Markers of inflammation: data from the MOSAIC randomised trial of CPAP for minimally symptomatic OSA

J R Stradling; S E Craig; M Kohler; D Nicoll; L Ayers; A J Nunn; D J Bratton

doi:10.1136/thoraxjnl-2014-205958

Markers of inflammation: data from the MOSAIC randomised trial of CPAP for minimally symptomatic OSA

Thorax. 2015 Feb;70(2):181-2. doi: 10.1136/thoraxjnl-2014-205958. Epub 2014 Sep 2.

Authors

J R Stradling¹, S E Craig¹, M Kohler², D Nicoll¹, L Ayers³, A J Nunn⁴, D J Bratton⁴

Affiliations

¹ Oxford Centre for Respiratory Medicine and Oxford Biomedical Research Centre, Churchill Hospital Campus, Oxford University Hospitals NHS Trust, Oxford, UK.
² Oxford Centre for Respiratory Medicine and Oxford Biomedical Research Centre, Churchill Hospital Campus, Oxford University Hospitals NHS Trust, Oxford, UK Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland.
³ Department of Clinical Immunology, Churchill Hospital Campus, Oxford University Hospitals NHS Trust, Oxford, UK.
⁴ MRC Clinical Trials Unit at UCL, Aviation House, London, UK.

PMID: 25182045
DOI: 10.1136/thoraxjnl-2014-205958

Abstract

The Multi-centre Obstructive Sleep Apnoea Interventional Cardiovascular (MOSAIC) trial compared 6 months of CPAP therapy, versus no CPAP, in 391 patients with minimally symptomatic obstructive sleep apnoea (OSA). We now report some exploratory outcomes, markers of systemic inflammation (interleukin 6 (IL-6), IL-10, C reactive protein, tumour necrosis factor). We found no consistent changes (all p values >0.13).

Trial registration number: ISRCTN 34164388.

Keywords: Cytokine Biology; Sleep apnoea.

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Publication types

Letter
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
C-Reactive Protein / metabolism*
Continuous Positive Airway Pressure
Humans
Inflammation / blood*
Inflammation / etiology
Interleukin-10 / blood*
Interleukin-6 / blood*
Patient Compliance
Sleep Apnea, Obstructive / complications*
Sleep Apnea, Obstructive / therapy
Tumor Necrosis Factor-alpha / blood*

Substances

Biomarkers
Interleukin-6
Tumor Necrosis Factor-alpha
Interleukin-10
C-Reactive Protein

Associated data

ISRCTN/ISRCTN34164388

Abstract

Publication types

MeSH terms

Substances

Associated data

Grants and funding