEGEYTI-- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  170 dhgEPI---GRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPItlYLEKEREkeisddeaeeekgekeeedkddee 246
Cdd:PRK05218 163 ---EEIekeERGTEITLHLKEDEDEFLDEWRIRSIIKKYSDFIPVPI--KLEKEEE------------------------ 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  247 kpkiedvgsdeeddsgkdkkkktkkikekyidqEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQ 326
Cdd:PRK05218 214 ---------------------------------ETINSASALWTRSKSEITDEEYKEFYKHLAHDFDDPLFWIHNNVEGP 260
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  327 LEFRALLFIPRRAPFDLFENKKKKNNIkLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRK 406
Cdd:PRK05218 261 FEYTGLLYIPKKAPFDLFNRDRKGGLK-LYVKRVFIMDDAEELLPEYLRFVKGVIDSEDLPLNVSREILQEDRVVKKIRK 339
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  407 NIVKKCLELFSELAE-DKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGdEMTSLSEYVSRMKETQKSIYY 485
Cdd:PRK05218 340 AITKKVLDELEKLAKnDREKYEKFWKEFGPVLKEGLYEDFANREKLAKLLRFASTHEG-KYVSLAEYVERMKEGQKKIYY 418
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  486 ITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLE-LPEDEEEKKKMEESKAKFENLC 564
Cdd:PRK05218 419 ITGDSREAAKNSPHLELFKKKGIEVLLLTDPIDEFWISYLEEFDGKPFKSVARGDLDlGKEDEEEKEEKEEAEEEFKPLL 498
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  565 KLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQAlrdnstMGYMMAKKHLEINPDHPIVETLRQkaea 644
Cdd:PRK05218 499 ERLKEALGDKVKDVRLSHRLTDSPACLVADEGDMSTQMEKLLKAAG------QEVPESKPILEINPNHPLVKKLAD---- 568
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*
gi 20149594  645 DKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLG 689
Cdd:PRK05218 569 EADEAKFKDLAELLYDQALLAEGGSLEDPAAFVKRLNELLLKLLA 613
HtpG COG0326
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
14-689 0e+00

Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440095 [Multi-domain]  Cd Length: 616  Bit Score: 729.23  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  14 TFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGM 93
Cdd:COG0326   5 TGEFQAEVKQLLDLMIHSLYSNKEIFLRELISNASDAIDKLRFLALTDPELKEEDGDLKIRIEVDKEAKTLTISDNGIGM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  94 TKADLINNLGTIAKSGTKAFMEALQ--AGADISMIGQFGVGFYSAYLVAEKVVVITKH--NDDEQYAWESSAGGSFTVRA 169
Cdd:COG0326  85 TREEVIENLGTIAKSGTREFLEKLKgdQKKDSDLIGQFGVGFYSAFMVADKVEVVTRSagEDAEAVRWESDGDGEYTIEE 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594 170 dhGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPItlYLEKEREKEISDdeaeeekgekeeedkddeekpk 249
Cdd:COG0326 165 --AEKAERGTEITLHLKEDAEEFLEEWRLREIIKKYSDFIPVPI--KMEGEEEETEED---------------------- 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594 250 iedvgsdeeddsgkdkkkktkkikekyidqEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEF 329
Cdd:COG0326 219 ------------------------------ETINSATALWTRSKSEITDEEYKEFYKHLFHDFEDPLFWIHLNVEGPFEY 268
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594 330 RALLFIPRRAPFDLFENKKKKNNIkLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIV 409
Cdd:COG0326 269 TGLLYIPKKAPFDLYDRDRKGGIK-LYVKRVFIMDDAEDLLPEYLRFVRGVVDSPDLPLNVSREILQEDRQLKKIRKAIT 347
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594 410 KKCLELFSELAE-DKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSqSGDEMTSLSEYVSRMKETQKSIYYITG 488
Cdd:COG0326 348 KKVLDELEKLAKnDREKYEKFWKEFGLVLKEGALEDFKNREKIADLLRFEST-KEGGYVTLAEYVERMKEGQKKIYYITG 426
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594 489 ESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKeGLELPEDEEEKKKMEESKAKFENLCKLMK 568
Cdd:COG0326 427 ESREAAEQSPHLEIFKAKGIEVLLLTDPIDEFLISHLEEFDGKKFKSVDS-GDLDLDKLEEKKESEEEEEEFKPLLERFK 505
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594 569 EILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAqalrdnstMGYMM--AKKHLEINPDHPIVETLRqkaeADK 646
Cdd:COG0326 506 EALGDKVKDVRVSARLTDSPACLVADEGDMSRRMEKMLKA--------MGQDMpeAKPILEINPNHPLVKKLA----AEE 573
                       650       660       670       680
                ....*....|....*....|....*....|....*....|...
gi 20149594 647 NDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLG 689
Cdd:COG0326 574 DEELFKDLAELLYDQALLAEGGLLEDPAAFVKRLNKLLEKALG 616
PTZ00130 PTZ00130
heat shock protein 90; Provisional
17-693 2.92e-165

