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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 4
2001 4
2002 7
2003 20
2004 29
2005 27
2006 43
2007 51
2008 52
2009 49
2010 48
2011 65
2012 74
2013 71
2014 67
2015 78
2016 55
2017 57
2018 74
2019 81
2020 89
2021 81
2022 76
2023 107
2024 35

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1,183 results

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Page 1
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.
Konermann S, Brigham MD, Trevino AE, Joung J, Abudayyeh OO, Barcena C, Hsu PD, Habib N, Gootenberg JS, Nishimasu H, Nureki O, Zhang F. Konermann S, et al. Nature. 2015 Jan 29;517(7536):583-8. doi: 10.1038/nature14136. Epub 2014 Dec 10. Nature. 2015. PMID: 25494202 Free PMC article.
We also synthesized a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes that, upon activation, confer resistance to a BRAF inhibitor. ...
We also synthesized a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes that, upon a …
Database resources of the national center for biotechnology information.
Sayers EW, Bolton EE, Brister JR, Canese K, Chan J, Comeau DC, Connor R, Funk K, Kelly C, Kim S, Madej T, Marchler-Bauer A, Lanczycki C, Lathrop S, Lu Z, Thibaud-Nissen F, Murphy T, Phan L, Skripchenko Y, Tse T, Wang J, Williams R, Trawick BW, Pruitt KD, Sherry ST. Sayers EW, et al. Nucleic Acids Res. 2022 Jan 7;50(D1):D20-D26. doi: 10.1093/nar/gkab1112. Nucleic Acids Res. 2022. PMID: 34850941 Free PMC article.
Resources receiving significant updates in the past year include PubMed, PMC, Bookshelf, RefSeq, SRA, Virus, dbSNP, dbVar, ClinicalTrials.gov, MMDB, iCn3D and PubChem. ...
Resources receiving significant updates in the past year include PubMed, PMC, Bookshelf, RefSeq, SRA, Virus, dbSNP, dbVar, ClinicalTr …
CDD/SPARCLE: the conserved domain database in 2020.
Lu S, Wang J, Chitsaz F, Derbyshire MK, Geer RC, Gonzales NR, Gwadz M, Hurwitz DI, Marchler GH, Song JS, Thanki N, Yamashita RA, Yang M, Zhang D, Zheng C, Lanczycki CJ, Marchler-Bauer A. Lu S, et al. Nucleic Acids Res. 2020 Jan 8;48(D1):D265-D268. doi: 10.1093/nar/gkz991. Nucleic Acids Res. 2020. PMID: 31777944 Free PMC article.
CDD staff has continued to characterize protein families via conserved domain architectures and has built up a significant corpus of curated domain architectures in support of naming bacterial proteins in RefSeq. These architecture definitions are available via SPARCLE, th …
CDD staff has continued to characterize protein families via conserved domain architectures and has built up a significant corpus of curated …
Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation.
O'Leary NA, Wright MW, Brister JR, Ciufo S, Haddad D, McVeigh R, Rajput B, Robbertse B, Smith-White B, Ako-Adjei D, Astashyn A, Badretdin A, Bao Y, Blinkova O, Brover V, Chetvernin V, Choi J, Cox E, Ermolaeva O, Farrell CM, Goldfarb T, Gupta T, Haft D, Hatcher E, Hlavina W, Joardar VS, Kodali VK, Li W, Maglott D, Masterson P, McGarvey KM, Murphy MR, O'Neill K, Pujar S, Rangwala SH, Rausch D, Riddick LD, Schoch C, Shkeda A, Storz SS, Sun H, Thibaud-Nissen F, Tolstoy I, Tully RE, Vatsan AR, Wallin C, Webb D, Wu W, Landrum MJ, Kimchi A, Tatusova T, DiCuccio M, Kitts P, Murphy TD, Pruitt KD. O'Leary NA, et al. Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45. doi: 10.1093/nar/gkv1189. Epub 2015 Nov 8. Nucleic Acids Res. 2016. PMID: 26553804 Free PMC article.
