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Volume 5(3);  2024 May 1

Articles from this journal are generally available in PMC after a 6-month delay (embargo); however, the delay may vary at the discretion of the publisher.

News in Depth

Q&A: Owen Witte on Translational Research in Cancer
Blood Cancer Discov. 2024 May 1; 5(3): 136–138. doi: 10.1158/2643-3230.BCD-24-0069
PMCID:
PMC11061582

In the Spotlight

Hematopoietic Clonal Evolution Goes Spatial
Rebecca Austin, Iannis Aifantis
Blood Cancer Discov. 2024 May 1; 5(3): 139–141. Published online 2024 May 1. doi: 10.1158/2643-3230.BCD-24-0057
PMCID:
PMC11061586
“Myeloid” Mutations in ALL Are Not Uncommon: Implications for Etiology and Therapies
Ilaria Iacobucci
Blood Cancer Discov. 2024 May 1; 5(3): 142–145. Published online 2024 May 1. doi: 10.1158/2643-3230.BCD-24-0015
PMCID:
PMC11061583

In Focus

Round Table Discussion on Optimal Clinical Trial Design in Precursor Multiple Myeloma
Irene M. Ghobrial, Nicole Gormley, Shaji K. Kumar, Maria-Victoria Mateos, P. Leif Bergsagel, Marta Chesi, Madhav V. Dhodapkar, Angela Dispenzieri, Rafael Fonseca, Gad Getz, Efstathios Kastritis, Sigurdur Y. Kristinsson, Jose Angel Martinez-Climent, Salomon Manier, Catherine R. Marinac, Francesco Maura, Gareth J. Morgan, Faith E. Davies, Omar Nadeem, Mario Nuvolone, Bruno Paiva, Elizabeth O'Donnell, Felipe Prosper, Urvi A. Shah, Romanos Sklavenitis-Pistofidis, Adam S. Sperling, George S. Vassiliou, Nikhil C. Munshi, Philip E. Castle, Kenneth C. Anderson, Jesus F. San Miguel
Blood Cancer Discov. 2024 May 1; 5(3): 146–152. Published online 2024 May 1. doi: 10.1158/2643-3230.BCD-24-0022
PMCID:
PMC11061588

Research Brief

Spatial Mapping of Hematopoietic Clones in Human Bone Marrow
Andrew L. Young, Hannah C. Davis, Maggie J. Cox, Tyler M. Parsons, Samantha C. Burkart, Diane E. Bender, Lulu Sun, Stephen T. Oh, Grant A. Challen
Blood Cancer Discov. 2024 May 1; 5(3): 153–163. Published online 2024 Mar 14. doi: 10.1158/2643-3230.BCD-23-0110
PMCID:
PMC11062237

Research Articles

Acute Lymphoblastic Leukemia with Myeloid Mutations Is a High-Risk Disease Associated with Clonal Hematopoiesis
Caner Saygin, Pu Zhang, Jacob Stauber, Ibrahim Aldoss, Adam S. Sperling, Lachelle D. Weeks, Marlise R. Luskin, Todd C. Knepper, Pankhuri Wanjari, Peng Wang, Angela M. Lager, Carrie Fitzpatrick, Jeremy P. Segal, Mehdi Gharghabi, Sandeep Gurbuxani, Girish Venkataraman, Jason X. Cheng, Bart J. Eisfelder, Oliver Bohorquez, Anand A. Patel, Sheethal Umesh Nagalakshmi, Savita Jayaram, Olatoyosi M. Odenike, Richard A. Larson, Lucy A. Godley, Daniel A. Arber, Christopher J. Gibson, Nikhil C. Munshi, Guido Marcucci, Benjamin L. Ebert, John M. Greally, Ulrich Steidl, Rosa Lapalombella, Bijal D. Shah, Wendy Stock
Blood Cancer Discov. 2024 May 1; 5(3): 164–179. Published online 2023 Dec 26. doi: 10.1158/2643-3230.BCD-23-0106
PMCID:
PMC11061587
Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts
Elyse A. Olesinski, Karanpreet Singh Bhatia, Chuqi Wang, Marissa S. Pioso, Xiao Xian Lin, Ahmed M. Mamdouh, Shu Xuan Ng, Vedant Sandhu, Shaista Shabbir Jasdanwala, Binyam Yilma, Stephan Bohl, Jeremy A. Ryan, Disha Malani, Marlise R. Luskin, Olli Kallioniemi, Kimmo Porkka, Sophia Adamia, Wee Joo Chng, Motomi Osato, David M. Weinstock, Jacqueline S. Garcia, Anthony Letai, Shruti Bhatt
Blood Cancer Discov. 2024 May 1; 5(3): 180–201. Published online 2024 May 1. doi: 10.1158/2643-3230.BCD-24-0001
PMCID:
PMC11061585
Human ASXL1-Mutant Hematopoiesis Is Driven by a Truncated Protein Associated with Aberrant Deubiquitination of H2AK119
Thomas Köhnke, Kevin A. Nuno, Catherine C. Alder, Eric J. Gars, Paul Phan, Amy C. Fan, Ravindra Majeti
Blood Cancer Discov. 2024 May 1; 5(3): 202–223. Published online 2024 Feb 14. doi: 10.1158/2643-3230.BCD-23-0235
PMCID:
PMC11061584

Articles from Blood Cancer Discovery are provided here courtesy of American Association for Cancer Research