heat shock protein 90; Provisional


Pssm-ID: 185466 [Multi-domain]  Cd Length: 814  Bit Score: 496.10  E-value: 2.92e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   17 FQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKA 96
Cdd:PTZ00130  70 YQTEVTRLMDIIVNSLYTQKEVFLRELISNAADALEKIRFLSLSDESVLGEEKKLEIRISANKEKNILSITDTGIGMTKE 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   97 DLINNLGTIAKSGTKAFMEAL-QAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRAD-HGEP 174
Cdd:PTZ00130 150 DLINNLGTIAKSGTSNFLEAIsKSGGDMSLIGQFGVGFYSAFLVADKVIVYTKNNNDEQYIWESTADAKFTIYKDpRGST 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  175 IGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEIsddeaeeekgeKEEEDKDDEEKPKIEDVG 254
Cdd:PTZ00130 230 LKRGTRISLHLKEDATNLMNDKKLVDLISKYSQFIQYPIYLLHENVYTEEV-----------LADIAKEMENDPNYDSVK 298
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  255 SDEEDDSGKDKKKKTKKIKEKYIdqeeLNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF 334
Cdd:PTZ00130 299 VEETDDPNKKTRTVEKKVKKWKL----MNEQKPIWLRPPKELTDEDYKKFFSVLSGFNDEPLYHIHFFAEGEIEFKCLIY 374
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  335 IPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLE 414
Cdd:PTZ00130 375 IPSRAPSINDHLFTKQNSIKLYVRRVLVADEFVEFLPRYMSFVKGVVDSDDLPLNVSREQLQQNKILKAVSKRIVRKILD 454
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  415 LFSEL-AEDKEN-----------------------------YKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGD 464
Cdd:PTZ00130 455 TFRTLyKEGKKNketlraelaketdeekkkeiqkkinepstYKLIYKEYRKYLKTGCYEDDINRNKIVKLLLFKTMLHPK 534
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  465 EMtSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELP 544
Cdd:PTZ00130 535 SI-SLDTYIENMKPDQKFIYYASGDSYEYLSKIPQLQIFKKKNIDVVFLTESVDESCVQRVQEYDGKKFKSIQKGEITFE 613
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  545 EDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQaLRDNSTMGYMMAKK 624
Cdd:PTZ00130 614 LTEDEKKKEEKVKKMYKALIDVISDTLRNQIFKVEISRRLVDAPCAVVSTEWGLSGQMEKLMKIN-VNNSDQIKAMSGQK 692
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20149594  625 HLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDED 693
Cdd:PTZ00130 693 ILEINPDHPIMIDLLKRSVSNPKDSQLTESIKIIYQSAKLASGFDLEDTADLAQIVYDHINQKLGVDNN 761
HATPase_Hsp90-like cd16927
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
23-209 1.58e-110

Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.


Pssm-ID: 340404 [Multi-domain]  Cd Length: 189  Bit Score: 332.56  E-value: 1.58e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  23 QLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNL 102
Cdd:cd16927   2 QLLDLIIHSLYSNKEIFLRELISNASDALDKLRYLSLTDPSLLDDDPELEIRISPDKENRTLTISDTGIGMTKEELINNL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594 103 GTIAKSGTKAFMEALQAGA-DISMIGQFGVGFYSAYLVAEKVVVITKHN-DDEQYAWESSAGGSFTVRADHGEPiGRGTK 180
Cdd:cd16927  82 GTIARSGTKAFLEALQEGAkDSDLIGQFGVGFYSAFMVADKVTVTTKSAgDDEGYRWESDGGGSYTIEEAEGEL-GRGTK 160
                       170       180
                ....*....|....*....|....*....
gi 20149594 181 VILHLKEDQTEYLEERRVKEVVKKHSQFI 209
Cdd:cd16927 161 ITLHLKEDAKEFLEEARIKELVKKYSDFI 189
PRK14083 PRK14083
HSP90 family protein; Provisional
16-408 3.77e-32