The RefSeq project at the National Center for Biotechnology Information (NCBI) maintains and curates a publicly available database of annotated genomic, transcript, and protein sequence records (http://www.ncbi.nlm.nih.gov/refseq/). ...The RefSeq project augm …
The RefSeq project at the National Center for Biotechnology Information (NCBI) maintains and curates a publicly available database of …
In silico PCR primer designing and validation.
Kumar A, Chordia N. Kumar A, et al. Methods Mol Biol. 2015;1275:143-51. doi: 10.1007/978-1-4939-2365-6_10. Methods Mol Biol. 2015. PMID: 25697657
For designing the primer, DNA template sequence is required that can be taken from any of the available sequence databases, e.g., RefSeq database. The in silico validation can be carried out using BLAST tool and Gene Runner software, which check their efficiency and specif …
For designing the primer, DNA template sequence is required that can be taken from any of the available sequence databases, e.g., RefSeq …
The Gut Virome Database Reveals Age-Dependent Patterns of Virome Diversity in the Human Gut.
Gregory AC, Zablocki O, Zayed AA, Howell A, Bolduc B, Sullivan MB. Gregory AC, et al. Cell Host Microbe. 2020 Nov 11;28(5):724-740.e8. doi: 10.1016/j.chom.2020.08.003. Epub 2020 Aug 24. Cell Host Microbe. 2020. PMID: 32841606 Free PMC article.
The GVD contains 33,242 unique viral populations (approximately species-level taxa) and improves average viral detection rates over viral RefSeq and IMG/VR nearly 182-fold and 2.6-fold, respectively. GVD meta-analyses show highly personalized viromes, reveal that inter-stu …
The GVD contains 33,242 unique viral populations (approximately species-level taxa) and improves average viral detection rates over viral …
Managing Sequence Data.
O'Sullivan C, Busby B, Mizrachi IK. O'Sullivan C, et al. Methods Mol Biol. 2017;1525:79-106. doi: 10.1007/978-1-4939-6622-6_4. Methods Mol Biol. 2017. PMID: 27896718
Herpesvirus systematics.
Davison AJ. Davison AJ. Vet Microbiol. 2010 Jun 16;143(1):52-69. doi: 10.1016/j.vetmic.2010.02.014. Epub 2010 Feb 11. Vet Microbiol. 2010. PMID: 20346601 Free PMC article.
In contrast, secondary databases are open to curation by experts other than the original depositors, thus increasing the likelihood that they will remain up to date. One of the most promising secondary databases is RefSeq, which aims to furnish the best available annotatio …
In contrast, secondary databases are open to curation by experts other than the original depositors, thus increasing the likelihood that the …
Trait biases in microbial reference genomes.
Albright S, Louca S. Albright S, et al. Sci Data. 2023 Feb 9;10(1):84. doi: 10.1038/s41597-023-01994-7. Sci Data. 2023. PMID: 36759614 Free PMC article.
To address this gap, here we use 116,884 publicly available metagenome-assembled genomes (MAGs, completeness 80%) from 203 surveys worldwide as a culture-independent sample of bacterial and archaeal diversity, and compare these MAGs to the popular RefSeq genome database, w …
To address this gap, here we use 116,884 publicly available metagenome-assembled genomes (MAGs, completeness 80%) from 203 surveys worldwide …
Update on RefSeq microbial genomes resources.
Tatusova T, Ciufo S, Federhen S, Fedorov B, McVeigh R, O'Neill K, Tolstoy I, Zaslavsky L. Tatusova T, et al. Nucleic Acids Res. 2015 Jan;43(Database issue):D599-605. doi: 10.1093/nar/gku1062. Epub 2014 Dec 15. Nucleic Acids Res. 2015. PMID: 25510495 Free PMC article.
NCBI RefSeq genome collection http://www.ncbi.nlm.nih.gov/genome represents all three major domains of life: Eukarya, Bacteria and Archaea as well as Viruses. ...A number of improvements have been incorporated into the Prokaryotic Genome Annotation Pipeline. Several new fe …
NCBI RefSeq genome collection http://www.ncbi.nlm.nih.gov/genome represents all three major domains of life: Eukarya, Bacteria and Ar …
1,183 results