HSP90 family protein; Provisional


Pssm-ID: 237603 [Multi-domain]  Cd Length: 601  Bit Score: 132.37  E-value: 3.77e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   16 AFQAEIAQLMSLIINTFYSNKEIFLRELISNASDAldkIRYESLTDPSKldsgkELKIDIIP-NPQERTLTLVDTGIGMT 94
Cdd:PRK14083   4 RFQVDLRGVIDLLSRHLYSSPRVYVRELLQNAVDA---ITARRALDPTA-----PGRIRIELtDAGGGTLIVEDNGIGLT 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594   95 KADLINNLGTIAKSGTKAfmEALQAGADiSMIGQFGVGFYSAYLVAEKVVVITKHNDDEQ-YAWESSAGGSFTVRADHGE 173
Cdd:PRK14083  76 EEEVHEFLATIGRSSKRD--ENLGFARN-DFLGQFGIGLLSCFLVADEIVVVSRSAKDGPaVEWRGKADGTYSVRKLETE 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  174 PIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITlylekerekeisddeaeeekgekeeedkddeekpkIEDv 253
Cdd:PRK14083 153 RAEPGTTVYLRPRPDAEEWLERETVEELAKKYGSLLPVPIR-----------------------------------VEG- 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  254 gsdeeddsgkdkkkktkkikekyiDQEELNKTKPIWTRNPDDITQE-----EYGEfyKSLTNDWEDH--LAVKHFSVEGq 326
Cdd:PRK14083 197 ------------------------EKGGVNETPPPWTRDYPDPETRreallAYGE--ELLGFTPLDVipLDVPSGGLEG- 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594  327 lefrALLFIPRRAPFdlfenkKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRK 406
Cdd:PRK14083 250 ----VAYVLPYAVSP------AARRKHRVYLKRMLLSEEAENLLPDWAFFVRCVVNTDELRPTASREALYEDDALAAVRE 319

                 ..
gi 20149594  407 NI 408
Cdd:PRK14083 320 EL 321
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
35-186 2.99e-10

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 58.04  E-value: 2.99e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594     35 NKEIFLRELISNASDALDKIRYEsltdpskldsGKELKIDIIPNPQERTLTLVDTGIGMTKADLinnlgtiaksgTKAFM 114
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPE----------GGRITVTLERDGDHVEITVEDNGPGIPPEDL-----------EKIFE 59
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20149594    115 EALQAGADISMIGQFGVGFYSAYLVAEKVvvitkhnddeqyawessaGGSFTVRadhGEPiGRGTKVILHLK 186
Cdd:smart00387  60 PFFRTDKRSRKIGGTGLGLSIVKKLVELH------------------GGEISVE---SEP-GGGTTFTITLP 109
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
37-154 8.28e-07

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 48.87  E-value: 8.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594    37 EIFLRELISNASDAldkiryesltdpskldSGKELKIDIIPNPQERT-LTLVDTGIGMTKADLINNLGtIAKSGTKafme 115
Cdd:pfam13589   2 EGALAELIDNSIDA----------------DATNIKIEVNKNRGGGTeIVIEDDGHGMSPEELINALR-LATSAKE---- 60
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 20149594   116 alqAGADISMIGQFGVGFYSAYLV-AEKVVVITKHNDDEQ 154
Cdd:pfam13589  61 ---AKRGSTDLGRYGIGLKLASLSlGAKLTVTSKKEGKSS 97
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
35-189 2.41e-05

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 43.90  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149594    35 NKEIFLRELISNASDALDKIRYEsltdpskldsGKELKIDIIPnPQERTLTLVDTGIGMTKADLinnlgtiAKSGTKaFM 114
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAK----------AGEITVTLSE-GGELTLTVEDNGIGIPPEDL-------PRIFEP-FS 61
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20149594   115 EalqagADISMIGQFGVGFYSAYLVAEKVvvitkhnddeqyawessaGGSFTVRadhgEPIGRGTKVILHLKEDQ 189
Cdd:pfam02518  62 T-----ADKRGGGGTGLGLSIVRKLVELL------------------GGTITVE----SEPGGGTTVTLTLPLAQ 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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